Logo
full name
G protein subunit alpha o1

synonyms
G-ALPHA-o, GNAO, GNAO1, ENSG00000087258

HGNC
HGNC:4389

Entrez Gene
Gene:2775

ENSEMBL
ENSG00000087258

location
chr: 16
start: 56225251
stop: 56391356
strand: +

OMIM
OMIM:139311: GNAO1 (Autosomal dominant inheritance)
OMIM:615473: Epileptic encephalopathy, early infantile, 17
OMIM:617493: Neurodevelopmental disorder with involuntary movements

transcripts
NM_020988.2
NM_138736.2

pathways
Alcoholism [NCBI:585563] [KEGG:hsa05034] [PUBMED:16764827] [PUBMED:18616668] [PUBMED:19077056] [PUBMED:18991950] [PUBMED:19756388] [PUBMED:12068305] [PUBMED:16102840] [PUBMED:20947635] [PUBMED:20729980] [PUBMED:16278489] [PUBMED:17270154] [PUBMED:20626732] [PUBMED:18310464] [PUBMED:10774721] [PUBMED:19342616] [PUBMED:12605085] [PUBMED:15500908] [PUBMED:14729391] [PUBMED:12085089] [PUBMED:16776597]
Beta-catenin independent WNT signaling [NCBI:1269610] [REACTOME:R-HSA-3858494] [PUBMED:22935904] [PUBMED:21903638] [PUBMED:23256519] [PUBMED:8065359] [PUBMED:7739543] [PUBMED:23140633]
Ca2+ pathway [NCBI:1269615] [REACTOME:R-HSA-4086398] [PUBMED:21903638] [PUBMED:21181886] [PUBMED:16099039]
Chagas disease (American trypanosomiasis) [NCBI:147809] [KEGG:hsa05142] [PUBMED:12377585] [PUBMED:9794425] [PUBMED:1717552] [PUBMED:16238097] [PUBMED:10066513] [PUBMED:12874238] [PUBMED:12036740] [PUBMED:15917295] [PUBMED:12055254] [PUBMED:17651955] [PUBMED:1396957] [PUBMED:16175174] [PUBMED:2194668] [PUBMED:9190942] [PUBMED:12377942] [PUBMED:12427093] [PUBMED:10234174] [PUBMED:16030288] [PUBMED:15223603] [PUBMED:17110955]
Chaperonin-mediated protein folding [NCBI:1268694] [REACTOME:R-HSA-390466] [PUBMED:11868281] [PUBMED:15519848]
Cholinergic synapse [NCBI:217716] [KEGG:hsa04725] [PUBMED:20060019] [PUBMED:11283752] [PUBMED:15165747] [PUBMED:12893537] [PUBMED:11738031] [PUBMED:21550798] [PUBMED:19712465] [PUBMED:12690458] [PUBMED:12436417] [PUBMED:19378880] [PUBMED:11923408] [PUBMED:20446119]
Circadian entrainment [NCBI:698773] [KEGG:hsa04713] [PUBMED:15016477] [PUBMED:12700026] [PUBMED:20605968] [PUBMED:15813931] [PUBMED:15930378] [PUBMED:12573527] [PUBMED:17586087] [PUBMED:20664079] [PUBMED:17646042] [PUBMED:17167088] [PUBMED:16217123] [PUBMED:11294753] [PUBMED:19109992] [PUBMED:10446325] [PUBMED:10208575] [PUBMED:11086993] [PUBMED:19449447]
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding [NCBI:1383060] [REACTOME:R-HSA-6814122] [PUBMED:16702223] [PUBMED:26613416] [PUBMED:19376773] [PUBMED:15889144] [PUBMED:25675501] [PUBMED:25659125] [PUBMED:17363375] [PUBMED:23637185] [PUBMED:16717095]
Dopaminergic synapse [NCBI:469199] [KEGG:hsa04728] [PUBMED:20727368] [PUBMED:10433257] [PUBMED:17408758] [PUBMED:15292232] [PUBMED:9457173] [PUBMED:17349698] [PUBMED:15521361] [PUBMED:18353279] [PUBMED:21303898] [PUBMED:19251795] [PUBMED:15381316] [PUBMED:15590733] [PUBMED:20224735] [PUBMED:19138563] [PUBMED:12967774]
Estrogen signaling pathway [NCBI:799177] [KEGG:hsa04915] [PUBMED:15695368] [PUBMED:16112267] [PUBMED:9278514] [PUBMED:19187465] [PUBMED:12421825] [PUBMED:12650715] [PUBMED:18253054] [PUBMED:16516516] [PUBMED:14573532] [PUBMED:18755790] [PUBMED:18538919] [PUBMED:19767412] [PUBMED:14993035] [PUBMED:19549587] [PUBMED:15862823] [PUBMED:20694192] [PUBMED:19464786] [PUBMED:21779010] [PUBMED:16270355] [PUBMED:21742056] [PUBMED:19700741] [PUBMED:21844907]
