full name
axin 1

synonyms
AXIN, PPP1R49, AXIN1, ENSG00000103126

HGNC
HGNC:903

Entrez Gene
Gene:8312

ENSEMBL
ENSG00000103126

location
chr: 16
start: 337440
stop: 405244
strand: -

OMIM
OMIM:603816: AXIN1
OMIM:607864: ?Caudal duplication anomaly
OMIM:114550: Hepatocellular carcinoma, somatic

transcripts
NM_181050.2
NM_003502.3

pathways
AMER1 mutants destabilize the destruction complex [NCBI:1268913] [REACTOME:R-HSA-4839748] [PUBMED:17510365] [PUBMED:21248786] [PUBMED:23256519]
APC truncation mutants have impaired AXIN binding [NCBI:1268909] [REACTOME:R-HSA-5467337] [PUBMED:10921899] [PUBMED:1338904] [PUBMED:11057903] [PUBMED:10213492] [PUBMED:8111410]
AXIN missense mutants destabilize the destruction complex [NCBI:1268912] [REACTOME:R-HSA-5467340] [PUBMED:12101426] [PUBMED:10862053] [PUBMED:11746989] [PUBMED:10700176]
AXIN mutants destabilize the destruction complex, activating WNT signaling [NCBI:1268910] [REACTOME:R-HSA-4839735] [PUBMED:15735151] [PUBMED:23256519] [PUBMED:12101426] [PUBMED:11746989] [PUBMED:10700176] [PUBMED:11585731]
Basal cell carcinoma [NCBI:83113] [KEGG:hsa05217] [PUBMED:15948971] [PUBMED:15978322] [PUBMED:15468170] [PUBMED:11276000] [PUBMED:11130178] [PUBMED:14737121] [PUBMED:15270885] [PUBMED:16306523] [PUBMED:14556242] [PUBMED:15656799] [PUBMED:16054233] [PUBMED:12588368] [PUBMED:16881963] [PUBMED:11736900]
Beta-catenin phosphorylation cascade [NCBI:1269597] [REACTOME:R-HSA-196299] [PUBMED:11955436] [PUBMED:12000790]
Breast cancer [NCBI:1435207] [KEGG:hsa05224] [PUBMED:24649067] [PUBMED:26040571] [PUBMED:11879567] [PUBMED:22722193] [PUBMED:26028978] [PUBMED:25013431] [PUBMED:11737884] [PUBMED:23702927] [PUBMED:21076461] [PUBMED:21898546] [PUBMED:27390604] [PUBMED:24291072] [PUBMED:26968398] [PUBMED:20087430] [PUBMED:23000897] [PUBMED:25544707] [PUBMED:24596345] [PUBMED:23988612] [PUBMED:24111892] [PUBMED:25907219] [PUBMED:15343273] [PUBMED:21965336] [PUBMED:23881035] [PUBMED:23196196] [PUBMED:22178455] [PUBMED:20436504] [PUBMED:19088017] [PUBMED:16113099] [PUBMED:20971825]
C-MYC pathway [NCBI:169344] [Pathway Interaction Database:myc_pathway] [PUBMED:17558397] [PUBMED:10611234] [PUBMED:14563837] [PUBMED:12660246] [PUBMED:11018017] [PUBMED:12769844] [PUBMED:11445536] [PUBMED:17967894] [PUBMED:15199070] [PUBMED:17146439] [PUBMED:9708738] [PUBMED:20008325] [PUBMED:19131971] [PUBMED:12177005] [PUBMED:15048125] [PUBMED:15361884] [PUBMED:14749374] [PUBMED:15150404] [PUBMED:15103331] [PUBMED:12776177] [PUBMED:11673469] [PUBMED:9312026] [PUBMED:17597761] [PUBMED:12769843] [PUBMED:9927431] [PUBMED:10882073] [PUBMED:16537924]
