Logo
full name
integrin subunit beta 3

synonyms
BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT, ITGB3, ENSG00000259207

HGNC
HGNC:6156

Entrez Gene
Gene:3690

ENSEMBL
ENSG00000259207
ENSG00000259753

location
chr: 17
start: 45331208
stop: 45390077
strand: +

OMIM
OMIM:173470: ITGB3 (Autosomal dominant inheritance,Autosomal recessive inheritance)
OMIM:187800: Bleeding disorder, platelet-type, 16, autosomal dominant
OMIM:273800: Glanzmann thrombasthenia
OMIM:608446: {Myocardial infarction, susceptibility to}

transcripts
NM_000212.2

pathways
ARMS-mediated activation [NCBI:1269471] [REACTOME:R-HSA-170984] [PUBMED:9069267]
Arf6 signaling events [NCBI:138034] [Pathway Interaction Database:arf6_pathway] [PUBMED:18164504] [PUBMED:15509780] [PUBMED:11481345] [PUBMED:18084281] [PUBMED:15775968] [PUBMED:18094045] [PUBMED:17409355] [PUBMED:11532961] [PUBMED:10480924] [PUBMED:15126638] [PUBMED:17398097] [PUBMED:18026091] [PUBMED:17353194] [PUBMED:15793570] [PUBMED:16650966] [PUBMED:12920129] [PUBMED:11278939] [PUBMED:9742223] [PUBMED:11062263] [PUBMED:16461286] [PUBMED:10779358] [PUBMED:18003747] [PUBMED:15923660] [PUBMED:10642533] [PUBMED:11342560] [PUBMED:10448098] [PUBMED:11226253] [PUBMED:18490450] [PUBMED:19193766] [PUBMED:10913124] [PUBMED:10811902] [PUBMED:17077126] [PUBMED:11533043] [PUBMED:12447393] [PUBMED:10333475] [PUBMED:9550703] [PUBMED:10075920] [PUBMED:9417041] [PUBMED:17719203] [PUBMED:14625293] [PUBMED:17122362] [PUBMED:17846866]
Arrhythmogenic right ventricular cardiomyopathy (ARVC) [NCBI:117293] [KEGG:hsa05412] [PUBMED:16823481] [PUBMED:19205777] [PUBMED:11716909] [PUBMED:12270949] [PUBMED:18382419] [PUBMED:16101641] [PUBMED:16124859] [PUBMED:17413274]
Axon guidance [NCBI:83065] [KEGG:hsa04360] [NCBI:1270303] [REACTOME:R-HSA-422475] [PUBMED:14682358] [PUBMED:15084255] [PUBMED:11687826] [PUBMED:15818466] [PUBMED:15363605] [PUBMED:12471249] [PUBMED:15630019] [PUBMED:11891122] [PUBMED:15960985] [PUBMED:12677003]
Cell surface interactions at the vascular wall [NCBI:1269373] [REACTOME:R-HSA-202733] [PUBMED:17525755] [PUBMED:11282294] [PUBMED:10798271] [PUBMED:8578462] [PUBMED:14615387] [PUBMED:16115029]
Cytokine Signaling in Immune system [NCBI:1269310] [REACTOME:R-HSA-1280215] [PUBMED:12613569]
DAP12 interactions [NCBI:1269283] [REACTOME:R-HSA-2172127] [PUBMED:19120482] [PUBMED:17220916] [PUBMED:9490415] [PUBMED:18192027] [PUBMED:15884055]
DAP12 signaling [NCBI:1269284] [REACTOME:R-HSA-2424491] [PUBMED:15884055] [PUBMED:17110943] [PUBMED:17220916]
Developmental Biology [NCBI:1270302] [REACTOME:R-HSA-1266738]
Dilated cardiomyopathy [NCBI:121494] [KEGG:hsa05414] [PUBMED:11524405] [PUBMED:11805847] [PUBMED:12270949] [PUBMED:14522402] [PUBMED:19017683] [PUBMED:15146239] [PUBMED:18672201] [PUBMED:19273156] [PUBMED:19246813] [PUBMED:11716909] [PUBMED:16817756]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Diseases of signal transduction [NCBI:1268855] [REACTOME:R-HSA-5663202] [PUBMED:12509752]