G-protein activation [NCBI:1269585] [REACTOME:R-HSA-202040] [PUBMED:12184727] [PUBMED:15294442] [PUBMED:9218123]
G-protein mediated events [NCBI:1269586] [REACTOME:R-HSA-112040] [PUBMED:9422713] [PUBMED:9218123]
GABAergic synapse [NCBI:377263] [KEGG:hsa04727] [PUBMED:21555068] [PUBMED:20655485] [PUBMED:16932937] [PUBMED:17499108] [PUBMED:12086709] [PUBMED:20655481] [PUBMED:21376567] [PUBMED:19374920] [PUBMED:17499109] [PUBMED:10780899] [PUBMED:16787421] [PUBMED:15210304] [PUBMED:18382465] [PUBMED:12888801] [PUBMED:9364667]
Glutamatergic synapse [NCBI:213818] [KEGG:hsa04724] [PUBMED:10481192] [PUBMED:11561058] [PUBMED:18425072] [PUBMED:17706608] [PUBMED:20055706] [PUBMED:19112153] [PUBMED:17663464] [PUBMED:19110202] [PUBMED:19559598] [PUBMED:9665875] [PUBMED:11672421] [PUBMED:18464791] [PUBMED:12399578] [PUBMED:14684436]
LPA receptor mediated events [NCBI:137928] [Pathway Interaction Database:lysophospholipid_pathway] [PUBMED:10601262] [PUBMED:16289596] [PUBMED:7809106] [PUBMED:10342794] [PUBMED:15928312] [PUBMED:16769764] [PUBMED:11243883] [PUBMED:14688263] [PUBMED:10551845] [PUBMED:16687414] [PUBMED:9819398] [PUBMED:7527052] [PUBMED:9600933] [PUBMED:2551506] [PUBMED:15988003] [PUBMED:10644509] [PUBMED:16199135] [PUBMED:15728708] [PUBMED:1637305] [PUBMED:7476905] [PUBMED:7510708] [PUBMED:8647803] [PUBMED:10420989] [PUBMED:12880866] [PUBMED:10766839] [PUBMED:12181443] [PUBMED:15461590] [PUBMED:16452634] [PUBMED:16197369] [PUBMED:10779388] [PUBMED:10506190] [PUBMED:9305878] [PUBMED:16904289] [PUBMED:15878967] [PUBMED:15143197] [PUBMED:11948806] [PUBMED:11040035] [PUBMED:12393875] [PUBMED:9407095] [PUBMED:15280372] [PUBMED:16890224] [PUBMED:8805276]
Long-term depression [NCBI:83086] [KEGG:hsa04730] [PUBMED:9602501] [PUBMED:9735948] [PUBMED:14509570] [PUBMED:11427694] [PUBMED:12415297]
Melanogenesis [NCBI:83092] [KEGG:hsa04916] [PUBMED:11041354] [PUBMED:10347209] [PUBMED:15016298] [PUBMED:11023702] [PUBMED:11602344] [PUBMED:12753399] [PUBMED:10841026] [PUBMED:16822996] [PUBMED:15383650] [PUBMED:9263329] [PUBMED:16246839] [PUBMED:10643996] [PUBMED:12894244]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Morphine addiction [NCBI:552665] [KEGG:hsa05032] [PUBMED:8785060] [PUBMED:16581089] [PUBMED:21872647] [PUBMED:14625081] [PUBMED:20962224] [PUBMED:15661627] [PUBMED:1346804] [PUBMED:12859419] [PUBMED:8096779] [PUBMED:18349442] [PUBMED:21930931] [PUBMED:10066284] [PUBMED:14969742] [PUBMED:8987801] [PUBMED:12217944] [PUBMED:11750924] [PUBMED:11152760]
Opioid Signalling [NCBI:1269584] [REACTOME:R-HSA-111885] [PUBMED:9422713] [PUBMED:9218123] [PUBMED:16612131]
Oxytocin signaling pathway [NCBI:952859] [KEGG:hsa04921] [PUBMED:23356278] [PUBMED:9219843] [PUBMED:20626426] [PUBMED:18555543] [PUBMED:22190926] [PUBMED:21981277] [PUBMED:9575824] [PUBMED:22227279] [PUBMED:19840865] [PUBMED:11861513] [PUBMED:9326674] [PUBMED:12433531] [PUBMED:18655881] [PUBMED:23335873] [PUBMED:22902539] [PUBMED:16156781] [PUBMED:20141572] [PUBMED:14715914] [PUBMED:12009385] [PUBMED:16787565] [PUBMED:16966388]
PLC beta mediated events [NCBI:1269587] [REACTOME:R-HSA-112043] [PUBMED:9218123] [PUBMED:16183910] [PUBMED:1335363]
Protein folding [NCBI:1268693] [REACTOME:R-HSA-391251] [PUBMED:15459659] [PUBMED:18395510] [PUBMED:15519848]