Canonical Wnt signaling pathway [NCBI:138032] [Pathway Interaction Database:wnt_canonical_pathway] [PUBMED:16849322] [PUBMED:10228155] [PUBMED:11007767] [PUBMED:10023673] [PUBMED:19061640] [PUBMED:10074433] [PUBMED:9554852] [PUBMED:10196136] [PUBMED:18772438] [PUBMED:19309792] [PUBMED:16263762] [PUBMED:16890161] [PUBMED:16341017] [PUBMED:17569865] [PUBMED:16314428] [PUBMED:17529994] [PUBMED:10421629] [PUBMED:11751573] [PUBMED:20177058] [PUBMED:15024404] [PUBMED:12000790] [PUBMED:19107203] [PUBMED:10684251] [PUBMED:9482734] [PUBMED:16547521] [PUBMED:10092233] [PUBMED:18077588] [PUBMED:16303557] [PUBMED:19556239] [PUBMED:19561074] [PUBMED:11274398] [PUBMED:14966280] [PUBMED:9566905] [PUBMED:11834740] [PUBMED:19801552] [PUBMED:12554650] [PUBMED:16341016] [PUBMED:17510365] [PUBMED:15459103] [PUBMED:18929646] [PUBMED:15327768] [PUBMED:9312064]
Colorectal cancer [NCBI:83106] [KEGG:hsa05210] [PUBMED:15479695] [PUBMED:11459867] [PUBMED:9196022] [PUBMED:11170304] [PUBMED:12951588] [PUBMED:15349822] [PUBMED:15711891] [PUBMED:16042571] [PUBMED:15000146] [PUBMED:12737309] [PUBMED:10505543] [PUBMED:11078609] [PUBMED:11223406] [PUBMED:16326109] [PUBMED:16699851] [PUBMED:11477132] [PUBMED:12621137] [PUBMED:15573119] [PUBMED:16555243] [PUBMED:15310786]
Degradation of AXIN [NCBI:1269606] [REACTOME:R-HSA-4641257] [PUBMED:21478859] [PUBMED:14551908] [PUBMED:22363759] [PUBMED:20858899] [PUBMED:21799911]
Degradation of beta-catenin by the destruction complex [NCBI:1269596] [REACTOME:R-HSA-195253] [PUBMED:17143292]
Deubiquitination [NCBI:1427860] [REACTOME:R-HSA-5688426] [PUBMED:19243136] [PUBMED:20074029] [PUBMED:15571815] [PUBMED:20418328] [PUBMED:16325574] [PUBMED:12944365] [PUBMED:23845989] [PUBMED:22201797]
Disassembly of the destruction complex and recruitment of AXIN to the membrane [NCBI:1269601] [REACTOME:R-HSA-4641262] [PUBMED:10647780] [PUBMED:10581160] [PUBMED:14551908] [PUBMED:15084453] [PUBMED:19619488] [PUBMED:19759537] [PUBMED:14731402] [PUBMED:18234723] [PUBMED:15459103] [PUBMED:22363759] [PUBMED:17318175] [PUBMED:11336703] [PUBMED:16341017] [PUBMED:10421629] [PUBMED:17569865]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Diseases of signal transduction [NCBI:1268855] [REACTOME:R-HSA-5663202] [PUBMED:12509752]
Endometrial cancer [NCBI:83109] [KEGG:hsa05213] [PUBMED:14747944] [PUBMED:11431710] [PUBMED:7585656] [PUBMED:16508724] [PUBMED:15284264] [PUBMED:17028294] [PUBMED:16248975] [PUBMED:15947972]
Hippo signaling pathway [NCBI:749777] [KEGG:hsa04390] [PUBMED:18955139] [PUBMED:20439427] [PUBMED:20951342] [PUBMED:21138973] [PUBMED:18328423] [PUBMED:21324984] [PUBMED:23034192] [PUBMED:21808241] [PUBMED:17975546] [PUBMED:22750148] [PUBMED:21084559] [PUBMED:19846288] [PUBMED:22895435] [PUBMED:22683405] [PUBMED:22658639] [PUBMED:22153608] [PUBMED:20945341] [PUBMED:22830020] [PUBMED:21874053] [PUBMED:21376238]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Misspliced GSK3beta mutants stabilize beta-catenin [NCBI:1268921] [REACTOME:R-HSA-5339716] [PUBMED:15306667] [PUBMED:19237556]
