full name
erb-b2 receptor tyrosine kinase 2
synonyms
CD340, HER-2, HER-2%2Fneu, HER2, MLN, ERBB2, ENSG00000141736
HGNC
HGNC:3430
Entrez Gene
Gene:2064
ENSEMBL
ENSG00000141736
location
chr: 17
start: 37844167
stop: 37884915
strand: +
OMIM
OMIM:164870:
ERBB2
(Autosomal recessive inheritance)
OMIM:211980:
Adenocarcinoma of lung, somatic
OMIM:613659:
Gastric cancer, somatic
OMIM:137800:
Glioblastoma, somatic
transcripts
NM_001005862.1
NM_004448.2
pathways
ARMS-mediated activation
[NCBI:1269471]
[REACTOME:R-HSA-170984]
[PUBMED:9069267]
Adaptive Immune System
[NCBI:1269171]
[REACTOME:R-HSA-1280218]
[PUBMED:16551257]
[PUBMED:21682741]
[PUBMED:11861602]
Adherens junction
[NCBI:83070]
[KEGG:hsa04520]
[PUBMED:11703922]
[PUBMED:10890911]
[PUBMED:15551862]
[PUBMED:15561584]
[PUBMED:10959047]
[PUBMED:11984870]
[PUBMED:10204118]
[PUBMED:15489912]
[PUBMED:14623871]
[PUBMED:15001769]
[PUBMED:12640114]
[PUBMED:12665527]
[PUBMED:11171368]
Axon guidance
[NCBI:83065]
[KEGG:hsa04360]
[NCBI:1270303]
[REACTOME:R-HSA-422475]
[PUBMED:14682358]
[PUBMED:15084255]
[PUBMED:11687826]
[PUBMED:15818466]
[PUBMED:15363605]
[PUBMED:12471249]
[PUBMED:15630019]
[PUBMED:11891122]
[PUBMED:15960985]
[PUBMED:12677003]
Bladder cancer
[NCBI:83115]
[KEGG:hsa05219]
[PUBMED:15551095]
[PUBMED:15746962]
[PUBMED:11103787]
[PUBMED:16474624]
[PUBMED:17158541]
[PUBMED:12850530]
[PUBMED:17149381]
[PUBMED:16110317]
Breast cancer
[NCBI:1435207]
[KEGG:hsa05224]
[PUBMED:24649067]
[PUBMED:26040571]
[PUBMED:11879567]
[PUBMED:22722193]
[PUBMED:26028978]
[PUBMED:25013431]
[PUBMED:11737884]
[PUBMED:23702927]
[PUBMED:21076461]
[PUBMED:21898546]
[PUBMED:27390604]
[PUBMED:24291072]
[PUBMED:26968398]
[PUBMED:20087430]
[PUBMED:23000897]
[PUBMED:25544707]
[PUBMED:24596345]
[PUBMED:23988612]
[PUBMED:24111892]
[PUBMED:25907219]
[PUBMED:15343273]
[PUBMED:21965336]
[PUBMED:23881035]
[PUBMED:23196196]
[PUBMED:22178455]
[PUBMED:20436504]
[PUBMED:19088017]
[PUBMED:16113099]
[PUBMED:20971825]
Calcium signaling pathway
[NCBI:83050]
[KEGG:hsa04020]
[PUBMED:11080247]
[PUBMED:14572802]
[PUBMED:11413485]
[PUBMED:22129055]
[PUBMED:10508738]
[PUBMED:15000521]
[PUBMED:9235901]
[PUBMED:7861177]
[PUBMED:9149541]
[PUBMED:14517314]
[PUBMED:15111104]
[PUBMED:11698232]
[PUBMED:10331643]
[PUBMED:12838335]
[PUBMED:8125957]
[PUBMED:19172794]
[PUBMED:10997573]
[PUBMED:21338471]
[PUBMED:11299192]
[PUBMED:22002090]
[PUBMED:12972622]
Central carbon metabolism in cancer
[NCBI:1059538]
[KEGG:hsa05230]
[PUBMED:16982728]
[PUBMED:21127244]
[PUBMED:22349059]
[PUBMED:19270154]
[PUBMED:24113830]
[PUBMED:22156302]
[PUBMED:21801601]
[PUBMED:15916903]
[PUBMED:18177721]
[PUBMED:22237205]
[PUBMED:20520704]
[PUBMED:23018234]
[PUBMED:23897900]
[PUBMED:24398961]
[PUBMED:24079832]
[PUBMED:18538731]
[PUBMED:19460998]
[PUBMED:22307140]
[PUBMED:18766298]
[PUBMED:22101401]
[PUBMED:23071355]
[PUBMED:21508971]
[PUBMED:24738035]
[PUBMED:22750268]
[PUBMED:21258394]
[PUBMED:23279446]
[PUBMED:21340684]
Constitutive Signaling by Aberrant PI3K in Cancer
[NCBI:1268880]
[REACTOME:R-HSA-2219530]
[PUBMED:18317450]
[PUBMED:19962665]
[PUBMED:20009532]
[PUBMED:20713702]
[PUBMED:21478295]
[PUBMED:16339315]
[PUBMED:18079394]
[PUBMED:17626883]
Cytokine Signaling in Immune system
[NCBI:1269310]
[REACTOME:R-HSA-1280215]
[PUBMED:12613569]
DAP12 interactions
