full name
polo like kinase 1

synonyms
PLK, STPK13, PLK1, ENSG00000166851

HGNC
HGNC:9077

Entrez Gene
Gene:5347

ENSEMBL
ENSG00000166851

location
chr: 16
start: 23690201
stop: 23701688
strand: +

transcripts
NM_005030.3

pathways
APC/C-mediated degradation of cell cycle proteins [NCBI:1269838] [REACTOME:R-HSA-174143] [PUBMED:15678131] [PUBMED:12049731]
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 [NCBI:1269851] [REACTOME:R-HSA-174178] [PUBMED:16413484] [PUBMED:15678131]
AURKA Activation by TPX2 [NCBI:1383018] [REACTOME:R-HSA-8854518] [PUBMED:14580337] [PUBMED:21147853] [PUBMED:22094468] [PUBMED:21347367]
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins [NCBI:1269842] [REACTOME:R-HSA-176814] [PUBMED:15678131]
Activation of NIMA Kinases NEK9, NEK6, NEK7 [NCBI:1269816] [REACTOME:R-HSA-2980767] [PUBMED:21642957] [PUBMED:12840024] [PUBMED:19941817] [PUBMED:12101123]
Anchoring of the basal body to the plasma membrane [NCBI:1268847] [REACTOME:R-HSA-5620912] [PUBMED:21816947] [PUBMED:23747070] [PUBMED:19575670] [PUBMED:13978319] [PUBMED:23348840] [PUBMED:25047614] [PUBMED:20819941] [PUBMED:5661997] [PUBMED:21422230] [PUBMED:24469809] [PUBMED:23530209] [PUBMED:21725307] [PUBMED:21680046] [PUBMED:23351793] [PUBMED:21427764] [PUBMED:11676918] [PUBMED:22653444]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
Cell cycle [NCBI:83054] [KEGG:hsa04110] [PUBMED:7973727] [PUBMED:17568790] [PUBMED:9832503] [PUBMED:16936746] [PUBMED:9029154] [PUBMED:12573239] [PUBMED:19020303] [PUBMED:9618481] [PUBMED:12809600] [PUBMED:8242749] [PUBMED:10385618] [PUBMED:17426725] [PUBMED:17018296] [PUBMED:16212951] [PUBMED:12925736] [PUBMED:11099028] [PUBMED:15568976] [PUBMED:15838516] [PUBMED:15838523] [PUBMED:15876871] [PUBMED:7908906] [PUBMED:9889196]
Centrosome maturation [NCBI:1269805] [REACTOME:R-HSA-380287] [PUBMED:17178454] [PUBMED:18437411]
Cilium Assembly [NCBI:1268846] [REACTOME:R-HSA-5617833] [PUBMED:21427764] [PUBMED:23351793] [PUBMED:25040720] [PUBMED:17955020] [PUBMED:22118932] [PUBMED:22653444] [PUBMED:22389062] [PUBMED:20399632] [PUBMED:25047619] [PUBMED:20395968] [PUBMED:23945166] [PUBMED:19575670] [PUBMED:24296415] [PUBMED:20145001] [PUBMED:19602418]
Condensation of Prophase Chromosomes [NCBI:1269813] [REACTOME:R-HSA-2299718] [PUBMED:18367646] [PUBMED:12208845] [PUBMED:21498573] [PUBMED:20966048] [PUBMED:12086618] [PUBMED:20622854]
Cyclin A/B1 associated events during G2/M transition [NCBI:1269800] [REACTOME:R-HSA-69273] [PUBMED:18228324]
FOXM1 transcription factor network [NCBI:137935] [Pathway Interaction Database:foxm1pathway] [PUBMED:17141659] [PUBMED:12482952] [PUBMED:16913845] [PUBMED:16809346] [PUBMED:15671063] [PUBMED:16504183] [PUBMED:15082532] [PUBMED:15531365] [PUBMED:17366632] [PUBMED:16314512] [PUBMED:17173139] [PUBMED:16618419] [PUBMED:15024056] [PUBMED:11682060] [PUBMED:15654331] [PUBMED:15817462] [PUBMED:17404569] [PUBMED:16875671] [PUBMED:16965535] [PUBMED:17101782]
FoxO family signaling [NCBI:138036] [Pathway Interaction Database:foxopathway] [PUBMED:17038621] [PUBMED:15788402] [PUBMED:14976264] [PUBMED:11864996] [PUBMED:12517744] [PUBMED:11050388] [PUBMED:10960473] [PUBMED:10783894] [PUBMED:11154281] [PUBMED:11313479] [PUBMED:11777915] [PUBMED:11980723] [PUBMED:10102273] [PUBMED:15509806] [PUBMED:11237865] [PUBMED:16751106] [PUBMED:12857750] [PUBMED:15538382] [PUBMED:12239572] [PUBMED:12048180] [PUBMED:11884717] [PUBMED:11884591] [PUBMED:15084260] [PUBMED:11964479] [PUBMED:10217147] [PUBMED:15109499] [PUBMED:16964248] [PUBMED:15905404] [PUBMED:11607034] [PUBMED:15668399] [PUBMED:15220471] [PUBMED:10358075] [PUBMED:16424905]
