full name
chromatin licensing and DNA replication factor 1

synonyms
DUP, RIS2, CDT1, ENSG00000167513

HGNC
HGNC:24576

Entrez Gene
Gene:81620

ENSEMBL
ENSG00000167513

location
chr: 16
start: 88870186
stop: 88875666
strand: +

OMIM
OMIM:605525: CDT1 (Autosomal recessive inheritance)
OMIM:613804: Meier-Gorlin syndrome 4

transcripts
NM_030928.3

pathways
Activation of the pre-replicative complex [NCBI:1269773] [REACTOME:R-HSA-68962] [PUBMED:10402192] [PUBMED:10801458] [PUBMED:11323433] [PUBMED:12169736] [PUBMED:9765232] [PUBMED:9829972] [PUBMED:10970868] [PUBMED:7502077] [PUBMED:9353276] [PUBMED:11459976] [PUBMED:11395502] [PUBMED:11779870] [PUBMED:9038340]
Assembly of the pre-replicative complex [NCBI:1269833] [REACTOME:R-HSA-68867] [PUBMED:11801723] [PUBMED:9829972] [PUBMED:9288745] [PUBMED:9407030] [PUBMED:9927482] [PUBMED:9335335] [PUBMED:11046155]
Association of licensing factors with the pre-replicative complex [NCBI:1269795] [REACTOME:R-HSA-69298]
CDT1 association with the CDC6:ORC:origin complex [NCBI:1269836] [REACTOME:R-HSA-68827] [PUBMED:11125146] [PUBMED:11836525] [PUBMED:11175741] [PUBMED:10766248] [PUBMED:10766247] [PUBMED:10898791] [PUBMED:9635433] [PUBMED:9442876]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
DNA Replication [NCBI:198771] [WikiPathways:WP466] [NCBI:1269875] [REACTOME:R-HSA-69306] [PUBMED:11257218] [PUBMED:12045100] [PUBMED:1536007] [PUBMED:10966477] [PUBMED:1579437] [PUBMED:8223461]
DNA Replication Pre-Initiation [NCBI:1269832] [REACTOME:R-HSA-69002]
E2F mediated regulation of DNA replication [NCBI:1269774] [REACTOME:R-HSA-113510] [PUBMED:12726857] [PUBMED:12393009] [PUBMED:12473340]
G1/S Transition [NCBI:1269768] [REACTOME:R-HSA-69206]
G1/S-Specific Transcription [NCBI:1269772] [REACTOME:R-HSA-69205]
M/G1 Transition [NCBI:1269831] [REACTOME:R-HSA-68874]
Mitotic G1-G1/S phases [NCBI:1269764] [REACTOME:R-HSA-453279]
Orc1 removal from chromatin [NCBI:1269782] [REACTOME:R-HSA-68949] [PUBMED:11931757] [PUBMED:11809796] [PUBMED:11739726] [PUBMED:1110244]
RB in Cancer [NCBI:920977] [WikiPathways:WP2446] [PUBMED:7565706] [PUBMED:8242749] [PUBMED:15469821]
Regulation of DNA replication [NCBI:1269794] [REACTOME:R-HSA-69304]
Removal of licensing factors from origins [NCBI:1269796] [REACTOME:R-HSA-69300]
S Phase [NCBI:1269777] [REACTOME:R-HSA-69242]
Switching of origins to a post-replicative state [NCBI:1269781] [REACTOME:R-HSA-69052]
Synthesis of DNA [NCBI:1269779] [REACTOME:R-HSA-69239]