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Genes
NOS2
Gene - NOS2
full name
nitric oxide synthase 2
synonyms
HEP-NOS, INOS, NOS, NOS2A, NOS2, ENSG00000007171
HGNC
HGNC:7873
Entrez Gene
Gene:4843
ENSEMBL
ENSG00000007171
location
chr: 17
start: 26083792
stop: 26127555
strand: -
OMIM
OMIM:163730
: NOS2
OMIM:611162
: {Malaria, resistance to}
transcripts
NM_000625.4
pathways
ATF-2 transcription factor network
[NCBI:138006]
[Pathway Interaction Database:atf2_pathway]
[PUBMED:12048217]
[PUBMED:19255142]
[PUBMED:11739785]
[PUBMED:7624151]
[PUBMED:19822663]
[PUBMED:17590016]
[PUBMED:7535770]
[PUBMED:18396163]
[PUBMED:20507983]
[PUBMED:19422799]
[PUBMED:7824938]
[PUBMED:11713276]
[PUBMED:17258390]
[PUBMED:10454570]
[PUBMED:20067572]
[PUBMED:10364225]
[PUBMED:12121977]
[PUBMED:12110590]
[PUBMED:19176525]
[PUBMED:16511568]
[PUBMED:17079470]
[PUBMED:17267404]
[PUBMED:10777595]
[PUBMED:2516827]
[PUBMED:18397884]
[PUBMED:10207054]
[PUBMED:9436983]
[PUBMED:7737130]
[PUBMED:10982836]
[PUBMED:9006914]
[PUBMED:19592489]
[PUBMED:17158955]
[PUBMED:17189429]
[PUBMED:11566021]
[PUBMED:17626013]
[PUBMED:17036053]
[PUBMED:20702711]
[PUBMED:10085140]
[PUBMED:20032511]
[PUBMED:17219413]
[PUBMED:17337306]
[PUBMED:9511728]
[PUBMED:12196528]
[PUBMED:19304750]
[PUBMED:17700520]
[PUBMED:16373341]
[PUBMED:12833146]
[PUBMED:1827203]
[PUBMED:17699753]
[PUBMED:9990041]
[PUBMED:15304344]
[PUBMED:11231009]
[PUBMED:18385943]
[PUBMED:18387947]
[PUBMED:18638549]
[PUBMED:15767263]
[PUBMED:10777545]
[PUBMED:14630918]
[PUBMED:18802055]
[PUBMED:10037779]
[PUBMED:12052888]
[PUBMED:8943243]
[PUBMED:20181929]
[PUBMED:19647037]
[PUBMED:8382609]
[PUBMED:16405968]
[PUBMED:1641004]
Amoebiasis
[NCBI:167324]
[KEGG:hsa05146]
[PUBMED:9832261]
[PUBMED:16380324]
[PUBMED:14700586]
[PUBMED:18725798]
[PUBMED:12142490]
[PUBMED:10637584]
[PUBMED:20145703]
[PUBMED:11378035]
[PUBMED:12160867]
[PUBMED:15813717]
[PUBMED:19207103]
[PUBMED:12660071]
[PUBMED:20303955]
[PUBMED:11352795]
[PUBMED:14502002]
[PUBMED:10756002]
[PUBMED:17702556]
[PUBMED:17576362]
Apelin signaling pathway
[NCBI:1492886]
[KEGG:hsa04371]
[PUBMED:23973488]
[PUBMED:16182514]
[PUBMED:21725702]
[PUBMED:22842084]
[PUBMED:27825851]
[PUBMED:27650065]
[PUBMED:22140623]
[PUBMED:23943882]
[PUBMED:26944568]
[PUBMED:24055369]
[PUBMED:26385179]
[PUBMED:26143239]
[PUBMED:22028387]
[PUBMED:26254105]
[PUBMED:26756969]
[PUBMED:22995518]
[PUBMED:27979574]
[PUBMED:23924696]
[PUBMED:21464822]
[PUBMED:25914650]
[PUBMED:24990699]
[PUBMED:26607438]
[PUBMED:25164121]
[PUBMED:25275559]
[PUBMED:25139773]
[PUBMED:25931124]
[PUBMED:19093215]
[PUBMED:20539939]
[PUBMED:25652330]
