full name
mitogen-activated protein kinase kinase 4

synonyms
JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1, MAP2K4, ENSG00000065559

HGNC
HGNC:6844

Entrez Gene
Gene:6416

ENSEMBL
ENSG00000065559

location
chr: 17
start: 11924135
stop: 12047148
strand: +

transcripts
NM_001281435.1
NM_003010.3

pathways
Activated TLR4 signalling [NCBI:1269236] [REACTOME:R-HSA-166054] [PUBMED:15276183] [PUBMED:15588429] [PUBMED:15845500] [PUBMED:15596121]
CD40/CD40L signaling [NCBI:138061] [Pathway Interaction Database:cd40_pathway] [PUBMED:11967542] [PUBMED:11304555] [PUBMED:11714736] [PUBMED:17878343] [PUBMED:12354380] [PUBMED:11406619] [PUBMED:9133417] [PUBMED:7527023] [PUBMED:18997794] [PUBMED:1374165] [PUBMED:1385114] [PUBMED:12958312] [PUBMED:10764746] [PUBMED:11909853] [PUBMED:10318845] [PUBMED:7533327] [PUBMED:16260598] [PUBMED:18997792] [PUBMED:12818164] [PUBMED:10748139] [PUBMED:9718306] [PUBMED:10395671] [PUBMED:17878362] [PUBMED:7544915] [PUBMED:12370254] [PUBMED:8910514] [PUBMED:17143273] [PUBMED:10433725] [PUBMED:14981114] [PUBMED:16622006] [PUBMED:12122011] [PUBMED:12133933]
CDC42 signaling events [NCBI:137994] [Pathway Interaction Database:cdc42_pathway] [PUBMED:7629060] [PUBMED:7652575] [PUBMED:8653792] [PUBMED:18448434] [PUBMED:19822663] [PUBMED:19454477] [PUBMED:18662680] [PUBMED:15882626] [PUBMED:11948177] [PUBMED:9860974] [PUBMED:15225553] [PUBMED:8643625] [PUBMED:8107774] [PUBMED:8670801] [PUBMED:8034624] [PUBMED:10934474] [PUBMED:10734320] [PUBMED:17522712] [PUBMED:11525734] [PUBMED:15649357] [PUBMED:10473551] [PUBMED:16157700] [PUBMED:9822598] [PUBMED:15723051] [PUBMED:7600582] [PUBMED:18319301] [PUBMED:9042860] [PUBMED:10613909] [PUBMED:17580073] [PUBMED:12745076] [PUBMED:16253996] [PUBMED:10840034] [PUBMED:10360579] [PUBMED:11907268] [PUBMED:10934475] [PUBMED:10219243] [PUBMED:17038317] [PUBMED:8910292] [PUBMED:9403696] [PUBMED:11285260] [PUBMED:10995437] [PUBMED:9368021] [PUBMED:14970210] [PUBMED:9694656] [PUBMED:14505571] [PUBMED:17115031] [PUBMED:9317150] [PUBMED:14653992] [PUBMED:17081755] [PUBMED:12676083] [PUBMED:18216334] [PUBMED:19826000] [PUBMED:8702968] [PUBMED:11304531] [PUBMED:10973943] [PUBMED:11309380] [PUBMED:18586681] [PUBMED:15479449] [PUBMED:19097998] [PUBMED:16892055] [PUBMED:17244649] [PUBMED:8625410] [PUBMED:8497321] [PUBMED:15485841] [PUBMED:16407834] [PUBMED:11804587] [PUBMED:9867866] [PUBMED:10747870] [PUBMED:7600581] [PUBMED:12610628] [PUBMED:19435802] [PUBMED:15572110] [PUBMED:7592586] [PUBMED:11696321] [PUBMED:10559936]
Cellular Senescence [NCBI:1270426] [REACTOME:R-HSA-2559583] [PUBMED:21078816] [PUBMED:18711403] [PUBMED:22048312] [PUBMED:19818705] [PUBMED:17662938] [PUBMED:23746838] [PUBMED:9282108] [PUBMED:17667954] [PUBMED:13905658]
Cellular responses to stress [NCBI:1270414] [REACTOME:R-HSA-2262752] [PUBMED:15709958]
Cellular roles of Anthrax toxin [NCBI:138076] [Pathway Interaction Database:anthraxpathway] [PUBMED:12202685] [PUBMED:15031715] [PUBMED:3123387] [PUBMED:11700562] [PUBMED:12700348] [PUBMED:8051159] [PUBMED:15772169] [PUBMED:12867985] [PUBMED:14688124] [PUBMED:15659071] [PUBMED:16473908] [PUBMED:10080100] [PUBMED:9703991] [PUBMED:12724519] [PUBMED:10580119] [PUBMED:11790132] [PUBMED:12468536] [PUBMED:16401723] [PUBMED:15010463] [PUBMED:12724328] [PUBMED:10338520] [PUBMED:9563949] [PUBMED:16429160] [PUBMED:6285339] [PUBMED:3917427] [PUBMED:12488448] [PUBMED:1438214] [PUBMED:9234799] [PUBMED:16254597] [PUBMED:15814721] [PUBMED:16141341] [PUBMED:1644824] [PUBMED:16242117] [PUBMED:16293226]
