full name
nucleotide binding oligomerization domain containing 2

synonyms
ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1, NOD2, ENSG00000167207

HGNC
HGNC:5331

Entrez Gene
Gene:64127

ENSEMBL
ENSG00000167207

location
chr: 16
start: 50727507
stop: 50766990
strand: +

OMIM
OMIM:605956: NOD2 (Autosomal dominant inheritance)
OMIM:186580: Blau syndrome
OMIM:266600: {Inflammatory bowel disease 1, Crohn disease}
OMIM:607507: {Psoriatic arthritis, susceptibility to}
OMIM:617321: {Yao syndrome}

transcripts
NM_022162.1

pathways
Activated TLR4 signalling [NCBI:1269236] [REACTOME:R-HSA-166054] [PUBMED:15276183] [PUBMED:15588429] [PUBMED:15845500] [PUBMED:15596121]
Canonical NF-kappaB pathway [NCBI:138030] [Pathway Interaction Database:nfkappabcanonicalpathway] [PUBMED:7878466] [PUBMED:10688673] [PUBMED:16497931] [PUBMED:10755617] [PUBMED:9660950] [PUBMED:9346241] [PUBMED:10195894] [PUBMED:10521409] [PUBMED:12917691] [PUBMED:15620648] [PUBMED:14695475] [PUBMED:14651848] [PUBMED:11319224] [PUBMED:9150141] [PUBMED:9819420] [PUBMED:15218148] [PUBMED:7739562] [PUBMED:12657630] [PUBMED:12867425] [PUBMED:16267042]
Cytokine Signaling in Immune system [NCBI:1269310] [REACTOME:R-HSA-1280215] [PUBMED:12613569]
Deubiquitination [NCBI:1427860] [REACTOME:R-HSA-5688426] [PUBMED:19243136] [PUBMED:20074029] [PUBMED:15571815] [PUBMED:20418328] [PUBMED:16325574] [PUBMED:12944365] [PUBMED:23845989] [PUBMED:22201797]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Inflammatory bowel disease (IBD) [NCBI:842771] [KEGG:hsa05321] [PUBMED:17499605] [PUBMED:12006974] [PUBMED:18053739] [PUBMED:20134493] [PUBMED:10898785] [PUBMED:18563156] [PUBMED:23176791] [PUBMED:18200661] [PUBMED:12797537] [PUBMED:21487504] [PUBMED:19381306] [PUBMED:21681604] [PUBMED:19322214] [PUBMED:16493424] [PUBMED:18242222] [PUBMED:12042806] [PUBMED:9759857]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Interleukin-1 signaling [NCBI:1269320] [REACTOME:R-HSA-446652] [PUBMED:19302047] [PUBMED:19022706]
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 [NCBI:1269212] [REACTOME:R-HSA-450321] [PUBMED:15837794] [PUBMED:11460167]
MAP kinase activation in TLR cascade [NCBI:1269211] [REACTOME:R-HSA-450294] [PUBMED:17637696] [PUBMED:11861597] [PUBMED:19196711] [PUBMED:11242034]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
MyD88 cascade initiated on plasma membrane [NCBI:1269207] [REACTOME:R-HSA-975871] [PUBMED:15728506] [PUBMED:16239509]
MyD88 dependent cascade initiated on endosome [NCBI:1269228] [REACTOME:R-HSA-975155] [PUBMED:20237413] [PUBMED:15276183] [PUBMED:18652679]
MyD88-independent TLR3/TLR4 cascade [NCBI:1269220] [REACTOME:R-HSA-166166] [PUBMED:15276183]
MyD88:Mal cascade initiated on plasma membrane [NCBI:1269237] [REACTOME:R-HSA-166058] [PUBMED:15276183]
NOD-like receptor signaling pathway [NCBI:122191] [KEGG:hsa04621] [PUBMED:25330206] [PUBMED:21575908] [PUBMED:23846113] [PUBMED:26549800] [PUBMED:16493424] [PUBMED:23124073] [PUBMED:24840700] [PUBMED:27291964] [PUBMED:27012466] [PUBMED:24707857] [PUBMED:19767725] [PUBMED:25879280] [PUBMED:23215645] [PUBMED:22819539] [PUBMED:23702978] [PUBMED:20643110] [PUBMED:25879288] [PUBMED:26655628] [PUBMED:25145756] [PUBMED:24718315] [PUBMED:26482951] [PUBMED:25526305] [PUBMED:26121197] [PUBMED:22430786]