[PUBMED:18272138]
[PUBMED:23603510]
Arginine and proline metabolism
[NCBI:82957]
[KEGG:hsa00330]
[PUBMED:15590624]
[PUBMED:5288244]
[PUBMED:16499623]
Arginine biosynthesis
[NCBI:82943]
[KEGG:hsa00220]
Calcium signaling pathway
[NCBI:83050]
[KEGG:hsa04020]
[PUBMED:11080247]
[PUBMED:14572802]
[PUBMED:11413485]
[PUBMED:22129055]
[PUBMED:10508738]
[PUBMED:15000521]
[PUBMED:9235901]
[PUBMED:7861177]
[PUBMED:9149541]
[PUBMED:14517314]
[PUBMED:15111104]
[PUBMED:11698232]
[PUBMED:10331643]
[PUBMED:12838335]
[PUBMED:8125957]
[PUBMED:19172794]
[PUBMED:10997573]
[PUBMED:21338471]
[PUBMED:11299192]
[PUBMED:22002090]
[PUBMED:12972622]
Chagas disease (American trypanosomiasis)
[NCBI:147809]
[KEGG:hsa05142]
[PUBMED:12377585]
[PUBMED:9794425]
[PUBMED:1717552]
[PUBMED:16238097]
[PUBMED:10066513]
[PUBMED:12874238]
[PUBMED:12036740]
[PUBMED:15917295]
[PUBMED:12055254]
[PUBMED:17651955]
[PUBMED:1396957]
[PUBMED:16175174]
[PUBMED:2194668]
[PUBMED:9190942]
[PUBMED:12377942]
[PUBMED:12427093]
[PUBMED:10234174]
[PUBMED:16030288]
[PUBMED:15223603]
[PUBMED:17110955]
Cytokine Signaling in Immune system
[NCBI:1269310]
[REACTOME:R-HSA-1280215]
[PUBMED:12613569]
HIF-1 signaling pathway
[NCBI:695200]
[KEGG:hsa04066]
[PUBMED:11902584]
[PUBMED:20965423]
[PUBMED:20679415]
[PUBMED:15031665]
[PUBMED:18259201]
[PUBMED:22205687]
[PUBMED:19364912]
[PUBMED:19147540]
[PUBMED:15448722]
[PUBMED:16234508]
[PUBMED:18505681]
[PUBMED:20836033]
[PUBMED:19861159]
[PUBMED:17955264]
[PUBMED:22562152]
HIF-1-alpha transcription factor network
[NCBI:138045]
[Pathway Interaction Database:hif1_tfpathway]
[PUBMED:11707426]
[PUBMED:9242677]
[PUBMED:9038135]
[PUBMED:15310764]
[PUBMED:11278891]
[PUBMED:8816435]
[PUBMED:8663540]
[PUBMED:15235127]
[PUBMED:12042299]
[PUBMED:15312748]
[PUBMED:14612449]
[PUBMED:11342587]
[PUBMED:12615703]
[PUBMED:9632793]
[PUBMED:12228247]
[PUBMED:15044468]
[PUBMED:8408001]
[PUBMED:9822602]
[PUBMED:15252039]
[PUBMED:13679920]
[PUBMED:11877282]
[PUBMED:15235597]
[PUBMED:15199161]
[PUBMED:15104534]
[PUBMED:10594042]
[PUBMED:12354771]
[PUBMED:10446188]
[PUBMED:9436976]
[PUBMED:11823643]
[PUBMED:12370277]
[PUBMED:8955077]
[PUBMED:12879018]
[PUBMED:14645546]
[PUBMED:9486205]
[PUBMED:9887100]
[PUBMED:8089148]
[PUBMED:15466858]
[PUBMED:11708773]
[PUBMED:15611046]
[PUBMED:14742449]
[PUBMED:15280364]
[PUBMED:12215445]
[PUBMED:15611089]
[PUBMED:10777486]
[PUBMED:9707622]
[PUBMED:8917528]
[PUBMED:15563275]
[PUBMED:12067980]
[PUBMED:10353251]
Hemostasis
[NCBI:1269340]
[REACTOME:R-HSA-109582]
IL12-mediated signaling events
[NCBI:137922]
[Pathway Interaction Database:il12_2pathway]
[PUBMED:12874225]
[PUBMED:12221108]
