full name
glutamate ionotropic receptor NMDA type subunit 2A

synonyms
EPND, GluN2A, NMDAR2A, NR2A, GRIN2A, ENSG00000183454

HGNC
HGNC:4585

Entrez Gene
Gene:2903

ENSEMBL
ENSG00000183454

location
chr: 16
start: 9847265
stop: 10276611
strand: -

OMIM
OMIM:138253: GRIN2A (Autosomal dominant inheritance)
OMIM:245570: Epilepsy, focal, with speech disorder and with or without mental retardation

transcripts
NM_000833.3
NM_001134407.1
NM_001134408.1

pathways
ARMS-mediated activation [NCBI:1269471] [REACTOME:R-HSA-170984] [PUBMED:9069267]
Activation of NMDA receptor upon glutamate binding and postsynaptic events [NCBI:1268798] [REACTOME:R-HSA-442755] [PUBMED:18616423]
Alcoholism [NCBI:585563] [KEGG:hsa05034] [PUBMED:16764827] [PUBMED:18991950] [PUBMED:18616668] [PUBMED:19077056] [PUBMED:19756388] [PUBMED:20947635] [PUBMED:16102840] [PUBMED:17270154] [PUBMED:16278489] [PUBMED:18310464] [PUBMED:19342616] [PUBMED:15500908] [PUBMED:14729391] [PUBMED:16776597] [PUBMED:10774721] [PUBMED:12605085] [PUBMED:12085089] [PUBMED:12068305] [PUBMED:20729980] [PUBMED:20626732]
Alzheimer's disease [NCBI:83097] [KEGG:hsa05010] [PUBMED:18782350] [PUBMED:18035450] [PUBMED:10527810] [PUBMED:16677790] [PUBMED:15295589] [PUBMED:15363492] [PUBMED:15750290] [PUBMED:15864339] [PUBMED:18675468] [PUBMED:9848086] [PUBMED:11484003] [PUBMED:17568632] [PUBMED:15177383] [PUBMED:17055782] [PUBMED:15232608] [PUBMED:10830966] [PUBMED:16529745]
Alzheimers Disease [NCBI:672448] [WikiPathways:WP2059]
Amphetamine addiction [NCBI:547607] [KEGG:hsa05031] [PUBMED:18617632] [PUBMED:16724157] [PUBMED:16776597] [PUBMED:18632938] [PUBMED:19222557] [PUBMED:14746512] [PUBMED:8630246] [PUBMED:14622123] [PUBMED:10774721] [PUBMED:21338876] [PUBMED:8753884] [PUBMED:14529709] [PUBMED:17728700] [PUBMED:21989194] [PUBMED:10414964] [PUBMED:18440072] [PUBMED:16151049] [PUBMED:19199083]
Amyotrophic lateral sclerosis (ALS) [NCBI:83099] [KEGG:hsa05014] [NCBI:920975] [WikiPathways:WP2447] [PUBMED:17015226] [PUBMED:16723044] [PUBMED:16026864] [PUBMED:16924260] [PUBMED:10970056] [PUBMED:11513882] [PUBMED:21569822] [PUBMED:12531867] [PUBMED:16713195] [PUBMED:16603792] [PUBMED:16050975] [PUBMED:11870681] [PUBMED:17409386] [PUBMED:18519638] [PUBMED:11239414] [PUBMED:16909017] [PUBMED:17434459] [PUBMED:17566607] [PUBMED:12728264] [PUBMED:12595144] [PUBMED:14739060] [PUBMED:16909020] [PUBMED:14569202] [PUBMED:11715057] [PUBMED:15310460]
Axon guidance [NCBI:83065] [KEGG:hsa04360] [NCBI:1270303] [REACTOME:R-HSA-422475] [PUBMED:14682358] [PUBMED:11687826] [PUBMED:15084255] [PUBMED:15818466] [PUBMED:12471249] [PUBMED:15363605] [PUBMED:15630019] [PUBMED:11891122] [PUBMED:15960985] [PUBMED:12677003]
CREB phosphorylation through the activation of CaMKII [NCBI:1268805] [REACTOME:R-HSA-442729] [PUBMED:16799259]
