full name
glutamate-ammonia ligase

synonyms
GLNS, GS, PIG43, PIG59, GLUL, ENSG00000135821

HGNC
HGNC:4341

Entrez Gene
Gene:2752

ENSEMBL
ENSG00000135821

location
chr: 1
start: 182350839
stop: 182361341
strand: -

OMIM
OMIM:138290: GLUL (Autosomal recessive inheritance)
OMIM:610015: Glutamine deficiency, congenital

transcripts
NM_001033044.2
NM_002065.5
NM_001033056.2

pathways
Alanine, aspartate and glutamate metabolism [NCBI:101142] [KEGG:hsa00250] [PUBMED:9687539]
Amino acid synthesis and interconversion (transamination) [NCBI:1270159] [REACTOME:R-HSA-70614]
Arginine biosynthesis [NCBI:82943] [KEGG:hsa00220]
Astrocytic Glutamate-Glutamine Uptake And Metabolism [NCBI:1268785] [REACTOME:R-HSA-210455]
Biosynthesis of amino acids [NCBI:790012] [KEGG:hsa01230]
GABA shunt [NCBI:142350] [BIOCYC:HUMAN_GLUDEG-I-PWY] [PUBMED:9816471] [PUBMED:15528998] [PUBMED:15571623] [PUBMED:13044808] [PUBMED:12208142] [PUBMED:8156960] [PUBMED:15003233] [PUBMED:8207021]
GABAergic synapse [NCBI:377263] [KEGG:hsa04727] [PUBMED:20655485] [PUBMED:21555068] [PUBMED:12086709] [PUBMED:17499108] [PUBMED:17499109] [PUBMED:19374920] [PUBMED:21376567] [PUBMED:20655481] [PUBMED:16787421] [PUBMED:15210304] [PUBMED:18382465] [PUBMED:9364667] [PUBMED:12888801] [PUBMED:16932937] [PUBMED:10780899]
Glutamatergic synapse [NCBI:213818] [KEGG:hsa04724] [PUBMED:18425072] [PUBMED:10481192] [PUBMED:11561058] [PUBMED:17706608] [PUBMED:19112153] [PUBMED:17663464] [PUBMED:19110202] [PUBMED:9665875] [PUBMED:19559598] [PUBMED:18464791] [PUBMED:11672421] [PUBMED:14684436] [PUBMED:12399578] [PUBMED:20055706]
Glyoxylate and dicarboxylate metabolism [NCBI:83002] [KEGG:hsa00630] [PUBMED:10978349] [PUBMED:16407450] [PUBMED:21252347] [PUBMED:11513957] [PUBMED:9596633] [PUBMED:18065535] [PUBMED:18819910]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of amino acids and derivatives [NCBI:1270158] [REACTOME:R-HSA-71291]
Neuronal System [NCBI:1268763] [REACTOME:R-HSA-112316]
Neurotransmitter uptake and Metabolism In Glial Cells [NCBI:1268784] [REACTOME:R-HSA-112313]
Nitrogen metabolism [NCBI:83025] [KEGG:hsa00910] [PUBMED:14702404] [PUBMED:26610025] [PUBMED:11921398] [PUBMED:18021072] [PUBMED:15528644] [PUBMED:17408485] [PUBMED:26610024] [PUBMED:19247843] [PUBMED:11004450] [PUBMED:22221911]
Transmission across Chemical Synapses [NCBI:1268766] [REACTOME:R-HSA-112315]
glutamate dependent acid resistance [NCBI:142441] [BIOCYC:HUMAN_PWY0-1305]
glutamine biosynthesis [NCBI:142149] [BIOCYC:HUMAN_GLNSYN-PWY] [PUBMED:9359847] [PUBMED:2185740]