[NCBI:1269283]
[REACTOME:R-HSA-2172127]
[PUBMED:19120482]
[PUBMED:17220916]
[PUBMED:9490415]
[PUBMED:18192027]
[PUBMED:15884055]
DAP12 signaling
[NCBI:1269284]
[REACTOME:R-HSA-2424491]
[PUBMED:15884055]
[PUBMED:17110943]
[PUBMED:17220916]
Developmental Biology
[NCBI:1270302]
[REACTOME:R-HSA-1266738]
Disease
[NCBI:1268854]
[REACTOME:R-HSA-1643685]
Diseases of signal transduction
[NCBI:1268855]
[REACTOME:R-HSA-5663202]
[PUBMED:12509752]
Downregulation of ERBB2 signaling
[NCBI:1457793]
[REACTOME:R-HSA-8863795]
[PUBMED:19933325]
[PUBMED:21376233]
[PUBMED:17210635]
[PUBMED:12239347]
[PUBMED:25081058]
Downregulation of ERBB2:ERBB3 signaling
[NCBI:1269495]
[REACTOME:R-HSA-1358803]
Downstream signal transduction
[NCBI:1269479]
[REACTOME:R-HSA-186763]
[PUBMED:10508235]
[PUBMED:9739761]
Downstream signaling events of B Cell Receptor (BCR)
[NCBI:1269185]
[REACTOME:R-HSA-1168372]
[PUBMED:17052215]
[PUBMED:19909372]
EGFR tyrosine kinase inhibitor resistance
[NCBI:1404798]
[KEGG:hsa01521]
[PUBMED:16843264]
[PUBMED:23401451]
[PUBMED:20966921]
[PUBMED:24307395]
[PUBMED:22956644]
[PUBMED:25232485]
[PUBMED:24493829]
[PUBMED:23071030]
[PUBMED:18483355]
[PUBMED:24202392]
[PUBMED:19632948]
[PUBMED:23361103]
[PUBMED:26579470]
[PUBMED:22970367]
[PUBMED:23358468]
[PUBMED:17554333]
[PUBMED:25337673]
[PUBMED:22474259]
[PUBMED:20551942]
ERBB2 Activates PTK6 Signaling
[NCBI:1383024]
[REACTOME:R-HSA-8847993]
[PUBMED:20687930]
[PUBMED:1349015]
[PUBMED:26247733]
[PUBMED:18719096]
[PUBMED:8940083]
[PUBMED:21847121]
ERBB2 Regulates Cell Motility
[NCBI:1383023]
[REACTOME:R-HSA-6785631]
[PUBMED:15156151]
[PUBMED:18955552]
[PUBMED:20937854]
[PUBMED:18045866]
Endocrine resistance
[NCBI:1404799]
[KEGG:hsa01522]
[PUBMED:24415977]
[PUBMED:23625614]
[PUBMED:24841429]
[PUBMED:15613444]
[PUBMED:23714450]
[PUBMED:20960099]
[PUBMED:22771991]
[PUBMED:19701242]
[PUBMED:24289103]
[PUBMED:24130921]
[PUBMED:23344024]
[PUBMED:22015292]
[PUBMED:26122181]
[PUBMED:26473850]
[PUBMED:18804516]
[PUBMED:24565562]
[PUBMED:26849149]
[PUBMED:25907219]
[PUBMED:20887199]
Endometrial cancer
[NCBI:83109]
[KEGG:hsa05213]
[PUBMED:14747944]
[PUBMED:11431710]
[PUBMED:7585656]
[PUBMED:16508724]
[PUBMED:15284264]
[PUBMED:17028294]
[PUBMED:16248975]
[PUBMED:15947972]
ErbB receptor signaling network
[NCBI:138016]
[Pathway Interaction Database:erbb_network_pathway]
[PUBMED:19173594]
[PUBMED:1688559]
[PUBMED:6265789]
[PUBMED:8188716]
[PUBMED:9029149]
[PUBMED:15192046]
[PUBMED:6090945]
[PUBMED:9618494]
[PUBMED:9135143]
[PUBMED:14661053]
[PUBMED:7929212]
[PUBMED:7902537]
[PUBMED:18782861]
[PUBMED:10348342]
[PUBMED:7991602]
[PUBMED:7515147]
[PUBMED:1706616]
[PUBMED:6254071]
[PUBMED:2466334]
[PUBMED:17684490]
[PUBMED:10353604]
[PUBMED:9130710]
[PUBMED:12466964]
[PUBMED:8617750]
[PUBMED:3261240]
[PUBMED:9419975]
[PUBMED:7518560]
[PUBMED:2543678]
[PUBMED:9168114]
[PUBMED:6315706]
[PUBMED:16946702]
[PUBMED:219373]
[PUBMED:7679104]
[PUBMED:8570211]
[PUBMED:10527633]
[PUBMED:17646177]
[PUBMED:18721752]
[PUBMED:9105049]
[PUBMED:7929151]
[PUBMED:8045292]
[PUBMED:15568014]
[PUBMED:11071886]
[PUBMED:8702723]
[PUBMED:9556621]
[PUBMED:10722704]
[PUBMED:17389679]
[PUBMED:9275162]
[PUBMED:9168115]
[PUBMED:10214951]
[PUBMED:1840698]
[PUBMED:7509075]
ErbB signaling pathway
[NCBI:83049]
[KEGG:hsa04012]
[PUBMED:16377102]