Downstream signal transduction [NCBI:1269479] [REACTOME:R-HSA-186763] [PUBMED:10508235] [PUBMED:9739761]
ECM proteoglycans [NCBI:1270256] [REACTOME:R-HSA-3000178] [PUBMED:20301236] [PUBMED:21307119]
ECM-receptor interaction [NCBI:83068] [KEGG:hsa04512] [PUBMED:7698997] [PUBMED:15381249] [PUBMED:12796473] [PUBMED:11331578] [PUBMED:15036264] [PUBMED:12125070] [PUBMED:12736199] [PUBMED:15229478] [PUBMED:11572082] [PUBMED:10617638] [PUBMED:12845610] [PUBMED:12921709]
Elastic fibre formation [NCBI:1270251] [REACTOME:R-HSA-1566948] [PUBMED:16261592]
Ephrin B reverse signaling [NCBI:138052] [Pathway Interaction Database:ephrinbrevpathway] [PUBMED:15351694] [PUBMED:11557983] [PUBMED:14576067] [PUBMED:7973638] [PUBMED:8755474] [PUBMED:15536074] [PUBMED:14988728] [PUBMED:8878483] [PUBMED:8918835] [PUBMED:11983165] [PUBMED:12709432] [PUBMED:8761303] [PUBMED:14499344] [PUBMED:11301003]
Extracellular matrix organization [NCBI:1270244] [REACTOME:R-HSA-1474244] [PUBMED:21123617] [PUBMED:21917992] [PUBMED:12845610]
FCERI mediated MAPK activation [NCBI:1269299] [REACTOME:R-HSA-2871796] [PUBMED:19290926] [PUBMED:19909365] [PUBMED:17122878]
Fc epsilon receptor (FCERI) signaling [NCBI:1269298] [REACTOME:R-HSA-2454202] [PUBMED:15099567] [PUBMED:21799019]
Fluid shear stress and atherosclerosis [NCBI:1474302] [KEGG:hsa05418] [PUBMED:23429585] [PUBMED:21050140] [PUBMED:17599600] [PUBMED:24190880] [PUBMED:22003002] [PUBMED:24876354] [PUBMED:24947523] [PUBMED:23899566] [PUBMED:26597822] [PUBMED:20353494] [PUBMED:22076424] [PUBMED:20538799] [PUBMED:25165867] [PUBMED:20032497] [PUBMED:23084990] [PUBMED:26822720] [PUBMED:24573382] [PUBMED:23555159] [PUBMED:26212910] [PUBMED:21457103] [PUBMED:19151844] [PUBMED:15388638] [PUBMED:16765337] [PUBMED:27027326] [PUBMED:25638487] [PUBMED:21733876]
Focal adhesion [NCBI:83067] [KEGG:hsa04510] [PUBMED:10698680] [PUBMED:15459662] [PUBMED:14756624] [PUBMED:11573199] [PUBMED:12640026] [PUBMED:15179030] [PUBMED:15108811] [PUBMED:15053919] [PUBMED:11082269] [PUBMED:15034601] [PUBMED:12235283] [PUBMED:14519391] [PUBMED:11146675] [PUBMED:11229600] [PUBMED:15688067] [PUBMED:14744429] [PUBMED:11882383]
Frs2-mediated activation [NCBI:1269470] [REACTOME:R-HSA-170968] [PUBMED:9069267]
GRB2 events in EGFR signaling [NCBI:1269382] [REACTOME:R-HSA-179812] [PUBMED:11706405] [PUBMED:11498013]
GRB2:SOS provides linkage to MAPK signaling for Integrins [NCBI:1269360] [REACTOME:R-HSA-354194] [PUBMED:9566877] [PUBMED:7997267] [PUBMED:12005431]
Gastrin-CREB signalling pathway via PKC and MAPK [NCBI:1269592] [REACTOME:R-HSA-881907] [PUBMED:10413847] [PUBMED:7491953] [PUBMED:17698287]
