full name
integrin subunit alpha L

synonyms
CD11A, LFA-1, LFA1A, ITGAL, ENSG00000005844

HGNC
HGNC:6148

Entrez Gene
Gene:3683

ENSEMBL
ENSG00000005844

location
chr: 16
start: 30483983
stop: 30534506
strand: +

transcripts
NM_002209.2
NM_001114380.1

pathways
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
CXCR3-mediated signaling events [NCBI:138011] [Pathway Interaction Database:cxcr3pathway] [PUBMED:15528361] [PUBMED:16210647] [PUBMED:9541591] [PUBMED:16368892] [PUBMED:9660793] [PUBMED:17289675] [PUBMED:16467404] [PUBMED:18291705] [PUBMED:18375741] [PUBMED:15150261] [PUBMED:9625760] [PUBMED:18174362] [PUBMED:11554781] [PUBMED:12750173] [PUBMED:12782716] [PUBMED:11136732] [PUBMED:11739530] [PUBMED:18292502]
Cell adhesion molecules (CAMs) [NCBI:83069] [KEGG:hsa04514] [PUBMED:15923648] [PUBMED:12500939] [PUBMED:15056568] [PUBMED:14519386] [PUBMED:12234363] [PUBMED:10964748] [PUBMED:15071551] [PUBMED:15551862] [PUBMED:14690046] [PUBMED:9150551] [PUBMED:14519398] [PUBMED:14556710] [PUBMED:11860281] [PUBMED:10664064] [PUBMED:9597126] [PUBMED:11050419] [PUBMED:12367625] [PUBMED:10798271] [PUBMED:16034094] [PUBMED:15115723] [PUBMED:15728677] [PUBMED:11910893] [PUBMED:15561584] [PUBMED:15882774] [PUBMED:12810109]
Cell surface interactions at the vascular wall [NCBI:1269373] [REACTOME:R-HSA-202733] [PUBMED:17525755] [PUBMED:11282294] [PUBMED:10798271] [PUBMED:8578462] [PUBMED:14615387] [PUBMED:16115029]
Epstein-Barr virus infection [NCBI:585562] [KEGG:hsa05169] [PUBMED:1658397] [PUBMED:10683340] [PUBMED:19375142] [PUBMED:12438576] [PUBMED:12910248] [PUBMED:10400785] [PUBMED:16007144] [PUBMED:14576817] [PUBMED:18559925] [PUBMED:16352731] [PUBMED:7895172] [PUBMED:15510157] [PUBMED:21518914] [PUBMED:10891508] [PUBMED:14673102] [PUBMED:17159145] [PUBMED:15542638] [PUBMED:18786993] [PUBMED:16603506] [PUBMED:10644367] [PUBMED:15021898] [PUBMED:10666279] [PUBMED:9565632]
Extracellular matrix organization [NCBI:1270244] [REACTOME:R-HSA-1474244] [PUBMED:21123617] [PUBMED:21917992] [PUBMED:12845610]
HTLV-I infection [NCBI:373901] [KEGG:hsa05166] [PUBMED:17446673] [PUBMED:16436385] [PUBMED:14686485] [PUBMED:19861996] [PUBMED:19092975] [PUBMED:11325603] [PUBMED:16155602] [PUBMED:12910251] [PUBMED:16155605] [PUBMED:16036567] [PUBMED:11244044] [PUBMED:18702816] [PUBMED:15569630] [PUBMED:21114861] [PUBMED:16155611] [PUBMED:17384582] [PUBMED:16155608] [PUBMED:10602469] [PUBMED:19014483] [PUBMED:9325311]
Hemostasis [NCBI:1269340] [REACTOME:R-HSA-109582]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell [NCBI:1269201] [REACTOME:R-HSA-198933] [PUBMED:17218381] [PUBMED:16603343] [PUBMED:16616474] [PUBMED:11244041] [PUBMED:16132082] [PUBMED:18425107]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Integrin cell surface interactions [NCBI:1270260] [REACTOME:R-HSA-216083] [PUBMED:10215583] [PUBMED:15147720] [PUBMED:12231361] [PUBMED:8866399] [PUBMED:19273203]
Leukocyte transendothelial migration [NCBI:83083] [KEGG:hsa04670] [PUBMED:15629883] [PUBMED:10975856] [PUBMED:14976004] [PUBMED:15265790] [PUBMED:15173832] [PUBMED:12540948] [PUBMED:15771581] [PUBMED:15604886] [PUBMED:14977592]
