full name
aurora kinase B

synonyms
AIK2, AIM-1, AIM1, ARK2, AurB, aurkb-sv1, aurkb-sv2, IPL1, PPP1R48, STK12, STK5, AURKB, ENSG00000178999

HGNC
HGNC:11390

Entrez Gene
Gene:9212

ENSEMBL
ENSG00000178999

location
chr: 17
start: 8108049
stop: 8113944
strand: -

transcripts
NM_001256834.1
NM_004217.3

pathways
APC/C-mediated degradation of cell cycle proteins [NCBI:1269838] [REACTOME:R-HSA-174143] [PUBMED:15678131] [PUBMED:12049731]
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 [NCBI:1269851] [REACTOME:R-HSA-174178] [PUBMED:16413484] [PUBMED:15678131]
Aurora A signaling [NCBI:137925] [Pathway Interaction Database:aurora_a_pathway] [PUBMED:17308110] [PUBMED:16894566] [PUBMED:16631581] [PUBMED:17229885] [PUBMED:15128871] [PUBMED:14990569] [PUBMED:12177045] [PUBMED:14580337] [PUBMED:14724178] [PUBMED:17545617] [PUBMED:15687499] [PUBMED:11163242] [PUBMED:14603251] [PUBMED:17060449] [PUBMED:12208850] [PUBMED:12815066] [PUBMED:17125467] [PUBMED:13678582] [PUBMED:15987997] [PUBMED:15966895] [PUBMED:11976319] [PUBMED:14702041] [PUBMED:16246726] [PUBMED:17452972] [PUBMED:12082625] [PUBMED:11039908] [PUBMED:14667408] [PUBMED:12577065] [PUBMED:14600264] [PUBMED:11756469] [PUBMED:16772293] [PUBMED:12023018] [PUBMED:15469940] [PUBMED:16082213]
Aurora B signaling [NCBI:138080] [Pathway Interaction Database:aurora_b_pathway] [PUBMED:14960279] [PUBMED:15249581] [PUBMED:17129783] [PUBMED:15263015] [PUBMED:15854913] [PUBMED:14605209] [PUBMED:12689593] [PUBMED:15499654] [PUBMED:17483322] [PUBMED:15316025] [PUBMED:11350965] [PUBMED:11516652] [PUBMED:11976319] [PUBMED:16222246] [PUBMED:12925766] [PUBMED:15260989] [PUBMED:16764853] [PUBMED:15796717] [PUBMED:16916643] [PUBMED:14667408] [PUBMED:17389228] [PUBMED:16687578] [PUBMED:14722118] [PUBMED:12082625] [PUBMED:17356064] [PUBMED:16222244] [PUBMED:11756469] [PUBMED:17457057] [PUBMED:15350530] [PUBMED:17322402] [PUBMED:11856369] [PUBMED:17199039] [PUBMED:17129782] [PUBMED:12419797] [PUBMED:16046481] [PUBMED:15064709] [PUBMED:12458200] [PUBMED:15064354] [PUBMED:14674694] [PUBMED:16179162] [PUBMED:17543862] [PUBMED:17215513] [PUBMED:12686604] [PUBMED:16537398]
Aurora C signaling [NCBI:138003] [Pathway Interaction Database:aurora_c_pathway] [PUBMED:15316025] [PUBMED:15499654]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
FOXM1 transcription factor network [NCBI:137935] [Pathway Interaction Database:foxm1pathway] [PUBMED:17141659] [PUBMED:12482952] [PUBMED:16913845] [PUBMED:16809346] [PUBMED:15671063] [PUBMED:16504183] [PUBMED:15082532] [PUBMED:15531365] [PUBMED:17366632] [PUBMED:16314512] [PUBMED:17173139] [PUBMED:16618419] [PUBMED:15024056] [PUBMED:11682060] [PUBMED:15654331] [PUBMED:15817462] [PUBMED:17404569] [PUBMED:16875671] [PUBMED:16965535] [PUBMED:17101782]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
Generic Transcription Pathway [NCBI:1269650] [REACTOME:R-HSA-212436] [PUBMED:15175151] [PUBMED:14744435] [PUBMED:15680972] [PUBMED:11395415] [PUBMED:15896744] [PUBMED:10235266] [PUBMED:14986688] [PUBMED:12023297] [PUBMED:15680973] [PUBMED:16751179] [PUBMED:11861166] [PUBMED:16429119] [PUBMED:16719718] [PUBMED:16921404] [PUBMED:15690163]
M Phase [NCBI:1269810] [REACTOME:R-HSA-68886]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Mitotic Anaphase [NCBI:1269825] [REACTOME:R-HSA-68882]
Mitotic Metaphase and Anaphase [NCBI:1269823] [REACTOME:R-HSA-2555396]
Mitotic Prometaphase [NCBI:1269820] [REACTOME:R-HSA-68877]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