Ceramide signaling pathway [NCBI:138023] [Pathway Interaction Database:ceramide_pathway] [PUBMED:11350735] [PUBMED:10400650] [PUBMED:9287216] [PUBMED:9488730] [PUBMED:8702918] [PUBMED:10969079] [PUBMED:10433354] [PUBMED:14739942] [PUBMED:9446561] [PUBMED:8808629] [PUBMED:8681376] [PUBMED:7477354] [PUBMED:14689449] [PUBMED:12866359] [PUBMED:9873064] [PUBMED:8933152] [PUBMED:10438487] [PUBMED:15881228] [PUBMED:10508159] [PUBMED:7519779] [PUBMED:8387486] [PUBMED:12154098] [PUBMED:7559390] [PUBMED:12486111] [PUBMED:14670935] [PUBMED:15901738] [PUBMED:15051724] [PUBMED:8393446] [PUBMED:9094715] [PUBMED:11723139] [PUBMED:10395296] [PUBMED:8681377] [PUBMED:11148216] [PUBMED:12566438] [PUBMED:15164763] [PUBMED:10026132] [PUBMED:10962008]
Chagas disease (American trypanosomiasis) [NCBI:147809] [KEGG:hsa05142] [PUBMED:12377585] [PUBMED:9794425] [PUBMED:1717552] [PUBMED:16238097] [PUBMED:10066513] [PUBMED:12874238] [PUBMED:12036740] [PUBMED:15917295] [PUBMED:12055254] [PUBMED:17651955] [PUBMED:1396957] [PUBMED:16175174] [PUBMED:2194668] [PUBMED:9190942] [PUBMED:12377942] [PUBMED:12427093] [PUBMED:10234174] [PUBMED:16030288] [PUBMED:15223603] [PUBMED:17110955]
Cytokine Signaling in Immune system [NCBI:1269310] [REACTOME:R-HSA-1280215] [PUBMED:12613569]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Ephrin B reverse signaling [NCBI:138052] [Pathway Interaction Database:ephrinbrevpathway] [PUBMED:15351694] [PUBMED:11557983] [PUBMED:14576067] [PUBMED:7973638] [PUBMED:8755474] [PUBMED:15536074] [PUBMED:14988728] [PUBMED:8878483] [PUBMED:8918835] [PUBMED:11983165] [PUBMED:12709432] [PUBMED:8761303] [PUBMED:14499344] [PUBMED:11301003]
Epithelial cell signaling in Helicobacter pylori infection [NCBI:83102] [KEGG:hsa05120] [PUBMED:11389469] [PUBMED:15694859] [PUBMED:14700549] [PUBMED:12197905]
Epstein-Barr virus infection [NCBI:585562] [KEGG:hsa05169] [PUBMED:1658397] [PUBMED:10683340] [PUBMED:19375142] [PUBMED:12438576] [PUBMED:12910248] [PUBMED:10400785] [PUBMED:16007144] [PUBMED:14576817] [PUBMED:18559925] [PUBMED:16352731] [PUBMED:7895172] [PUBMED:15510157] [PUBMED:21518914] [PUBMED:10891508] [PUBMED:14673102] [PUBMED:17159145] [PUBMED:15542638] [PUBMED:18786993] [PUBMED:16603506] [PUBMED:10644367] [PUBMED:15021898] [PUBMED:10666279] [PUBMED:9565632]
ErbB signaling pathway [NCBI:83049] [KEGG:hsa04012] [PUBMED:16377102] [PUBMED:14967450] [PUBMED:9642287] [PUBMED:9872057] [PUBMED:10880430] [PUBMED:12851486] [PUBMED:16729045] [PUBMED:15863494] [PUBMED:15864276] [PUBMED:17000658] [PUBMED:16729043] [PUBMED:10490623] [PUBMED:11252954] [PUBMED:14744244] [PUBMED:16829981]
ErbB1 downstream signaling [NCBI:138057] [Pathway Interaction Database:erbb1_downstream_pathway] [PUBMED:1330321] [PUBMED:7939666] [PUBMED:9448004] [PUBMED:3497813] [PUBMED:7680434] [PUBMED:18567582] [PUBMED:12503606] [PUBMED:12183455] [PUBMED:8073291] [PUBMED:17563371] [PUBMED:8378775] [PUBMED:19219045] [PUBMED:1990291] [PUBMED:15550174] [PUBMED:16508002] [PUBMED:17881733] [PUBMED:11278353] [PUBMED:9889102] [PUBMED:14699061] [PUBMED:8248196] [PUBMED:8262053] [PUBMED:11319218] [PUBMED:19595761] [PUBMED:17360704] [PUBMED:15048123] [PUBMED:19341767] [PUBMED:9837959] [PUBMED:14993287] [PUBMED:19710016] [PUBMED:18516090] [PUBMED:9733714] [PUBMED:8052307] [PUBMED:10567369] [PUBMED:9335504] [PUBMED:9580112] [PUBMED:11018520] [PUBMED:10499589] [PUBMED:19706684] [PUBMED:8910