Home
About
Citations
Statistics
Download
Login
Home
Genes
MDM4
Gene - MDM4
full name
MDM4, p53 regulator
synonyms
HDMX, MDMX, MRP1, MDM4, ENSG00000198625
HGNC
HGNC:6974
Entrez Gene
Gene:4194
ENSEMBL
ENSG00000198625
location
chr: 1
start: 204485507
stop: 204596131
strand: +
OMIM
OMIM:602704
: MDM4
OMIM:618849
: ?Bone marrow failure syndrome 6
transcripts
NM_002393.4
NM_001204171.1
NM_001278516.1
NM_001278518.1
NM_001278519.1
NM_001278517.1
NM_001204172.1
pathways
Cell Cycle
[NCBI:1269741]
[REACTOME:R-HSA-1640170]
Cell Cycle Checkpoints
[NCBI:1269742]
[REACTOME:R-HSA-69620]
Cellular Senescence
[NCBI:1270426]
[REACTOME:R-HSA-2559583]
[PUBMED:21078816]
[PUBMED:18711403]
[PUBMED:22048312]
[PUBMED:19818705]
[PUBMED:17662938]
[PUBMED:23746838]
[PUBMED:9282108]
[PUBMED:17667954]
[PUBMED:13905658]
Cellular responses to stress
[NCBI:1270414]
[REACTOME:R-HSA-2262752]
[PUBMED:15709958]
Deubiquitination
[NCBI:1427860]
[REACTOME:R-HSA-5688426]
[PUBMED:19243136]
[PUBMED:20074029]
[PUBMED:15571815]
[PUBMED:20418328]
[PUBMED:16325574]
[PUBMED:12944365]
[PUBMED:23845989]
[PUBMED:22201797]
G1/S DNA Damage Checkpoints
[NCBI:1269743]
[REACTOME:R-HSA-69615]
Gene Expression
[NCBI:1269649]
[REACTOME:R-HSA-74160]
Generic Transcription Pathway
[NCBI:1269650]
[REACTOME:R-HSA-212436]
[PUBMED:15175151]
[PUBMED:14744435]
[PUBMED:15680972]
[PUBMED:11395415]
[PUBMED:15896744]
[PUBMED:10235266]
[PUBMED:14986688]
[PUBMED:12023297]
[PUBMED:15680973]
[PUBMED:16751179]
[PUBMED:11861166]
[PUBMED:16429119]
[PUBMED:16719718]
[PUBMED:16921404]
[PUBMED:15690163]
Metabolism of proteins
[NCBI:1268677]
[REACTOME:R-HSA-392499]
MicroRNAs in cancer
[NCBI:852705]
[KEGG:hsa05206]
[PUBMED:23075324]
[PUBMED:21742789]
[PUBMED:22351564]
[PUBMED:18817506]
[PUBMED:22345301]
[PUBMED:21402473]
[PUBMED:22926415]
[PUBMED:23165235]
[PUBMED:19630570]
[PUBMED:21565290]
[PUBMED:23091478]
[PUBMED:23462054]
[PUBMED:23316212]
[PUBMED:19773200]
[PUBMED:22035854]
[PUBMED:20221895]
[PUBMED:20345848]
[PUBMED:22580099]
[PUBMED:20128019]
Oncogene Induced Senescence
[NCBI:1270427]
[REACTOME:R-HSA-2559585]
[PUBMED:10722742]
[PUBMED:20583212]
[PUBMED:8521522]
[PUBMED:20534573]
[PUBMED:11234019]
[PUBMED:14729966]
[PUBMED:12839923]
[PUBMED:8319905]
[PUBMED:18365017]
[PUBMED:15572696]
[PUBMED:9529249]
[PUBMED:10733595]
[PUBMED:9824166]
[PUBMED:11782450]
[PUBMED:8259215]
[PUBMED:7588608]
[PUBMED:8552081]
[PUBMED:9704925]
[PUBMED:22336108]
[PUBMED:11883935]
Oxidative Stress Induced Senescence
[NCBI:1270428]
[REACTOME:R-HSA-2559580]
[PUBMED:17344414]
[PUBMED:17332741]
[PUBMED:8622688]
