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Genes
SOCS1
Gene - SOCS1
full name
suppressor of cytokine signaling 1
synonyms
CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3, SOCS1, ENSG00000185338
HGNC
HGNC:19383
Entrez Gene
Gene:8651
ENSEMBL
ENSG00000185338
location
chr: 16
start: 11348274
stop: 11350039
strand: -
transcripts
NM_003745.1
pathways
Activated TLR4 signalling
[NCBI:1269236]
[REACTOME:R-HSA-166054]
[PUBMED:15276183]
[PUBMED:15588429]
[PUBMED:15845500]
[PUBMED:15596121]
Adaptive Immune System
[NCBI:1269171]
[REACTOME:R-HSA-1280218]
[PUBMED:16551257]
[PUBMED:21682741]
[PUBMED:11861602]
Antigen processing: Ubiquitination & Proteasome degradation
[NCBI:1269193]
[REACTOME:R-HSA-983168]
[PUBMED:12648452]
[PUBMED:11917093]
[PUBMED:19489725]
[PUBMED:14734113]
[PUBMED:20351195]
[PUBMED:17145306]
Class I MHC mediated antigen processing & presentation
[NCBI:1269192]
[REACTOME:R-HSA-983169]
[PUBMED:8717519]
[PUBMED:17145306]
[PUBMED:18926908]
[PUBMED:17055423]
[PUBMED:12495737]
[PUBMED:18641646]
[PUBMED:18243674]
Cytokine Signaling in Immune system
[NCBI:1269310]
[REACTOME:R-HSA-1280215]
[PUBMED:12613569]
Growth hormone receptor signaling
[NCBI:1269327]
[REACTOME:R-HSA-982772]
[PUBMED:15601831]
[PUBMED:8548048]
[PUBMED:17488973]
[PUBMED:20664532]
IFN-gamma pathway
[NCBI:138040]
[Pathway Interaction Database:ifngpathway]
[PUBMED:9724754]
[PUBMED:10657627]
[PUBMED:10067896]
[PUBMED:9271410]
[PUBMED:8608598]
[PUBMED:15878863]
[PUBMED:11971965]
[PUBMED:11438544]
[PUBMED:15051500]
[PUBMED:17032168]
[PUBMED:11909529]
[PUBMED:11171987]
[PUBMED:7514165]
[PUBMED:12817007]
[PUBMED:8232552]
[PUBMED:10485906]
[PUBMED:8755534]
[PUBMED:10490100]
[PUBMED:8156998]
[PUBMED:11972023]
[PUBMED:8986769]
[PUBMED:12438563]
[PUBMED:10022928]
[PUBMED:12270932]
[PUBMED:7510216]
[PUBMED:15311277]
[PUBMED:14670297]
[PUBMED:12048245]
[PUBMED:10777554]
[PUBMED:12138178]
[PUBMED:9336467]
[PUBMED:7690989]
[PUBMED:1281555]
[PUBMED:17606919]
[PUBMED:10805787]
[PUBMED:12050152]
[PUBMED:8608597]
[PUBMED:15879117]
[PUBMED:12855578]
[PUBMED:10995751]
[PUBMED:10490099]
[PUBMED:7777519]
IL12-mediated signaling events
[NCBI:137922]
[Pathway Interaction Database:il12_2pathway]
[PUBMED:12874225]
[PUBMED:12221108]
[PUBMED:16380506]
[PUBMED:9768751]
[PUBMED:17114419]
[PUBMED:10358173]
[PUBMED:9890938]
[PUBMED:12213961]
[PUBMED:11120802]
[PUBMED:9202126]
[PUBMED:16641133]
[PUBMED:10198225]
[PUBMED:16763563]
[PUBMED:15728489]
[PUBMED:8103068]
[PUBMED:10903740]
[PUBMED:10201984]
[PUBMED:7638186]
[PUBMED:11894097]
[PUBMED:16220539]
[PUBMED:10961885]
[PUBMED:7594594]
[PUBMED:17110450]
[PUBMED:9582275]
[PUBMED:10320373]
[PUBMED:7528775]
[PUBMED:11207258]
[PUBMED:9038232]
[PUBMED:15522880]
[PUBMED:11175814]
[PUBMED:9531298]
[PUBMED:7722452]
[PUBMED:8943050]