CREB phosphorylation through the activation of Ras [NCBI:1268801] [REACTOME:R-HSA-442742] [PUBMED:12819448]
Calcium signaling pathway [NCBI:83050] [KEGG:hsa04020] [PUBMED:11080247] [PUBMED:11413485] [PUBMED:10508738] [PUBMED:14572802] [PUBMED:15000521] [PUBMED:22129055] [PUBMED:7861177] [PUBMED:9149541] [PUBMED:9235901] [PUBMED:10331643] [PUBMED:11698232] [PUBMED:15111104] [PUBMED:12838335] [PUBMED:10997573] [PUBMED:19172794] [PUBMED:12972622] [PUBMED:21338471] [PUBMED:22002090] [PUBMED:11299192] [PUBMED:14517314] [PUBMED:8125957]
Circadian entrainment [NCBI:698773] [KEGG:hsa04713] [PUBMED:15016477] [PUBMED:15813931] [PUBMED:15930378] [PUBMED:12573527] [PUBMED:20664079] [PUBMED:17586087] [PUBMED:11294753] [PUBMED:17646042] [PUBMED:10446325] [PUBMED:17167088] [PUBMED:19109992] [PUBMED:16217123] [PUBMED:19449447] [PUBMED:10208575] [PUBMED:11086993] [PUBMED:12700026] [PUBMED:20605968]
Cocaine addiction [NCBI:546258] [KEGG:hsa05030] [PUBMED:15091342] [PUBMED:16278489] [PUBMED:14566342] [PUBMED:16251986] [PUBMED:12064476] [PUBMED:11595774] [PUBMED:19403004] [PUBMED:18440072] [PUBMED:15582154] [PUBMED:14746512] [PUBMED:10234039] [PUBMED:11268215] [PUBMED:12818179]
Cytokine Signaling in Immune system [NCBI:1269310] [REACTOME:R-HSA-1280215] [PUBMED:12613569]
DAP12 interactions [NCBI:1269283] [REACTOME:R-HSA-2172127] [PUBMED:19120482] [PUBMED:17220916] [PUBMED:9490415] [PUBMED:18192027] [PUBMED:15884055]
DAP12 signaling [NCBI:1269284] [REACTOME:R-HSA-2424491] [PUBMED:15884055] [PUBMED:17110943] [PUBMED:17220916]
Developmental Biology [NCBI:1270302] [REACTOME:R-HSA-1266738]
Dopaminergic synapse [NCBI:469199] [KEGG:hsa04728] [PUBMED:20727368] [PUBMED:17408758] [PUBMED:10433257] [PUBMED:9457173] [PUBMED:17349698] [PUBMED:15521361] [PUBMED:21303898] [PUBMED:18353279] [PUBMED:19251795] [PUBMED:15381316] [PUBMED:15590733] [PUBMED:20224735] [PUBMED:12967774] [PUBMED:19138563] [PUBMED:15292232]
Downstream signal transduction [NCBI:1269479] [REACTOME:R-HSA-186763] [PUBMED:10508235] [PUBMED:9739761]
Downstream signaling of activated FGFR1 [NCBI:1269392] [REACTOME:R-HSA-5654687] [PUBMED:8752212]
Downstream signaling of activated FGFR2 [NCBI:1269403] [REACTOME:R-HSA-5654696] [PUBMED:8752212]
Downstream signaling of activated FGFR3 [NCBI:1269413] [REACTOME:R-HSA-5654708] [PUBMED:8752212]
Downstream signaling of activated FGFR4 [NCBI:1269422] [REACTOME:R-HSA-5654716] [PUBMED:8752212]
FCERI mediated MAPK activation [NCBI:1269299] [REACTOME:R-HSA-2871796] [PUBMED:19290926] [PUBMED:19909365] [PUBMED:17122878]
FRS-mediated FGFR1 signaling [NCBI:1269393] [REACTOME:R-HSA-5654693] [PUBMED:15863030] [PUBMED:11447289] [PUBMED:18452557] [PUBMED:16682955]