Hematopoietic cell lineage [NCBI:83078] [KEGG:hsa04640] [PUBMED:15629410] [PUBMED:15738953] [PUBMED:11905810] [PUBMED:15156179] [PUBMED:12415312] [PUBMED:14985712] [PUBMED:9927518] [PUBMED:15771582] [PUBMED:14670296] [PUBMED:12360214]
Hemostasis [NCBI:1269340] [REACTOME:R-HSA-109582]
Hypertrophic cardiomyopathy (HCM) [NCBI:114229] [KEGG:hsa05410] [PUBMED:11805847] [PUBMED:18572189] [PUBMED:14711353] [PUBMED:19136482] [PUBMED:18056765] [PUBMED:11225594] [PUBMED:12844200] [PUBMED:10615904] [PUBMED:11716909] [PUBMED:11371514] [PUBMED:12270949]
IGF1R signaling cascade [NCBI:1269618] [REACTOME:R-HSA-2428924] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22649417] [PUBMED:21042815] [PUBMED:18927274] [PUBMED:20098959]
IL4-mediated signaling events [NCBI:137933] [Pathway Interaction Database:il4_2pathway] [PUBMED:8602263] [PUBMED:15199062] [PUBMED:7705411] [PUBMED:11160325] [PUBMED:8557643] [PUBMED:8134361] [PUBMED:1948049] [PUBMED:10843732] [PUBMED:11034397] [PUBMED:8624802] [PUBMED:14557412] [PUBMED:1997653] [PUBMED:10586089] [PUBMED:14634100] [PUBMED:17541284] [PUBMED:8124718] [PUBMED:16210622] [PUBMED:7822337] [PUBMED:11572871] [PUBMED:2147202] [PUBMED:10228008] [PUBMED:7675087] [PUBMED:12574343] [PUBMED:14603527] [PUBMED:15659391] [PUBMED:11160269] [PUBMED:7760829] [PUBMED:7973658] [PUBMED:10072514] [PUBMED:9013879] [PUBMED:8624803] [PUBMED:10490661] [PUBMED:14978013] [PUBMED:10364072] [PUBMED:12459556] [PUBMED:11714803] [PUBMED:8602264] [PUBMED:9811885] [PUBMED:12776189] [PUBMED:15728454] [PUBMED:10601358] [PUBMED:11739727] [PUBMED:11160275] [PUBMED:9852037] [PUBMED:9670964] [PUBMED:15004182] [PUBMED:8266078] [PUBMED:3144043] [PUBMED:8992992] [PUBMED:8089482] [PUBMED:9651359] [PUBMED:16810739] [PUBMED:7499365] [PUBMED:7721786] [PUBMED:9065461] [PUBMED:11241672] [PUBMED:10950967] [PUBMED:8810328] [PUBMED:8624821] [PUBMED:9110977] [PUBMED:8609418] [PUBMED:15187136] [PUBMED:9414268] [PUBMED:8916957] [PUBMED:10201892] [PUBMED:17200144] [PUBMED:8458387] [PUBMED:11544308] [PUBMED:10657944] [PUBMED:15153491] [PUBMED:7544011] [PUBMED:8266076] [PUBMED:11801631] [PUBMED:12044779] [PUBMED:8621475] [PUBMED:9697832] [PUBMED:12242343] [PUBMED:7694370] [PUBMED:9380721] [PUBMED:9541585] [PUBMED:7807002] [PUBMED:16537510] [PUBMED:8258319] [PUBMED:9799097] [PUBMED:12023955] [PUBMED:8085155]
IRS-mediated signalling [NCBI:1269431] [REACTOME:R-HSA-112399]
IRS-related events triggered by IGF1R [NCBI:1269620] [REACTOME:R-HSA-2428928] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22649417] [PUBMED:18927274] [PUBMED:21042815] [PUBMED:20098959]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Insulin receptor signalling cascade [NCBI:1269429] [REACTOME:R-HSA-74751] [PUBMED:9677303] [PUBMED:11282018]
Integrin alphaIIb beta3 signaling [NCBI:1269359] [REACTOME:R-HSA-354192] [PUBMED:10605720] [PUBMED:14754902] [PUBMED:17624957] [PUBMED:16102042] [PUBMED:15205259] [PUBMED:10508650]