[PUBMED:7553885]
[PUBMED:9454765]
IL2-mediated signaling events
[NCBI:137976]
[Pathway Interaction Database:il2_1pathway]
[PUBMED:7568005]
[PUBMED:10962026]
[PUBMED:1545122]
[PUBMED:10602027]
[PUBMED:15170389]
[PUBMED:9092570]
[PUBMED:7509794]
[PUBMED:15356145]
[PUBMED:9973481]
[PUBMED:10899310]
[PUBMED:9195132]
[PUBMED:7544001]
[PUBMED:7777534]
[PUBMED:12681450]
[PUBMED:7665592]
[PUBMED:8702919]
[PUBMED:1708096]
[PUBMED:8643566]
[PUBMED:7988557]
[PUBMED:7737351]
[PUBMED:1532814]
[PUBMED:8262551]
[PUBMED:8025955]
[PUBMED:10993906]
[PUBMED:3095922]
[PUBMED:8805624]
[PUBMED:9391116]
[PUBMED:7973658]
[PUBMED:11331873]
[PUBMED:10421845]
[PUBMED:8119884]
[PUBMED:7781605]
[PUBMED:12543077]
[PUBMED:9133424]
[PUBMED:1618313]
[PUBMED:1940342]
[PUBMED:9382798]
[PUBMED:10514520]
[PUBMED:7973659]
[PUBMED:1639773]
[PUBMED:9029085]
[PUBMED:7760801]
[PUBMED:1460037]
[PUBMED:9202126]
[PUBMED:1652056]
[PUBMED:12393431]
[PUBMED:8397196]
[PUBMED:2047859]
[PUBMED:7688728]
[PUBMED:8700888]
[PUBMED:7528668]
[PUBMED:9305919]
[PUBMED:2303462]
[PUBMED:7568001]
[PUBMED:9822600]
[PUBMED:7543676]
[PUBMED:7499365]
[PUBMED:10843677]
[PUBMED:7600304]
[PUBMED:7719937]
[PUBMED:9590209]
[PUBMED:9794391]
[PUBMED:10849428]
[PUBMED:8294403]
[PUBMED:10373548]
[PUBMED:2590941]
[PUBMED:9512511]
[PUBMED:6434688]
[PUBMED:9697832]
[PUBMED:10982827]
[PUBMED:10214954]
[PUBMED:10825200]
[PUBMED:1535827]
[PUBMED:10369681]
[PUBMED:7719938]
[PUBMED:1655887]
[PUBMED:8376945]
[PUBMED:1996324]
[PUBMED:7479881]
[PUBMED:10962581]
[PUBMED:7973657]
[PUBMED:1631559]
[PUBMED:10066828]
[PUBMED:9169478]
[PUBMED:8552611]
[PUBMED:8483935]
[PUBMED:2106566]
[PUBMED:16199887]
IL4-mediated signaling events
[NCBI:137933]
[Pathway Interaction Database:il4_2pathway]
[PUBMED:8602263]
[PUBMED:15199062]
[PUBMED:7705411]
[PUBMED:11160325]
[PUBMED:8557643]
[PUBMED:8134361]
[PUBMED:1948049]
[PUBMED:10843732]
[PUBMED:11034397]
[PUBMED:8624802]
[PUBMED:14557412]
[PUBMED:1997653]
[PUBMED:10586089]
[PUBMED:14634100]
[PUBMED:17541284]
[PUBMED:8124718]
[PUBMED:16210622]
[PUBMED:7822337]
[PUBMED:11572871]
[PUBMED:2147202]
[PUBMED:10228008]
[PUBMED:7675087]
[PUBMED:12574343]
[PUBMED:14603527]
[PUBMED:15659391]
[PUBMED:11160269]
[PUBMED:7760829]
[PUBMED:7973658]
[PUBMED:10072514]
[PUBMED:9013879]
[PUBMED:8624803]
[PUBMED:10490661]
[PUBMED:14978013]
[PUBMED:10364072]
[PUBMED:12459556]
[PUBMED:11714803]
[PUBMED:8602264]
[PUBMED:9811885]
[PUBMED:12776189]
[PUBMED:15728454]
[PUBMED:10601358]
[PUBMED:11739727]
[PUBMED:11160275]
[PUBMED:9852037]
[PUBMED:9670964]
[PUBMED:15004182]
[PUBMED:8266078]
[PUBMED:3144043]
[PUBMED:8992992]
[PUBMED:8089482]
[PUBMED:9651359]
[PUBMED:16810739]
[PUBMED:7499365]
[PUBMED:7721786]
[PUBMED:9065461]
[PUBMED:11241672]
[PUBMED:10950967]
[PUBMED:8810328]
[PUBMED:8624821]
[PUBMED:9110977]
[PUBMED:8609418]
