full name
protein tyrosine phosphatase, receptor type C

synonyms
B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, PTPRC, ENSG00000081237

HGNC
HGNC:9666

Entrez Gene
Gene:5788

ENSEMBL
ENSG00000081237
ENSG00000262418

location
chr: 1
start: 198608098
stop: 198726605
strand: +

OMIM
OMIM:151460: PTPRC (Autosomal recessive inheritance)
OMIM:608971: Severe combined immunodeficiency, T cell-negative, B-cell/natural killer-cell positive
OMIM:609532: {Hepatitis C virus, susceptibility to}

transcripts
NM_002838.4
NM_080921.3
NM_001267798.1
NR_052021.1

pathways
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
Axon guidance [NCBI:83065] [KEGG:hsa04360] [NCBI:1270303] [REACTOME:R-HSA-422475] [PUBMED:14682358] [PUBMED:15084255] [PUBMED:11687826] [PUBMED:15818466] [PUBMED:15363605] [PUBMED:12471249] [PUBMED:15630019] [PUBMED:11891122] [PUBMED:15960985] [PUBMED:12677003]
BCR signaling pathway [NCBI:138058] [Pathway Interaction Database:bcr_5pathway] [PUBMED:7687428] [PUBMED:16200195] [PUBMED:12730099] [PUBMED:10770799] [PUBMED:14563325] [PUBMED:9763608] [PUBMED:15541657] [PUBMED:11781242] [PUBMED:11102801] [PUBMED:9586640] [PUBMED:11279148] [PUBMED:7499277] [PUBMED:7542197] [PUBMED:9820480] [PUBMED:9221755] [PUBMED:11909947] [PUBMED:9360945] [PUBMED:9058799] [PUBMED:10339589] [PUBMED:11226282] [PUBMED:9271416] [PUBMED:9620684] [PUBMED:11163197] [PUBMED:10820378] [PUBMED:11356195] [PUBMED:11080163] [PUBMED:10755621] [PUBMED:7717978] [PUBMED:7618087] [PUBMED:11577348] [PUBMED:1279802] [PUBMED:10640270] [PUBMED:11356834] [PUBMED:12867038] [PUBMED:12780340] [PUBMED:10430908] [PUBMED:7528218]
CXCR4-mediated signaling events [NCBI:137910] [Pathway Interaction Database:cxcr4_pathway] [PUBMED:18799424] [PUBMED:17537990] [PUBMED:10881171] [PUBMED:17675482] [PUBMED:11157475] [PUBMED:12077227] [PUBMED:11544290] [PUBMED:8752280] [PUBMED:12535795] [PUBMED:19380820] [PUBMED:10952719] [PUBMED:16230460] [PUBMED:12682230] [PUBMED:16503409] [PUBMED:10644702] [PUBMED:9722546] [PUBMED:11784854] [PUBMED:10491003] [PUBMED:10521508] [PUBMED:10606629] [PUBMED:15615703] [PUBMED:17568820] [PUBMED:10753828] [PUBMED:12519755] [PUBMED:12032308] [PUBMED:8752281] [PUBMED:10570282] [PUBMED:11369622] [PUBMED:15728464] [PUBMED:12590707] [PUBMED:16038794] [PUBMED:14662753] [PUBMED:18596232] [PUBMED:17056591] [PUBMED:14602072] [PUBMED:15994292] [PUBMED:16919488] [PUBMED:15872091] [PUBMED:10506573] [PUBMED:12036857] [PUBMED:15618472] [PUBMED:14704365] [PUBMED:18227351] [PUBMED:11641392] [PUBMED:18319399] [PUBMED:12133960] [PUBMED:15630457]