[PUBMED:7588633]
[PUBMED:15563468]
[PUBMED:15287722]
[PUBMED:11062067]
[PUBMED:16337592]
[PUBMED:14532106]
[PUBMED:17254968]
[PUBMED:15866172]
[PUBMED:9628874]
[PUBMED:12171911]
[PUBMED:7816143]
[PUBMED:22020331]
[PUBMED:11564866]
[PUBMED:9162092]
[PUBMED:8974401]
[PUBMED:19451217]
[PUBMED:12808055]
[PUBMED:17210787]
[PUBMED:8846784]
[PUBMED:19462008]
[PUBMED:12134156]
[PUBMED:8626550]
[PUBMED:8774846]
[PUBMED:12189133]
[PUBMED:9195981]
[PUBMED:8622669]
[PUBMED:8259215]
[PUBMED:19528227]
[PUBMED:9564042]
[PUBMED:9529249]
[PUBMED:16436515]
[PUBMED:19451218]
[PUBMED:17395714]
[PUBMED:9030721]
[PUBMED:12435631]
[PUBMED:22325352]
Post-translational protein modification
[NCBI:1268701]
[REACTOME:R-HSA-597592]
Regulation of TP53 Activity
[NCBI:1383076]
[REACTOME:R-HSA-5633007]
[PUBMED:19450511]
[PUBMED:20457558]
[PUBMED:23825024]
[PUBMED:25641576]
Regulation of TP53 Activity through Methylation
[NCBI:1383082]
[REACTOME:R-HSA-6804760]
[PUBMED:18833288]
[PUBMED:17805299]
[PUBMED:15186775]
[PUBMED:11511361]
[PUBMED:16415881]
[PUBMED:22362889]
[PUBMED:20118233]
[PUBMED:15525938]
[PUBMED:21625555]
[PUBMED:15448695]
[PUBMED:20870725]
[PUBMED:10518217]
[PUBMED:17108971]
Regulation of TP53 Activity through Phosphorylation
[NCBI:1383080]
[REACTOME:R-HSA-6804756]
[PUBMED:11780126]
[PUBMED:21317932]
[PUBMED:15866171]
[PUBMED:12393879]
[PUBMED:11740489]
[PUBMED:11447225]
[PUBMED:9733515]
[PUBMED:12851404]
[PUBMED:10884347]
[PUBMED:10710310]
[PUBMED:11239457]
[PUBMED:9925639]
[PUBMED:11546806]
[PUBMED:11551930]
[PUBMED:10570149]
[PUBMED:18490454]
[PUBMED:17591690]
[PUBMED:19965871]
[PUBMED:12064478]
[PUBMED:10673501]
[PUBMED:22611192]
[PUBMED:9843217]
[PUBMED:15053879]
[PUBMED:12914926]
[PUBMED:10673500]
[PUBMED:17349958]
[PUBMED:14702041]
[PUBMED:20959462]
[PUBMED:10435622]
[PUBMED:9733514]
Regulation of TP53 Degradation
[NCBI:1383079]
[REACTOME:R-HSA-6804757]
[PUBMED:21730132]
[PUBMED:10570149]
[PUBMED:15563468]
[PUBMED:16845383]
[PUBMED:11923872]
[PUBMED:11883935]
[PUBMED:17290220]
[PUBMED:17121812]
[PUBMED:10673500]
[PUBMED:9843217]
[PUBMED:9529249]
[PUBMED:21730163]
[PUBMED:11715018]
[PUBMED:9733514]
[PUBMED:19838211]
[PUBMED:10608892]
[PUBMED:16474402]
[PUBMED:19450511]
[PUBMED:16163388]
[PUBMED:10722742]
[PUBMED:21986495]
[PUBMED:15788536]
[PUBMED:19816404]
[PUBMED:11359766]
[PUBMED:11504915]
[PUBMED:9733515]
[PUBMED:19756449]
[PUBMED:11983168]
[PUBMED:8319905]
[PUBMED:20438709]
Regulation of TP53 Expression and Degradation
[NCBI:1383077]
[REACTOME:R-HSA-6806003]
[PUBMED:11883935]
[PUBMED:11923872]
[PUBMED:19293287]