[PUBMED:15187136]
[PUBMED:9414268]
[PUBMED:8916957]
[PUBMED:10201892]
[PUBMED:17200144]
[PUBMED:8458387]
[PUBMED:11544308]
[PUBMED:10657944]
[PUBMED:15153491]
[PUBMED:7544011]
[PUBMED:8266076]
[PUBMED:11801631]
[PUBMED:12044779]
[PUBMED:8621475]
[PUBMED:9697832]
[PUBMED:12242343]
[PUBMED:7694370]
[PUBMED:9380721]
[PUBMED:9541585]
[PUBMED:7807002]
[PUBMED:16537510]
[PUBMED:8258319]
[PUBMED:9799097]
[PUBMED:12023955]
[PUBMED:8085155]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Insulin signaling pathway
[NCBI:83090]
[KEGG:hsa04910]
[PUBMED:11742412]
[PUBMED:11343120]
[PUBMED:15733744]
[PUBMED:11282018]
[PUBMED:10196204]
[PUBMED:18291668]
[PUBMED:9609110]
[PUBMED:10567225]
[PUBMED:12791379]
[PUBMED:9748166]
[PUBMED:15624019]
[PUBMED:9445476]
[PUBMED:9346240]
[PUBMED:14635525]
[PUBMED:16288289]
[PUBMED:12867054]
[PUBMED:15229476]
[PUBMED:17344645]
[PUBMED:9609111]
Interferon Signaling
[NCBI:1269311]
[REACTOME:R-HSA-913531]
[PUBMED:18929502]
[PUBMED:15607020]
[PUBMED:15864272]
[PUBMED:14525967]
[PUBMED:19059436]
Interferon alpha/beta signaling
[NCBI:1269312]
[REACTOME:R-HSA-909733]
[PUBMED:8621447]
[PUBMED:8605876]
[PUBMED:8702790]
[PUBMED:17969444]
Interferon gamma signaling
[NCBI:1269314]
[REACTOME:R-HSA-877300]
[PUBMED:9462485]
[PUBMED:18929502]
[PUBMED:9143700]
[PUBMED:14525967]
Interleukin-4 and 13 signaling
[NCBI:1470923]
[REACTOME:R-HSA-6785807]
[PUBMED:12704343]
[PUBMED:10358772]
Jak-STAT signaling pathway
[NCBI:83077]
[KEGG:hsa04630]
[PUBMED:21034406]
[PUBMED:22339650]
[PUBMED:16204702]
[PUBMED:25587654]
[PUBMED:24069565]
[PUBMED:22383755]
[PUBMED:24606160]
[PUBMED:10851053]
[PUBMED:23735217]
[PUBMED:25217450]
[PUBMED:21372217]
MicroRNAs in cancer
[NCBI:852705]
[KEGG:hsa05206]
[PUBMED:23075324]
[PUBMED:21742789]
[PUBMED:22351564]
[PUBMED:18817506]
[PUBMED:22345301]
[PUBMED:21402473]
[PUBMED:22926415]
[PUBMED:23165235]
[PUBMED:19630570]
[PUBMED:21565290]
[PUBMED:23091478]
[PUBMED:23462054]
[PUBMED:23316212]
[PUBMED:19773200]
[PUBMED:22035854]
[PUBMED:20221895]
[PUBMED:20345848]
[PUBMED:22580099]
[PUBMED:20128019]
MyD88:Mal cascade initiated on plasma membrane
[NCBI:1269237]
[REACTOME:R-HSA-166058]
[PUBMED:15276183]
Osteoclast differentiation
[NCBI:193147]
[KEGG:hsa04380]
[PUBMED:17633024]
[PUBMED:18382763]
[PUBMED:18329366]
[PUBMED:17869613]
[PUBMED:18722561]
[PUBMED:15122243]
[PUBMED:20703218]
[PUBMED:12748652]
[PUBMED:12110142]
[PUBMED:19585227]
[PUBMED:15546140]
[PUBMED:16184196]
[PUBMED:15817678]
[PUBMED:20392226]
[PUBMED:16313349]
[PUBMED:16313342]
[PUBMED:17380158]
[PUBMED:18451259]
Prolactin signaling pathway
[NCBI:814182]
[KEGG:hsa04917]
[PUBMED:17519353]
[PUBMED:17535875]
[PUBMED:20149678]
[PUBMED:12670737]
[PUBMED:17307904]
[PUBMED:18601698]
[PUBMED:17975019]
[PUBMED:16231422]
[PUBMED:18219564]
