Logo
full name
poly(A)-specific ribonuclease

synonyms
DAN, PARN, ENSG00000140694

HGNC
HGNC:8609

Entrez Gene
Gene:5073

ENSEMBL
ENSG00000140694

location
chr: 16
start: 14529557
stop: 14724128
strand: -

OMIM
OMIM:604212: PARN
OMIM:616353: Dyskeratosis congenita, autosomal recessive 6
OMIM:616371: Pulmonary fibrosis and/or bone marrow failure, telomere-related, 4

transcripts
NM_001134477.2
NM_001242992.1
NM_002582.3

pathways
ATF4 activates genes [NCBI:1268762] [REACTOME:R-HSA-380994] [PUBMED:18840095] [PUBMED:16931790] [PUBMED:14742429] [PUBMED:16687408] [PUBMED:20022965] [PUBMED:18426796] [PUBMED:14630918] [PUBMED:16912112]
Deadenylation of mRNA [NCBI:1269713] [REACTOME:R-HSA-429947] [PUBMED:17245413] [PUBMED:17052452] [PUBMED:15475613] [PUBMED:18608124] [PUBMED:11283721] [PUBMED:16141059] [PUBMED:19239894] [PUBMED:14749774]
Deadenylation-dependent mRNA decay [NCBI:1269712] [REACTOME:R-HSA-429914] [PUBMED:19239894] [PUBMED:14749774] [PUBMED:17245413] [PUBMED:15475613] [PUBMED:16141059] [PUBMED:11283721]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
KSRP (KHSRP) binds and destabilizes mRNA [NCBI:1269729] [REACTOME:R-HSA-450604] [PUBMED:16391004] [PUBMED:12704645] [PUBMED:12440953]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
PERK regulates gene expression [NCBI:1268761] [REACTOME:R-HSA-381042] [PUBMED:18048764] [PUBMED:17956313] [PUBMED:18038217] [PUBMED:18436705]
RNA degradation [NCBI:117291] [KEGG:hsa03018] [PUBMED:16939780] [PUBMED:17560162] [PUBMED:17471261] [PUBMED:16968219] [PUBMED:16766188] [PUBMED:17447862] [PUBMED:19239894]
Regulation of mRNA stability by proteins that bind AU-rich elements [NCBI:1269725] [REACTOME:R-HSA-450531] [PUBMED:12440953] [PUBMED:12704645] [PUBMED:15460540] [PUBMED:16391004]
Unfolded Protein Response (UPR) [NCBI:1268756] [REACTOME:R-HSA-381119] [PUBMED:18436705] [PUBMED:18038217] [PUBMED:27067637] [PUBMED:16365312] [PUBMED:18048764] [PUBMED:15952902]