N-cadherin signaling events [NCBI:137919] [Pathway Interaction Database:ncadherinpathway] [PUBMED:16319177] [PUBMED:19075000] [PUBMED:15121175] [PUBMED:15226396] [PUBMED:17765222] [PUBMED:7885471] [PUBMED:11086998] [PUBMED:2318342] [PUBMED:8050374] [PUBMED:9655503] [PUBMED:7962102] [PUBMED:7599959] [PUBMED:17459003] [PUBMED:9852580] [PUBMED:9052794] [PUBMED:17005551] [PUBMED:1837087] [PUBMED:1639850] [PUBMED:16176974] [PUBMED:16807326] [PUBMED:15716354] [PUBMED:8707857] [PUBMED:19162191] [PUBMED:12099895] [PUBMED:8113807] [PUBMED:16228908] [PUBMED:17538019] [PUBMED:11056534] [PUBMED:11809840] [PUBMED:11571292] [PUBMED:12377785] [PUBMED:8909549] [PUBMED:3780667] [PUBMED:9655504] [PUBMED:14610057] [PUBMED:15569714] [PUBMED:15662031] [PUBMED:15809310] [PUBMED:15247242] [PUBMED:2762814] [PUBMED:17289573] [PUBMED:17921113] [PUBMED:9712659] [PUBMED:12578907] [PUBMED:16515543] [PUBMED:15034585] [PUBMED:11106648] [PUBMED:11228159] [PUBMED:9786960] [PUBMED:12604612] [PUBMED:11466312] [PUBMED:11238727] [PUBMED:12640032] [PUBMED:1487503] [PUBMED:15383621] [PUBMED:8816706] [PUBMED:17481398] [PUBMED:9545083] [PUBMED:14657280] [PUBMED:12213839] [PUBMED:10930450]
Pathways in cancer [NCBI:83105] [KEGG:hsa05200] [PUBMED:12244301] [PUBMED:15156182] [PUBMED:16899407] [PUBMED:12621137] [PUBMED:21193867] [PUBMED:16001072] [PUBMED:11707511] [PUBMED:11253051] [PUBMED:11071626] [PUBMED:17251915] [PUBMED:11736900] [PUBMED:16557281] [PUBMED:16699851] [PUBMED:16189702] [PUBMED:11902573] [PUBMED:16555243] [PUBMED:8069858] [PUBMED:15310786] [PUBMED:9834202] [PUBMED:16700615] [PUBMED:12545153] [PUBMED:15656799] [PUBMED:12154354] [PUBMED:11895903] [PUBMED:11527574] [PUBMED:16326109] [PUBMED:16339096] [PUBMED:11160144] [PUBMED:15724144] [PUBMED:12951584] [PUBMED:10647931] [PUBMED:16881963] [PUBMED:15557758] [PUBMED:11477132] [PUBMED:15721476] [PUBMED:15625120] [PUBMED:16236521] [PUBMED:14967450] [PUBMED:15942304] [PUBMED:17287871] [PUBMED:14634372] [PUBMED:15573119] [PUBMED:15009714] [PUBMED:16112428] [PUBMED:15611513] [PUBMED:16001050] [PUBMED:15349822] [PUBMED:16551846] [PUBMED:15978322] [PUBMED:15774796] [PUBMED:16352814] [PUBMED:12951588] [PUBMED:10944551] [PUBMED:10740269] [PUBMED:15639402] [PUBMED:12407699] [PUBMED:11130178] [PUBMED:15109562] [PUBMED:11170304] [PUBMED:11276000] [PUBMED:9643506] [PUBMED:16248975] [PUBMED:16242838] [PUBMED:12946833] [PUBMED:11559746] [PUBMED:9196022] [PUBMED:12079267] [PUBMED:15468170] [PUBMED:16064138] [PUBMED:14580692] [PUBMED:15082523] [PUBMED:15551095] [PUBMED:17062879] [PUBMED:17211469] [PUBMED:11720739] [PUBMED:12588368] [PUBMED:11057895] [PUBMED:9422516] [PUBMED:12894244] [PUBMED:15479695] [PUBMED:16189154] [PUBMED:12878745] [PUBMED:11900250] [PUBMED:11103787] [PUBMED:15122209] [PUBMED:12711111] [PUBMED:12243753] [PUBMED:16306523] [PUBMED:16702400] [PUBMED:15270885] [PUBMED:14685170] [PUBMED:14586404] [PUBMED:11078609] [PUBMED:15284264] [PUBMED:10505543] [PUBMED:11223406] [PUBMED:14982876] [PUBMED:12648469] [PUBMED:12867060] [PUBMED:15711891] [PUBMED:12094241] [PUBMED:16642045] [PUBMED:11463388] [PUBMED:12762887] [PUBMED:15746962] [PUBMED:15823750] [PUBMED:16750612] [PUBMED:16484590] [PUBMED:11459867] [PUBMED:16146838] [PUBMED:14556242] [PUBMED:15947972] [PUBMED:12563308] [PUBMED:16946003] [PUBMED:15948971] [PUBMED:11407945] [PUBMED:12737309] [PUBMED:16095998] [PUBMED:12351585] [PUBMED:24508914] [PUBMED:12084351] [PUBMED:11807782] [PUBMED:14695152] [PUBMED:10453277] [PUBMED:17554387] [PUBMED:15841168] [PUBMED:12616528] [PUBMED:10403855] [PUBMED:16054233] [PUBMED:16474624] [PUBMED:16822996] [PUBMED:17028294] [PUBMED:11224709] [PUBMED:11750244] [PUBMED:11905738] [PUBMED:15719031] [PUBMED:10843728] [PUBMED:16110317] [PUBMED:11721960] [PUBMED:12741677] [PUBMED:7585656] [PUBMED:12801837] [PUBMED:16551847] [PUBMED:12459728] [PUBMED:11431710] [PUBMED:12468433] [PUBMED:11165748] [PUBMED:16042571] [PUBMED:16508724] [PUBMED:15000146] [PUBMED:17149381] [PUBMED:15948711] [PUBMED:14747944] [PUBMED:14737121] [PUBMED:12379883] [PUBMED:17158541] [PUBMED:12850530] [PUBMED:10835690] [PUBMED:16870043]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
Presenilin action in Notch and Wnt signaling [NCBI:137914] [Pathway Interaction Database:ps1pathway] [PUBMED:10391247] [PUBMED:11921277] [PUBMED:11357136] [PUBMED:15620650] [PUBMED:11739397] [PUBMED:15747065] [PUBMED:10359821] [PUBMED:15327768] [PUBMED:12554650] [PUBMED:15292388] [PUBMED:11266469] [PUBMED:12794186] [PUBMED:10882062] [PUBMED:8923452] [PUBMED:12050670] [PUBMED:10201374] [PUBMED:12857724] [PUBMED:9171444]
S33 mutants of beta-catenin aren't phosphorylated [NCBI:1268920] [REACTOME:R-HSA-5358747] [PUBMED:10487827] [PUBMED:12067995] [PUBMED:10921899] [PUBMED:18757411]
S37 mutants of beta-catenin aren't phosphorylated [NCBI:1268919] [REACTOME:R-HSA-5358749] [PUBMED:10487827] [PUBMED:12067995] [PUBMED:10921899]
S45 mutants of beta-catenin aren't phosphorylated [NCBI:1268917] [REACTOME:R-HSA-5358751] [PUBMED:9065402] [PUBMED:12000790] [PUBMED:10921899]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by WNT in cancer [NCBI:1268906] [REACTOME:R-HSA-4791275] [PUBMED:7749328] [PUBMED:6318122] [PUBMED:22438566] [PUBMED:17510365] [PUBMED:10700176] [PUBMED:10733430] [PUBMED:17143297] [PUBMED:18311776] [PUBMED:11375957]
Signaling by Wnt [NCBI:1269594] [REACTOME:R-HSA-195721] [PUBMED:19530173] [PUBMED:23256519] [PUBMED:22952392] [PUBMED:19204114] [PUBMED:19365405] [PUBMED:19619488] [PUBMED:17143292] [PUBMED:17230199] [PUBMED:18710302] [PUBMED:16099039] [PUBMED:20576942] [PUBMED:10858654] [PUBMED:12967557]
Signaling pathways regulating pluripotency of stem cells [NCBI:1026136] [KEGG:hsa04550] [PUBMED:20705693] [PUBMED:23653415] [PUBMED:16518401] [PUBMED:17211451] [PUBMED:22649650] [PUBMED:24910449] [PUBMED:19551525] [PUBMED:22298652] [PUBMED:23370346] [PUBMED:24315442] [PUBMED:18414030] [PUBMED:17647265] [PUBMED:18295576] [PUBMED:24957798] [PUBMED:24147644] [PUBMED:16153702] [PUBMED:19427042] [PUBMED:18220859] [PUBMED:19571885] [PUBMED:23585347]