287] [PUBMED:10469645] [PUBMED:11073940] [PUBMED:9315636] [PUBMED:2189103] [PUBMED:14765121] [PUBMED:14970219] [PUBMED:8332195] [PUBMED:16239230] [PUBMED:8621729] [PUBMED:11889038] [PUBMED:11029289] [PUBMED:11152283] [PUBMED:8071311] [PUBMED:12932319] [PUBMED:19541618] [PUBMED:2123453] [PUBMED:9384584] [PUBMED:8140422] [PUBMED:10644690] [PUBMED:18156174] [PUBMED:15718470] [PUBMED:12172553] [PUBMED:10082559] [PUBMED:17079732] [PUBMED:12446727] [PUBMED:9989263] [PUBMED:12551925] [PUBMED:10856237] [PUBMED:8013650] [PUBMED:7600581] [PUBMED:8688081] [PUBMED:8397445] [PUBMED:16135787] [PUBMED:7637810] [PUBMED:9438848] [PUBMED:12515821] [PUBMED:12881422] [PUBMED:9305638] [PUBMED:15284024] [PUBMED:3136398] [PUBMED:10597268] [PUBMED:10648629] [PUBMED:9790194] [PUBMED:9797479] [PUBMED:16093354] [PUBMED:7741752] [PUBMED:10891480] [PUBMED:17052213] [PUBMED:8221888] [PUBMED:9593664] [PUBMED:16892053] [PUBMED:8413226] [PUBMED:9407138] [PUBMED:9710644] [PUBMED:8248197] [PUBMED:12414794] [PUBMED:1653949] [PUBMED:12181570] [PUBMED:9550702] [PUBMED:12110590] [PUBMED:10400627] [PUBMED:9927426] [PUBMED:12242303] [PUBMED:10480933] [PUBMED:9665134] [PUBMED:11238956] [PUBMED:16984645] [PUBMED:7761091] [PUBMED:17322878] [PUBMED:12640115] [PUBMED:14963038] [PUBMED:17486115] [PUBMED:8503013] [PUBMED:16155590] [PUBMED:16628218] [PUBMED:1406636] [PUBMED:9430728] [PUBMED:19401591] [PUBMED:17053785] [PUBMED:7992057] [PUBMED:14609431] [PUBMED:9346240] [PUBMED:8626780] [PUBMED:8940018] [PUBMED:12454019] [PUBMED:10441128] [PUBMED:14747473] [PUBMED:11777939] [PUBMED:8614832] [PUBMED:8378774] [PUBMED:19121340] [PUBMED:18775988] [PUBMED:15039778] [PUBMED:9770464] [PUBMED:10567531] [PUBMED:8180183] [PUBMED:10675331] [PUBMED:1545823] [PUBMED:7958858] [PUBMED:11948693] [PUBMED:2109185] [PUBMED:8942998] [PUBMED:1637333] [PUBMED:14690430] [PUBMED:11134016] [PUBMED:12429840] [PUBMED:8621573] [PUBMED:7600582] [PUBMED:8226933] [PUBMED:10201527] [PUBMED:12832467] [PUBMED:3492494] [PUBMED:15034142] [PUBMED:9596579] [PUBMED:7889942] [PUBMED:8524316] [PUBMED:7731720] [PUBMED:8386592] [PUBMED:16407412] [PUBMED:6334806] [PUBMED:11703925] [PUBMED:11099046] [PUBMED:7876145] [PUBMED:14498832]
FCERI mediated MAPK activation [NCBI:1269299] [REACTOME:R-HSA-2871796] [PUBMED:19290926] [PUBMED:19909365] [PUBMED:17122878]
Fc epsilon RI signaling pathway [NCBI:83082] [KEGG:hsa04664] [PUBMED:16470226] [PUBMED:12145654] [PUBMED:11079101] [PUBMED:10586892] [PUBMED:14630197] [PUBMED:12360215] [PUBMED:11449275]
Fc epsilon receptor (FCERI) signaling [NCBI:1269298] [REACTOME:R-HSA-2454202] [PUBMED:15099567] [PUBMED:21799019]
Fc-epsilon receptor I signaling in mast cells [NCBI:138050] [Pathway Interaction Database:fcer1pathway] [PUBMED:9556577] [PUBMED:8629002] [PUBMED:12217401] [PUBMED:15010370] [PUBMED:15608142] [PUBMED:7561053] [PUBMED:7537741] [PUBMED:7963537] [PUBMED:8947047] [PUBMED:1384468] [PUBMED:14757742] [PUBMED:16174756] [PUBMED:10583594] [PUBMED:7513150] [PUBMED:12089510] [PUBMED:10811803] [PUBMED:9268346] [PUBMED:12640123] [PUBMED:9108083] [PUBMED:8602265] [PUBMED:11340169] [PUBMED:12953098] [PUBMED:11465115] [PUBMED:7730640] [PUBMED:9550384] [PUBMED:7518558] [PUBMED:11137136] [PUBMED:15282299] [PUBMED:14634134] [PUBMED:8534912] [PUBMED:16002993] [PUBMED:12192036] [PUBMED:7608202] [PUBMED:11714805] [PUBMED:11970986] [PUBMED:10903718] [PUBMED:15265912] [PUBMED:15477350]