FoxO signaling pathway [NCBI:921162] [KEGG:hsa04068] [PUBMED:23325358] [PUBMED:15005655] [PUBMED:18951090] [PUBMED:22761423] [PUBMED:22902436] [PUBMED:16288288] [PUBMED:19701188] [PUBMED:16964248] [PUBMED:18045156] [PUBMED:18403263] [PUBMED:21613825] [PUBMED:21440011] [PUBMED:17470511] [PUBMED:21238503] [PUBMED:17522590] [PUBMED:15084259] [PUBMED:23801966] [PUBMED:17569704] [PUBMED:15516968]
G2/M Transition [NCBI:1269799] [REACTOME:R-HSA-69275]
Golgi Cisternae Pericentriolar Stack Reorganization [NCBI:1269812] [REACTOME:R-HSA-162658] [PUBMED:18434598] [PUBMED:17431394] [PUBMED:18385516] [PUBMED:12839990] [PUBMED:17182854] [PUBMED:20083603] [PUBMED:11285137] [PUBMED:15576368] [PUBMED:12695496] [PUBMED:20937827] [PUBMED:11408587] [PUBMED:16533948] [PUBMED:12015985] [PUBMED:9458043] [PUBMED:9753325] [PUBMED:10679020] [PUBMED:11739401] [PUBMED:15232108] [PUBMED:15678101]
Loss of Nlp from mitotic centrosomes [NCBI:1269809] [REACTOME:R-HSA-380259] [PUBMED:12852856]
Loss of proteins required for interphase microtubule organization from the centrosome [NCBI:1269808] [REACTOME:R-HSA-380284] [PUBMED:12140259] [PUBMED:12852856]
M Phase [NCBI:1269810] [REACTOME:R-HSA-68886]
Mitotic Anaphase [NCBI:1269825] [REACTOME:R-HSA-68882]
Mitotic G2-G2/M phases [NCBI:1269797] [REACTOME:R-HSA-453274]
Mitotic Metaphase and Anaphase [NCBI:1269823] [REACTOME:R-HSA-2555396]
Mitotic Metaphase/Anaphase Transition [NCBI:1269824] [REACTOME:R-HSA-68881]
Mitotic Prometaphase [NCBI:1269820] [REACTOME:R-HSA-68877]
Mitotic Prophase [NCBI:1269811] [REACTOME:R-HSA-68875]
Mitotic Telophase/Cytokinesis [NCBI:1269829] [REACTOME:R-HSA-68884]
Nuclear Envelope Breakdown [NCBI:1269815] [REACTOME:R-HSA-2980766] [PUBMED:19234477]
Oocyte meiosis [NCBI:126909] [KEGG:hsa04114] [PUBMED:16760654] [PUBMED:17480229] [PUBMED:15136768] [PUBMED:18946022] [PUBMED:18598214] [PUBMED:16518630] [PUBMED:18631137] [PUBMED:15182704] [PUBMED:15182701] [PUBMED:16554437] [PUBMED:14691134] [PUBMED:18550795] [PUBMED:18096427] [PUBMED:14517314] [PUBMED:18311174]
Organelle biogenesis and maintenance [NCBI:1268838] [REACTOME:R-HSA-1852241] [PUBMED:8608592] [PUBMED:16103713]
PLK1 signaling events [NCBI:138007] [Pathway Interaction Database:plk1_pathway] [PUBMED:15070733] [PUBMED:18418076] [PUBMED:15350223] [PUBMED:16885021] [PUBMED:12167714] [PUBMED:16966375] [PUBMED:18615013] [PUBMED:18662541] [PUBMED:18521620] [PUBMED:7790358] [PUBMED:8428596] [PUBMED:12852857] [PUBMED:18427546] [PUBMED:17446864] [PUBMED:16760428] [PUBMED:15148369] [PUBMED:16885022] [PUBMED:9734353] [PUBMED:18331714] [PUBMED:16980960] [PUBMED:18378770] [PUBMED:16860740] [PUBMED:15964272] [PUBMED:10980711] [PUBMED:11050165] [PUBMED:16580887] [PUBMED:17360533] [PUBMED:15678101] [PUBMED:11897663] [PUBMED:16418575] [PUBMED:17218258] [PUBMED:14734534] [PUBMED:18566290] [PUBMED:17081991] [PUBMED:15469984] [PUBMED:11447294] [PUBMED:17351640] [PUBMED:16934469] [PUBMED:18552834] [PUBMED:17488623] [PUBMED:8991084] [PUBMED:17785528] [PUBMED:18477460] [PUBMED:19351716] [PUBMED:12939256] [PUBMED:12852856] [PUBMED:15737063]
Phosphorylation of Emi1 [NCBI:1269840] [REACTOME:R-HSA-176417]
Phosphorylation of the APC/C [NCBI:1269843] [REACTOME:R-HSA-176412] [PUBMED:10793135]
Polo-like kinase mediated events [NCBI:1269804] [REACTOME:R-HSA-156711] [PUBMED:15692562] [PUBMED:22391450] [PUBMED:15654331] [PUBMED:15070733] [PUBMED:23109430] [PUBMED:19160488]