FRS-mediated FGFR2 signaling [NCBI:1269404] [REACTOME:R-HSA-5654700] [PUBMED:18452557] [PUBMED:11447289] [PUBMED:16682955] [PUBMED:15863030]
FRS-mediated FGFR3 signaling [NCBI:1269414] [REACTOME:R-HSA-5654706] [PUBMED:15863030] [PUBMED:11447289] [PUBMED:18452557] [PUBMED:16682955]
FRS-mediated FGFR4 signaling [NCBI:1269423] [REACTOME:R-HSA-5654712] [PUBMED:18452557] [PUBMED:11447289] [PUBMED:16682955] [PUBMED:15863030]
Fc epsilon receptor (FCERI) signaling [NCBI:1269298] [REACTOME:R-HSA-2454202] [PUBMED:21799019] [PUBMED:15099567]
Frs2-mediated activation [NCBI:1269470] [REACTOME:R-HSA-170968] [PUBMED:9069267]
GRB2 events in EGFR signaling [NCBI:1269382] [REACTOME:R-HSA-179812] [PUBMED:11706405] [PUBMED:11498013]
Gastrin-CREB signalling pathway via PKC and MAPK [NCBI:1269592] [REACTOME:R-HSA-881907] [PUBMED:10413847] [PUBMED:7491953] [PUBMED:17698287]
Glutamatergic synapse [NCBI:213818] [KEGG:hsa04724] [PUBMED:18425072] [PUBMED:10481192] [PUBMED:11561058] [PUBMED:17706608] [PUBMED:19112153] [PUBMED:17663464] [PUBMED:19110202] [PUBMED:9665875] [PUBMED:19559598] [PUBMED:18464791] [PUBMED:11672421] [PUBMED:14684436] [PUBMED:12399578] [PUBMED:20055706]
Hypothetical Network for Drug Addiction [NCBI:198776] [WikiPathways:WP666] [PUBMED:18179280]
IGF1R signaling cascade [NCBI:1269618] [REACTOME:R-HSA-2428924] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22649417] [PUBMED:21042815] [PUBMED:18927274] [PUBMED:20098959]
IRS-mediated signalling [NCBI:1269431] [REACTOME:R-HSA-112399]
IRS-related events triggered by IGF1R [NCBI:1269620] [REACTOME:R-HSA-2428928] [PUBMED:20975071] [PUBMED:17598937] [PUBMED:22649417] [PUBMED:18927274] [PUBMED:21042815] [PUBMED:20098959]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Insulin receptor signalling cascade [NCBI:1269429] [REACTOME:R-HSA-74751] [PUBMED:9677303] [PUBMED:11282018]
Interleukin receptor SHC signaling [NCBI:1269322] [REACTOME:R-HSA-912526] [PUBMED:8294403]
Interleukin-2 signaling [NCBI:1269321] [REACTOME:R-HSA-451927] [PUBMED:17936914] [PUBMED:18817510] [PUBMED:18062768] [PUBMED:19543225]
Interleukin-3, 5 and GM-CSF signaling [NCBI:1269323] [REACTOME:R-HSA-512988] [PUBMED:10450743] [PUBMED:9766809]
Long-term potentiation [NCBI:83085] [KEGG:hsa04720] [PUBMED:15803158] [PUBMED:15652868] [PUBMED:11378299] [PUBMED:10652548] [PUBMED:15857686] [PUBMED:14715912] [PUBMED:9697848]
MAPK family signaling cascades [NCBI:1269501] [REACTOME:R-HSA-5683057] [PUBMED:21167873] [PUBMED:17161475] [PUBMED:22535895] [PUBMED:21372320]
MAPK1/MAPK3 signaling [NCBI:1269502] [REACTOME:R-HSA-5684996] [PUBMED:25378393] [PUBMED:18199641] [PUBMED:17496909] [PUBMED:15520807] [PUBMED:16393692] [PUBMED:19520853] [PUBMED:22569528] [PUBMED:21779496] [PUBMED:17496910]