[PUBMED:14967450]
[PUBMED:9642287]
[PUBMED:9872057]
[PUBMED:10880430]
[PUBMED:12851486]
[PUBMED:16729045]
[PUBMED:15863494]
[PUBMED:15864276]
[PUBMED:17000658]
[PUBMED:16729043]
[PUBMED:10490623]
[PUBMED:11252954]
[PUBMED:14744244]
[PUBMED:16829981]
ErbB2/ErbB3 signaling events
[NCBI:137955]
[Pathway Interaction Database:erbb2erbb3pathway]
[PUBMED:9677338]
[PUBMED:11546794]
[PUBMED:9710588]
[PUBMED:11984589]
[PUBMED:19474313]
[PUBMED:12072561]
[PUBMED:18760695]
[PUBMED:18614687]
[PUBMED:11027222]
[PUBMED:12466964]
[PUBMED:10704452]
[PUBMED:19535578]
[PUBMED:7556067]
[PUBMED:16481445]
[PUBMED:10493750]
[PUBMED:17998937]
[PUBMED:17210635]
[PUBMED:18799465]
[PUBMED:12411582]
[PUBMED:15520002]
[PUBMED:10531446]
[PUBMED:10101228]
[PUBMED:10399934]
[PUBMED:8815893]
[PUBMED:19179536]
[PUBMED:7877996]
[PUBMED:11173924]
[PUBMED:12651161]
[PUBMED:9362461]
[PUBMED:18426980]
[PUBMED:19019207]
[PUBMED:9338783]
[PUBMED:11312610]
[PUBMED:11940572]
[PUBMED:8707830]
[PUBMED:11564761]
[PUBMED:9049301]
[PUBMED:9694850]
[PUBMED:10582594]
[PUBMED:9637684]
[PUBMED:8702681]
ErbB4 signaling events
[NCBI:137991]
[Pathway Interaction Database:erbb4_pathway]
[PUBMED:16815842]
[PUBMED:8617750]
[PUBMED:9663464]
[PUBMED:12466964]
[PUBMED:15345710]
[PUBMED:16061658]
[PUBMED:12954715]
[PUBMED:17463226]
[PUBMED:17646177]
[PUBMED:17085783]
[PUBMED:18721752]
[PUBMED:15023535]
[PUBMED:9556621]
[PUBMED:12807903]
[PUBMED:17486069]
[PUBMED:10358079]
[PUBMED:12454007]
[PUBMED:8702723]
[PUBMED:10693928]
[PUBMED:18334649]
[PUBMED:10725395]
[PUBMED:11731109]
[PUBMED:7477376]
[PUBMED:16837552]
[PUBMED:15863494]
[PUBMED:19047365]
[PUBMED:10722704]
[PUBMED:19193720]
[PUBMED:10348342]
[PUBMED:17018285]
[PUBMED:9135143]
[PUBMED:9618494]
[PUBMED:12716924]
[PUBMED:18819924]
[PUBMED:10867024]
[PUBMED:15985438]
[PUBMED:7559778]
[PUBMED:7759543]
[PUBMED:12824469]
[PUBMED:10744726]
[PUBMED:15746097]
[PUBMED:18653779]
[PUBMED:15534001]
[PUBMED:17460065]
[PUBMED:10508857]
[PUBMED:15282549]
[PUBMED:9362517]
[PUBMED:9685416]
[PUBMED:11679632]
[PUBMED:10839362]
[PUBMED:10353604]
FCERI mediated MAPK activation
[NCBI:1269299]
[REACTOME:R-HSA-2871796]
[PUBMED:19290926]
[PUBMED:19909365]
[PUBMED:17122878]
Fc epsilon receptor (FCERI) signaling
[NCBI:1269298]
[REACTOME:R-HSA-2454202]
[PUBMED:15099567]
[PUBMED:21799019]
Focal adhesion
[NCBI:83067]
[KEGG:hsa04510]
[PUBMED:10698680]
[PUBMED:15459662]
[PUBMED:14756624]
[PUBMED:11573199]
[PUBMED:12640026]
[PUBMED:15179030]
[PUBMED:15108811]
[PUBMED:15053919]
[PUBMED:11082269]
[PUBMED:15034601]
[PUBMED:12235283]
[PUBMED:14519391]
[PUBMED:11146675]
[PUBMED:11229600]
[PUBMED:15688067]
[PUBMED:14744429]
[PUBMED:11882383]
Frs2-mediated activation
[NCBI:1269470]
[REACTOME:R-HSA-170968]
[PUBMED:9069267]
GAB1 signalosome
[NCBI:1269384]
[REACTOME:R-HSA-180292]
[PUBMED:15550174]
GRB2 events in EGFR signaling
[NCBI:1269382]
[REACTOME:R-HSA-179812]
[PUBMED:11706405]
[PUBMED:11498013]
GRB2 events in ERBB2 signaling
[NCBI:1269491]
[REACTOME:R-HSA-1963640]
GRB7 events in ERBB2 signaling
[NCBI:1269494]
[REACTOME:R-HSA-1306955]
Gastrin-CREB signalling pathway via PKC and MAPK
[NCBI:1269592]
[REACTOME:R-HSA-881907]
[PUBMED:10413847]
[PUBMED:7491953]
[PUBMED:17698287]
Gene Expression
[NCBI:1269649]
[REACTOME:R-HSA-74160]
Generic Transcription Pathway
[NCBI:1269650]