[PUBMED:16380506]
[PUBMED:9768751]
[PUBMED:17114419]
[PUBMED:10358173]
[PUBMED:9890938]
[PUBMED:12213961]
[PUBMED:11120802]
[PUBMED:9202126]
[PUBMED:16641133]
[PUBMED:10198225]
[PUBMED:16763563]
[PUBMED:15728489]
[PUBMED:8103068]
[PUBMED:10903740]
[PUBMED:10201984]
[PUBMED:7638186]
[PUBMED:11894097]
[PUBMED:16220539]
[PUBMED:10961885]
[PUBMED:7594594]
[PUBMED:17110450]
[PUBMED:9582275]
[PUBMED:10320373]
[PUBMED:7528775]
[PUBMED:11207258]
[PUBMED:9038232]
[PUBMED:15522880]
[PUBMED:11175814]
[PUBMED:9531298]
[PUBMED:7722452]
[PUBMED:8943050]
[PUBMED:7553885]
[PUBMED:9454765]
IL23-mediated signaling events
[NCBI:138000]
[Pathway Interaction Database:il23pathway]
[PUBMED:16200068]
[PUBMED:12023338]
[PUBMED:17030949]
[PUBMED:16670770]
[PUBMED:17074928]
[PUBMED:15583831]
[PUBMED:16919486]
[PUBMED:12417590]
[PUBMED:16622035]
[PUBMED:16698929]
[PUBMED:14978083]
[PUBMED:12610626]
[PUBMED:15308705]
[PUBMED:16200070]
[PUBMED:15657292]
[PUBMED:16648837]
[PUBMED:11114383]
[PUBMED:12023369]
[PUBMED:9038232]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Interleukin-4 and 13 signaling
[NCBI:1470923]
[REACTOME:R-HSA-6785807]
[PUBMED:12704343]
[PUBMED:10358772]
Leishmaniasis
[NCBI:144181]
[KEGG:hsa05140]
[PUBMED:11890722]
[PUBMED:7916951]
[PUBMED:10417174]
[PUBMED:11298294]
[PUBMED:10586030]
[PUBMED:15322192]
[PUBMED:15831826]
[PUBMED:11728310]
[PUBMED:15039466]
[PUBMED:10462516]
[PUBMED:10608501]
[PUBMED:15721837]
[PUBMED:15639739]
[PUBMED:14762510]
[PUBMED:18793215]
[PUBMED:7591091]
[PUBMED:12438359]
[PUBMED:18070909]
[PUBMED:17543969]
[PUBMED:15983048]
[PUBMED:16848789]
[PUBMED:10770277]
[PUBMED:9504340]
Metabolic pathways
[NCBI:132956]
[KEGG:hsa01100]
Nitric oxide stimulates guanylate cyclase
[NCBI:1269343]
[REACTOME:R-HSA-392154]
[PUBMED:12881475]
Pathways in cancer
[NCBI:83105]
[KEGG:hsa05200]
[PUBMED:12244301]
[PUBMED:15156182]
[PUBMED:16899407]
[PUBMED:12621137]
[PUBMED:21193867]
[PUBMED:16001072]
[PUBMED:11707511]
[PUBMED:11253051]
[PUBMED:11071626]
[PUBMED:17251915]
[PUBMED:11736900]
[PUBMED:16557281]
[PUBMED:16699851]
[PUBMED:16189702]
[PUBMED:11902573]
[PUBMED:16555243]
[PUBMED:8069858]
[PUBMED:15310786]
[PUBMED:9834202]
[PUBMED:16700615]
[PUBMED:12545153]
[PUBMED:15656799]
[PUBMED:12154354]
[PUBMED:11895903]
[PUBMED:11527574]
[PUBMED:16326109]
[PUBMED:16339096]
[PUBMED:11160144]
[PUBMED:15724144]
[PUBMED:12951584]
[PUBMED:10647931]
[PUBMED:16881963]
[PUBMED:15557758]
[PUBMED:11477132]
[PUBMED:15721476]
[PUBMED:15625120]
[PUBMED:16236521]
[PUBMED:14967450]
[PUBMED:15942304]
[PUBMED:17287871]
[PUBMED:14634372]
[PUBMED:15573119]
[PUBMED:15009714]
[PUBMED:16112428]
[PUBMED:15611513]