Fluid shear stress and atherosclerosis [NCBI:1474302] [KEGG:hsa05418] [PUBMED:23429585] [PUBMED:21050140] [PUBMED:17599600] [PUBMED:24190880] [PUBMED:22003002] [PUBMED:24876354] [PUBMED:24947523] [PUBMED:23899566] [PUBMED:26597822] [PUBMED:20353494] [PUBMED:22076424] [PUBMED:20538799] [PUBMED:25165867] [PUBMED:20032497] [PUBMED:23084990] [PUBMED:26822720] [PUBMED:24573382] [PUBMED:23555159] [PUBMED:26212910] [PUBMED:21457103] [PUBMED:19151844] [PUBMED:15388638] [PUBMED:16765337] [PUBMED:27027326] [PUBMED:25638487] [PUBMED:21733876]
GnRH signaling pathway [NCBI:83091] [KEGG:hsa04912] [PUBMED:15080147] [PUBMED:15982836] [PUBMED:14596811] [PUBMED:15613448] [PUBMED:12943720] [PUBMED:10707049] [PUBMED:15350605] [PUBMED:12963732]
HTLV-I infection [NCBI:373901] [KEGG:hsa05166] [PUBMED:17446673] [PUBMED:16436385] [PUBMED:14686485] [PUBMED:19861996] [PUBMED:19092975] [PUBMED:11325603] [PUBMED:16155602] [PUBMED:12910251] [PUBMED:16155605] [PUBMED:16036567] [PUBMED:11244044] [PUBMED:18702816] [PUBMED:15569630] [PUBMED:21114861] [PUBMED:16155611] [PUBMED:17384582] [PUBMED:16155608] [PUBMED:10602469] [PUBMED:19014483] [PUBMED:9325311]
Hepatitis B [NCBI:694606] [KEGG:hsa05161] [PUBMED:19854353] [PUBMED:11604508] [PUBMED:11325602] [PUBMED:18931690] [PUBMED:16891440] [PUBMED:17158882] [PUBMED:11099494] [PUBMED:9325306] [PUBMED:18024894] [PUBMED:11483993] [PUBMED:15107488] [PUBMED:11278872] [PUBMED:21647825] [PUBMED:11287574] [PUBMED:18481805] [PUBMED:17188775] [PUBMED:19784739] [PUBMED:19263472] [PUBMED:16203685] [PUBMED:18605975] [PUBMED:10454581] [PUBMED:22504921] [PUBMED:21334391] [PUBMED:20657822] [PUBMED:18046710] [PUBMED:9843511] [PUBMED:15542625] [PUBMED:21618535] [PUBMED:15132991] [PUBMED:15173177] [PUBMED:12771941] [PUBMED:21994545] [PUBMED:8764004] [PUBMED:16459163] [PUBMED:9738022] [PUBMED:11821950] [PUBMED:12839924]
IL6-mediated signaling events [NCBI:137932] [Pathway Interaction Database:il6_7pathway] [PUBMED:8559663] [PUBMED:8662591] [PUBMED:11689697] [PUBMED:11727828] [PUBMED:10383440] [PUBMED:10777583] [PUBMED:16774741] [PUBMED:12754507] [PUBMED:9295319] [PUBMED:15722452] [PUBMED:10859312] [PUBMED:9590172] [PUBMED:9880505] [PUBMED:12445202] [PUBMED:8134389] [PUBMED:10409724] [PUBMED:8164674] [PUBMED:8272872] [PUBMED:9794795] [PUBMED:7678052] [PUBMED:8511589] [PUBMED:8668165] [PUBMED:9724754] [PUBMED:8083235] [PUBMED:12754505] [PUBMED:8621622] [PUBMED:16254248] [PUBMED:12361954] [PUBMED:10605021] [PUBMED:9388184] [PUBMED:15935617] [PUBMED:11120832] [PUBMED:7875298] [PUBMED:9973404] [PUBMED:11335711] [PUBMED:9632795] [PUBMED:11468294] [PUBMED:7898939] [PUBMED:8626374] [PUBMED:8670868] [PUBMED:7537214] [PUBMED:15677447] [PUBMED:2261637] [PUBMED:9874564] [PUBMED:12829785] [PUBMED:8537375] [PUBMED:8272873] [PUBMED:7523403] [PUBMED:11251120] [PUBMED:9163525] [PUBMED:3136546] [PUBMED:10727406] [PUBMED:10023775] [PUBMED:12754506] [PUBMED:12456685] [PUBMED:2788034] [PUBMED:10446219] [PUBMED:15572665] [PUBMED:1662392] [PUBMED:15010462] [PUBMED:8140422] [PUBMED:8467812]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Infectious disease [NCBI:1269056] [REACTOME:R-HSA-5663205]
Influenza A [NCBI:217173] [KEGG:hsa05164] [PUBMED:17267598] [PUBMED:18049471] [PUBMED:16882036] [PUBMED:11907320] [PUBMED:17944269] [PUBMED:20629046] [PUBMED:17072332] [PUBMED:18588994] [PUBMED:19864182] [PUBMED:19290913] [PUBMED:19420020] [PUBMED:17213831] [PUBMED:9060654] [PUBMED:19481124] [PUBMED:16494716] [PUBMED:21147034] [PUBMED:18980544] [PUBMED:20020828] [PUBMED:15502848] [PUBMED:19782761]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Interleukin-1 signaling [NCBI:1269320] [REACTOME:R-HSA-446652] [PUBMED:19302047] [PUBMED:19022706]