[REACTOME:R-HSA-212436]
[PUBMED:15175151]
[PUBMED:14744435]
[PUBMED:15680972]
[PUBMED:11395415]
[PUBMED:15896744]
[PUBMED:10235266]
[PUBMED:14986688]
[PUBMED:12023297]
[PUBMED:15680973]
[PUBMED:16751179]
[PUBMED:11861166]
[PUBMED:16429119]
[PUBMED:16719718]
[PUBMED:16921404]
[PUBMED:15690163]
HIF-1 signaling pathway
[NCBI:695200]
[KEGG:hsa04066]
[PUBMED:11902584]
[PUBMED:20965423]
[PUBMED:20679415]
[PUBMED:15031665]
[PUBMED:18259201]
[PUBMED:22205687]
[PUBMED:19364912]
[PUBMED:19147540]
[PUBMED:15448722]
[PUBMED:16234508]
[PUBMED:18505681]
[PUBMED:20836033]
[PUBMED:19861159]
[PUBMED:17955264]
[PUBMED:22562152]
IGF1R signaling cascade
[NCBI:1269618]
[REACTOME:R-HSA-2428924]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22649417]
[PUBMED:21042815]
[PUBMED:18927274]
[PUBMED:20098959]
IRS-mediated signalling
[NCBI:1269431]
[REACTOME:R-HSA-112399]
IRS-related events triggered by IGF1R
[NCBI:1269620]
[REACTOME:R-HSA-2428928]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22649417]
[PUBMED:18927274]
[PUBMED:21042815]
[PUBMED:20098959]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Insulin receptor signalling cascade
[NCBI:1269429]
[REACTOME:R-HSA-74751]
[PUBMED:9677303]
[PUBMED:11282018]
Interleukin receptor SHC signaling
[NCBI:1269322]
[REACTOME:R-HSA-912526]
[PUBMED:8294403]
Interleukin-2 signaling
[NCBI:1269321]
[REACTOME:R-HSA-451927]
[PUBMED:17936914]
[PUBMED:18817510]
[PUBMED:19543225]
[PUBMED:18062768]
Interleukin-3, 5 and GM-CSF signaling
[NCBI:1269323]
[REACTOME:R-HSA-512988]
[PUBMED:10450743]
[PUBMED:9766809]
MAPK family signaling cascades
[NCBI:1269501]
[REACTOME:R-HSA-5683057]
[PUBMED:21167873]
[PUBMED:17161475]
[PUBMED:22535895]
[PUBMED:21372320]
MAPK1/MAPK3 signaling
[NCBI:1269502]
[REACTOME:R-HSA-5684996]
[PUBMED:25378393]
[PUBMED:18199641]
[PUBMED:17496909]
[PUBMED:21779496]
[PUBMED:15520807]
[PUBMED:16393692]
[PUBMED:19520853]
[PUBMED:17496910]
[PUBMED:22569528]
MicroRNAs in cancer
[NCBI:852705]
[KEGG:hsa05206]
[PUBMED:23075324]
[PUBMED:21742789]
[PUBMED:22351564]
[PUBMED:18817506]
[PUBMED:22345301]
[PUBMED:21402473]
[PUBMED:22926415]
[PUBMED:23165235]
[PUBMED:19630570]
[PUBMED:21565290]
[PUBMED:23091478]
[PUBMED:23462054]
[PUBMED:23316212]
[PUBMED:19773200]
[PUBMED:22035854]
[PUBMED:20221895]
[PUBMED:20345848]
[PUBMED:22580099]
[PUBMED:20128019]
NCAM signaling for neurite out-growth
[NCBI:1270312]
[REACTOME:R-HSA-375165]
[PUBMED:18760361]
[PUBMED:12587671]
[PUBMED:15662836]
[PUBMED:17975827]
[PUBMED:15153429]
[PUBMED:12700044]
NGF signalling via TRKA from the plasma membrane
[NCBI:1269460]
[REACTOME:R-HSA-187037]
[PUBMED:11520933]
[PUBMED:12676795]
[PUBMED:10851172]
[PUBMED:10579918]
Negative regulation of the PI3K/AKT network
[NCBI:1269191]
[REACTOME:R-HSA-199418]
Non-small cell lung cancer
[NCBI:83119]
[KEGG:hsa05223]
[PUBMED:11895903]
[PUBMED:21753699]
[PUBMED:23733083]
[PUBMED:11902573]
[PUBMED:19629074]
[PUBMED:12867060]
[PUBMED:22154278]
[PUBMED:10944551]
[PUBMED:16112428]
[PUBMED:15942304]
[PUBMED:12407699]
[PUBMED:15948711]
[PUBMED:18593892]
[PUBMED:23201355]
[PUBMED:21855164]
[PUBMED:12379883]
[PUBMED:17625570]
[PUBMED:12741677]
[PUBMED:22736493]
[PUBMED:21850578]
[PUBMED:16870043]
[PUBMED:16189154]
PI3K events in ERBB2 signaling
[NCBI:1269492]
[REACTOME:R-HSA-1963642]
PI3K/AKT Signaling in Cancer