Integrin cell surface interactions [NCBI:1270260] [REACTOME:R-HSA-216083] [PUBMED:10215583] [PUBMED:15147720] [PUBMED:12231361] [PUBMED:8866399] [PUBMED:19273203]
Integrins in angiogenesis [NCBI:137999] [Pathway Interaction Database:avb3_integrin_pathway] [PUBMED:10837460] [PUBMED:9182576] [PUBMED:12642872] [PUBMED:15711558] [PUBMED:10037797] [PUBMED:10196194] [PUBMED:11877390] [PUBMED:16418218] [PUBMED:16600665] [PUBMED:16982628] [PUBMED:15479743] [PUBMED:16720645] [PUBMED:11684710] [PUBMED:10821695] [PUBMED:12237112] [PUBMED:12750158] [PUBMED:11551924] [PUBMED:8794870] [PUBMED:10022831] [PUBMED:15187087] [PUBMED:16195423] [PUBMED:16760434] [PUBMED:12682293] [PUBMED:9420328] [PUBMED:15247219] [PUBMED:9490736] [PUBMED:11313365]
Interleukin receptor SHC signaling [NCBI:1269322] [REACTOME:R-HSA-912526] [PUBMED:8294403]
Interleukin-2 signaling [NCBI:1269321] [REACTOME:R-HSA-451927] [PUBMED:17936914] [PUBMED:18817510] [PUBMED:19543225] [PUBMED:18062768]
Interleukin-3, 5 and GM-CSF signaling [NCBI:1269323] [REACTOME:R-HSA-512988] [PUBMED:10450743] [PUBMED:9766809]
L1CAM interactions [NCBI:1270323] [REACTOME:R-HSA-373760] [PUBMED:9211984] [PUBMED:18760361] [PUBMED:14709786] [PUBMED:17189949] [PUBMED:19356150]
MAP2K and MAPK activation [NCBI:1269287] [REACTOME:R-HSA-5674135] [PUBMED:21779496] [PUBMED:20674547] [PUBMED:22569528] [PUBMED:22177953] [PUBMED:19091303]
MAPK family signaling cascades [NCBI:1269501] [REACTOME:R-HSA-5683057] [PUBMED:21167873] [PUBMED:17161475] [PUBMED:22535895] [PUBMED:21372320]
MAPK1/MAPK3 signaling [NCBI:1269502] [REACTOME:R-HSA-5684996] [PUBMED:25378393] [PUBMED:18199641] [PUBMED:17496909] [PUBMED:21779496] [PUBMED:15520807] [PUBMED:16393692] [PUBMED:19520853] [PUBMED:17496910] [PUBMED:22569528]
MicroRNAs in cancer [NCBI:852705] [KEGG:hsa05206] [PUBMED:23075324] [PUBMED:21742789] [PUBMED:22351564] [PUBMED:18817506] [PUBMED:22345301] [PUBMED:21402473] [PUBMED:22926415] [PUBMED:23165235] [PUBMED:19630570] [PUBMED:21565290] [PUBMED:23091478] [PUBMED:23462054] [PUBMED:23316212] [PUBMED:19773200] [PUBMED:22035854] [PUBMED:20221895] [PUBMED:20345848] [PUBMED:22580099] [PUBMED:20128019]
Molecules associated with elastic fibres [NCBI:1270252] [REACTOME:R-HSA-2129379] [PUBMED:18228265] [PUBMED:12082143]
NCAM signaling for neurite out-growth [NCBI:1270312] [REACTOME:R-HSA-375165] [PUBMED:18760361] [PUBMED:12587671] [PUBMED:15662836] [PUBMED:17975827] [PUBMED:15153429] [PUBMED:12700044]
NGF signalling via TRKA from the plasma membrane [NCBI:1269460] [REACTOME:R-HSA-187037] [PUBMED:11520933] [PUBMED:12676795] [PUBMED:10851172] [PUBMED:10579918]