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 [NCBI:1269212] [REACTOME:R-HSA-450321] [PUBMED:15837794] [PUBMED:11460167]
JNK signaling in the CD4+ TCR pathway [NCBI:138066] [Pathway Interaction Database:tcrjnkpathway] [PUBMED:12917261] [PUBMED:8631303] [PUBMED:9891069] [PUBMED:14557276] [PUBMED:10567356]
MAP kinase activation in TLR cascade [NCBI:1269211] [REACTOME:R-HSA-450294] [PUBMED:17637696] [PUBMED:11861597] [PUBMED:19196711] [PUBMED:11242034]
MAP3K8 (TPL2)-dependent MAPK1/3 activation [NCBI:1309122] [REACTOME:R-HSA-5684264] [PUBMED:22733995] [PUBMED:21135874]
MAPK signaling pathway [NCBI:83048] [KEGG:hsa04010] [PUBMED:11749383] [PUBMED:12566928] [PUBMED:12849693] [PUBMED:12676795] [PUBMED:12947395] [PUBMED:14597384] [PUBMED:11369511] [PUBMED:12191611] [PUBMED:12390245]
MyD88 cascade initiated on plasma membrane [NCBI:1269207] [REACTOME:R-HSA-975871] [PUBMED:15728506] [PUBMED:16239509]
MyD88 dependent cascade initiated on endosome [NCBI:1269228] [REACTOME:R-HSA-975155] [PUBMED:20237413] [PUBMED:15276183] [PUBMED:18652679]
MyD88-independent TLR3/TLR4 cascade [NCBI:1269220] [REACTOME:R-HSA-166166] [PUBMED:15276183]
MyD88:Mal cascade initiated on plasma membrane [NCBI:1269237] [REACTOME:R-HSA-166058] [PUBMED:15276183]
Nephrin/Neph1 signaling in the kidney podocyte [NCBI:138072] [Pathway Interaction Database:nephrin_neph1_pathway] [PUBMED:12660326] [PUBMED:18212058] [PUBMED:12832477] [PUBMED:10504499] [PUBMED:12846735] [PUBMED:18385666] [PUBMED:12668668] [PUBMED:19142224] [PUBMED:14633607] [PUBMED:16525419] [PUBMED:10514378] [PUBMED:17923684] [PUBMED:18274541] [PUBMED:17079490] [PUBMED:11733557] [PUBMED:16968782] [PUBMED:15200416] [PUBMED:12424224] [PUBMED:11562357] [PUBMED:18715943] [PUBMED:11549599] [PUBMED:15339792] [PUBMED:10742096] [PUBMED:14570703] [PUBMED:19179337] [PUBMED:19497968] [PUBMED:12578837] [PUBMED:18562307] [PUBMED:18046313] [PUBMED:12646566] [PUBMED:15579503] [PUBMED:18033240] [PUBMED:16543952]
Oxidative Stress Induced Senescence [NCBI:1270428] [REACTOME:R-HSA-2559580] [PUBMED:17344414] [PUBMED:17332741] [PUBMED:8622688] [PUBMED:7588633] [PUBMED:15563468] [PUBMED:15287722] [PUBMED:11062067] [PUBMED:16337592] [PUBMED:14532106] [PUBMED:17254968] [PUBMED:15866172] [PUBMED:9628874] [PUBMED:12171911] [PUBMED:7816143] [PUBMED:22020331] [PUBMED:11564866] [PUBMED:9162092] [PUBMED:8974401] [PUBMED:19451217] [PUBMED:12808055] [PUBMED:17210787] [PUBMED:8846784] [PUBMED:19462008] [PUBMED:12134156] [PUBMED:8626550] [PUBMED:8774846] [PUBMED:12189133] [PUBMED:9195981] [PUBMED:8622669] [PUBMED:8259215] [PUBMED:19528227] [PUBMED:9564042] [PUBMED:9529249] [PUBMED:16436515] [PUBMED:19451218] [PUBMED:17395714] [PUBMED:9030721] [PUBMED:12435631] [PUBMED:22325352]
RAC1 signaling pathway [NCBI:169355] [Pathway Interaction