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Genes
CDC6
Gene - CDC6
full name
cell division cycle 6
synonyms
CDC18L, HsCDC18, HsCDC6, CDC6, ENSG00000094804
HGNC
HGNC:1744
Entrez Gene
Gene:990
ENSEMBL
ENSG00000094804
location
chr: 17
start: 38444146
stop: 38459413
strand: +
OMIM
OMIM:602627
: CDC6
(Autosomal recessive inheritance)
OMIM:613805
: ?Meier-Gorlin syndrome 5
transcripts
NM_001254.3
pathways
Activation of ATR in response to replication stress
[NCBI:1269757]
[REACTOME:R-HSA-176187]
[PUBMED:12791985]
Activation of the pre-replicative complex
[NCBI:1269773]
[REACTOME:R-HSA-68962]
[PUBMED:10402192]
[PUBMED:11779870]
[PUBMED:10801458]
[PUBMED:12169736]
[PUBMED:11323433]
[PUBMED:9038340]
[PUBMED:9765232]
[PUBMED:9829972]
[PUBMED:10970868]
[PUBMED:9353276]
[PUBMED:7502077]
[PUBMED:11459976]
[PUBMED:11395502]
Assembly of the pre-replicative complex
[NCBI:1269833]
[REACTOME:R-HSA-68867]
[PUBMED:11801723]
[PUBMED:9829972]
[PUBMED:9288745]
[PUBMED:9407030]
[PUBMED:9927482]
[PUBMED:9335335]
[PUBMED:11046155]
Association of licensing factors with the pre-replicative complex
[NCBI:1269795]
[REACTOME:R-HSA-69298]
CDC6 association with the ORC:origin complex
[NCBI:1269835]
[REACTOME:R-HSA-68689]
[PUBMED:11532947]
[PUBMED:11046155]
[PUBMED:9566895]
[PUBMED:9312054]
[PUBMED:10712901]
[PUBMED:9520412]
[PUBMED:9889196]
[PUBMED:10339564]
[PUBMED:10995389]
[PUBMED:7641697]
[PUBMED:10801458]
CDK-mediated phosphorylation and removal of Cdc6
[NCBI:1269783]
[REACTOME:R-HSA-69017]
[PUBMED:12045100]
[PUBMED:11046155]
CDT1 association with the CDC6:ORC:origin complex
[NCBI:1269836]
[REACTOME:R-HSA-68827]
[PUBMED:11125146]
[PUBMED:11836525]
[PUBMED:10766247]
[PUBMED:11175741]
[PUBMED:10898791]
[PUBMED:10766248]
[PUBMED:9442876]
[PUBMED:9635433]
Cell Cycle
[NCBI:1269741]
[REACTOME:R-HSA-1640170]
Cell Cycle Checkpoints
[NCBI:1269742]
[REACTOME:R-HSA-69620]
Cell Cycle, Mitotic
[NCBI:1269763]
[REACTOME:R-HSA-69278]
Cell cycle
[NCBI:83054]
[KEGG:hsa04110]
[PUBMED:7973727]
[PUBMED:17568790]
[PUBMED:9832503]
[PUBMED:16936746]
[PUBMED:9029154]
[PUBMED:12573239]
[PUBMED:19020303]
[PUBMED:9618481]
[PUBMED:12809600]
[PUBMED:8242749]
[PUBMED:10385618]
[PUBMED:17426725]
[PUBMED:17018296]
[PUBMED:16212951]
[PUBMED:12925736]
[PUBMED:11099028]
[PUBMED:15568976]
[PUBMED:15838516]
[PUBMED:15838523]
[PUBMED:15876871]
[PUBMED:7908906]
[PUBMED:9889196]
DNA Replication
[NCBI:1269875]
[REACTOME:R-HSA-69306]
[PUBMED:11257218]
[PUBMED:12045100]
[PUBMED:1536007]
[PUBMED:10966477]
[PUBMED:1579437]
[PUBMED:8223461]
DNA Replication Pre-Initiation
[NCBI:1269832]
[REACTOME:R-HSA-69002]
E2F mediated regulation of DNA replication
[NCBI:1269774]
[REACTOME:R-HSA-113510]
[PUBMED:12393009]
[PUBMED:12726857]
[PUBMED:12473340]
E2F transcription factor network
[NCBI:137934]
[Pathway Interaction Database:e2f_pathway]
[PUBMED:15175242]
[PUBMED:11034215]
[PUBMED:8832394]
[PUBMED:7479977]
[PUBMED:12077144]
[PUBMED:11274364]
[PUBMED:8618861]
[PUBMED:11857079]
[PUBMED:7958837]
[PUBMED:15014447]
[PUBMED:9774682]
[PUBMED:9704927]
[PUBMED:9271400]
[PUBMED:8334989]
[PUBMED:16288221]
[PUBMED:10766737]
[PUBMED:8657141]
[PUBMED:8552092]
[PUBMED:11101847]
[PUBMED:12757710]
[PUBMED:17704056]
[PUBMED:7705662]
[PUBMED:15897886]
[PUBMED:9192872]
[PUBMED:9778043]
[PUBMED:12766778]
[PUBMED:15510213]
[PUBMED:11418595]
[PUBMED:10454584]
[PUBMED:10783242]
[PUBMED:11904439]
[PUBMED:16179649]
[PUBMED:7791762]
[PUBMED:11719808]
[PUBMED:12389032]
[PUBMED:8264596]
[PUBMED:19491197]
[PUBMED:15713665]
[PUBMED:16357170]
[PUBMED:9689056]
[PUBMED:12748276]
[PUBMED:2524830]
[PUBMED:14633988]
[PUBMED:12697828]
[PUBMED:12101096]
[PUBMED:11799067]
[PUBMED:15133492]
[PUBMED:16892051]
[PUBMED:8943353]
[PUBMED:9724731]
[PUBMED:10030670]
[PUBMED:11459832]
[PUBMED:8114719]
[PUBMED:9520412]
[PUBMED:18348985]
[PUBMED:9020173]
[PUBMED:11389439]
[PUBMED:16211008]
[PUBMED:12411495]
[PUBMED:7958836]
[PUBMED:12909625]
[PUBMED:15306814]
[PUBMED:10688648]
[PUBMED:12611887]
[PUBMED:9191053]
[PUBMED:10373518]
[PUBMED:10187822]
G0 and Early G1
[NCBI:1269765]
[REACTOME:R-HSA-1538133]
G1/S Transition
[NCBI:1269768]
[REACTOME:R-HSA-69206]
G1/S-Specific Transcription
[NCBI:1269772]
[REACTOME:R-HSA-69205]
G2/M Checkpoints
[NCBI:1269753]
[REACTOME:R-HSA-69481]
M/G1 Transition
[NCBI:1269831]
[REACTOME:R-HSA-68874]
Mitotic G1-G1/S phases
[NCBI:1269764]
[REACTOME:R-HSA-453279]
Orc1 removal from chromatin
[NCBI:1269782]
[REACTOME:R-HSA-68949]
[PUBMED:11931757]
[PUBMED:11739726]
[PUBMED:11809796]
[PUBMED:1110244]
Regulation of DNA replication
[NCBI:1269794]
[REACTOME:R-HSA-69304]
Removal of licensing factors from origins
[NCBI:1269796]
[REACTOME:R-HSA-69300]
S Phase
[NCBI:1269777]
[REACTOME:R-HSA-69242]
Switching of origins to a post-replicative state
[NCBI:1269781]
[REACTOME:R-HSA-69052]
Synthesis of DNA
[NCBI:1269779]
[REACTOME:R-HSA-69239]