[NCBI:1268879]
[REACTOME:R-HSA-2219528]
[PUBMED:20713702]
[PUBMED:10555148]
[PUBMED:19644473]
[PUBMED:17611497]
[PUBMED:21478295]
[PUBMED:17626883]
[PUBMED:16339315]
[PUBMED:18317450]
[PUBMED:18079394]
[PUBMED:9467011]
[PUBMED:17604717]
[PUBMED:9326929]
[PUBMED:18954143]
[PUBMED:20009532]
[PUBMED:19962665]
[PUBMED:21430697]
[PUBMED:19487573]
[PUBMED:10866302]
PI3K/AKT activation
[NCBI:1269473]
[REACTOME:R-HSA-198203]
[PUBMED:10579926]
[PUBMED:12123609]
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
[NCBI:1383020]
[REACTOME:R-HSA-6811558]
[PUBMED:12422219]
[PUBMED:16979564]
[PUBMED:19805105]
[PUBMED:17200115]
[PUBMED:21827948]
[PUBMED:19576174]
[PUBMED:18753295]
[PUBMED:19896968]
[PUBMED:16456541]
[PUBMED:25495341]
[PUBMED:15464023]
[PUBMED:23758345]
[PUBMED:9367159]
[PUBMED:9211928]
[PUBMED:17245604]
PIP3 activates AKT signaling
[NCBI:1269188]
[REACTOME:R-HSA-1257604]
PLCG1 events in ERBB2 signaling
[NCBI:1269493]
[REACTOME:R-HSA-1251932]
Pancreatic cancer
[NCBI:83108]
[KEGG:hsa05212]
[PUBMED:12079267]
[PUBMED:14967450]
[PUBMED:15774796]
[PUBMED:10740269]
[PUBMED:12946833]
[PUBMED:16702400]
[PUBMED:14586404]
[PUBMED:15823750]
[PUBMED:12648469]
[PUBMED:11407945]
[PUBMED:12459728]
[PUBMED:14580692]
[PUBMED:11707511]
[PUBMED:12545153]
Pathways in cancer
[NCBI:83105]
[KEGG:hsa05200]
[PUBMED:12244301]
[PUBMED:15156182]
[PUBMED:16899407]
[PUBMED:12621137]
[PUBMED:21193867]
[PUBMED:16001072]
[PUBMED:11707511]
[PUBMED:11253051]
[PUBMED:11071626]
[PUBMED:17251915]
[PUBMED:11736900]
[PUBMED:16557281]
[PUBMED:16699851]
[PUBMED:16189702]
[PUBMED:11902573]
[PUBMED:16555243]
[PUBMED:8069858]
[PUBMED:15310786]
[PUBMED:9834202]
[PUBMED:16700615]
[PUBMED:12545153]
[PUBMED:15656799]
[PUBMED:12154354]
[PUBMED:11895903]
[PUBMED:11527574]
[PUBMED:16326109]
[PUBMED:16339096]
[PUBMED:11160144]
[PUBMED:15724144]
[PUBMED:12951584]
[PUBMED:10647931]
[PUBMED:16881963]
[PUBMED:15557758]
[PUBMED:11477132]
[PUBMED:15721476]
[PUBMED:15625120]
[PUBMED:16236521]
[PUBMED:14967450]
[PUBMED:15942304]
[PUBMED:17287871]
[PUBMED:14634372]
[PUBMED:15573119]
[PUBMED:15009714]
[PUBMED:16112428]
[PUBMED:15611513]
[PUBMED:16001050]
[PUBMED:15349822]
[PUBMED:16551846]
[PUBMED:15978322]
[PUBMED:15774796]
[PUBMED:16352814]
[PUBMED:12951588]
[PUBMED:10944551]
[PUBMED:10740269]
[PUBMED:15639402]
[PUBMED:12407699]
[PUBMED:11130178]
[PUBMED:15109562]
[PUBMED:11170304]
[PUBMED:11276000]
[PUBMED:9643506]
[PUBMED:16248975]
[PUBMED:16242838]
[PUBMED:12946833]
[PUBMED:11559746]
[PUBMED:9196022]
[PUBMED:12079267]
[PUBMED:15468170]
[PUBMED:16064138]
[PUBMED:14580692]
[PUBMED:15082523]
[PUBMED:15551095]
[PUBMED:17062879]
[PUBMED:17211469]
[PUBMED:11720739]
[PUBMED:12588368]
[PUBMED:11057895]
[PUBMED:9422516]
[PUBMED:12894244]
[PUBMED:15479695]
[PUBMED:16189154]
[PUBMED:12878745]
[PUBMED:11900250]
[PUBMED:11103787]
[PUBMED:15122209]
[PUBMED:12711111]
[PUBMED:12243753]
[PUBMED:16306523]
[PUBMED:16702400]
[PUBMED:15270885]
[PUBMED:14685170]
[PUBMED:14586404]
[PUBMED:11078609]
[PUBMED:15284264]
[PUBMED:10505543]
[PUBMED:11223406]
[PUBMED:14982876]
[PUBMED:12648469]
[PUBMED:12867060]
[PUBMED:15711891]
[PUBMED:12094241]
[PUBMED:16642045]
[PUBMED:11463388]
[PUBMED:12762887]
[PUBMED:15746962]
[PUBMED:15823750]
[PUBMED:16750612]
[PUBMED:16484590]
[PUBMED:11459867]
[PUBMED:16146838]