Database:rac1_pathway] [PUBMED:19158278] [PUBMED:16702231] [PUBMED:16440308] [PUBMED:14765121] [PUBMED:12453877] [PUBMED:12657629] [PUBMED:9799233] [PUBMED:9694656] [PUBMED:9317150] [PUBMED:14970210] [PUBMED:8305740] [PUBMED:8805275] [PUBMED:17178910] [PUBMED:11060298] [PUBMED:11304531] [PUBMED:11804587] [PUBMED:11470914] [PUBMED:11309380] [PUBMED:17244649] [PUBMED:11021801] [PUBMED:7592586] [PUBMED:15681696] [PUBMED:7744004] [PUBMED:15225553] [PUBMED:10559936] [PUBMED:19917258] [PUBMED:7600581] [PUBMED:19363480] [PUBMED:18423204] [PUBMED:20097736] [PUBMED:19852956] [PUBMED:12181570] [PUBMED:19822663] [PUBMED:7652575] [PUBMED:7629060] [PUBMED:8107774] [PUBMED:16636067] [PUBMED:9042860] [PUBMED:12213441] [PUBMED:10679324] [PUBMED:12682053] [PUBMED:18198193] [PUBMED:16542153] [PUBMED:7600582] [PUBMED:18948007] [PUBMED:18319301] [PUBMED:10559253] [PUBMED:17115053] [PUBMED:10473551] [PUBMED:17682062] [PUBMED:17164293] [PUBMED:15557278] [PUBMED:15677464] [PUBMED:16837009] [PUBMED:12796474] [PUBMED:10559863] [PUBMED:9535855] [PUBMED:8910292] [PUBMED:11432831] [PUBMED:17981134] [PUBMED:16762923] [PUBMED:8798539] [PUBMED:18160398] [PUBMED:16099876] [PUBMED:14681219]
Regulation of Androgen receptor activity [NCBI:138027] [Pathway Interaction Database:ar_tf_pathway] [PUBMED:15650026] [PUBMED:17045208] [PUBMED:10364196] [PUBMED:16860317] [PUBMED:10611280] [PUBMED:10930412] [PUBMED:1525041] [PUBMED:10779504] [PUBMED:12514133] [PUBMED:1985913] [PUBMED:11931767] [PUBMED:17011549] [PUBMED:15640443] [PUBMED:16322096] [PUBMED:15923603] [PUBMED:14985354] [PUBMED:15743818] [PUBMED:12949936] [PUBMED:11994312] [PUBMED:10567371] [PUBMED:11875111] [PUBMED:15604291] [PUBMED:12890669] [PUBMED:14729952] [PUBMED:9211894] [PUBMED:9162033] [PUBMED:16705743] [PUBMED:16849544] [PUBMED:16923962] [PUBMED:11591700] [PUBMED:16051670] [PUBMED:8643509] [PUBMED:17108144] [PUBMED:16914734] [PUBMED:12682292] [PUBMED:3353726] [PUBMED:11585838] [PUBMED:16282370] [PUBMED:10381882] [PUBMED:15199155] [PUBMED:16455820] [PUBMED:14612401] [PUBMED:10625666] [PUBMED:17679089] [PUBMED:16461774]
Regulation of p38-alpha and p38-beta [NCBI:137964] [Pathway Interaction Database:p38alphabetapathway] [PUBMED:16461893] [PUBMED:7997261] [PUBMED:16943189] [PUBMED:14585994] [PUBMED:10391943] [PUBMED:14661019] [PUBMED:11359773] [PUBMED:7914033] [PUBMED:8910287] [PUBMED:7744004] [PUBMED:10190877] [PUBMED:7592586] [PUBMED:16849316] [PUBMED:7693711] [PUBMED:11847341] [PUBMED:7839144] [PUBMED:9790884] [PUBMED:7499279] [PUBMED:14592977] [PUBMED:12110590] [PUBMED:14634666] [PUBMED:8107774] [PUBMED:8622669] [PUBMED:8798750] [PUBMED:11278799] [PUBMED:15864310] [PUBMED:16407200]
RhoA signaling pathway [NCBI:169356] [Pathway Interaction Database:rhoa_pathway] [PUBMED:8641286] [PUBMED:16705166] [PUBMED:9510209] [PUBMED:18267089] [PUBMED:15866170] [PUBMED:18303050] [PUBMED:17588931] [PUBMED:18941185] [PUBMED:16164598] [PUBMED:11238375] [PUBMED:18559669] [PUBMED:18025109] [PUBMED:16427251] [PUBMED:11122380] [PUBMED:8632828] [PUBMED:15866889] [PUBMED:9707430] [PUBMED:9456324] [PUBMED:8662509] [PUBMED:12429848] [PUBMED:9294169] [PUBMED:9042860] [PUBMED:9582304] [PUBMED:15170389] [PUBMED:10744700] [PUBMED:10893221] [PUBMED:14681219] [PUBMED:9121475] [PUBMED:8858161] [PUBMED:18309323] [PUBMED:9710582] [PUBMED:9265657] [PUBMED:19625450] [PUBMED:15068801] [PUBMED:11278519] [PUBMED:12732141] [PUBMED:9529607] [PUBMED:12600823] [PUBMED:9697773] [PUBMED:10085083] [PUBMED:12802051] [PUBMED:11018042] [PUBMED:7600583] [PUBMED:9693382] [PUBMED:12899698] [PUBMED:8702756] [PUBMED:10556088] [PUBMED:10037681] [PUBMED:1643657] [PUBMED:12034774] [PUBMED:9670022] [PUBMED:12574166] [PUBMED:12584113] [PUBMED:11877391] [PUBMED:9920882] [PUBMED:8995216] [PUBMED:7929302] [PUBMED:10428028] [PUBMED:15793569] [PUBMED:14595335] [PUBMED:10436006] [PUBMED:9482732] [PUBMED:11342553] [PUBMED:9351440]
Signaling by Interleukins [NCBI:1269318] [REACTOME:R-HSA-449147] [PUBMED:19302047] [PUBMED:12445398]