RHO GTPase Effectors [NCBI:1269509] [REACTOME:R-HSA-195258] [PUBMED:9694656] [PUBMED:18066052] [PUBMED:11018042] [PUBMED:10470034] [PUBMED:8702756] [PUBMED:21730051] [PUBMED:8571126] [PUBMED:19513348] [PUBMED:17244649] [PUBMED:11145705] [PUBMED:24128008] [PUBMED:23716662] [PUBMED:8617235] [PUBMED:8543060] [PUBMED:11804587] [PUBMED:24969695] [PUBMED:12635176] [PUBMED:12778124] [PUBMED:18006505] [PUBMED:1660188] [PUBMED:21351730] [PUBMED:16507994] [PUBMED:14595335] [PUBMED:10072071] [PUBMED:10591629] [PUBMED:10753910] [PUBMED:23875749] [PUBMED:17151359] [PUBMED:10652353] [PUBMED:12221077] [PUBMED:10559936] [PUBMED:12783890] [PUBMED:11948177] [PUBMED:18237546] [PUBMED:16079795] [PUBMED:10924361] [PUBMED:14514689] [PUBMED:8107774] [PUBMED:8756646] [PUBMED:16979770] [PUBMED:16636067] [PUBMED:9751706] [PUBMED:10619026] [PUBMED:23444367] [PUBMED:15546864] [PUBMED:12473120] [PUBMED:8816443] [PUBMED:9199170] [PUBMED:12514133] [PUBMED:16762923] [PUBMED:12110184] [PUBMED:16431929] [PUBMED:10975528] [PUBMED:10940294] [PUBMED:9535855] [PUBMED:7559638] [PUBMED:11162552] [PUBMED:19737400] [PUBMED:9988689] [PUBMED:12732141] [PUBMED:8798539] [PUBMED:24914801] [PUBMED:11689693] [PUBMED:8769096] [PUBMED:9368021]
RHO GTPases Activate Formins [NCBI:1269519] [REACTOME:R-HSA-5663220] [PUBMED:20233848] [PUBMED:15507212] [PUBMED:16292343] [PUBMED:12906795] [PUBMED:11779461] [PUBMED:21397845] [PUBMED:12577064] [PUBMED:17198702] [PUBMED:15006353] [PUBMED:20101212] [PUBMED:15944396] [PUBMED:10678165] [PUBMED:16943183] [PUBMED:16439214] [PUBMED:16472745] [PUBMED:10958683] [PUBMED:12732141] [PUBMED:15085137] [PUBMED:24914801] [PUBMED:9497258] [PUBMED:21576392] [PUBMED:21868368]
Regulation of TP53 Activity [NCBI:1383076] [REACTOME:R-HSA-5633007] [PUBMED:19450511] [PUBMED:20457558] [PUBMED:23825024] [PUBMED:25641576]
Regulation of TP53 Activity through Phosphorylation [NCBI:1383080] [REACTOME:R-HSA-6804756] [PUBMED:11780126] [PUBMED:21317932] [PUBMED:15866171] [PUBMED:12393879] [PUBMED:11740489] [PUBMED:11447225] [PUBMED:9733515] [PUBMED:12851404] [PUBMED:10884347] [PUBMED:10710310] [PUBMED:11239457] [PUBMED:9925639] [PUBMED:11546806] [PUBMED:11551930] [PUBMED:10570149] [PUBMED:18490454] [PUBMED:17591690] [PUBMED:19965871] [PUBMED:12064478] [PUBMED:10673501] [PUBMED:22611192] [PUBMED:9843217] [PUBMED:15053879] [PUBMED:12914926] [PUBMED:10673500] [PUBMED:17349958] [PUBMED:14702041] [PUBMED:20959462] [PUBMED:10435622] [PUBMED:9733514]
Regulation of mitotic cell cycle [NCBI:1269837] [REACTOME:R-HSA-453276]
Resolution of Sister Chromatid Cohesion [NCBI:1269821] [REACTOME:R-HSA-2500257] [PUBMED:16541025] [PUBMED:15339662] [PUBMED:17112726] [PUBMED:9649503] [PUBMED:21111234] [PUBMED:15737063] [PUBMED:17113138] [PUBMED:21987589] [PUBMED:14730319] [PUBMED:11509732] [PUBMED:19696148] [PUBMED:21878504] [PUBMED:15723797]
SUMO E3 ligases SUMOylate target proteins [NCBI:1268743] [REACTOME:R-HSA-3108232] [PUBMED:20674646] [PUBMED:17763827] [PUBMED:19471022] [PUBMED:23746258] [PUBMED:24016193] [PUBMED:23503365] [PUBMED:21252943] [PUBMED:17000644] [PUBMED:24273646] [PUBMED:22811915] [PUBMED:21693764] [PUBMED:23277067] [PUBMED:21102611]
SUMOylation [NCBI:1268738] [REACTOME:R-HSA-2990846] [PUBMED:21102611] [PUBMED:20674646] [PUBMED:23514139] [PUBMED:19923268] [PUBMED:20462400] [PUBMED:17768054]
SUMOylation of DNA replication proteins [NCBI:1339113] [REACTOME:R-HSA-4615885] [PUBMED:22812528] [PUBMED:17031663] [PUBMED:22918591] [PUBMED:22732495] [PUBMED:16368276]
Separation of Sister Chromatids [NCBI:1269826] [REACTOME:R-HSA-2467813] [PUBMED:11081627] [PUBMED:10411507] [PUBMED:12070128] [PUBMED:12194817] [PUBMED:11509732]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by Aurora kinases [NCBI:138033] [Pathway Interaction Database:aurora_kinase_pathway]
Signaling by Rho GTPases [NCBI:1269507] [REACTOME:R-HSA-194315] [PUBMED:16212495] [PUBMED:15630019]
Transcriptional Regulation by TP53 [NCBI:1269654] [REACTOME:R-HSA-3700989] [PUBMED:26122615] [PUBMED:19410540]