full name
ring finger and WD repeat domain 2

synonyms
COP1, RNF200, RP11-318C24.3, RFWD2, ENSG00000143207

HGNC
HGNC:17440

Entrez Gene
Gene:64326

ENSEMBL
ENSG00000143207

location
chr: 1
start: 175913967
stop: 176176386
strand: -

transcripts
NM_001001740.2
NM_022457.5

pathways
Autodegradation of the E3 ubiquitin ligase COP1 [NCBI:1269747] [REACTOME:R-HSA-349425] [PUBMED:16931761]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle Checkpoints [NCBI:1269742] [REACTOME:R-HSA-69620]
Direct p53 effectors [NCBI:137939] [Pathway Interaction Database:p53downstreampathway] [PUBMED:7479001] [PUBMED:19626115] [PUBMED:10692390] [PUBMED:15289308] [PUBMED:14688482] [PUBMED:16301995] [PUBMED:11850816] [PUBMED:12370809] [PUBMED:16260627] [PUBMED:15186775] [PUBMED:15580302] [PUBMED:10748162] [PUBMED:10919640] [PUBMED:19011621] [PUBMED:12438652] [PUBMED:11559530] [PUBMED:11641774] [PUBMED:11971958] [PUBMED:9659898] [PUBMED:9343394] [PUBMED:10716435] [PUBMED:17146433] [PUBMED:17719542] [PUBMED:17938176] [PUBMED:17409421] [PUBMED:11032029] [PUBMED:15781865] [PUBMED:11463392] [PUBMED:9736732] [PUBMED:17268548] [PUBMED:8570655] [PUBMED:18046411] [PUBMED:12944906] [PUBMED:16249378] [PUBMED:15273740] [PUBMED:15598651] [PUBMED:10618379] [PUBMED:15958553] [PUBMED:17189187] [PUBMED:17145718] [PUBMED:11988847] [PUBMED:8119988] [PUBMED:12089322] [PUBMED:16286009] [PUBMED:12890671] [PUBMED:12402042] [PUBMED:10618714] [PUBMED:14730312] [PUBMED:12857899] [PUBMED:14963330] [PUBMED:11278953] [PUBMED:11973653] [PUBMED:12692263] [PUBMED:10984493] [PUBMED:10640990] [PUBMED:11545734] [PUBMED:16151013] [PUBMED:12372430] [PUBMED:16651407] [PUBMED:9891062] [PUBMED:12606722] [PUBMED:12453409] [PUBMED:15377670] [PUBMED:12667443] [PUBMED:17707234] [PUBMED:9920903] [PUBMED:14992722] [PUBMED:15790310] [PUBMED:15831478] [PUBMED:11314010] [PUBMED:10329733] [PUBMED:17264218] [PUBMED:11511362] [PUBMED:11919562] [PUBMED:11814693] [PUBMED:17554199] [PUBMED:18250150] [PUBMED:10518217] [PUBMED:10891498] [PUBMED:10973264] [PUBMED:15077116] [PUBMED:16230375] [PUBMED:18485870] [PUBMED:7796420] [PUBMED:15710382] [PUBMED:17409411] [PUBMED:8319905] [PUBMED:10684646] [PUBMED:7566179] [PUBMED:8887630] [PUBMED:11807984] [PUBMED:9841917] [PUBMED:12654245] [PUBMED:9023107] [PUBMED:15103385] [PUBMED:11684014] [PUBMED:17110336] [PUBMED:11278253] [PUBMED:14576823] [PUBMED:8418500] [PUBMED:11350971] [PUBMED:11840333] [PUBMED:7651818] [PUBMED:7651386] [PUBMED:15378026] [PUBMED:15607964] [PUBMED:11279192] [PUBMED:10777218] [PUBMED:15334053] [PUBMED:12138177] [PUBMED:9619826] [PUBMED:16278683] [PUBMED:17189186] [PUBMED:16140933] [PUBMED:10094469] [PUBMED:9926927] [PUBMED:17719541] [PUBMED:15735003] [PUBMED:12853982] [PUBMED:14707288] [PUBMED:10777207]
G1/S DNA Damage Checkpoints [NCBI:1269743] [REACTOME:R-HSA-69615]
Stabilization of p53 [NCBI:1269746] [REACTOME:R-HSA-69541] [PUBMED:11331603] [PUBMED:10673500] [PUBMED:10673501] [PUBMED:10710310]
Ubiquitin mediated proteolysis [NCBI:83056] [KEGG:hsa04120] [PUBMED:16405856] [PUBMED:12944364] [PUBMED:16922408] [PUBMED:17588513] [PUBMED:16922367] [PUBMED:16922370] [PUBMED:16816840]
p53 pathway [NCBI:138067] [Pathway Interaction Database:p53regulationpathway] [PUBMED:9153395] [PUBMED:15448695] [PUBMED:10734067] [PUBMED:11340074] [PUBMED:15525938] [PUBMED:17189186] [PUBMED:18454141] [PUBMED:11715018] [PUBMED:9733514] [PUBMED:12963717] [PUBMED:15989956] [PUBMED:10581258] [PUBMED:18566590] [PUBMED:15029243] [PUBMED:14612427] [PUBMED:19011621] [PUBMED:12842086] [PUBMED:16377624] [PUBMED:17268548] [PUBMED:16845383] [PUBMED:17534149] [PUBMED:12397361] [PUBMED:11740489] [PUBMED:12110584] [PUBMED:11713287] [PUBMED:17646389] [PUBMED:14654783] [PUBMED:9153396] [PUBMED:18243116] [PUBMED:10673501] [PUBMED:17719542] [PUBMED:11983168] [PUBMED:12397362] [PUBMED:17189187] [PUBMED:16757976] [PUBMED:12667443] [PUBMED:9733515] [PUBMED:9878046] [PUBMED:9363941] [PUBMED:11504915] [PUBMED:11359766] [PUBMED:9529248] [PUBMED:17936559] [PUBMED:15210108] [PUBMED:17293853] [PUBMED:16107876] [PUBMED:9724636] [PUBMED:17707234] [PUBMED:10606744] [PUBMED:11780126] [PUBMED:10821866] [PUBMED:18485870] [PUBMED:17110336] [PUBMED:11046142] [PUBMED:11331603] [PUBMED:19597489] [PUBMED:16163388] [PUBMED:14671306] [PUBMED:17108971] [PUBMED:15242646] [PUBMED:15314173] [PUBMED:12654245] [PUBMED:15308643] [PUBMED:9744860] [PUBMED:17906639] [PUBMED:9891054] [PUBMED:17098746] [PUBMED:17349958] [PUBMED:11030628] [PUBMED:15103385] [PUBMED:14744935] [PUBMED:9529249] [PUBMED:11283254] [PUBMED:11606419] [PUBMED:11078726] [PUBMED:10611322] [PUBMED:9288740] [PUBMED:11127820] [PUBMED:19357310] [PUBMED:9450543]
p53 signaling pathway [NCBI:83055] [KEGG:hsa04115] [PUBMED:16557269] [PUBMED:10714958] [PUBMED:12505356] [PUBMED:16915296] [PUBMED:16697662] [PUBMED:15116721] [PUBMED:11313928] [PUBMED:11747320] [PUBMED:17409411] [PUBMED:15838523]
p53-Dependent G1 DNA Damage Response [NCBI:1269745] [REACTOME:R-HSA-69563] [PUBMED:9153396] [PUBMED:8247533] [PUBMED:1423616] [PUBMED:9153395]
p53-Dependent G1/S DNA damage checkpoint [NCBI:1269744] [REACTOME:R-HSA-69580] [PUBMED:1323840]