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) [NCBI:137930] [Pathway Interaction Database:met_pathway] [PUBMED:10793146] [PUBMED:8906793] [PUBMED:11929826] [PUBMED:10022866] [PUBMED:11532961] [PUBMED:12475979] [PUBMED:1718989] [PUBMED:1846706] [PUBMED:10970810] [PUBMED:10516287] [PUBMED:12138161] [PUBMED:11046147] [PUBMED:18073207] [PUBMED:12951049] [PUBMED:15494312] [PUBMED:9001234] [PUBMED:11352916] [PUBMED:11896055] [PUBMED:9440692] [PUBMED:8607979] [PUBMED:12244132] [PUBMED:11162460] [PUBMED:11809798] [PUBMED:9693375] [PUBMED:14636584] [PUBMED:17297451] [PUBMED:17682062] [PUBMED:19628037] [PUBMED:11069926] [PUBMED:18819921] [PUBMED:16423831] [PUBMED:10558875] [PUBMED:16858414] [PUBMED:10995442] [PUBMED:20332103] [PUBMED:11146548] [PUBMED:18346875] [PUBMED:17894413] [PUBMED:9252406] [PUBMED:17635922] [PUBMED:11134526] [PUBMED:2005882] [PUBMED:19609305] [PUBMED:8380735] [PUBMED:16537482] [PUBMED:10618718] [PUBMED:9591773] [PUBMED:12894582] [PUBMED:9748249] [PUBMED:11741535] [PUBMED:17881575] [PUBMED:10713050] [PUBMED:1655790] [PUBMED:11784715] [PUBMED:10753869] [PUBMED:10713700] [PUBMED:11118451] [PUBMED:16952352] [PUBMED:15314156] [PUBMED:19272169] [PUBMED:12802068] [PUBMED:17363898] [PUBMED:7513258] [PUBMED:1827664] [PUBMED:2541345] [PUBMED:8387483] [PUBMED:16620780] [PUBMED:11445578] [PUBMED:10734310] [PUBMED:16227611] [PUBMED:12941962] [PUBMED:15735664] [PUBMED:19071214] [PUBMED:7731718] [PUBMED:19289496] [PUBMED:11438654] [PUBMED:11896612] [PUBMED:11894096] [PUBMED:11896575] [PUBMED:7499247] [PUBMED:12147692] [PUBMED:11948414] [PUBMED:19881549] [PUBMED:19525225] [PUBMED:14684163] [PUBMED:17055484] [PUBMED:9668053] [PUBMED:10531383] [PUBMED:9681449] [PUBMED:1655405] [PUBMED:12686592] [PUBMED:19109251] [PUBMED:10679787] [PUBMED:9487126] [PUBMED:9886295] [PUBMED:12058075] [PUBMED:15452053] [PUBMED:9184210] [PUBMED:10871282] [PUBMED:17329361] [PUBMED:2554238]
Signaling events mediated by focal adhesion kinase [NCBI:169348] [Pathway Interaction Database:fak_pathway] [PUBMED:18793427] [PUBMED:15340073] [PUBMED:16054026] [PUBMED:12932330] [PUBMED:20038548] [PUBMED:7542255] [PUBMED:8939916] [PUBMED:16000375] [PUBMED:10856236] [PUBMED:17164291] [PUBMED:9148935] [PUBMED:10893408] [PUBMED:10512882] [PUBMED:11839772] [PUBMED:11553710] [PUBMED:7566154] [PUBMED:20018869] [PUBMED:12839996] [PUBMED:11799111] [PUBMED:16308318] [PUBMED:11331870] [PUBMED:12681445] [PUBMED:11369769] [PUBMED:11739801] [PUBMED:9860979] [PUBMED:8947559] [PUBMED:11017882] [PUBMED:7509446] [PUBMED:10791986] [PUBMED:9128257] [PUBMED:19297531] [PUBMED:17325207] [PUBMED:17093062] [PUBMED:10593973] [PUBMED:20308429] [PUBMED:8922390] [PUBMED:19776348] [PUBMED:9374537] [PUBMED:10976102] [PUBMED:10373530] [PUBMED:19883375] [PUBMED:10430888] [PUBMED:12820964] [PUBMED:9425168] [PUBMED:14743221] [PUBMED:18854312] [PUBMED:12952943] [PUBMED:15962308] [PUBMED:11927607] [PUBMED:15657076] [PUBMED:15039571] [PUBMED:18303050] [PUBMED:11799401] [PUBMED:15247219] [PUBMED:12702722] [PUBMED:10998418] [PUBMED:7615549] [PUBMED:18195107] [PUBMED:9032297] [PUBMED:10873807] [PUBMED:10777511] [PUBMED:12502711] [PUBMED:9566877] [PUBMED:8649427] [PUBMED:19473962] [PUBMED:9808620] [PUBMED:15914540] [PUBMED:1385445] [PUBMED:18223254] [PUBMED:11909938] [PUBMED:15166238] [PUBMED:7622520] [PUBMED:8824286] [PUBMED:8662921] [PUBMED:8707856] [PUBMED:10330411] [PUBMED:10446223] [PUBMED:20150423] [PUBMED:11604500] [PUBMED:9234