Nectin adhesion pathway [NCBI:138054] [Pathway Interaction Database:nectin_pathway] [PUBMED:15504743] [PUBMED:9845526] [PUBMED:10225955] [PUBMED:12054561] [PUBMED:10974003] [PUBMED:18547333] [PUBMED:14526080] [PUBMED:17965016] [PUBMED:16472674] [PUBMED:12687012] [PUBMED:15263019] [PUBMED:16679515] [PUBMED:15485841] [PUBMED:15857834] [PUBMED:16216929] [PUBMED:10744716] [PUBMED:15277544] [PUBMED:10617658] [PUBMED:16128743] [PUBMED:12400007] [PUBMED:12694536] [PUBMED:18505795] [PUBMED:11544254] [PUBMED:11024295]
Non-integrin membrane-ECM interactions [NCBI:1270254] [REACTOME:R-HSA-3000171] [PUBMED:15039999] [PUBMED:20565253]
Oncogenic MAPK signaling [NCBI:1457781] [REACTOME:R-HSA-6802957] [PUBMED:25907612] [PUBMED:24651010] [PUBMED:24202393] [PUBMED:25435214] [PUBMED:21993244] [PUBMED:24814062] [PUBMED:22589270]
Osteoclast differentiation [NCBI:193147] [KEGG:hsa04380] [PUBMED:17633024] [PUBMED:18382763] [PUBMED:18329366] [PUBMED:17869613] [PUBMED:18722561] [PUBMED:15122243] [PUBMED:20703218] [PUBMED:12748652] [PUBMED:12110142] [PUBMED:19585227] [PUBMED:15546140] [PUBMED:16184196] [PUBMED:15817678] [PUBMED:20392226] [PUBMED:16313349] [PUBMED:16313342] [PUBMED:17380158] [PUBMED:18451259]
Osteopontin-mediated events [NCBI:137960] [Pathway Interaction Database:avb3_opn_pathway] [PUBMED:9727056] [PUBMED:9585425] [PUBMED:16888388] [PUBMED:16474180] [PUBMED:15757900] [PUBMED:9682033] [PUBMED:12529435] [PUBMED:15142256] [PUBMED:14624447] [PUBMED:15711558] [PUBMED:9988732] [PUBMED:12730217] [PUBMED:11600576] [PUBMED:8744948] [PUBMED:16691505] [PUBMED:11940607] [PUBMED:16006560] [PUBMED:10766830] [PUBMED:10559185]
PECAM1 interactions [NCBI:1269375] [REACTOME:R-HSA-210990] [PUBMED:12681475] [PUBMED:14619965]
PI3K-Akt signaling pathway [NCBI:692234] [KEGG:hsa04151] [PUBMED:12048182] [PUBMED:11357143] [PUBMED:21440011] [PUBMED:15209374] [PUBMED:12669022] [PUBMED:18842113] [PUBMED:16847462] [PUBMED:12660731] [PUBMED:17360849] [PUBMED:9838078] [PUBMED:15505410] [PUBMED:16248975] [PUBMED:12531180] [PUBMED:21779440] [PUBMED:16187290] [PUBMED:15784165] [PUBMED:21620960]
Paradoxical activation of RAF signaling by kinase inactive BRAF [NCBI:1457785] [REACTOME:R-HSA-6802955] [PUBMED:25435214] [PUBMED:20674547] [PUBMED:24957944] [PUBMED:23352452] [PUBMED:20130576] [PUBMED:23680146] [PUBMED:16364920] [PUBMED:25907612] [PUBMED:15035987] [PUBMED:20179705] [PUBMED:19727074] [PUBMED:20141835] [PUBMED:22510884]
Phagosome [NCBI:153910] [KEGG:hsa04145] [PUBMED:17637737] [PUBMED:18513324] [PUBMED:15894272] [PUBMED:10684585] [PUBMED:18492791] [PUBMED:15036145] [PUBMED:17245426]
Platelet Aggregation (Plug Formation) [NCBI:1269358] [REACTOME:R-HSA-76009] [PUBMED:18174460] [PUBMED:17585075]
Platelet activation [NCBI:952858] [KEGG:hsa04611] [PUBMED:20002545] [PUBMED:18363565] [PUBMED:18544684] [PUBMED:18174460] [PUBMED:23106920] [PUBMED:18550847] [PUBMED:22119499] [PUBMED:19630797] [PUBMED:19286885] [PUBMED:17158345] [PUBMED:20089227] [PUBMED:22701130] [PUBMED:21071698] [PUBMED:23805129] [PUBMED:16149014] [PUBMED:18641368]
