Logo
full name
vesicle associated membrane protein 2

synonyms
SYB2, VAMP-2, VAMP2, ENSG00000220205

HGNC
HGNC:12643

Entrez Gene
Gene:6844

ENSEMBL
ENSG00000220205

location
chr: 17
start: 8062465
stop: 8066293
strand: -

OMIM
OMIM:185881: VAMP2
OMIM:618760: Neurodevelopmental disorder with hypotonia and autistic features with or without hyperkinetic movements

transcripts
NM_014232.2

pathways
Acetylcholine Neurotransmitter Release Cycle [NCBI:1268773] [REACTOME:R-HSA-264642] [PUBMED:18029057]
Cargo recognition for clathrin-mediated endocytosis [NCBI:1427859] [REACTOME:R-HSA-8856825] [PUBMED:24186068] [PUBMED:12952941] [PUBMED:19696796] [PUBMED:14985334] [PUBMED:20448150] [PUBMED:20485680] [PUBMED:16382132] [PUBMED:23482940] [PUBMED:16870701]
Clathrin derived vesicle budding [NCBI:1269881] [REACTOME:R-HSA-421837]
Clathrin-mediated endocytosis [NCBI:1427858] [REACTOME:R-HSA-8856828] [PUBMED:16516836] [PUBMED:15339664] [PUBMED:19754444] [PUBMED:8552632] [PUBMED:21779028] [PUBMED:12353027] [PUBMED:23891661] [PUBMED:21613550] [PUBMED:20059951] [PUBMED:21447041] [PUBMED:17620409] [PUBMED:16903783] [PUBMED:21445324] [PUBMED:19696798] [PUBMED:26246598] [PUBMED:25085911] [PUBMED:24186068] [PUBMED:26829388] [PUBMED:27092250] [PUBMED:24581490] [PUBMED:26042225] [PUBMED:23823722] [PUBMED:24789820] [PUBMED:9736607] [PUBMED:23637288] [PUBMED:22233676] [PUBMED:19458185] [PUBMED:26403691] [PUBMED:19296720] [PUBMED:15703209] [PUBMED:20428113] [PUBMED:8953040] [PUBMED:1177317] [PUBMED:9092476] [PUBMED:26872272] [PUBMED:19092055]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Dopamine Neurotransmitter Release Cycle [NCBI:1268772] [REACTOME:R-HSA-212676] [PUBMED:16613554]
Effects of Botulinum toxin [NCBI:138028] [Pathway Interaction Database:botulinumtoxinpathway] [PUBMED:10582602] [PUBMED:8175689] [PUBMED:9783260] [PUBMED:8051110] [PUBMED:9886085] [PUBMED:7737992] [PUBMED:12089155] [PUBMED:8223654] [PUBMED:16052212] [PUBMED:15218059] [PUBMED:8505288] [PUBMED:15489225] [PUBMED:15935055] [PUBMED:14504267] [PUBMED:8103915] [PUBMED:7527117] [PUBMED:15123599] [PUBMED:9712688] [PUBMED:9252191]
GABA synthesis, release, reuptake and degradation [NCBI:1268774] [REACTOME:R-HSA-888590] [PUBMED:19428801] [PUBMED:16787421]
Glutamate Neurotransmitter Release Cycle [NCBI:1268771] [REACTOME:R-HSA-210500] [PUBMED:8825650] [PUBMED:11001057] [PUBMED:16990140] [PUBMED:10440375] [PUBMED:16704978] [PUBMED:17478680] [PUBMED:9701566]
Golgi Associated Vesicle Biogenesis [NCBI:1269882] [REACTOME:R-HSA-432722]
Infectious disease [NCBI:1269056] [REACTOME:R-HSA-5663205]
Insulin processing [NCBI:1268747] [REACTOME:R-HSA-264876] [PUBMED:11815450] [PUBMED:16714477] [PUBMED:16549443] [PUBMED:11815463] [PUBMED:9631292]