[PUBMED:14556242]
[PUBMED:15947972]
[PUBMED:12563308]
[PUBMED:16946003]
[PUBMED:15948971]
[PUBMED:11407945]
[PUBMED:12737309]
[PUBMED:16095998]
[PUBMED:12351585]
[PUBMED:24508914]
[PUBMED:12084351]
[PUBMED:11807782]
[PUBMED:14695152]
[PUBMED:10453277]
[PUBMED:17554387]
[PUBMED:15841168]
[PUBMED:12616528]
[PUBMED:10403855]
[PUBMED:16054233]
[PUBMED:16474624]
[PUBMED:16822996]
[PUBMED:17028294]
[PUBMED:11224709]
[PUBMED:11750244]
[PUBMED:11905738]
[PUBMED:15719031]
[PUBMED:10843728]
[PUBMED:16110317]
[PUBMED:11721960]
[PUBMED:12741677]
[PUBMED:7585656]
[PUBMED:12801837]
[PUBMED:16551847]
[PUBMED:12459728]
[PUBMED:11431710]
[PUBMED:12468433]
[PUBMED:11165748]
[PUBMED:16042571]
[PUBMED:16508724]
[PUBMED:15000146]
[PUBMED:17149381]
[PUBMED:15948711]
[PUBMED:14747944]
[PUBMED:14737121]
[PUBMED:12379883]
[PUBMED:17158541]
[PUBMED:12850530]
[PUBMED:10835690]
[PUBMED:16870043]
Platinum drug resistance
[NCBI:1404797]
[KEGG:hsa01524]
[PUBMED:24074238]
[PUBMED:26867799]
[PUBMED:14609433]
[PUBMED:26184483]
[PUBMED:24874729]
[PUBMED:15607932]
[PUBMED:25546083]
[PUBMED:25058905]
[PUBMED:19190080]
[PUBMED:14576837]
[PUBMED:20811617]
[PUBMED:21892204]
[PUBMED:20647037]
[PUBMED:17336087]
[PUBMED:26886018]
[PUBMED:23442359]
[PUBMED:17625587]
Prolonged ERK activation events
[NCBI:1269469]
[REACTOME:R-HSA-169893]
[PUBMED:12765839]
[PUBMED:9069267]
Prostate cancer
[NCBI:83111]
[KEGG:hsa05215]
[PUBMED:12878745]
[PUBMED:11900250]
[PUBMED:11527574]
[PUBMED:11750244]
[PUBMED:16551847]
[PUBMED:10835690]
[PUBMED:8069858]
[PUBMED:15724144]
[PUBMED:10453277]
[PUBMED:15082523]
[PUBMED:9422516]
Proteoglycans in cancer
[NCBI:782000]
[KEGG:hsa05205]
[PUBMED:19433454]
[PUBMED:20655987]
[PUBMED:18798267]
[PUBMED:10633082]
[PUBMED:10687947]
[PUBMED:22735579]
[PUBMED:24412155]
[PUBMED:9346940]
[PUBMED:22087031]
[PUBMED:22194599]
[PUBMED:14711376]
[PUBMED:19255147]
[PUBMED:15655247]
[PUBMED:11717317]
[PUBMED:17971838]
[PUBMED:18413366]
[PUBMED:20974860]
[PUBMED:11830493]
[PUBMED:23058688]
[PUBMED:18450475]
[PUBMED:12748184]
[PUBMED:19733083]
[PUBMED:18812315]
[PUBMED:12509413]
[PUBMED:21155971]
[PUBMED:11931647]
[PUBMED:18949819]
[PUBMED:12729888]
[PUBMED:15994311]
[PUBMED:23305321]
[PUBMED:18505598]
[PUBMED:22563565]
[PUBMED:22033227]
RAF/MAP kinase cascade
[NCBI:1269285]
[REACTOME:R-HSA-5673001]
[PUBMED:21167873]
[PUBMED:24937142]
[PUBMED:20674547]
[PUBMED:17496910]
[PUBMED:22177953]
[PUBMED:17496919]
[PUBMED:22569528]
[PUBMED:22535895]
[PUBMED:12068308]
[PUBMED:17496923]
[PUBMED:19091303]
[PUBMED:21372320]
[PUBMED:21388974]
[PUBMED:15520807]
RET signaling
[NCBI:1427866]
[REACTOME:R-HSA-8853659]
[PUBMED:15013219]
[PUBMED:17036197]
Role of LAT2/NTAL/LAB on calcium mobilization
[NCBI:1269302]
[REACTOME:R-HSA-2730905]
[PUBMED:17993265]
[PUBMED:20643813]
[PUBMED:17420272]
SHC1 events in EGFR signaling
[NCBI:1269383]
[REACTOME:R-HSA-180336]
[PUBMED:11498013]
[PUBMED:8755247]
SHC1 events in ERBB2 signaling
[NCBI:1269490]
[REACTOME:R-HSA-1250196]
SOS-mediated signalling
[NCBI:1269440]
[REACTOME:R-HSA-112412]
Sema4D in semaphorin signaling
[NCBI:1270305]
[REACTOME:R-HSA-400685]
[PUBMED:16314868]
[PUBMED:14770294]
[PUBMED:15818466]
Sema4D induced cell migration and growth-cone collapse
[NCBI:1270307]
[REACTOME:R-HSA-416572]
[PUBMED:12220504]
[PUBMED:18374575]