NCAM signaling for neurite out-growth [NCBI:1270312] [REACTOME:R-HSA-375165] [PUBMED:18760361] [PUBMED:12587671] [PUBMED:15662836] [PUBMED:17975827] [PUBMED:15153429] [PUBMED:12700044]
NGF signalling via TRKA from the plasma membrane [NCBI:1269460] [REACTOME:R-HSA-187037] [PUBMED:11520933] [PUBMED:12676795] [PUBMED:10851172] [PUBMED:10579918]
Neuroactive ligand-receptor interaction [NCBI:83053] [KEGG:hsa04080]
Neuronal System [NCBI:1268763] [REACTOME:R-HSA-112316]
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell [NCBI:1268786] [REACTOME:R-HSA-112314]
Nicotine addiction [NCBI:583255] [KEGG:hsa05033] [PUBMED:15661626] [PUBMED:19498417] [PUBMED:12436424] [PUBMED:19669944] [PUBMED:19434058] [PUBMED:19184650] [PUBMED:15165747] [PUBMED:14708004] [PUBMED:18723034] [PUBMED:18640919] [PUBMED:11906697] [PUBMED:17009926] [PUBMED:14747518] [PUBMED:20485364] [PUBMED:16251989] [PUBMED:12716925] [PUBMED:20833261]
Post NMDA receptor activation events [NCBI:1268800] [REACTOME:R-HSA-438064] [PUBMED:18616423]
Prolonged ERK activation events [NCBI:1269469] [REACTOME:R-HSA-169893] [PUBMED:12765839] [PUBMED:9069267]
RAF/MAP kinase cascade [NCBI:1269285] [REACTOME:R-HSA-5673001] [PUBMED:21167873] [PUBMED:20674547] [PUBMED:17496910] [PUBMED:24937142] [PUBMED:17496919] [PUBMED:22177953] [PUBMED:12068308] [PUBMED:19091303] [PUBMED:21372320] [PUBMED:17496923] [PUBMED:15520807] [PUBMED:21388974] [PUBMED:22569528] [PUBMED:22535895]
Rap1 signaling pathway [NCBI:868086] [KEGG:hsa04015] [PUBMED:17624944] [PUBMED:18363565] [PUBMED:10579920] [PUBMED:19159611] [PUBMED:12508104] [PUBMED:12765839] [PUBMED:11331911] [PUBMED:17182900] [PUBMED:15803158] [PUBMED:19615876] [PUBMED:21402149] [PUBMED:14607972] [PUBMED:17624948] [PUBMED:19710505] [PUBMED:17383543] [PUBMED:15780587] [PUBMED:12351703]
Ras activation uopn Ca2+ infux through NMDA receptor [NCBI:1268802] [REACTOME:R-HSA-442982] [PUBMED:14622581]
Ras signaling pathway [NCBI:868085] [KEGG:hsa04014] [PUBMED:23506953] [PUBMED:18437264] [PUBMED:12778136] [PUBMED:22233291] [PUBMED:11313946] [PUBMED:15062121] [PUBMED:22189424] [PUBMED:19091743] [PUBMED:17428555] [PUBMED:18568040] [PUBMED:20420946] [PUBMED:14663478] [PUBMED:12217381] [PUBMED:21686117] [PUBMED:16966426] [PUBMED:12642680] [PUBMED:21111786] [PUBMED:16869784] [PUBMED:10712923] [PUBMED:22020205] [PUBMED:15572660] [PUBMED:18413813] [PUBMED:21196257] [PUBMED:17384584]
Reelin signaling pathway [NCBI:137980] [Pathway Interaction Database:reelinpathway] [PUBMED:12526739] [PUBMED:12899622] [PUBMED:10939329] [PUBMED:14517291] [PUBMED:15987942] [PUBMED:15062102] [PUBMED:16148228] [PUBMED:10827199] [PUBMED:15091337] [PUBMED:12882964] [PUBMED:15590913] [PUBMED:14724251] [PUBMED:15361067] [PUBMED:14578885] [PUBMED:12376533]