[PUBMED:16001050]
[PUBMED:15349822]
[PUBMED:16551846]
[PUBMED:15978322]
[PUBMED:15774796]
[PUBMED:16352814]
[PUBMED:12951588]
[PUBMED:10944551]
[PUBMED:10740269]
[PUBMED:15639402]
[PUBMED:12407699]
[PUBMED:11130178]
[PUBMED:15109562]
[PUBMED:11170304]
[PUBMED:11276000]
[PUBMED:9643506]
[PUBMED:16248975]
[PUBMED:16242838]
[PUBMED:12946833]
[PUBMED:11559746]
[PUBMED:9196022]
[PUBMED:12079267]
[PUBMED:15468170]
[PUBMED:16064138]
[PUBMED:14580692]
[PUBMED:15082523]
[PUBMED:15551095]
[PUBMED:17062879]
[PUBMED:17211469]
[PUBMED:11720739]
[PUBMED:12588368]
[PUBMED:11057895]
[PUBMED:9422516]
[PUBMED:12894244]
[PUBMED:15479695]
[PUBMED:16189154]
[PUBMED:12878745]
[PUBMED:11900250]
[PUBMED:11103787]
[PUBMED:15122209]
[PUBMED:12711111]
[PUBMED:12243753]
[PUBMED:16306523]
[PUBMED:16702400]
[PUBMED:15270885]
[PUBMED:14685170]
[PUBMED:14586404]
[PUBMED:11078609]
[PUBMED:15284264]
[PUBMED:10505543]
[PUBMED:11223406]
[PUBMED:14982876]
[PUBMED:12648469]
[PUBMED:12867060]
[PUBMED:15711891]
[PUBMED:12094241]
[PUBMED:16642045]
[PUBMED:11463388]
[PUBMED:12762887]
[PUBMED:15746962]
[PUBMED:15823750]
[PUBMED:16750612]
[PUBMED:16484590]
[PUBMED:11459867]
[PUBMED:16146838]
[PUBMED:14556242]
[PUBMED:15947972]
[PUBMED:12563308]
[PUBMED:16946003]
[PUBMED:15948971]
[PUBMED:11407945]
[PUBMED:12737309]
[PUBMED:16095998]
[PUBMED:12351585]
[PUBMED:24508914]
[PUBMED:12084351]
[PUBMED:11807782]
[PUBMED:14695152]
[PUBMED:10453277]
[PUBMED:17554387]
[PUBMED:15841168]
[PUBMED:12616528]
[PUBMED:10403855]
[PUBMED:16054233]
[PUBMED:16474624]
[PUBMED:16822996]
[PUBMED:17028294]
[PUBMED:11224709]
[PUBMED:11750244]
[PUBMED:11905738]
[PUBMED:15719031]
[PUBMED:10843728]
[PUBMED:16110317]
[PUBMED:11721960]
[PUBMED:12741677]
[PUBMED:7585656]
[PUBMED:12801837]
[PUBMED:16551847]
[PUBMED:12459728]
[PUBMED:11431710]
[PUBMED:12468433]
[PUBMED:11165748]
[PUBMED:16042571]
[PUBMED:16508724]
[PUBMED:15000146]
[PUBMED:17149381]
[PUBMED:15948711]
[PUBMED:14747944]
[PUBMED:14737121]
[PUBMED:12379883]
[PUBMED:17158541]
[PUBMED:12850530]
[PUBMED:10835690]
[PUBMED:16870043]
Peroxisome
[NCBI:131226]
[KEGG:hsa04146]
[PUBMED:17055079]
[PUBMED:16631601]
[PUBMED:17055078]
[PUBMED:17010456]
Pertussis
[NCBI:218111]
[KEGG:hsa05133]
[PUBMED:20610650]
[PUBMED:12701623]
[PUBMED:15201703]
[PUBMED:18401006]
[PUBMED:20210554]
[PUBMED:16622221]
[PUBMED:17148436]
[PUBMED:21204863]
[PUBMED:20404851]
[PUBMED:10540218]
[PUBMED:16999837]
[PUBMED:16481212]
[PUBMED:16863919]
[PUBMED:16390441]
[PUBMED:21423776]
[PUBMED:17328678]
[PUBMED:12915094]
Platelet homeostasis
[NCBI:1269341]
[REACTOME:R-HSA-418346]
[PUBMED:10798271]
ROS, RNS production in phagocytes