Cell adhesion molecules (CAMs) [NCBI:83069] [KEGG:hsa04514] [PUBMED:15923648] [PUBMED:12500939] [PUBMED:15056568] [PUBMED:14519386] [PUBMED:12234363] [PUBMED:10964748] [PUBMED:15071551] [PUBMED:15551862] [PUBMED:14690046] [PUBMED:9150551] [PUBMED:14519398] [PUBMED:14556710] [PUBMED:11860281] [PUBMED:10664064] [PUBMED:9597126] [PUBMED:11050419] [PUBMED:12367625] [PUBMED:10798271] [PUBMED:16034094] [PUBMED:15115723] [PUBMED:15728677] [PUBMED:11910893] [PUBMED:15561584] [PUBMED:15882774] [PUBMED:12810109]
Developmental Biology [NCBI:1270302] [REACTOME:R-HSA-1266738]
Fc gamma R-mediated phagocytosis [NCBI:114228] [KEGG:hsa04666] [PUBMED:11304556] [PUBMED:11244038] [PUBMED:10755615] [PUBMED:17308335] [PUBMED:12821647] [PUBMED:15466916] [PUBMED:17050193] [PUBMED:11228151] [PUBMED:12488490] [PUBMED:10224668] [PUBMED:11708889] [PUBMED:9581795] [PUBMED:10586078] [PUBMED:9417101] [PUBMED:15485887] [PUBMED:18322649] [PUBMED:10577498] [PUBMED:10376013] [PUBMED:10601359] [PUBMED:9545263]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Neutrophil degranulation [NCBI:1457780] [REACTOME:R-HSA-6798695] [PUBMED:20338884] [PUBMED:1378856] [PUBMED:17627888] [PUBMED:23650620] [PUBMED:8692836]
Other semaphorin interactions [NCBI:1270311] [REACTOME:R-HSA-416700]
Phosphorylation of CD3 and TCR zeta chains [NCBI:1269173] [REACTOME:R-HSA-202427] [PUBMED:10375551]
Primary immunodeficiency [NCBI:83125] [KEGG:hsa05340] [PUBMED:11941303] [PUBMED:18093537] [PUBMED:11058677] [PUBMED:17952897] [PUBMED:14699405] [PUBMED:15661024] [PUBMED:14647478] [PUBMED:17960151] [PUBMED:16261175]
Semaphorin interactions [NCBI:1270304] [REACTOME:R-HSA-373755] [PUBMED:12593985] [PUBMED:12471249] [PUBMED:18269210] [PUBMED:16939971] [PUBMED:18374575]
T cell receptor signaling pathway [NCBI:83080] [KEGG:hsa04660] [PUBMED:17395537] [PUBMED:15308211] [PUBMED:15928679] [PUBMED:14656980] [PUBMED:17187070] [PUBMED:15084594] [PUBMED:16799472] [PUBMED:12669022] [PUBMED:15286727] [PUBMED:15122199] [PUBMED:19132916] [PUBMED:15489916] [PUBMED:11905831] [PUBMED:12195013] [PUBMED:15343367] [PUBMED:12133805] [PUBMED:14647476] [PUBMED:15771581] [PUBMED:15099566] [PUBMED:14617194] [PUBMED:19290929] [PUBMED:15345216]
TCR signaling [NCBI:1269172] [REACTOME:R-HSA-202403] [PUBMED:10375551] [PUBMED:12876557] [PUBMED:9989491]
TCR signaling in naive CD4+ T cells [NCBI:137998] [Pathway Interaction Database:tcr_pathway] [PUBMED:11376344] [PUBMED:9094314] [PUBMED:8083187] [PUBMED:11994416] [PUBMED:16365455] [PUBMED:10072079] [PUBMED:12361955] [PUBMED:12755691] [PUBMED:8642247] [PUBMED:15125833] [PUBMED:7509360] [PUBMED:11353765] [PUBMED:12941616] [PUBMED:8700169] [PUBMED:11120819] [PUBMED:15899849] [PUBMED:8990121] [PUBMED:8702662] [PUBMED:8164687] [PUBMED:2141684] [PUBMED:11567141] [PUBMED:9846481] [PUBMED:9489702] [PUBMED:10811803] [PUBMED:11368773] [PUBMED:14557276] [PUBMED:2548204] [PUBMED:10318843] [PUBMED:15536066] [PUBMED:10652356] [PUBMED:7568038] [PUBMED:11