[PUBMED:15210733]
[PUBMED:15818466]
Semaphorin interactions
[NCBI:1270304]
[REACTOME:R-HSA-373755]
[PUBMED:12593985]
[PUBMED:12471249]
[PUBMED:18269210]
[PUBMED:16939971]
[PUBMED:18374575]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by EGFR
[NCBI:1269380]
[REACTOME:R-HSA-177929]
[PUBMED:10459005]
[PUBMED:10404636]
[PUBMED:12297041]
[PUBMED:15142631]
Signaling by ERBB2
[NCBI:1269489]
[REACTOME:R-HSA-1227986]
Signaling by GPCR
[NCBI:1269543]
[REACTOME:R-HSA-372790]
[PUBMED:16902930]
[PUBMED:10202136]
[PUBMED:18043707]
Signaling by Insulin receptor
[NCBI:1269428]
[REACTOME:R-HSA-74752]
[PUBMED:8276779]
Signaling by Interleukins
[NCBI:1269318]
[REACTOME:R-HSA-449147]
[PUBMED:19302047]
[PUBMED:12445398]
Signaling by Leptin
[NCBI:1269632]
[REACTOME:R-HSA-2586552]
[PUBMED:22211890]
[PUBMED:23562747]
[PUBMED:20600241]
[PUBMED:21622208]
[PUBMED:23579596]
[PUBMED:22458591]
[PUBMED:21489811]
[PUBMED:19724019]
[PUBMED:21331644]
[PUBMED:22448029]
[PUBMED:21147620]
[PUBMED:20198122]
[PUBMED:21677426]
[PUBMED:20029269]
[PUBMED:22249808]
[PUBMED:22991412]
[PUBMED:21527729]
[PUBMED:17937601]
[PUBMED:20553370]
[PUBMED:21713385]
[PUBMED:23565489]
[PUBMED:22289780]
Signaling by PDGF
[NCBI:1269478]
[REACTOME:R-HSA-186797]
[PUBMED:15207811]
[PUBMED:10508235]
[PUBMED:9739761]
Signaling by PTK6
[NCBI:1383025]
[REACTOME:R-HSA-8848021]
[PUBMED:15539407]
[PUBMED:15572663]
[PUBMED:25999240]
[PUBMED:20929863]
[PUBMED:23352614]
[PUBMED:20554524]
[PUBMED:23814047]
[PUBMED:21205088]
[PUBMED:18172307]
[PUBMED:25897081]
[PUBMED:18829532]
[PUBMED:24788754]
[PUBMED:25019382]
[PUBMED:8940083]
[PUBMED:19393627]
[PUBMED:18719096]
[PUBMED:22547065]
[PUBMED:21847121]
[PUBMED:19439179]
[PUBMED:22231447]
[PUBMED:25733683]
[PUBMED:20606012]
[PUBMED:18077133]
[PUBMED:15471878]
[PUBMED:20687930]
[PUBMED:23928995]
[PUBMED:16179349]
[PUBMED:26247733]
[PUBMED:11114724]
[PUBMED:17483331]
[PUBMED:22084245]
[PUBMED:10913193]
Signaling by SCF-KIT
[NCBI:1269487]
[REACTOME:R-HSA-1433557]
[PUBMED:17350321]
[PUBMED:16483568]
[PUBMED:7688988]
[PUBMED:19540337]
[PUBMED:16475976]
[PUBMED:15526160]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
[NCBI:1269617]
[REACTOME:R-HSA-2404192]
[PUBMED:21042815]
[PUBMED:18927274]
[PUBMED:20098959]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22044904]
[PUBMED:22649417]
Signaling by VEGF
[NCBI:1269480]
[REACTOME:R-HSA-194138]
[PUBMED:15585754]
[PUBMED:13678960]
[PUBMED:16336962]
[PUBMED:16835467]
Signaling by the B Cell Receptor (BCR)
[NCBI:1269183]
[REACTOME:R-HSA-983705]
[PUBMED:1702903]
[PUBMED:2011584]
[PUBMED:1081164]
[PUBMED:19065780]
[PUBMED:16849466]
[PUBMED:1375264]
[PUBMED:7538118]
[PUBMED:11901194]
[PUBMED:8580068]
[PUBMED:19249086]
[PUBMED:18596693]
[PUBMED:10648173]
[PUBMED:4589993]
[PUBMED:8163536]
[PUBMED:1376928]
[PUBMED:7688784]
[PUBMED:6335036]
[PUBMED:17052215]
[PUBMED:18818202]
[PUBMED:20206686]
[PUBMED:7592958]
[PUBMED:7524079]
[PUBMED:15489917]
[PUBMED:15509800]
[PUBMED:18187424]
[PUBMED:7927516]
[PUBMED:803528]
[PUBMED:19909372]
[PUBMED:20192804]
[PUBMED:8306975]
Signalling by NGF
[NCBI:1269443]
[REACTOME:R-HSA-166520]
Signalling to ERKs
[NCBI:1269464]
[REACTOME:R-HSA-187687]
[PUBMED:10508738]
Signalling to RAS
[NCBI:1269465]
[REACTOME:R-HSA-167044]
[PUBMED:11520933]
Signalling to p38 via RIT and RIN
[NCBI:1269468]