[NCBI:1269138]
[REACTOME:R-HSA-1222556]
[PUBMED:23617726]
[PUBMED:19369951]
Salmonella infection
[NCBI:375172]
[KEGG:hsa05132]
[PUBMED:18407067]
[PUBMED:18411289]
[PUBMED:18778407]
[PUBMED:20123714]
[PUBMED:20158475]
[PUBMED:19779561]
[PUBMED:18026123]
[PUBMED:19930040]
[PUBMED:12675800]
[PUBMED:11755407]
[PUBMED:11489966]
[PUBMED:19775254]
[PUBMED:20943123]
[PUBMED:17690885]
[PUBMED:16938850]
[PUBMED:20526845]
[PUBMED:11567004]
[PUBMED:17074883]
[PUBMED:11825778]
[PUBMED:17071592]
[PUBMED:16800847]
[PUBMED:16611232]
[PUBMED:10499590]
Signaling by Interleukins
[NCBI:1269318]
[REACTOME:R-HSA-449147]
[PUBMED:19302047]
[PUBMED:12445398]
Signaling mediated by p38-alpha and p38-beta
[NCBI:138012]
[Pathway Interaction Database:p38alphabetadownstreampathway]
[PUBMED:11909979]
[PUBMED:7923353]
[PUBMED:14612426]
[PUBMED:12138194]
[PUBMED:9069290]
[PUBMED:9130707]
[PUBMED:10362538]
[PUBMED:9155018]
[PUBMED:11239470]
[PUBMED:9685422]
[PUBMED:9628874]
[PUBMED:9873047]
[PUBMED:10978317]
[PUBMED:11741533]
[PUBMED:7923354]
[PUBMED:9468497]
[PUBMED:9647257]
[PUBMED:8910365]
[PUBMED:8626550]
[PUBMED:9776729]
[PUBMED:10581204]
[PUBMED:7839144]
[PUBMED:7750577]
[PUBMED:11604491]
[PUBMED:11792706]
[PUBMED:7535770]
[PUBMED:10212189]
[PUBMED:10747897]
[PUBMED:9687510]
[PUBMED:11777913]
[PUBMED:9155017]
[PUBMED:7737130]
[PUBMED:9792677]
[PUBMED:11532965]
[PUBMED:9822687]
[PUBMED:8650547]
[PUBMED:9582321]
[PUBMED:9858528]
Small cell lung cancer
[NCBI:83118]
[KEGG:hsa05222]
[PUBMED:12711111]
[PUBMED:11463388]
[PUBMED:12741677]
[PUBMED:11905738]
[PUBMED:11807782]
[PUBMED:12379883]
[PUBMED:12243753]
[PUBMED:12616528]
[PUBMED:11720739]
[PUBMED:15109562]
[PUBMED:12407699]
[PUBMED:10944551]
[PUBMED:16112428]
[PUBMED:11559746]
[PUBMED:16064138]
[PUBMED:11902573]
Toxoplasmosis
[NCBI:169642]
[KEGG:hsa05145]
[PUBMED:18617274]
[PUBMED:19400868]
[PUBMED:17024357]
[PUBMED:19744886]
[PUBMED:19891610]
[PUBMED:17110955]
[PUBMED:12106793]
[PUBMED:12580944]
[PUBMED:12857995]
[PUBMED:10234174]
[PUBMED:18327664]
[PUBMED:10525166]
[PUBMED:18059289]
[PUBMED:18775432]
[PUBMED:14642303]
[PUBMED:15361242]
[PUBMED:16339966]
[PUBMED:14987366]
[PUBMED:15639739]
Tuberculosis
[NCBI:213780]
[KEGG:hsa05152]
[PUBMED:20199890]
[PUBMED:21274449]
[PUBMED:17359235]
[PUBMED:20415982]
[PUBMED:18541216]
[PUBMED:19369951]
[PUBMED:15083155]
[PUBMED:11378475]
[PUBMED:15228522]
[PUBMED:19634703]
[PUBMED:21274433]
[PUBMED:19563525]
[PUBMED:18407066]
[PUBMED:18288961]
[PUBMED:16200082]
[PUBMED:17785780]
[PUBMED:11932234]
citrulline-nitric oxide cycle
[NCBI:703092]
[BIOCYC:HUMAN_PWY-4983]
[PUBMED:7511585]
[PUBMED:2236071]
[PUBMED:1731766]