175263] [PUBMED:9438848] [PUBMED:9692882] [PUBMED:10209031] [PUBMED:7509083] [PUBMED:12874226] [PUBMED:8673706] [PUBMED:16733527] [PUBMED:9822663] [PUBMED:12738795] [PUBMED:11904433] [PUBMED:8084588] [PUBMED:8114715] [PUBMED:9312162] [PUBMED:8790380] [PUBMED:9677202] [PUBMED:15802604] [PUBMED:14702343] [PUBMED:10903746] [PUBMED:10807788] [PUBMED:8176201] [PUBMED:9207119] [PUBMED:10790433] [PUBMED:8892604] [PUBMED:9665884] [PUBMED:1639064] [PUBMED:12421919] [PUBMED:8246987] [PUBMED:9710204] [PUBMED:8146197] [PUBMED:2190221] [PUBMED:10229072] [PUBMED:10021361] [PUBMED:9924026] [PUBMED:12186560] [PUBMED:16649996] [PUBMED:11287959] [PUBMED:12917261] [PUBMED:7545666] [PUBMED:11250890] [PUBMED:12842872] [PUBMED:15879121] [PUBMED:11567140] [PUBMED:10209041] [PUBMED:10556826] [PUBMED:8183372] [PUBMED:12397360] [PUBMED:10506192] [PUBMED:10861059] [PUBMED:12507424] [PUBMED:12845325] [PUBMED:10745081] [PUBMED:8195151] [PUBMED:12024036] [PUBMED:7524075] [PUBMED:1464315] [PUBMED:12138205] [PUBMED:7544353] [PUBMED:16906149] [PUBMED:9637919] [PUBMED:2470098] [PUBMED:3919143] [PUBMED:16005298] [PUBMED:10918068] [PUBMED:8636141] [PUBMED:16921383] [PUBMED:8479536] [PUBMED:7556092] [PUBMED:16582901] [PUBMED:8805223] [PUBMED:15933714] [PUBMED:10224278] [PUBMED:9819387] [PUBMED:12881521] [PUBMED:14988727] [PUBMED:16849481] [PUBMED:11390650]
TCR signaling in naive CD8+ T cells [NCBI:138055] [Pathway Interaction Database:cd8tcrpathway] [PUBMED:9094314] [PUBMED:15125833] [PUBMED:11994416] [PUBMED:7509360] [PUBMED:12755691] [PUBMED:8642247] [PUBMED:12361955] [PUBMED:11956228] [PUBMED:10072079] [PUBMED:8977171] [PUBMED:2141684] [PUBMED:8700169] [PUBMED:8164687] [PUBMED:9489702] [PUBMED:8702662] [PUBMED:2548204] [PUBMED:11175263] [PUBMED:8114715] [PUBMED:10209031] [PUBMED:15536066] [PUBMED:7678351] [PUBMED:8673703] [PUBMED:7830771] [PUBMED:7509083] [PUBMED:16733527] [PUBMED:9438848] [PUBMED:8790380] [PUBMED:1639064] [PUBMED:15980863] [PUBMED:8084588] [PUBMED:14702343] [PUBMED:10790433] [PUBMED:10807788] [PUBMED:16169499] [PUBMED:15802604] [PUBMED:8892604] [PUBMED:2114552] [PUBMED:12421919] [PUBMED:12917261] [PUBMED:8146197] [PUBMED:1335364] [PUBMED:10021361] [PUBMED:8183372] [PUBMED:8627172] [PUBMED:8898939] [PUBMED:2190221] [PUBMED:9710204] [PUBMED:11287959] [PUBMED:14764585] [PUBMED:12954628] [PUBMED:10209041] [PUBMED:1464315] [PUBMED:12507424] [PUBMED:12732656] [PUBMED:8195151] [PUBMED:12138205] [PUBMED:16005298] [PUBMED:9312149] [PUBMED:7544353] [PUBMED:16906149] [PUBMED:9637919] [PUBMED:12845325] [PUBMED:2470098] [PUBMED:10918068] [PUBMED:16116204] [PUBMED:16921383] [PUBMED:10562325] [PUBMED:9819387] [PUBMED:16582901] [PUBMED:8034711] [PUBMED:8479536] [PUBMED:10640739] [PUBMED:3919143] [PUBMED:10224278] [PUBMED:10811865]