Platelet activation, signaling and aggregation [NCBI:1269350] [REACTOME:R-HSA-76002] [PUBMED:16543958] [PUBMED:8704248] [PUBMED:2018971] [PUBMED:1672265] [PUBMED:17059469] [PUBMED:12681240] [PUBMED:12411949] [PUBMED:11511514]
Platelet degranulation [NCBI:1269367] [REACTOME:R-HSA-114608] [PUBMED:14630798]
Prolonged ERK activation events [NCBI:1269469] [REACTOME:R-HSA-169893] [PUBMED:12765839] [PUBMED:9069267]
Proteoglycans in cancer [NCBI:782000] [KEGG:hsa05205] [PUBMED:19433454] [PUBMED:20655987] [PUBMED:18798267] [PUBMED:10633082] [PUBMED:10687947] [PUBMED:22735579] [PUBMED:24412155] [PUBMED:9346940] [PUBMED:22087031] [PUBMED:22194599] [PUBMED:14711376] [PUBMED:19255147] [PUBMED:15655247] [PUBMED:11717317] [PUBMED:17971838] [PUBMED:18413366] [PUBMED:20974860] [PUBMED:11830493] [PUBMED:23058688] [PUBMED:18450475] [PUBMED:12748184] [PUBMED:19733083] [PUBMED:18812315] [PUBMED:12509413] [PUBMED:21155971] [PUBMED:11931647] [PUBMED:18949819] [PUBMED:12729888] [PUBMED:15994311] [PUBMED:23305321] [PUBMED:18505598] [PUBMED:22563565] [PUBMED:22033227]
RAF/MAP kinase cascade [NCBI:1269285] [REACTOME:R-HSA-5673001] [PUBMED:21167873] [PUBMED:24937142] [PUBMED:20674547] [PUBMED:17496910] [PUBMED:22177953] [PUBMED:17496919] [PUBMED:22569528] [PUBMED:22535895] [PUBMED:12068308] [PUBMED:17496923] [PUBMED:19091303] [PUBMED:21372320] [PUBMED:21388974] [PUBMED:15520807]
RET signaling [NCBI:1427866] [REACTOME:R-HSA-8853659] [PUBMED:15013219] [PUBMED:17036197]
Rap1 signaling pathway [NCBI:868086] [KEGG:hsa04015] [PUBMED:17624944] [PUBMED:12351703] [PUBMED:10579920] [PUBMED:19159611] [PUBMED:18363565] [PUBMED:12765839] [PUBMED:12508104] [PUBMED:11331911] [PUBMED:17182900] [PUBMED:15803158] [PUBMED:19615876] [PUBMED:21402149] [PUBMED:17624948] [PUBMED:17383543] [PUBMED:14607972] [PUBMED:15780587] [PUBMED:19710505]
Regulation of actin cytoskeleton [NCBI:83089] [KEGG:hsa04810] [PUBMED:11152757] [PUBMED:11082272] [PUBMED:10574699] [PUBMED:11082269] [PUBMED:14657486] [PUBMED:14744429] [PUBMED:12700767]
Response to elevated platelet cytosolic Ca2+ [NCBI:1269365] [REACTOME:R-HSA-76005] [PUBMED:8424766]
S1P1 pathway [NCBI:137937] [Pathway Interaction Database:s1p_s1p1_pathway] [PUBMED:10198065] [PUBMED:12782628] [PUBMED:15750791] [PUBMED:11741892] [PUBMED:12963813] [PUBMED:11150298] [PUBMED:10463951] [PUBMED:9660876] [PUBMED:12087059] [PUBMED:12796504] [PUBMED:12175535] [PUBMED:11709084] [PUBMED:17050692] [PUBMED:12586615] [PUBMED:17257496]
S1P3 pathway [NCBI:138063] [Pathway Interaction Database:s1p_s1p3_pathway] [PUBMED:12577307] [PUBMED:11853542] [PUBMED:17158356] [PUBMED:15138255] [PUBMED:14732717] [PUBMED:11150298] [PUBMED:14657000] [PUBMED:9854026] [PUBMED:10617617] [PUBMED:16527273]
SHC1 events in EGFR signaling [NCBI:1269383] [REACTOME:R-HSA-180336] [PUBMED:11498013] [PUBMED:8755247]