[REACTOME:R-HSA-187706]
[PUBMED:10712923]
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
[NCBI:1427841]
[REACTOME:R-HSA-8866910]
[PUBMED:14744778]
[PUBMED:9162057]
[PUBMED:22735262]
[PUBMED:26832794]
[PUBMED:10648798]
[PUBMED:10497269]
[PUBMED:9850080]
[PUBMED:9687504]
[PUBMED:7891714]
[PUBMED:15870067]
[PUBMED:9182571]
[PUBMED:8895516]
Tight junction
[NCBI:83071]
[KEGG:hsa04530]
[PUBMED:25152334]
[PUBMED:16650994]
[PUBMED:22892070]
[PUBMED:18946474]
[PUBMED:12042308]
[PUBMED:23885123]
[PUBMED:16771626]
[PUBMED:17182900]
[PUBMED:21283798]
[PUBMED:25757376]
[PUBMED:22928510]
[PUBMED:22169974]
[PUBMED:25469537]
[PUBMED:24651541]
[PUBMED:15820555]
[PUBMED:17525755]
[PUBMED:27353478]
[PUBMED:17950242]
[PUBMED:18005931]
[PUBMED:24548561]
[PUBMED:21781017]
[PUBMED:20094051]
[PUBMED:20134025]
[PUBMED:22896795]
[PUBMED:18094055]
[PUBMED:25483301]
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
[NCBI:1427839]
[REACTOME:R-HSA-8864260]
[PUBMED:2010091]
[PUBMED:11744733]
[PUBMED:24469049]
[PUBMED:23382213]
[PUBMED:19798054]
[PUBMED:9162057]
[PUBMED:21084835]
[PUBMED:22735262]
[PUBMED:21375726]
[PUBMED:14744778]
[PUBMED:10648798]
[PUBMED:26832794]
[PUBMED:24835590]
[PUBMED:9687504]
[PUBMED:20805990]
[PUBMED:10497269]
[PUBMED:16420676]
[PUBMED:12072434]
[PUBMED:9850080]
[PUBMED:9182571]
[PUBMED:8988173]
[PUBMED:1998122]
[PUBMED:22371483]
[PUBMED:15870067]
[PUBMED:12586840]
[PUBMED:8895516]
[PUBMED:7891714]
[PUBMED:11694877]
[PUBMED:19115315]
[PUBMED:15475956]
[PUBMED:25114211]
VEGFA-VEGFR2 Pathway
[NCBI:1269483]
[REACTOME:R-HSA-4420097]
[PUBMED:17344076]
[PUBMED:16633338]
[PUBMED:19230644]
[PUBMED:13678960]
VEGFR2 mediated cell proliferation
[NCBI:1269485]
[REACTOME:R-HSA-5218921]
[PUBMED:22866201]
[PUBMED:22180219]
[PUBMED:22762016]
Validated targets of C-MYC transcriptional repression
[NCBI:169353]
[Pathway Interaction Database:myc_represspathway]
[PUBMED:17082179]
[PUBMED:11282029]
[PUBMED:9869632]
[PUBMED:15021909]
[PUBMED:16167342]
[PUBMED:18056446]
[PUBMED:18045875]
[PUBMED:1670896]
[PUBMED:18393360]
[PUBMED:7556187]
[PUBMED:11313917]
[PUBMED:17471507]
[PUBMED:12418961]
[PUBMED:9927431]
[PUBMED:9924025]
[PUBMED:18483244]
[PUBMED:14716294]
[PUBMED:15506972]
[PUBMED:15616584]
[PUBMED:12729735]
[PUBMED:19219026]
[PUBMED:12747840]
[PUBMED:2182320]
[PUBMED:12545156]
[PUBMED:15367674]
[PUBMED:11283613]
[PUBMED:12384701]
[PUBMED:18066065]
[PUBMED:18455888]
[PUBMED:10920185]
[PUBMED:17881732]
[PUBMED:20190815]
[PUBMED:16352593]
[PUBMED:17050536]
[PUBMED:11283614]
[PUBMED:16391002]
[PUBMED:11804592]
[PUBMED:7870572]
[PUBMED:16940161]
[PUBMED:12695333]
[PUBMED:17159920]
[PUBMED:8972190]
[PUBMED:9312026]
[PUBMED:17485441]
[PUBMED:16288014]
a6b1 and a6b4 Integrin signaling
[NCBI:138008]
[Pathway Interaction Database:a6b1_a6b4_integrin_pathway]
[PUBMED:8698818]
[PUBMED:16436605]
[PUBMED:7556090]
[PUBMED:16510594]
[PUBMED:1959558]
[PUBMED:8738575]
[PUBMED:16339173]
[PUBMED:12865436]
[PUBMED:9428518]
[PUBMED:17308105]
[PUBMED:12919677]
[PUBMED:11098055]
[PUBMED:11044453]
[PUBMED:9856810]
[PUBMED:10321801]
[PUBMED:8609714]
[PUBMED:8143784]
[PUBMED:1883873]
[PUBMED:9488728]
[PUBMED:1757471]
[PUBMED:1533398]
[PUBMED:16504015]
[PUBMED:10694273]
[PUBMED:12584562]
[PUBMED:17178732]
[PUBMED:10477766]
[PUBMED:15579904]
[PUBMED:11733063]