full name
Ras protein specific guanine nucleotide releasing factor 1
synonyms
CDC25, CDC25L, GNRP, GRF1, GRF55, H-GRF55, PP13187, ras-GRF1, RASGRF1, ENSG00000058335
HGNC
HGNC:9875
Entrez Gene
Gene:5923
ENSEMBL
ENSG00000058335
location
chr: 15
start: 79252289
stop: 79383215
strand: -
transcripts
NM_001145648.1
NM_002891.4
NM_153815.2
pathways
ARMS-mediated activation
[NCBI:1269471]
[REACTOME:R-HSA-170984]
[PUBMED:9069267]
Activation of NMDA receptor upon glutamate binding and postsynaptic events
[NCBI:1268798]
[REACTOME:R-HSA-442755]
[PUBMED:18616423]
Axon guidance
[NCBI:83065]
[KEGG:hsa04360]
[NCBI:1270303]
[REACTOME:R-HSA-422475]
[PUBMED:14682358]
[PUBMED:15084255]
[PUBMED:11687826]
[PUBMED:15818466]
[PUBMED:15363605]
[PUBMED:12471249]
[PUBMED:15630019]
[PUBMED:11891122]
[PUBMED:15960985]
[PUBMED:12677003]
CDC42 signaling events
[NCBI:137994]
[Pathway Interaction Database:cdc42_pathway]
[PUBMED:7629060]
[PUBMED:7652575]
[PUBMED:8653792]
[PUBMED:18448434]
[PUBMED:19822663]
[PUBMED:19454477]
[PUBMED:18662680]
[PUBMED:15882626]
[PUBMED:11948177]
[PUBMED:9860974]
[PUBMED:15225553]
[PUBMED:8643625]
[PUBMED:8107774]
[PUBMED:8670801]
[PUBMED:8034624]
[PUBMED:10934474]
[PUBMED:10734320]
[PUBMED:17522712]
[PUBMED:11525734]
[PUBMED:15649357]
[PUBMED:10473551]
[PUBMED:16157700]
[PUBMED:9822598]
[PUBMED:15723051]
[PUBMED:7600582]
[PUBMED:18319301]
[PUBMED:9042860]
[PUBMED:10613909]
[PUBMED:17580073]
[PUBMED:12745076]
[PUBMED:16253996]
[PUBMED:10840034]
[PUBMED:10360579]
[PUBMED:11907268]
[PUBMED:10934475]
[PUBMED:10219243]
[PUBMED:17038317]
[PUBMED:8910292]
[PUBMED:9403696]
[PUBMED:11285260]
[PUBMED:10995437]
[PUBMED:9368021]
[PUBMED:14970210]
[PUBMED:9694656]
[PUBMED:14505571]
[PUBMED:17115031]
[PUBMED:9317150]
[PUBMED:14653992]
[PUBMED:17081755]
[PUBMED:12676083]
[PUBMED:18216334]
[PUBMED:19826000]
[PUBMED:8702968]
[PUBMED:11304531]
[PUBMED:10973943]
[PUBMED:11309380]
[PUBMED:18586681]
[PUBMED:15479449]
[PUBMED:19097998]
[PUBMED:16892055]
[PUBMED:17244649]
[PUBMED:8625410]
[PUBMED:8497321]
[PUBMED:15485841]
[PUBMED:16407834]
[PUBMED:11804587]
[PUBMED:9867866]
[PUBMED:10747870]
[PUBMED:7600581]
[PUBMED:12610628]
[PUBMED:19435802]
[PUBMED:15572110]
[PUBMED:7592586]
[PUBMED:11696321]
[PUBMED:10559936]
CREB phosphorylation through the activation of Ras
[NCBI:1268801]
[REACTOME:R-HSA-442742]
[PUBMED:12819448]
Cytokine Signaling in Immune system
[NCBI:1269310]
[REACTOME:R-HSA-1280215]
[PUBMED:12613569]
DAP12 interactions
[NCBI:1269283]
[REACTOME:R-HSA-2172127]
[PUBMED:19120482]
[PUBMED:17220916]
[PUBMED:9490415]
[PUBMED:18192027]
[PUBMED:15884055]
DAP12 signaling
[NCBI:1269284]
[REACTOME:R-HSA-2424491]
[PUBMED:15884055]
[PUBMED:17110943]
[PUBMED:17220916]
Developmental Biology
[NCBI:1270302]
[REACTOME:R-HSA-1266738]
Downstream signal transduction
[NCBI:1269479]
[REACTOME:R-HSA-186763]
[PUBMED:10508235]
[PUBMED:9739761]
FCERI mediated MAPK activation
[NCBI:1269299]
[REACTOME:R-HSA-2871796]
[PUBMED:19290926]
[PUBMED:19909365]
[PUBMED:17122878]
Fc epsilon receptor (FCERI) signaling