SOS-mediated signalling [NCBI:1269440] [REACTOME:R-HSA-112412]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signal transduction by L1 [NCBI:1270326] [REACTOME:R-HSA-445144] [PUBMED:15597056] [PUBMED:12721290] [PUBMED:10608864] [PUBMED:17189949] [PUBMED:16597699] [PUBMED:10818153]
Signaling by BRAF and RAF fusions [NCBI:1457786] [REACTOME:R-HSA-6802952] [PUBMED:18974108] [PUBMED:24135138] [PUBMED:22745804] [PUBMED:25907612] [PUBMED:20526349] [PUBMED:15630448] [PUBMED:25204415] [PUBMED:24345920] [PUBMED:21424530] [PUBMED:23583981]
Signaling by EGFR [NCBI:1269380] [REACTOME:R-HSA-177929] [PUBMED:10459005] [PUBMED:10404636] [PUBMED:12297041] [PUBMED:15142631]
Signaling by GPCR [NCBI:1269543] [REACTOME:R-HSA-372790] [PUBMED:16902930] [PUBMED:10202136] [PUBMED:18043707]
Signaling by Insulin receptor [NCBI:1269428] [REACTOME:R-HSA-74752] [PUBMED:8276779]
Signaling by Interleukins [NCBI:1269318] [REACTOME:R-HSA-449147] [PUBMED:19302047] [PUBMED:12445398]
Signaling by Leptin [NCBI:1269632] [REACTOME:R-HSA-2586552] [PUBMED:22211890] [PUBMED:23562747] [PUBMED:20600241] [PUBMED:21622208] [PUBMED:23579596] [PUBMED:22458591] [PUBMED:21489811] [PUBMED:19724019] [PUBMED:21331644] [PUBMED:22448029] [PUBMED:21147620] [PUBMED:20198122] [PUBMED:21677426] [PUBMED:20029269] [PUBMED:22249808] [PUBMED:22991412] [PUBMED:21527729] [PUBMED:17937601] [PUBMED:20553370] [PUBMED:21713385] [PUBMED:23565489] [PUBMED:22289780]
Signaling by PDGF [NCBI:1269478] [REACTOME:R-HSA-186797] [PUBMED:15207811] [PUBMED:10508235] [PUBMED:9739761]
Signaling by RAS mutants [NCBI:1457782] [REACTOME:R-HSA-6802949] [PUBMED:21993244] [PUBMED:22589270] [PUBMED:24651010]
Signaling by SCF-KIT [NCBI:1269487] [REACTOME:R-HSA-1433557] [PUBMED:17350321] [PUBMED:16483568] [PUBMED:7688988] [PUBMED:19540337] [PUBMED:16475976] [PUBMED:15526160]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) [NCBI:1269617] [REACTOME:R-HSA-2404192] [PUBMED:21042815] [PUBMED:18927274] [PUBMED:20098959] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22044904] [PUBMED:22649417]
Signaling by VEGF [NCBI:1269480] [REACTOME:R-HSA-194138] [PUBMED:15585754] [PUBMED:13678960] [PUBMED:16336962] [PUBMED:16835467]
Signaling by high-kinase activity BRAF mutants [NCBI:1457783] [REACTOME:R-HSA-6802948] [PUBMED:16702958] [PUBMED:21190184] [PUBMED:23352452] [PUBMED:16364920] [PUBMED:22113612] [PUBMED:12068308] [PUBMED:15035987] [PUBMED:22510884] [PUBMED:25435214] [PUBMED:24202393]
Signaling by moderate kinase activity BRAF mutants [NCBI:1457784] [REACTOME:R-HSA-6802946] [PUBMED:25907612] [PUBMED:15035987] [PUBMED:24202393] [PUBMED:22510884] [PUBMED:25355519] [PUBMED:23352452]