T41 mutants of beta-catenin aren't phosphorylated [NCBI:1268918] [REACTOME:R-HSA-5358752] [PUBMED:12101426] [PUBMED:12439748] [PUBMED:22438566] [PUBMED:10921899] [PUBMED:23256519]
TCF dependent signaling in response to WNT [NCBI:1269599] [REACTOME:R-HSA-201681] [PUBMED:19619488] [PUBMED:23256519] [PUBMED:23343194]
TGF-beta receptor signaling [NCBI:138024] [Pathway Interaction Database:tgfbrpathway] [PUBMED:12118366] [PUBMED:8242743] [PUBMED:15221015] [PUBMED:9335507] [PUBMED:11278302] [PUBMED:16601693] [PUBMED:8391934] [PUBMED:1333888] [PUBMED:11438668] [PUBMED:17327236] [PUBMED:2879635] [PUBMED:11483955] [PUBMED:12717440] [PUBMED:8047140] [PUBMED:8576253] [PUBMED:9865696] [PUBMED:9346908] [PUBMED:17197390] [PUBMED:8533096] [PUBMED:8756725] [PUBMED:10615055] [PUBMED:10934479] [PUBMED:16251192] [PUBMED:7706248] [PUBMED:15946939] [PUBMED:7774578] [PUBMED:7988555] [PUBMED:11278251] [PUBMED:11027280] [PUBMED:17420258] [PUBMED:9169454] [PUBMED:12151385] [PUBMED:10757800] [PUBMED:12543979] [PUBMED:12475967] [PUBMED:9679059] [PUBMED:17673906] [PUBMED:9774674] [PUBMED:8893010] [PUBMED:1544886] [PUBMED:12958365] [PUBMED:12110587] [PUBMED:9233797] [PUBMED:11163210] [PUBMED:15496141] [PUBMED:7693660] [PUBMED:14657019] [PUBMED:12429842] [PUBMED:11124802] [PUBMED:11389444] [PUBMED:8798398] [PUBMED:15356634] [PUBMED:17272273] [PUBMED:1657407] [PUBMED:12589052] [PUBMED:11016919] [PUBMED:14718519] [PUBMED:10777621] [PUBMED:17384642] [PUBMED:1310899] [PUBMED:9856985] [PUBMED:10519551] [PUBMED:9155023] [PUBMED:12134160] [PUBMED:9215638] [PUBMED:12134149] [PUBMED:16157589] [PUBMED:12356868] [PUBMED:11387212] [PUBMED:12034739] [PUBMED:11739411] [PUBMED:15761148] [PUBMED:9463378] [PUBMED:11583628] [PUBMED:15684397] [PUBMED:8947046] [PUBMED:11781097]
Truncations of AMER1 destabilize the destruction complex [NCBI:1268915] [REACTOME:R-HSA-5467348] [PUBMED:19760609] [PUBMED:18311776] [PUBMED:17510365] [PUBMED:21248786]
Ub-specific processing proteases [NCBI:1427862] [REACTOME:R-HSA-5689880] [PUBMED:16325574]
Wnt signaling pathway [NCBI:83061] [KEGG:hsa04310] [PUBMED:12446114] [PUBMED:14745971] [PUBMED:14530294] [PUBMED:15102436] [PUBMED:14635791] [PUBMED:19482104] [PUBMED:23256519] [PUBMED:12967557] [PUBMED:11433294] [PUBMED:18838381]
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex [NCBI:1268916] [REACTOME:R-HSA-4839743] [PUBMED:9601641] [PUBMED:10733430] [PUBMED:9065402] [PUBMED:23256519] [PUBMED:11375957] [PUBMED:9065403]
truncated APC mutants destabilize the destruction complex [NCBI:1268907] [REACTOME:R-HSA-4839744] [PUBMED:1338904] [PUBMED:8756721] [PUBMED:9065402] [PUBMED:17143297] [PUBMED:23256519] [PUBMED:8111410] [PUBMED:23169527] [PUBMED:15327768] [PUBMED:22761442] [PUBMED:10921899] [PUBMED:9065401]