[NCBI:1269298]
[REACTOME:R-HSA-2454202]
[PUBMED:15099567]
[PUBMED:21799019]
Focal adhesion
[NCBI:83067]
[KEGG:hsa04510]
[PUBMED:10698680]
[PUBMED:15459662]
[PUBMED:14756624]
[PUBMED:11573199]
[PUBMED:12640026]
[PUBMED:15179030]
[PUBMED:15108811]
[PUBMED:15053919]
[PUBMED:11082269]
[PUBMED:15034601]
[PUBMED:12235283]
[PUBMED:14519391]
[PUBMED:11146675]
[PUBMED:11229600]
[PUBMED:15688067]
[PUBMED:14744429]
[PUBMED:11882383]
Frs2-mediated activation
[NCBI:1269470]
[REACTOME:R-HSA-170968]
[PUBMED:9069267]
GRB2 events in EGFR signaling
[NCBI:1269382]
[REACTOME:R-HSA-179812]
[PUBMED:11706405]
[PUBMED:11498013]
Gastrin-CREB signalling pathway via PKC and MAPK
[NCBI:1269592]
[REACTOME:R-HSA-881907]
[PUBMED:10413847]
[PUBMED:7491953]
[PUBMED:17698287]
IGF1R signaling cascade
[NCBI:1269618]
[REACTOME:R-HSA-2428924]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22649417]
[PUBMED:21042815]
[PUBMED:18927274]
[PUBMED:20098959]
IRS-mediated signalling
[NCBI:1269431]
[REACTOME:R-HSA-112399]
IRS-related events triggered by IGF1R
[NCBI:1269620]
[REACTOME:R-HSA-2428928]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22649417]
[PUBMED:18927274]
[PUBMED:21042815]
[PUBMED:20098959]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Insulin receptor signalling cascade
[NCBI:1269429]
[REACTOME:R-HSA-74751]
[PUBMED:9677303]
[PUBMED:11282018]
Interleukin receptor SHC signaling
[NCBI:1269322]
[REACTOME:R-HSA-912526]
[PUBMED:8294403]
Interleukin-2 signaling
[NCBI:1269321]
[REACTOME:R-HSA-451927]
[PUBMED:17936914]
[PUBMED:18817510]
[PUBMED:19543225]
[PUBMED:18062768]
Interleukin-3, 5 and GM-CSF signaling
[NCBI:1269323]
[REACTOME:R-HSA-512988]
[PUBMED:10450743]
[PUBMED:9766809]
MAPK family signaling cascades
[NCBI:1269501]
[REACTOME:R-HSA-5683057]
[PUBMED:21167873]
[PUBMED:17161475]
[PUBMED:22535895]
[PUBMED:21372320]
MAPK signaling pathway
[NCBI:83048]
[KEGG:hsa04010]
[PUBMED:11749383]
[PUBMED:12566928]
[PUBMED:12849693]
[PUBMED:12676795]
[PUBMED:12947395]
[PUBMED:14597384]
[PUBMED:11369511]
[PUBMED:12191611]
[PUBMED:12390245]
MAPK1/MAPK3 signaling
[NCBI:1269502]
[REACTOME:R-HSA-5684996]
[PUBMED:25378393]
[PUBMED:18199641]
[PUBMED:17496909]
[PUBMED:21779496]
[PUBMED:15520807]
[PUBMED:16393692]
[PUBMED:19520853]
[PUBMED:17496910]
[PUBMED:22569528]
NCAM signaling for neurite out-growth
[NCBI:1270312]
[REACTOME:R-HSA-375165]
[PUBMED:18760361]
[PUBMED:12587671]
[PUBMED:15662836]
[PUBMED:17975827]
[PUBMED:15153429]
[PUBMED:12700044]
NGF signalling via TRKA from the plasma membrane
[NCBI:1269460]
[REACTOME:R-HSA-187037]
[PUBMED:11520933]
[PUBMED:12676795]
[PUBMED:10851172]
[PUBMED:10579918]
Neuronal System
[NCBI:1268763]
[REACTOME:R-HSA-112316]
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
[NCBI:1268786]
[REACTOME:R-HSA-112314]
Neurotrophic factor-mediated Trk receptor signaling
[NCBI:137977]
[Pathway Interaction Database:trkrpathway]
[PUBMED:1849459]
[PUBMED:8226808]
[PUBMED:11163269]
[PUBMED:7510697]
[PUBMED:11027277]
[PUBMED:15758069]
[PUBMED:11425862]