Polo-like kinase signaling events in the cell cycle [NCBI:138077] [Pathway Interaction Database:plk_pathway]
Progesterone-mediated oocyte maturation [NCBI:119304] [KEGG:hsa04914] [PUBMED:10497333] [PUBMED:12084906] [PUBMED:12045215] [PUBMED:11063930] [PUBMED:12477927] [PUBMED:11148128] [PUBMED:11730319] [PUBMED:12374568]
RHO GTPase Effectors [NCBI:1269509] [REACTOME:R-HSA-195258] [PUBMED:9694656] [PUBMED:18066052] [PUBMED:11018042] [PUBMED:10470034] [PUBMED:8702756] [PUBMED:21730051] [PUBMED:8571126] [PUBMED:19513348] [PUBMED:17244649] [PUBMED:11145705] [PUBMED:24128008] [PUBMED:23716662] [PUBMED:8617235] [PUBMED:8543060] [PUBMED:11804587] [PUBMED:24969695] [PUBMED:12635176] [PUBMED:12778124] [PUBMED:18006505] [PUBMED:1660188] [PUBMED:21351730] [PUBMED:16507994] [PUBMED:14595335] [PUBMED:10072071] [PUBMED:10591629] [PUBMED:10753910] [PUBMED:23875749] [PUBMED:17151359] [PUBMED:10652353] [PUBMED:12221077] [PUBMED:10559936] [PUBMED:12783890] [PUBMED:11948177] [PUBMED:18237546] [PUBMED:16079795] [PUBMED:10924361] [PUBMED:14514689] [PUBMED:8107774] [PUBMED:8756646] [PUBMED:16979770] [PUBMED:16636067] [PUBMED:9751706] [PUBMED:10619026] [PUBMED:23444367] [PUBMED:15546864] [PUBMED:12473120] [PUBMED:8816443] [PUBMED:9199170] [PUBMED:12514133] [PUBMED:16762923] [PUBMED:12110184] [PUBMED:16431929] [PUBMED:10975528] [PUBMED:10940294] [PUBMED:9535855] [PUBMED:7559638] [PUBMED:11162552] [PUBMED:19737400] [PUBMED:9988689] [PUBMED:12732141] [PUBMED:8798539] [PUBMED:24914801] [PUBMED:11689693] [PUBMED:8769096] [PUBMED:9368021]
RHO GTPases Activate Formins [NCBI:1269519] [REACTOME:R-HSA-5663220] [PUBMED:20233848] [PUBMED:15507212] [PUBMED:16292343] [PUBMED:12906795] [PUBMED:11779461] [PUBMED:21397845] [PUBMED:12577064] [PUBMED:17198702] [PUBMED:15006353] [PUBMED:20101212] [PUBMED:15944396] [PUBMED:10678165] [PUBMED:16943183] [PUBMED:16439214] [PUBMED:16472745] [PUBMED:10958683] [PUBMED:12732141] [PUBMED:15085137] [PUBMED:24914801] [PUBMED:9497258] [PUBMED:21576392] [PUBMED:21868368]
Recruitment of mitotic centrosome proteins and complexes [NCBI:1269806] [REACTOME:R-HSA-380270] [PUBMED:18437411] [PUBMED:17178454]
Regulation of APC/C activators between G1/S and early anaphase [NCBI:1269839] [REACTOME:R-HSA-176408] [PUBMED:16508672] [PUBMED:12049731] [PUBMED:12208841] [PUBMED:15678131]
Regulation of PLK1 Activity at G2/M Transition [NCBI:1269803] [REACTOME:R-HSA-2565942] [PUBMED:12207013] [PUBMED:18615013] [PUBMED:13678582] [PUBMED:18378770] [PUBMED:18566290] [PUBMED:18477460] [PUBMED:22365832]
Regulation of mitotic cell cycle [NCBI:1269837] [REACTOME:R-HSA-453276]
Resolution of Sister Chromatid Cohesion [NCBI:1269821] [REACTOME:R-HSA-2500257] [PUBMED:16541025] [PUBMED:15339662] [PUBMED:17112726] [PUBMED:9649503] [PUBMED:21111234] [PUBMED:15737063] [PUBMED:17113138] [PUBMED:21987589] [PUBMED:14730319] [PUBMED:11509732] [PUBMED:19696148] [PUBMED:21878504] [PUBMED:15723797]
Separation of Sister Chromatids [NCBI:1269826] [REACTOME:R-HSA-2467813] [PUBMED:11081627] [PUBMED:10411507] [PUBMED:12070128] [PUBMED:12194817] [PUBMED:11509732]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by Rho GTPases [NCBI:1269507] [REACTOME:R-HSA-194315] [PUBMED:16212495] [PUBMED:15630019]
The role of GTSE1 in G2/M progression after G2 checkpoint [NCBI:1383017] [REACTOME:R-HSA-8852276] [PUBMED:10984615] [PUBMED:9724637] [PUBMED:20577264] [PUBMED:14707141] [PUBMED:23236459] [PUBMED:20018861] [PUBMED:12750368]