699] [PUBMED:18773890] [PUBMED:18757826] [PUBMED:9864370] [PUBMED:7983066] [PUBMED:18322799] [PUBMED:12006652] [PUBMED:16461767] [PUBMED:10385525] [PUBMED:14676198] [PUBMED:9858476] [PUBMED:18070912] [PUBMED:11058585] [PUBMED:12890755] [PUBMED:9184223] [PUBMED:12058076] [PUBMED:12226752] [PUBMED:19435801] [PUBMED:10212207] [PUBMED:10521463] [PUBMED:16159962] [PUBMED:7579684] [PUBMED:18362184] [PUBMED:7997267] [PUBMED:8816475] [PUBMED:11279163] [PUBMED:7537852] [PUBMED:11418135] [PUBMED:12167697] [PUBMED:12615911] [PUBMED:12876277]
TNF signaling pathway [NCBI:812256] [KEGG:hsa04668] [PUBMED:20489699] [PUBMED:14532286] [PUBMED:21232019] [PUBMED:11897488] [PUBMED:22296764] [PUBMED:10581243] [PUBMED:23085193] [PUBMED:23531747]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation [NCBI:1269229] [REACTOME:R-HSA-975138] [PUBMED:22511786] [PUBMED:18794297]
TRAIL signaling pathway [NCBI:137920] [Pathway Interaction Database:trail_pathway] [PUBMED:10958661] [PUBMED:9430226] [PUBMED:9311998] [PUBMED:16227629] [PUBMED:10521396] [PUBMED:9242610] [PUBMED:12668516] [PUBMED:15105837] [PUBMED:11461927] [PUBMED:16319225] [PUBMED:9082980] [PUBMED:9430227] [PUBMED:16980609] [PUBMED:10894160] [PUBMED:16940186] [PUBMED:16636669] [PUBMED:10783243] [PUBMED:11278665] [PUBMED:11376335] [PUBMED:9314565] [PUBMED:10521444] [PUBMED:10894161]
TRIF-mediated TLR3/TLR4 signaling [NCBI:1269221] [REACTOME:R-HSA-937061] [PUBMED:15814722] [PUBMED:12855817] [PUBMED:14739303]
Toll Like Receptor 10 (TLR10) Cascade [NCBI:1269206] [REACTOME:R-HSA-168142] [PUBMED:15728506] [PUBMED:18332149]
Toll Like Receptor 2 (TLR2) Cascade [NCBI:1269238] [REACTOME:R-HSA-181438] [PUBMED:10820283]
Toll Like Receptor 3 (TLR3) Cascade [NCBI:1269219] [REACTOME:R-HSA-168164] [PUBMED:19627256] [PUBMED:15733829] [PUBMED:18202435]
Toll Like Receptor 4 (TLR4) Cascade [NCBI:1269234] [REACTOME:R-HSA-166016]
Toll Like Receptor 5 (TLR5) Cascade [NCBI:1269226] [REACTOME:R-HSA-168176] [PUBMED:11489966] [PUBMED:11323673]
Toll Like Receptor 7/8 (TLR7/8) Cascade [NCBI:1269227] [REACTOME:R-HSA-168181] [PUBMED:14976262]
Toll Like Receptor 9 (TLR9) Cascade [NCBI:1269233] [REACTOME:R-HSA-168138] [PUBMED:14751759]
Toll Like Receptor TLR1:TLR2 Cascade [NCBI:1269239] [REACTOME:R-HSA-168179] [PUBMED:12975352]
Toll Like Receptor TLR6:TLR2 Cascade [NCBI:1269240] [REACTOME:R-HSA-168188] [PUBMED:14977973]
Toll-Like Receptors Cascades [NCBI:1269204] [REACTOME:R-HSA-168898] [PUBMED:15950447] [PUBMED:12893815] [PUBMED:15976490] [PUBMED:15585605] [PUBMED:14751757]
Toll-like receptor signaling pathway [NCBI:83076] [KEGG:hsa04620] [PUBMED:16924467] [PUBMED:17395581] [PUBMED:17637696] [PUBMED:12734364] [PUBMED:17507094] [PUBMED:14698224] [PUBMED:11101877] [PUBMED:16497588] [PUBMED:14751764] [PUBMED:17275323] [PUBMED:17457343] [PUBMED:16932750]
Uptake and actions of bacterial toxins [NCBI:1269144] [REACTOME:R-HSA-5339562] [PUBMED:20358680]
Uptake and function of anthrax toxins [NCBI:1269154] [REACTOME:R-HSA-5210891] [PUBMED:17335404] [PUBMED:9563949] [PUBMED:11104681] [PUBMED:6285339] [PUBMED:15353562] [PUBMED:17313374]
VEGFR3 signaling in lymphatic endothelium [NCBI:137996] [Pathway Interaction Database:lymphangiogenesis_pathway] [PUBMED:12881528] [PUBMED:8617204] [PUBMED:10449752] [PUBMED:9247316] [PUBMED:11335727] [PUBMED:9012504] [PUBMED:9435229] [PUBMED:16076871] [PUBMED:11532940] [PUBMED:9927207] [PUBMED:11553610] [PUBMED:7675451] [PUBMED:8662748] [PUBMED:16633338]