[PUBMED:23303139]
[PUBMED:17499002]
[PUBMED:15563468]
[PUBMED:17121812]
[PUBMED:21986495]
[PUBMED:15103385]
[PUBMED:9529249]
[PUBMED:21814038]
[PUBMED:19250907]
[PUBMED:8319905]
[PUBMED:7878469]
[PUBMED:12654245]
[PUBMED:16213212]
Stabilization of p53
[NCBI:1269746]
[REACTOME:R-HSA-69541]
[PUBMED:11331603]
[PUBMED:10673500]
[PUBMED:10673501]
[PUBMED:10710310]
Transcriptional Regulation by TP53
[NCBI:1269654]
[REACTOME:R-HSA-3700989]
[PUBMED:26122615]
[PUBMED:19410540]
Ub-specific processing proteases
[NCBI:1427862]
[REACTOME:R-HSA-5689880]
[PUBMED:16325574]
p53 pathway
[NCBI:138067]
[Pathway Interaction Database:p53regulationpathway]
[PUBMED:9153395]
[PUBMED:15448695]
[PUBMED:10734067]
[PUBMED:11340074]
[PUBMED:15525938]
[PUBMED:17189186]
[PUBMED:18454141]
[PUBMED:11715018]
[PUBMED:9733514]
[PUBMED:12963717]
[PUBMED:15989956]
[PUBMED:10581258]
[PUBMED:18566590]
[PUBMED:15029243]
[PUBMED:14612427]
[PUBMED:19011621]
[PUBMED:12842086]
[PUBMED:16377624]
[PUBMED:17268548]
[PUBMED:16845383]
[PUBMED:17534149]
[PUBMED:12397361]
[PUBMED:11740489]
[PUBMED:12110584]
[PUBMED:11713287]
[PUBMED:17646389]
[PUBMED:14654783]
[PUBMED:9153396]
[PUBMED:18243116]
[PUBMED:10673501]
[PUBMED:17719542]
[PUBMED:11983168]
[PUBMED:12397362]
[PUBMED:17189187]
[PUBMED:16757976]
[PUBMED:12667443]
[PUBMED:9733515]
[PUBMED:9878046]
[PUBMED:9363941]
[PUBMED:11504915]
[PUBMED:11359766]
[PUBMED:9529248]
[PUBMED:17936559]
[PUBMED:15210108]
[PUBMED:17293853]
[PUBMED:16107876]
[PUBMED:9724636]
[PUBMED:17707234]
[PUBMED:10606744]
[PUBMED:11780126]
[PUBMED:10821866]
[PUBMED:18485870]
[PUBMED:17110336]
[PUBMED:11046142]
[PUBMED:11331603]
[PUBMED:19597489]
[PUBMED:16163388]
[PUBMED:14671306]
[PUBMED:17108971]
[PUBMED:15242646]
[PUBMED:15314173]
[PUBMED:12654245]
[PUBMED:15308643]
[PUBMED:9744860]
[PUBMED:17906639]
[PUBMED:9891054]
[PUBMED:17098746]
[PUBMED:17349958]
[PUBMED:11030628]
[PUBMED:15103385]
[PUBMED:14744935]
[PUBMED:9529249]
[PUBMED:11283254]
[PUBMED:11606419]
[PUBMED:11078726]
[PUBMED:10611322]
[PUBMED:9288740]
[PUBMED:11127820]
[PUBMED:19357310]
[PUBMED:9450543]
p53 signaling pathway
[NCBI:83055]
[KEGG:hsa04115]
[PUBMED:16557269]
[PUBMED:10714958]
[PUBMED:12505356]
[PUBMED:16915296]
[PUBMED:16697662]
[PUBMED:15116721]
[PUBMED:11313928]
[PUBMED:11747320]
[PUBMED:17409411]
[PUBMED:15838523]
p53-Dependent G1 DNA Damage Response
[NCBI:1269745]
[REACTOME:R-HSA-69563]
[PUBMED:9153396]
[PUBMED:8247533]
[PUBMED:1423616]
[PUBMED:9153395]
p53-Dependent G1/S DNA damage checkpoint
[NCBI:1269744]
[REACTOME:R-HSA-69580]
[PUBMED:1323840]