[PUBMED:9475379]
[PUBMED:16677418]
[PUBMED:9626554]
[PUBMED:21664429]
[PUBMED:11606470]
Regulation of IFNA signaling
[NCBI:1269313]
[REACTOME:R-HSA-912694]
[PUBMED:16710296]
[PUBMED:16311601]
[PUBMED:10526574]
Regulation of IFNG signaling
[NCBI:1269315]
[REACTOME:R-HSA-877312]
[PUBMED:10526574]
[PUBMED:18031232]
[PUBMED:12645661]
Regulation of KIT signaling
[NCBI:1269488]
[REACTOME:R-HSA-1433559]
[PUBMED:10582339]
[PUBMED:16483568]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by Interleukins
[NCBI:1269318]
[REACTOME:R-HSA-449147]
[PUBMED:19302047]
[PUBMED:12445398]
Signaling by SCF-KIT
[NCBI:1269487]
[REACTOME:R-HSA-1433557]
[PUBMED:17350321]
[PUBMED:16483568]
[PUBMED:7688988]
[PUBMED:19540337]
[PUBMED:16475976]
[PUBMED:15526160]
Signaling events mediated by Stem cell factor receptor (c-Kit)
[NCBI:138068]
[Pathway Interaction Database:kitpathway]
[PUBMED:12909618]
[PUBMED:10364466]
[PUBMED:10673502]
[PUBMED:15315962]
[PUBMED:12192036]
[PUBMED:12444928]
[PUBMED:15504549]
[PUBMED:8950973]
[PUBMED:11071635]
[PUBMED:12149208]
[PUBMED:11369651]
[PUBMED:9038210]
[PUBMED:10679268]
[PUBMED:15465815]
[PUBMED:10523831]
[PUBMED:8611693]
[PUBMED:15676208]
[PUBMED:11805142]
[PUBMED:10637471]
[PUBMED:9872323]
[PUBMED:11809791]
[PUBMED:11520784]
[PUBMED:12691919]
[PUBMED:10397721]
[PUBMED:15611091]
[PUBMED:12356726]
[PUBMED:9528781]
[PUBMED:1381360]
[PUBMED:9651683]
[PUBMED:10849422]
[PUBMED:9355737]
Toll Like Receptor 2 (TLR2) Cascade
[NCBI:1269238]
[REACTOME:R-HSA-181438]
[PUBMED:10820283]
Toll Like Receptor 4 (TLR4) Cascade
[NCBI:1269234]
[REACTOME:R-HSA-166016]
Toll Like Receptor TLR1:TLR2 Cascade
[NCBI:1269239]
[REACTOME:R-HSA-168179]
[PUBMED:12975352]
Toll Like Receptor TLR6:TLR2 Cascade
[NCBI:1269240]
[REACTOME:R-HSA-168188]
[PUBMED:14977973]
Toll-Like Receptors Cascades
[NCBI:1269204]
[REACTOME:R-HSA-168898]
[PUBMED:15950447]
[PUBMED:12893815]
[PUBMED:15976490]
[PUBMED:15585605]
[PUBMED:14751757]
Toxoplasmosis
[NCBI:169642]
[KEGG:hsa05145]
[PUBMED:18617274]
[PUBMED:19400868]
[PUBMED:17024357]
[PUBMED:19744886]
[PUBMED:19891610]
[PUBMED:17110955]
[PUBMED:12106793]
[PUBMED:12580944]
[PUBMED:12857995]
[PUBMED:10234174]
[PUBMED:18327664]
[PUBMED:10525166]
[PUBMED:18059289]
[PUBMED:18775432]
[PUBMED:14642303]
[PUBMED:15361242]
[PUBMED:16339966]
[PUBMED:14987366]
[PUBMED:15639739]
Type II diabetes mellitus
[NCBI:83094]
[KEGG:hsa04930]
[PUBMED:12480546]
[PUBMED:15759102]
[PUBMED:9011569]
[PUBMED:11078440]
[PUBMED:11390407]
[PUBMED:15258147]
[PUBMED:15823385]
[PUBMED:11272200]
[PUBMED:11325516]
[PUBMED:15733744]
[PUBMED:9974390]
[PUBMED:7491105]
[PUBMED:15585596]
Ubiquitin mediated proteolysis
[NCBI:83056]
[KEGG:hsa04120]
[PUBMED:16405856]
[PUBMED:12944364]
[PUBMED:16922408]
[PUBMED:17588513]
[PUBMED:16922367]
[PUBMED:16922370]
[PUBMED:16816840]