Malaria [NCBI:152665] [KEGG:hsa05144] [PUBMED:15106591] [PUBMED:11224682] [PUBMED:17630968] [PUBMED:18250459] [PUBMED:16138104] [PUBMED:20091081] [PUBMED:8920859] [PUBMED:19101208] [PUBMED:16019257] [PUBMED:15464448] [PUBMED:11832955] [PUBMED:12364790] [PUBMED:10885986] [PUBMED:15094163] [PUBMED:14737184] [PUBMED:15463497] [PUBMED:16468982] [PUBMED:19967139]
Natural killer cell mediated cytotoxicity [NCBI:83079] [KEGG:hsa04650] [PUBMED:12530970] [PUBMED:15567854] [PUBMED:8942070] [PUBMED:11905813] [PUBMED:9143705] [PUBMED:9862693] [PUBMED:11895890] [PUBMED:12205470] [PUBMED:11836514] [PUBMED:15607806] [PUBMED:16002670] [PUBMED:15618404] [PUBMED:11390470] [PUBMED:11062493] [PUBMED:14710949] [PUBMED:12752668] [PUBMED:15607802] [PUBMED:16109839] [PUBMED:12766758] [PUBMED:16177799]
Neutrophil degranulation [NCBI:1457780] [REACTOME:R-HSA-6798695] [PUBMED:20338884] [PUBMED:1378856] [PUBMED:17627888] [PUBMED:23650620] [PUBMED:8692836]
Paxillin-dependent events mediated by a4b1 [NCBI:138021] [Pathway Interaction Database:a4b1_paxdep_pathway] [PUBMED:11533025] [PUBMED:12837751] [PUBMED:16227616] [PUBMED:7689608] [PUBMED:10604475] [PUBMED:10781578] [PUBMED:12794117] [PUBMED:16365170] [PUBMED:15793570] [PUBMED:16670268] [PUBMED:12589802] [PUBMED:7507598]
Rap1 signaling pathway [NCBI:868086] [KEGG:hsa04015] [PUBMED:17624944] [PUBMED:12351703] [PUBMED:10579920] [PUBMED:19159611] [PUBMED:18363565] [PUBMED:12765839] [PUBMED:12508104] [PUBMED:11331911] [PUBMED:17182900] [PUBMED:15803158] [PUBMED:19615876] [PUBMED:21402149] [PUBMED:17624948] [PUBMED:17383543] [PUBMED:14607972] [PUBMED:15780587] [PUBMED:19710505]
Regulation of actin cytoskeleton [NCBI:83089] [KEGG:hsa04810] [PUBMED:11152757] [PUBMED:11082272] [PUBMED:10574699] [PUBMED:11082269] [PUBMED:14657486] [PUBMED:14744429] [PUBMED:12700767]
Rheumatoid arthritis [NCBI:200309] [KEGG:hsa05323] [PUBMED:9627005] [PUBMED:17195034] [PUBMED:15059264] [PUBMED:17380158] [PUBMED:20651747] [PUBMED:19455385] [PUBMED:20305562] [PUBMED:20510236] [PUBMED:19184540] [PUBMED:20392226] [PUBMED:17502360] [PUBMED:16313349] [PUBMED:16127012] [PUBMED:15055519] [PUBMED:20036936] [PUBMED:11861618] [PUBMED:19585227] [PUBMED:20193003]
Staphylococcus aureus infection [NCBI:172846] [KEGG:hsa05150] [PUBMED:18837785] [PUBMED:16679003] [PUBMED:18544012] [PUBMED:15372083] [PUBMED:19112495] [PUBMED:16640587] [PUBMED:15561843] [PUBMED:16322743] [PUBMED:16710608] [PUBMED:16111912] [PUBMED:11361034] [PUBMED:12091905] [PUBMED:16724100] [PUBMED:16242332] [PUBMED:17132726] [PUBMED:20178484] [PUBMED:16086019] [PUBMED:12228315] [PUBMED:19503103] [PUBMED:14993252] [PUBMED:18061675] [PUBMED:17114475] [PUBMED:17848512] [PUBMED:17517597] [PUBMED:20133685] [PUBMED:18045383] [PUBMED:16184199] [PUBMED:17893203] [PUBMED:20062962] [PUBMED:15273292]
Viral myocarditis [NCBI:125138] [KEGG:hsa05416] [PUBMED:19357408] [PUBMED:18545064] [PUBMED:18357777] [PUBMED:11524405] [PUBMED:12920582] [PUBMED:14522402] [PUBMED:17200452] [PUBMED:18039131] [PUBMED:16413486] [PUBMED:12439638] [PUBMED:16817756] [PUBMED:16845885] [PUBMED:10051305] [PUBMED:10904843]