SALM protein interactions at the synapse [NCBI:1383059] [REACTOME:R-HSA-8849932] [PUBMED:16630835] [PUBMED:22046028] [PUBMED:21736948]
SHC1 events in EGFR signaling [NCBI:1269383] [REACTOME:R-HSA-180336] [PUBMED:11498013] [PUBMED:8755247]
SHC1 events in ERBB4 signaling [NCBI:1269497] [REACTOME:R-HSA-1250347]
SOS-mediated signalling [NCBI:1269440] [REACTOME:R-HSA-112412]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:19648010] [PUBMED:17604717] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:15863030] [PUBMED:21252999] [PUBMED:19379690] [PUBMED:19536106] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:15450248] [PUBMED:15520807] [PUBMED:16939974] [PUBMED:18483217] [PUBMED:18043707] [PUBMED:19762341] [PUBMED:21781017] [PUBMED:17084981] [PUBMED:19619488] [PUBMED:17496910]
Signaling by EGFR [NCBI:1269380] [REACTOME:R-HSA-177929] [PUBMED:10459005] [PUBMED:10404636] [PUBMED:15142631] [PUBMED:12297041]
Signaling by ERBB4 [NCBI:1269496] [REACTOME:R-HSA-1236394] [PUBMED:9275162] [PUBMED:9168115] [PUBMED:19193720] [PUBMED:16914727] [PUBMED:17545517] [PUBMED:7929212] [PUBMED:17018285] [PUBMED:9135143] [PUBMED:11679632] [PUBMED:15534001] [PUBMED:10744726] [PUBMED:8665853] [PUBMED:18653779] [PUBMED:7565730] [PUBMED:16978839] [PUBMED:15023535] [PUBMED:16061658] [PUBMED:17463226] [PUBMED:9556621] [PUBMED:18721752] [PUBMED:19047365] [PUBMED:12807903] [PUBMED:12869563] [PUBMED:10867024] [PUBMED:16778220] [PUBMED:16912174] [PUBMED:1706616] [PUBMED:8617750] [PUBMED:10722704]
Signaling by FGFR [NCBI:1269386] [REACTOME:R-HSA-190236] [PUBMED:12080084] [PUBMED:20602996] [PUBMED:15863030] [PUBMED:15567848] [PUBMED:7917292] [PUBMED:19247306] [PUBMED:16597617] [PUBMED:15863038]
Signaling by FGFR1 [NCBI:1269387] [REACTOME:R-HSA-5654736] [PUBMED:16597617] [PUBMED:19247306] [PUBMED:12080084] [PUBMED:15863038] [PUBMED:20602996] [PUBMED:15567848] [PUBMED:15863030] [PUBMED:7917292]
Signaling by FGFR2 [NCBI:1269399] [REACTOME:R-HSA-5654738] [PUBMED:16597617] [PUBMED:19247306] [PUBMED:15863038] [PUBMED:12080084] [PUBMED:15863030] [PUBMED:20602996] [PUBMED:15567848] [PUBMED:7917292]
Signaling by FGFR3 [NCBI:1269409] [REACTOME:R-HSA-5654741] [PUBMED:19247306] [PUBMED:16597617] [PUBMED:15863038] [PUBMED:12080084] [PUBMED:20602996] [PUBMED:15567848] [PUBMED:15863030] [PUBMED:7917292]
Signaling by FGFR4 [NCBI:1269419] [REACTOME:R-HSA-5654743] [PUBMED:12080084] [PUBMED:15863038] [PUBMED:7917292] [PUBMED:15863030] [PUBMED:19247306] [PUBMED:16597617] [PUBMED:15567848] [PUBMED:20602996]
Signaling by GPCR [NCBI:1269543] [REACTOME:R-HSA-372790] [PUBMED:16902930] [PUBMED:10202136] [PUBMED:18043707]
Signaling by Insulin receptor [NCBI:1269428] [REACTOME:R-HSA-74752] [PUBMED:8276779]