[PUBMED:11238898]
[PUBMED:11251075]
[PUBMED:8344249]
[PUBMED:9356464]
[PUBMED:11150291]
[PUBMED:10092678]
[PUBMED:1280261]
[PUBMED:11150334]
[PUBMED:11244088]
[PUBMED:10985348]
[PUBMED:15753086]
[PUBMED:1653651]
[PUBMED:11466412]
[PUBMED:15167895]
[PUBMED:1831195]
[PUBMED:10490030]
[PUBMED:8384556]
[PUBMED:16697063]
[PUBMED:17003042]
[PUBMED:15520226]
[PUBMED:15632082]
[PUBMED:16611639]
[PUBMED:16187212]
[PUBMED:9182757]
[PUBMED:1604323]
[PUBMED:16284401]
[PUBMED:8356095]
[PUBMED:10329710]
[PUBMED:9927421]
[PUBMED:9856458]
[PUBMED:10691301]
[PUBMED:1375038]
[PUBMED:10679771]
[PUBMED:15122257]
[PUBMED:15513915]
[PUBMED:16701206]
[PUBMED:1710174]
[PUBMED:8155326]
[PUBMED:8288573]
[PUBMED:7972023]
[PUBMED:7512734]
[PUBMED:10601297]
[PUBMED:16203995]
[PUBMED:12510192]
[PUBMED:16481401]
[PUBMED:8106527]
[PUBMED:11278445]
[PUBMED:9099755]
[PUBMED:1850821]
[PUBMED:9632781]
[PUBMED:10235685]
[PUBMED:15917464]
[PUBMED:9285826]
[PUBMED:12446789]
[PUBMED:7657612]
[PUBMED:1850549]
[PUBMED:12879077]
[PUBMED:16157584]
[PUBMED:10207144]
[PUBMED:12006576]
[PUBMED:8052307]
[PUBMED:8382740]
[PUBMED:10629055]
Post NMDA receptor activation events
[NCBI:1268800]
[REACTOME:R-HSA-438064]
[PUBMED:18616423]
Prolonged ERK activation events
[NCBI:1269469]
[REACTOME:R-HSA-169893]
[PUBMED:12765839]
[PUBMED:9069267]
RAF/MAP kinase cascade
[NCBI:1269285]
[REACTOME:R-HSA-5673001]
[PUBMED:21167873]
[PUBMED:24937142]
[PUBMED:20674547]
[PUBMED:17496910]
[PUBMED:22177953]
[PUBMED:17496919]
[PUBMED:22569528]
[PUBMED:22535895]
[PUBMED:12068308]
[PUBMED:17496923]
[PUBMED:19091303]
[PUBMED:21372320]
[PUBMED:21388974]
[PUBMED:15520807]
RET signaling
[NCBI:1427866]
[REACTOME:R-HSA-8853659]
[PUBMED:15013219]
[PUBMED:17036197]
Ras activation uopn Ca2+ infux through NMDA receptor
[NCBI:1268802]
[REACTOME:R-HSA-442982]
[PUBMED:14622581]
Ras signaling pathway
[NCBI:868085]
[KEGG:hsa04014]
[PUBMED:23506953]
[PUBMED:18437264]
[PUBMED:15062121]
[PUBMED:22189424]
[PUBMED:22233291]
[PUBMED:12778136]
[PUBMED:11313946]
[PUBMED:17428555]
[PUBMED:19091743]
[PUBMED:18568040]
[PUBMED:20420946]
[PUBMED:12217381]
[PUBMED:14663478]
[PUBMED:21686117]
[PUBMED:12642680]
[PUBMED:21196257]
[PUBMED:16869784]
[PUBMED:21111786]
[PUBMED:16966426]
[PUBMED:10712923]
[PUBMED:22020205]
[PUBMED:17384584]
[PUBMED:15572660]
[PUBMED:18413813]
Regulation of RAC1 activity
[NCBI:169346]
[Pathway Interaction Database:rac1_reg_pathway]
[PUBMED:8297393]
[PUBMED:12134164]
[PUBMED:15485841]
[PUBMED:11707441]
[PUBMED:17320046]
[PUBMED:9857026]
[PUBMED:9497316]
[PUBMED:17254573]
[PUBMED:15850775]
[PUBMED:8352776]
[PUBMED:15128856]
[PUBMED:17403664]
[PUBMED:8491184]
[PUBMED:7753201]
[PUBMED:9707409]
[PUBMED:12432077]
[PUBMED:8226937]
[PUBMED:19934221]
[PUBMED:17196961]
[PUBMED:17640372]
[PUBMED:11287617]
[PUBMED:12515821]
[PUBMED:16943182]
[PUBMED:19861492]
[PUBMED:10220378]
[PUBMED:11431473]
[PUBMED:10982832]
[PUBMED:7673236]
[PUBMED:10744696]
[PUBMED:17599059]
[PUBMED:17116687]
[PUBMED:12923183]
[PUBMED:10364228]
[PUBMED:16628218]