Signaling events mediated by PTP1B [NCBI:138017] [Pathway Interaction Database:ptp1bpathway] [PUBMED:12414790] [PUBMED:8223493] [PUBMED:12857726] [PUBMED:8999839] [PUBMED:14766979] [PUBMED:9355745] [PUBMED:11579209] [PUBMED:8940134] [PUBMED:12802338] [PUBMED:10807907] [PUBMED:15866871] [PUBMED:10751417] [PUBMED:11346638] [PUBMED:11970899] [PUBMED:9083103] [PUBMED:7693694] [PUBMED:11900546] [PUBMED:7983051] [PUBMED:11694501] [PUBMED:10514492] [PUBMED:12176037] [PUBMED:16644720] [PUBMED:16388599] [PUBMED:9624118] [PUBMED:9786960] [PUBMED:14966267] [PUBMED:15894168] [PUBMED:11773439] [PUBMED:11864611] [PUBMED:8548812] [PUBMED:16477024] [PUBMED:9418872] [PUBMED:9050838] [PUBMED:12424235] [PUBMED:12748279] [PUBMED:1383688] [PUBMED:8782827] [PUBMED:8626723] [PUBMED:11007774] [PUBMED:10993888] [PUBMED:15226396] [PUBMED:10066179] [PUBMED:10660596] [PUBMED:12554649] [PUBMED:11970898] [PUBMED:9566916]
Signaling events mediated by VEGFR1 and VEGFR2 [NCBI:137940] [Pathway Interaction Database:vegfr1_2_pathway] [PUBMED:9398617] [PUBMED:9405464] [PUBMED:11494124] [PUBMED:12963813] [PUBMED:11756651] [PUBMED:10744763] [PUBMED:15060076] [PUBMED:9600074] [PUBMED:10376603] [PUBMED:11425855] [PUBMED:16337972] [PUBMED:12154000] [PUBMED:11978735] [PUBMED:10692392] [PUBMED:16763158] [PUBMED:10361126] [PUBMED:10748121] [PUBMED:12598525] [PUBMED:15026417] [PUBMED:11948691] [PUBMED:16966330] [PUBMED:16835467] [PUBMED:10409677] [PUBMED:10908731] [PUBMED:8903320] [PUBMED:15962004] [PUBMED:16633338] [PUBMED:11387210] [PUBMED:16839566] [PUBMED:11312102] [PUBMED:10207622] [PUBMED:16787925] [PUBMED:12171920] [PUBMED:12509223] [PUBMED:16760434] [PUBMED:14724572] [PUBMED:11704645] [PUBMED:12821150] [PUBMED:12881528] [PUBMED:9790910] [PUBMED:10376602] [PUBMED:15247219] [PUBMED:11333271] [PUBMED:12214271] [PUBMED:9804796] [PUBMED:11986311] [PUBMED:9182576] [PUBMED:15217908] [PUBMED:10749680] [PUBMED:16763549]
Signalling by NGF [NCBI:1269443] [REACTOME:R-HSA-166520]
Signalling to ERKs [NCBI:1269464] [REACTOME:R-HSA-187687] [PUBMED:10508738]
Signalling to RAS [NCBI:1269465] [REACTOME:R-HSA-167044] [PUBMED:11520933]
Signalling to p38 via RIT and RIN [NCBI:1269468] [REACTOME:R-HSA-187706] [PUBMED:10712923]
Syndecan interactions [NCBI:1270255] [REACTOME:R-HSA-3000170] [PUBMED:17097330] [PUBMED:15774861] [PUBMED:20565253]
Thyroid hormone signaling pathway [NCBI:946598] [KEGG:hsa04919] [PUBMED:20005976] [PUBMED:17983645] [PUBMED:15345678] [PUBMED:16951130] [PUBMED:16214361] [PUBMED:18329679] [PUBMED:20051527] [PUBMED:17574003] [PUBMED:19716314] [PUBMED:19755667] [PUBMED:20868274] [PUBMED:21835053] [PUBMED:16051672] [PUBMED:19295177] [PUBMED:23021374] [PUBMED:22484490]
VEGFA-VEGFR2 Pathway [NCBI:1269483] [REACTOME:R-HSA-4420097] [PUBMED:17344076] [PUBMED:16633338] [PUBMED:19230644] [PUBMED:13678960]
VEGFR2 mediated cell proliferation [NCBI:1269485] [REACTOME:R-HSA-5218921] [PUBMED:22866201] [PUBMED:22180219] [PUBMED:22762016]
p130Cas linkage to MAPK signaling for integrins [NCBI:1269361] [REACTOME:R-HSA-372708] [PUBMED:16581250]