Signaling by Interleukins [NCBI:1269318] [REACTOME:R-HSA-449147] [PUBMED:19302047] [PUBMED:12445398]
Signaling by Leptin [NCBI:1269632] [REACTOME:R-HSA-2586552] [PUBMED:23562747] [PUBMED:22458591] [PUBMED:22211890] [PUBMED:20600241] [PUBMED:23579596] [PUBMED:21489811] [PUBMED:21622208] [PUBMED:22448029] [PUBMED:21147620] [PUBMED:21331644] [PUBMED:21677426] [PUBMED:22249808] [PUBMED:20029269] [PUBMED:17937601] [PUBMED:21527729] [PUBMED:22991412] [PUBMED:22289780] [PUBMED:20553370] [PUBMED:23565489] [PUBMED:19724019] [PUBMED:20198122] [PUBMED:21713385]
Signaling by PDGF [NCBI:1269478] [REACTOME:R-HSA-186797] [PUBMED:15207811] [PUBMED:10508235] [PUBMED:9739761]
Signaling by SCF-KIT [NCBI:1269487] [REACTOME:R-HSA-1433557] [PUBMED:16483568] [PUBMED:7688988] [PUBMED:16475976] [PUBMED:19540337] [PUBMED:15526160] [PUBMED:17350321]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) [NCBI:1269617] [REACTOME:R-HSA-2404192] [PUBMED:18927274] [PUBMED:20098959] [PUBMED:21042815] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22044904] [PUBMED:22649417]
Signaling by VEGF [NCBI:1269480] [REACTOME:R-HSA-194138] [PUBMED:15585754] [PUBMED:13678960] [PUBMED:16336962] [PUBMED:16835467]
Signalling by NGF [NCBI:1269443] [REACTOME:R-HSA-166520]
Signalling to ERKs [NCBI:1269464] [REACTOME:R-HSA-187687] [PUBMED:10508738]
Signalling to RAS [NCBI:1269465] [REACTOME:R-HSA-167044] [PUBMED:11520933]
Signalling to p38 via RIT and RIN [NCBI:1269468] [REACTOME:R-HSA-187706] [PUBMED:10712923]
Systemic lupus erythematosus [NCBI:83122] [KEGG:hsa05322] [PUBMED:12835292] [PUBMED:12965173] [PUBMED:16932712] [PUBMED:10025913] [PUBMED:17943287] [PUBMED:15972354] [PUBMED:15380523] [PUBMED:8048228] [PUBMED:18305268] [PUBMED:10430616] [PUBMED:15459673]
Transmission across Chemical Synapses [NCBI:1268766] [REACTOME:R-HSA-112315]
Unblocking of NMDA receptor, glutamate binding and activation [NCBI:1268799] [REACTOME:R-HSA-438066] [PUBMED:9481670]
VEGFA-VEGFR2 Pathway [NCBI:1269483] [REACTOME:R-HSA-4420097] [PUBMED:16633338] [PUBMED:17344076] [PUBMED:13678960] [PUBMED:19230644]
VEGFR2 mediated cell proliferation [NCBI:1269485] [REACTOME:R-HSA-5218921] [PUBMED:22180219] [PUBMED:22762016] [PUBMED:22866201]
cAMP signaling pathway [NCBI:1017634] [KEGG:hsa04024] [PUBMED:9204709] [PUBMED:21693691] [PUBMED:21744067] [PUBMED:21346730] [PUBMED:24062645] [PUBMED:18176800] [PUBMED:24450633] [PUBMED:22082266] [PUBMED:16460276] [PUBMED:16765984] [PUBMED:14715909] [PUBMED:7688165] [PUBMED:18064650] [PUBMED:11117527] [PUBMED:24281338] [PUBMED:11493633] [PUBMED:21852968] [PUBMED:15142747] [PUBMED:21212391] [PUBMED:19874988] [PUBMED:17077866] [PUBMED:22022314] [PUBMED:16571352] [PUBMED:10880354] [PUBMED:24613710] [PUBMED:18323530] [PUBMED:19460777]