[PUBMED:8288572]
[PUBMED:15306850]
[PUBMED:11396949]
[PUBMED:8496137]
[PUBMED:11912491]
[PUBMED:15649357]
[PUBMED:7980444]
[PUBMED:18325335]
[PUBMED:15242348]
[PUBMED:11955434]
[PUBMED:15039778]
[PUBMED:11685227]
[PUBMED:15897194]
[PUBMED:11130063]
[PUBMED:10559863]
[PUBMED:17052214]
[PUBMED:11099046]
[PUBMED:15728722]
[PUBMED:16520382]
[PUBMED:16492808]
[PUBMED:12547822]
[PUBMED:12446789]
[PUBMED:11274357]
[PUBMED:8419353]
[PUBMED:16481401]
[PUBMED:8276860]
[PUBMED:15005707]
[PUBMED:10499589]
[PUBMED:11336673]
[PUBMED:1903516]
[PUBMED:12829596]
[PUBMED:17332503]
[PUBMED:11146652]
[PUBMED:12134158]
[PUBMED:8643598]
[PUBMED:18212043]
SHC1 events in EGFR signaling
[NCBI:1269383]
[REACTOME:R-HSA-180336]
[PUBMED:11498013]
[PUBMED:8755247]
SOS-mediated signalling
[NCBI:1269440]
[REACTOME:R-HSA-112412]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by EGFR
[NCBI:1269380]
[REACTOME:R-HSA-177929]
[PUBMED:10459005]
[PUBMED:10404636]
[PUBMED:12297041]
[PUBMED:15142631]
Signaling by GPCR
[NCBI:1269543]
[REACTOME:R-HSA-372790]
[PUBMED:16902930]
[PUBMED:10202136]
[PUBMED:18043707]
Signaling by Insulin receptor
[NCBI:1269428]
[REACTOME:R-HSA-74752]
[PUBMED:8276779]
Signaling by Interleukins
[NCBI:1269318]
[REACTOME:R-HSA-449147]
[PUBMED:19302047]
[PUBMED:12445398]
Signaling by Leptin
[NCBI:1269632]
[REACTOME:R-HSA-2586552]
[PUBMED:22211890]
[PUBMED:23562747]
[PUBMED:20600241]
[PUBMED:21622208]
[PUBMED:23579596]
[PUBMED:22458591]
[PUBMED:21489811]
[PUBMED:19724019]
[PUBMED:21331644]
[PUBMED:22448029]
[PUBMED:21147620]
[PUBMED:20198122]
[PUBMED:21677426]
[PUBMED:20029269]
[PUBMED:22249808]
[PUBMED:22991412]
[PUBMED:21527729]
[PUBMED:17937601]
[PUBMED:20553370]
[PUBMED:21713385]
[PUBMED:23565489]
[PUBMED:22289780]
Signaling by PDGF
[NCBI:1269478]
[REACTOME:R-HSA-186797]
[PUBMED:15207811]
[PUBMED:10508235]
[PUBMED:9739761]
Signaling by SCF-KIT
[NCBI:1269487]
[REACTOME:R-HSA-1433557]
[PUBMED:17350321]
[PUBMED:16483568]
[PUBMED:7688988]
[PUBMED:19540337]
[PUBMED:16475976]
[PUBMED:15526160]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
[NCBI:1269617]
[REACTOME:R-HSA-2404192]
[PUBMED:21042815]
[PUBMED:18927274]
[PUBMED:20098959]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22044904]
[PUBMED:22649417]
Signaling by VEGF
[NCBI:1269480]
[REACTOME:R-HSA-194138]
[PUBMED:15585754]
[PUBMED:13678960]
[PUBMED:16336962]
[PUBMED:16835467]
Signalling by NGF
[NCBI:1269443]
[REACTOME:R-HSA-166520]
Signalling to ERKs
[NCBI:1269464]
[REACTOME:R-HSA-187687]
[PUBMED:10508738]
Signalling to RAS
[NCBI:1269465]
[REACTOME:R-HSA-167044]
[PUBMED:11520933]
Signalling to p38 via RIT and RIN
[NCBI:1269468]
[REACTOME:R-HSA-187706]
[PUBMED:10712923]
Transmission across Chemical Synapses
[NCBI:1268766]
[REACTOME:R-HSA-112315]
VEGFA-VEGFR2 Pathway
[NCBI:1269483]
[REACTOME:R-HSA-4420097]
[PUBMED:17344076]
[PUBMED:16633338]
[PUBMED:19230644]
[PUBMED:13678960]
VEGFR2 mediated cell proliferation
[NCBI:1269485]
[REACTOME:R-HSA-5218921]
[PUBMED:22866201]
[PUBMED:22180219]
[PUBMED:22762016]
