full name
CYLD lysine 63 deubiquitinase

synonyms
BRSS, CDMT, CYLD1, CYLDI, EAC, MFT, MFT1, SBS, TEM, USPL2, CYLD, ENSG00000083799

HGNC
HGNC:2584

Entrez Gene
Gene:1540

ENSEMBL
ENSG00000083799

location
chr: 16
start: 50775961
stop: 50835847
strand: +

OMIM
OMIM:605018: CYLD (Autosomal dominant inheritance)
OMIM:605041: Brooke-Spiegler syndrome
OMIM:132700: Cylindromatosis, familial
OMIM:601606: Trichoepithelioma, multiple familial, 1

transcripts
NM_015247.2
NM_001042355.1
NM_001042412.1

pathways
Canonical NF-kappaB pathway [NCBI:138030] [Pathway Interaction Database:nfkappabcanonicalpathway] [PUBMED:7878466] [PUBMED:10688673] [PUBMED:16497931] [PUBMED:10755617] [PUBMED:9660950] [PUBMED:9346241] [PUBMED:10195894] [PUBMED:10521409] [PUBMED:12917691] [PUBMED:15620648] [PUBMED:14695475] [PUBMED:14651848] [PUBMED:11319224] [PUBMED:9150141] [PUBMED:9819420] [PUBMED:15218148] [PUBMED:7739562] [PUBMED:12657630] [PUBMED:12867425] [PUBMED:16267042]
Death Receptor Signalling [NCBI:1269644] [REACTOME:R-HSA-73887]
Deubiquitination [NCBI:1427860] [REACTOME:R-HSA-5688426] [PUBMED:19243136] [PUBMED:20074029] [PUBMED:15571815] [PUBMED:20418328] [PUBMED:16325574] [PUBMED:12944365] [PUBMED:23845989] [PUBMED:22201797]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
NOD1/2 Signaling Pathway [NCBI:1269252] [REACTOME:R-HSA-168638] [PUBMED:18928408] [PUBMED:18585455] [PUBMED:18414735]
Negative regulators of RIG-I/MDA5 signaling [NCBI:1269264] [REACTOME:R-HSA-936440] [PUBMED:18703349] [PUBMED:18549796]
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways [NCBI:1269251] [REACTOME:R-HSA-168643] [PUBMED:18928408]
Osteoclast differentiation [NCBI:193147] [KEGG:hsa04380] [PUBMED:17633024] [PUBMED:18382763] [PUBMED:18329366] [PUBMED:17869613] [PUBMED:18722561] [PUBMED:15122243] [PUBMED:20703218] [PUBMED:12748652] [PUBMED:12110142] [PUBMED:19585227] [PUBMED:15546140] [PUBMED:16184196] [PUBMED:15817678] [PUBMED:20392226] [PUBMED:16313349] [PUBMED:16313342] [PUBMED:17380158] [PUBMED:18451259]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
RIG-I-like receptor signaling pathway [NCBI:117292] [KEGG:hsa04622] [PUBMED:19224920] [PUBMED:19076341] [PUBMED:18549796] [PUBMED:18591413] [PUBMED:19615405] [PUBMED:19120475] [PUBMED:18439848] [PUBMED:19120476] [PUBMED:15208624] [PUBMED:19539500] [PUBMED:18272355] [PUBMED:18984593]
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways [NCBI:1269259] [REACTOME:R-HSA-168928] [PUBMED:17395582] [PUBMED:17942531] [PUBMED:18701081] [PUBMED:17683970] [PUBMED:18989317] [PUBMED:16214811]
Regulation of TNFR1 signaling [NCBI:1309094] [REACTOME:R-HSA-5357905] [PUBMED:22435550] [PUBMED:11432772] [PUBMED:12724336]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
TNF receptor signaling pathway [NCBI:138053] [Pathway Interaction Database:tnfpathway] [PUBMED:17024246] [PUBMED:7923351] [PUBMED:9774977] [PUBMED:15258597] [PUBMED:11429546] [PUBMED:10848577] [PUBMED:12917689] [PUBMED:11031259] [PUBMED:8974401] [PUBMED:7758105] [PUBMED:10510344] [PUBMED:15793306] [PUBMED:12391233] [PUBMED:18450452] [PUBMED:15218148] [PUBMED:8692885] [PUBMED:10026132] [PUBMED:9275185] [PUBMED:11684013] [PUBMED:8521496] [PUBMED:12917690] [PUBMED:10795740] [PUBMED:16603398] [PUBMED:9405407] [PUBMED:2158863] [PUBMED:16260783] [PUBMED:8808629] [PUBMED:9034190] [PUBMED:16543241] [PUBMED:12077366] [PUBMED:9384583] [PUBMED:8612133] [PUBMED:9712898] [PUBMED:1313189] [PUBMED:8069916] [PUBMED:11907583] [PUBMED:9639556] [PUBMED:12917691] [PUBMED:9115275] [PUBMED:8681376] [PUBMED:10356400] [PUBMED:10801798] [PUBMED:10097111] [PUBMED:8565075] [PUBMED:10187805] [PUBMED:15357952] [PUBMED:9915703] [PUBMED:9564042] [PUBMED:8943045]
TNF signaling [NCBI:1269646] [REACTOME:R-HSA-75893] [PUBMED:12040173]
TNFR1-induced NFkappaB signaling pathway [NCBI:1309092] [REACTOME:R-HSA-5357956] [PUBMED:16603398] [PUBMED:17306544]
TNFR1-induced proapoptotic signaling [NCBI:1269647] [REACTOME:R-HSA-5357786] [PUBMED:12752666] [PUBMED:12887920] [PUBMED:12505355]
Ub-specific processing proteases [NCBI:1427862] [REACTOME:R-HSA-5689880] [PUBMED:16325574]