Rap1 signaling pathway [NCBI:868086] [KEGG:hsa04015] [PUBMED:17624944] [PUBMED:12351703] [PUBMED:10579920] [PUBMED:19159611] [PUBMED:18363565] [PUBMED:12765839] [PUBMED:12508104] [PUBMED:11331911] [PUBMED:17182900] [PUBMED:15803158] [PUBMED:19615876] [PUBMED:21402149] [PUBMED:17624948] [PUBMED:17383543] [PUBMED:14607972] [PUBMED:15780587] [PUBMED:19710505]
Retrograde endocannabinoid signaling [NCBI:537443] [KEGG:hsa04723] [PUBMED:16085309] [PUBMED:18515270] [PUBMED:15340387] [PUBMED:17636069] [PUBMED:17553427] [PUBMED:17404373] [PUBMED:19640475] [PUBMED:21117095] [PUBMED:18084639] [PUBMED:21187849] [PUBMED:18801434] [PUBMED:14978245] [PUBMED:21531987] [PUBMED:19553483] [PUBMED:19126760] [PUBMED:17419048] [PUBMED:18948642] [PUBMED:16968947]
S1P1 pathway [NCBI:137937] [Pathway Interaction Database:s1p_s1p1_pathway] [PUBMED:10198065] [PUBMED:12782628] [PUBMED:15750791] [PUBMED:11741892] [PUBMED:12963813] [PUBMED:11150298] [PUBMED:10463951] [PUBMED:9660876] [PUBMED:12087059] [PUBMED:12796504] [PUBMED:12175535] [PUBMED:11709084] [PUBMED:17050692] [PUBMED:12586615] [PUBMED:17257496]
S1P2 pathway [NCBI:138059] [Pathway Interaction Database:s1p_s1p2_pathway] [PUBMED:9854026] [PUBMED:10617617] [PUBMED:17431187] [PUBMED:12588974] [PUBMED:11094076] [PUBMED:15240112] [PUBMED:11853542] [PUBMED:12810709]
S1P3 pathway [NCBI:138063] [Pathway Interaction Database:s1p_s1p3_pathway] [PUBMED:12577307] [PUBMED:11853542] [PUBMED:17158356] [PUBMED:15138255] [PUBMED:14732717] [PUBMED:11150298] [PUBMED:14657000] [PUBMED:9854026] [PUBMED:10617617] [PUBMED:16527273]
S1P4 pathway [NCBI:138069] [Pathway Interaction Database:s1p_s1p4_pathway] [PUBMED:12875654] [PUBMED:12761884] [PUBMED:9988698]
S1P5 pathway [NCBI:137982] [Pathway Interaction Database:s1p_s1p5_pathway] [PUBMED:11705398] [PUBMED:15703400] [PUBMED:17255471] [PUBMED:12569073]
Serotonergic synapse [NCBI:525336] [KEGG:hsa04726] [PUBMED:9658404] [PUBMED:15034221] [PUBMED:11043573] [PUBMED:9651340] [PUBMED:9542727] [PUBMED:18676031] [PUBMED:12543273] [PUBMED:15710402] [PUBMED:16826372] [PUBMED:19545642] [PUBMED:11916537] [PUBMED:11701344] [PUBMED:12676358] [PUBMED:20561690] [PUBMED:16896947]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by GPCR [NCBI:1269543] [REACTOME:R-HSA-372790] [PUBMED:16902930] [PUBMED:10202136] [PUBMED:18043707]
Signaling by Wnt [NCBI:1269594] [REACTOME:R-HSA-195721] [PUBMED:19530173] [PUBMED:23256519] [PUBMED:22952392] [PUBMED:19204114] [PUBMED:19365405] [PUBMED:19619488] [PUBMED:17143292] [PUBMED:17230199] [PUBMED:18710302] [PUBMED:16099039] [PUBMED:20576942] [PUBMED:10858654] [PUBMED:12967557]
Sphingosine 1-phosphate (S1P) pathway [NCBI:137931] [Pathway Interaction Database:s1p_meta_pathway] [PUBMED:12815058] [PUBMED:17050692] [PUBMED:9854026] [PUBMED:16584625] [PUBMED:10617617] [PUBMED:16520486] [PUBMED:14570870] [PUBMED:11705398] [PUBMED:16996023] [PUBMED:12531554] [PUBMED:12761884]
Toxoplasmosis [NCBI:169642] [KEGG:hsa05145] [PUBMED:18617274] [PUBMED:19400868] [PUBMED:17024357] [PUBMED:19744886] [PUBMED:19891610] [PUBMED:17110955] [PUBMED:12106793] [PUBMED:12580944] [PUBMED:12857995] [PUBMED:10234174] [PUBMED:18327664] [PUBMED:10525166] [PUBMED:18059289] [PUBMED:18775432] [PUBMED:14642303] [PUBMED:15361242] [PUBMED:16339966] [PUBMED:14987366] [PUBMED:15639739]