NOD1/2 Signaling Pathway [NCBI:1269252] [REACTOME:R-HSA-168638] [PUBMED:18928408] [PUBMED:18585455] [PUBMED:18414735]
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways [NCBI:1269251] [REACTOME:R-HSA-168643] [PUBMED:18928408]
Ovarian tumor domain proteases [NCBI:1427863] [REACTOME:R-HSA-5689896] [PUBMED:23827681]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
Shigellosis [NCBI:83104] [KEGG:hsa05131] [PUBMED:11379633] [PUBMED:10491394] [PUBMED:17173036] [PUBMED:18202440] [PUBMED:17095701] [PUBMED:16622194] [PUBMED:16413487] [PUBMED:18005683] [PUBMED:15731041] [PUBMED:15073367] [PUBMED:12856283] [PUBMED:16939534] [PUBMED:17060328] [PUBMED:12065406] [PUBMED:8376337] [PUBMED:11207560] [PUBMED:8642302] [PUBMED:12356723] [PUBMED:15694852] [PUBMED:10369666] [PUBMED:14638419] [PUBMED:16441429] [PUBMED:16162672] [PUBMED:17719540] [PUBMED:7665485] [PUBMED:18059288] [PUBMED:18005697] [PUBMED:19165331] [PUBMED:12828640] [PUBMED:17662586] [PUBMED:9176079] [PUBMED:7591128] [PUBMED:15318166] [PUBMED:15950937]
Signaling by Interleukins [NCBI:1269318] [REACTOME:R-HSA-449147] [PUBMED:19302047] [PUBMED:12445398]
TAK1 activates NFkB by phosphorylation and activation of IKKs complex [NCBI:1269210] [REACTOME:R-HSA-445989] [PUBMED:15837794] [PUBMED:11460167]
TNF signaling pathway [NCBI:812256] [KEGG:hsa04668] [PUBMED:20489699] [PUBMED:14532286] [PUBMED:21232019] [PUBMED:11897488] [PUBMED:22296764] [PUBMED:10581243] [PUBMED:23085193] [PUBMED:23531747]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation [NCBI:1269229] [REACTOME:R-HSA-975138] [PUBMED:22511786] [PUBMED:18794297]
TRIF-mediated TLR3/TLR4 signaling [NCBI:1269221] [REACTOME:R-HSA-937061] [PUBMED:15814722] [PUBMED:12855817] [PUBMED:14739303]
Toll Like Receptor 10 (TLR10) Cascade [NCBI:1269206] [REACTOME:R-HSA-168142] [PUBMED:15728506] [PUBMED:18332149]
Toll Like Receptor 2 (TLR2) Cascade [NCBI:1269238] [REACTOME:R-HSA-181438] [PUBMED:10820283]
Toll Like Receptor 3 (TLR3) Cascade [NCBI:1269219] [REACTOME:R-HSA-168164] [PUBMED:19627256] [PUBMED:15733829] [PUBMED:18202435]
Toll Like Receptor 4 (TLR4) Cascade [NCBI:1269234] [REACTOME:R-HSA-166016]
Toll Like Receptor 5 (TLR5) Cascade [NCBI:1269226] [REACTOME:R-HSA-168176] [PUBMED:11489966] [PUBMED:11323673]
Toll Like Receptor 7/8 (TLR7/8) Cascade [NCBI:1269227] [REACTOME:R-HSA-168181] [PUBMED:14976262]
Toll Like Receptor 9 (TLR9) Cascade [NCBI:1269233] [REACTOME:R-HSA-168138] [PUBMED:14751759]
Toll Like Receptor TLR1:TLR2 Cascade [NCBI:1269239] [REACTOME:R-HSA-168179] [PUBMED:12975352]
Toll Like Receptor TLR6:TLR2 Cascade [NCBI:1269240] [REACTOME:R-HSA-168188] [PUBMED:14977973]
Toll-Like Receptors Cascades [NCBI:1269204] [REACTOME:R-HSA-168898] [PUBMED:15950447] [PUBMED:12893815] [PUBMED:15976490] [PUBMED:15585605] [PUBMED:14751757]
Tuberculosis [NCBI:213780] [KEGG:hsa05152] [PUBMED:20199890] [PUBMED:21274449] [PUBMED:17359235] [PUBMED:20415982] [PUBMED:18541216] [PUBMED:19369951] [PUBMED:15083155] [PUBMED:11378475] [PUBMED:15228522] [PUBMED:19634703] [PUBMED:21274433] [PUBMED:19563525] [PUBMED:18407066] [PUBMED:18288961] [PUBMED:16200082] [PUBMED:17785780] [PUBMED:11932234]
activated TAK1 mediates p38 MAPK activation [NCBI:1269213] [REACTOME:R-HSA-450302] [PUBMED:10878576] [PUBMED:8533096] [PUBMED:15837794]