Insulin secretion [NCBI:777534] [KEGG:hsa04911] [PUBMED:9715374] [PUBMED:10605628] [PUBMED:9914469] [PUBMED:17306374] [PUBMED:20055708] [PUBMED:15655710] [PUBMED:19817784] [PUBMED:19074620] [PUBMED:14693691] [PUBMED:17084085] [PUBMED:20551594] [PUBMED:19036624] [PUBMED:22970724] [PUBMED:20225132] [PUBMED:19817800] [PUBMED:22974438] [PUBMED:21934040] [PUBMED:15271645] [PUBMED:19660440] [PUBMED:11522660]
Insulin-mediated glucose transport [NCBI:137981] [Pathway Interaction Database:insulin_glucose_pathway] [PUBMED:16880201] [PUBMED:9267469] [PUBMED:17059388] [PUBMED:2123524] [PUBMED:8392229] [PUBMED:9819385] [PUBMED:11001060] [PUBMED:10394363] [PUBMED:10869347] [PUBMED:11994271] [PUBMED:11997497] [PUBMED:11309621] [PUBMED:16213228] [PUBMED:15616009] [PUBMED:9582355] [PUBMED:15254270] [PUBMED:12637568] [PUBMED:8816781] [PUBMED:11102509] [PUBMED:16055084] [PUBMED:10364240] [PUBMED:9712142]
Integration of energy metabolism [NCBI:1270101] [REACTOME:R-HSA-163685] [PUBMED:15509864] [PUBMED:12721358] [PUBMED:12626323]
Lysosome Vesicle Biogenesis [NCBI:1269883] [REACTOME:R-HSA-432720]
Membrane Trafficking [NCBI:1269877] [REACTOME:R-HSA-199991] [PUBMED:11031247]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Neuronal System [NCBI:1268763] [REACTOME:R-HSA-112316]
Neurotoxicity of clostridium toxins [NCBI:1269145] [REACTOME:R-HSA-168799] [PUBMED:6763707] [PUBMED:15217342] [PUBMED:8542759] [PUBMED:24106296] [PUBMED:14744243] [PUBMED:20233039] [PUBMED:12417130] [PUBMED:13678859]
Neurotransmitter Release Cycle [NCBI:1268768] [REACTOME:R-HSA-112310] [PUBMED:15217342] [PUBMED:16819626] [PUBMED:17880890] [PUBMED:16865347]
Norepinephrine Neurotransmitter Release Cycle [NCBI:1268769] [REACTOME:R-HSA-181430] [PUBMED:17891149] [PUBMED:17478680] [PUBMED:12519779]
Peptide hormone metabolism [NCBI:1268746] [REACTOME:R-HSA-2980736] [PUBMED:2663045] [PUBMED:21805235]
Regulation of insulin secretion [NCBI:1270102] [REACTOME:R-HSA-422356] [PUBMED:18200017] [PUBMED:11078440] [PUBMED:16321791] [PUBMED:11815463] [PUBMED:16556766]
SNARE interactions in vesicular transport [NCBI:83057] [KEGG:hsa04130] [PUBMED:9647644] [PUBMED:10839363] [PUBMED:15342965] [PUBMED:9710615] [PUBMED:12600315] [PUBMED:11555414] [PUBMED:11739776] [PUBMED:9843576] [PUBMED:11035026] [PUBMED:10097106] [PUBMED:10788491] [PUBMED:9614193] [PUBMED:9507000] [PUBMED:10085287] [PUBMED:9446565] [PUBMED:9813082] [PUBMED:11104523] [PUBMED:11252968] [PUBMED:10359608] [PUBMED:10036234] [PUBMED:9628864] [PUBMED:9707576] [PUBMED:10379359] [PUBMED:10872468] [PUBMED:9199167] [PUBMED:11208059] [PUBMED:11237004] [PUBMED:9614185] [PUBMED:11323436] [PUBMED:10564279] [PUBMED:11445562] [PUBMED:9817754] [PUBMED:9852078] [PUBMED:10213783] [PUBMED:10683148] [PUBMED:10982406] [PUBMED:10459012] [PUBMED:9553086] [PUBMED:10397773] [PUBMED:9427746] [PUBMED:12068098] [PUBMED:10873817] [PUBMED:9305917] [PUBMED:11115874] [PUBMED:9214619] [PUBMED:11278762] [PUBMED:11306253] [PUBMED:11737951] [PUBMED:16882042] [PUBMED:11251103] [PUBMED:9452464] [PUBMED:11029060] [PUBMED:12853481] [PUBMED:12669082] [PUBMED:9565594] [PUBMED:12893879] [PUBMED:11208143] [PUBMED:10557242] [PUBMED:9763449] [PUBMED:9647643] [PUBMED:10359592] [PUBMED:8621431] [PUBMED:10397763]
Salivary secretion [NCBI:153376] [KEGG:hsa04970] [PUBMED:8105741] [PUBMED:10682899] [PUBMED:10928320] [PUBMED:15709965] [PUBMED:17347411] [PUBMED:9720759] [PUBMED:16712780] [PUBMED:16799262] [PUBMED:17157080] [PUBMED:18626068] [PUBMED:15153696] [PUBMED:11936453] [PUBMED:20224180]
Serotonin Neurotransmitter Release Cycle [NCBI:1268770] [REACTOME:R-HSA-181429]
Synaptic vesicle cycle [NCBI:373900] [KEGG:hsa04721] [PUBMED:20634814] [PUBMED:17767192] [PUBMED:12094216] [PUBMED:16990140] [PUBMED:18726177] [PUBMED:18275379] [PUBMED:12827282] [PUBMED:12154365] [PUBMED:10212473] [PUBMED:15217342] [PUBMED:7791897] [PUBMED:12563290]
Toxicity of botulinum toxin type B (BoNT/B) [NCBI:1269147] [REACTOME:R-HSA-5250958] [PUBMED:14504267] [PUBMED:20233039] [PUBMED:15217342] [PUBMED:24165130] [PUBMED:7803399] [PUBMED:8542759] [PUBMED:23239348] [PUBMED:1331807] [PUBMED:15514477]
Toxicity of botulinum toxin type D (BoNT/D) [NCBI:1269151] [REACTOME:R-HSA-5250955] [PUBMED:21483489] [PUBMED:8226912] [PUBMED:20233039] [PUBMED:8175689] [PUBMED:21632541] [PUBMED:8542759]
Toxicity of botulinum toxin type F (BoNT/F) [NCBI:1269152] [REACTOME:R-HSA-5250981] [PUBMED:20233039] [PUBMED:8175689] [PUBMED:19650874] [PUBMED:8542759] [PUBMED:19476346]
Toxicity of botulinum toxin type G (BoNT/G) [NCBI:1269153] [REACTOME:R-HSA-5250989] [PUBMED:20233039] [PUBMED:23647335] [PUBMED:22454523] [PUBMED:8542759] [PUBMED:7910017] [PUBMED:8051110]
Toxicity of tetanus toxin (TeNT) [NCBI:1269149] [REACTOME:R-HSA-5250982] [PUBMED:13678859]
Translocation of GLUT4 to the plasma membrane [NCBI:1269896] [REACTOME:R-HSA-1445148] [PUBMED:21306486] [PUBMED:19389739] [PUBMED:18570632] [PUBMED:21216617] [PUBMED:21405107] [PUBMED:20417083]
Transmission across Chemical Synapses [NCBI:1268766] [REACTOME:R-HSA-112315]
Uptake and actions of bacterial toxins [NCBI:1269144] [REACTOME:R-HSA-5339562] [PUBMED:20358680]
Vasopressin-regulated water reabsorption [NCBI:143700] [KEGG:hsa04962] [PUBMED:14586738] [PUBMED:17956998] [PUBMED:11001488] [PUBMED:10073616] [PUBMED:18566824] [PUBMED:18431594] [PUBMED:11773613] [PUBMED:18655910] [PUBMED:10070156] [PUBMED:15522987] [PUBMED:10099706]
Vesicle-mediated transport [NCBI:1269876] [REACTOME:R-HSA-5653656]
trans-Golgi Network Vesicle Budding [NCBI:1269880] [REACTOME:R-HSA-199992] [PUBMED:11252894]