full name
NME/NM23 nucleoside diphosphate kinase 1

synonyms
AWD, GAAD, NB, NBS, NDKA, NDPK-A, NDPKA, NM23, NM23-H1, NME1, ENSG00000239672

HGNC
HGNC:7849

Entrez Gene
Gene:4830

ENSEMBL
ENSG00000239672

location
chr: 17
start: 49230920
stop: 49239450
strand: +

OMIM
OMIM:156490: NME1 (Autosomal dominant inheritance,Heterogeneous,Sporadic)
OMIM:256700: Neuroblastoma

transcripts
NM_198175.1
NM_000269.2

pathways
Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [NCBI:618580] [KEGG:hsa_M00049]
Arf6 downstream pathway [NCBI:138038] [Pathway Interaction Database:arf6downstreampathway] [PUBMED:12388770] [PUBMED:14565977] [PUBMED:10036235] [PUBMED:14764880] [PUBMED:12447393] [PUBMED:9312003] [PUBMED:17077126] [PUBMED:17363898] [PUBMED:14505574] [PUBMED:16280360] [PUBMED:17628206] [PUBMED:15601896] [PUBMED:10913182] [PUBMED:16452216] [PUBMED:7753201] [PUBMED:15210957] [PUBMED:16880525] [PUBMED:16181626] [PUBMED:17640372] [PUBMED:11481345] [PUBMED:17409355] [PUBMED:12379803] [PUBMED:18084281] [PUBMED:10589680] [PUBMED:11532961] [PUBMED:17353194] [PUBMED:8769418] [PUBMED:10779358] [PUBMED:18026091] [PUBMED:12509462] [PUBMED:15087504] [PUBMED:9664047]
Arf6 trafficking events [NCBI:137954] [Pathway Interaction Database:arf6_traffickingpathway] [PUBMED:10748097] [PUBMED:15590645] [PUBMED:15980073] [PUBMED:19644450] [PUBMED:16461286] [PUBMED:14675422] [PUBMED:16139226] [PUBMED:12589044] [PUBMED:15802264] [PUBMED:14585928] [PUBMED:17664335] [PUBMED:17719203] [PUBMED:12960436] [PUBMED:12447393] [PUBMED:11535619] [PUBMED:12657640] [PUBMED:16280360] [PUBMED:9314528] [PUBMED:19211056] [PUBMED:11533043] [PUBMED:12847086] [PUBMED:15146059] [PUBMED:9685333] [PUBMED:12925709] [PUBMED:15231847] [PUBMED:12810696] [PUBMED:14662749] [PUBMED:16030257] [PUBMED:12379803] [PUBMED:15775968] [PUBMED:11532961] [PUBMED:8769418]
CMP phosphorylation [NCBI:782393] [BIOCYC:HUMAN_PWY-7205]
E-cadherin signaling in the nascent adherens junction [NCBI:138005] [Pathway Interaction Database:ecadherin_nascentaj_pathway] [PUBMED:16371509] [PUBMED:9694656] [PUBMED:9214391] [PUBMED:17620337] [PUBMED:7969453] [PUBMED:11882288] [PUBMED:19158278] [PUBMED:11716761] [PUBMED:10402472] [PUBMED:15263019] [PUBMED:12427869] [PUBMED:11457821] [PUBMED:6976838] [PUBMED:10037790] [PUBMED:10660044] [PUBMED:15857834] [PUBMED:10202138] [PUBMED:10980705] [PUBMED:15159390] [PUBMED:2349235] [PUBMED:19114658] [PUBMED:14585958] [PUBMED:18632982] [PUBMED:12432063] [PUBMED:17261850] [PUBMED:10383446] [PUBMED:11329369] [PUBMED:14699157] [PUBMED:7954478] [PUBMED:10629228] [PUBMED:8207061] [PUBMED:15556934] [PUBMED:10473551] [PUBMED:12370292] [PUBMED:14610055] [PUBMED:16170364] [PUBMED:12770907] [PUBMED:17553930] [PUBMED:17164293] [PUBMED:2788574] [PUBMED:9512503] [PUBMED:10201395] [PUBMED:15254236] [PUBMED:15024035] [PUBMED:12447393] [PUBMED:11744701] [PUBMED:14668487] [PUBMED:18187454]
Guanine ribonucleotide biosynthesis IMP => GDP,GTP [NCBI:618581] [KEGG:hsa_M00050]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of nucleotides [NCBI:1270133] [REACTOME:R-HSA-15869] [PUBMED:17266529] [PUBMED:8283301] [PUBMED:20494131]
Purine metabolism [NCBI:82944] [KEGG:hsa00230] [NCBI:1270134] [REACTOME:R-HSA-73847] [PUBMED:4620886] [PUBMED:10986234] [PUBMED:10601204]
Pyrimidine metabolism [NCBI:82946] [KEGG:hsa00240] [NCBI:1270138] [REACTOME:R-HSA-73848] [PUBMED:16098809]
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP [NCBI:413360] [KEGG:hsa_M00052]
Regulation of CDC42 activity [NCBI:137990] [Pathway Interaction Database:cdc42_reg_pathway] [PUBMED:19581296] [PUBMED:17297291] [PUBMED:14506234] [PUBMED:17145773] [PUBMED:8798610] [PUBMED:17015620] [PUBMED:9535855] [PUBMED:15710388] [PUBMED:12547822] [PUBMED:15728722] [PUBMED:11285260] [PUBMED:11748279] [PUBMED:8969170] [PUBMED:17538024] [PUBMED:11336673] [PUBMED:12172552] [PUBMED:15850391] [PUBMED:18208356] [PUBMED:10523665] [PUBMED:1429634] [PUBMED:19156867] [PUBMED:19356586] [PUBMED:16616186] [PUBMED:15247287] [PUBMED:9497316] [PUBMED:10559246] [PUBMED:14506284] [PUBMED:16892055] [PUBMED:19525225] [PUBMED:11741931] [PUBMED:17562871] [PUBMED:18470881] [PUBMED:1439791] [PUBMED:10744696] [PUBMED:7673236] [PUBMED:12432077] [PUBMED:17196961] [PUBMED:10982832] [PUBMED:16968698] [PUBMED:11431473] [PUBMED:10676816] [PUBMED:15277544] [PUBMED:18728402] [PUBMED:15793564] [PUBMED:18056264] [PUBMED:9268338] [PUBMED:12517963] [PUBMED:1956381] [PUBMED:15504743] [PUBMED:17599059] [PUBMED:15649357] [PUBMED:10652228] [PUBMED:15306850] [PUBMED:19745154]
Regulation of RAC1 activity [NCBI:169346] [Pathway Interaction Database:rac1_reg_pathway] [PUBMED:8297393] [PUBMED:12134164] [PUBMED:15485841] [PUBMED:11707441] [PUBMED:17320046] [PUBMED:9857026] [PUBMED:9497316] [PUBMED:17254573] [PUBMED:15850775] [PUBMED:8352776] [PUBMED:15128856] [PUBMED:17403664] [PUBMED:8491184] [PUBMED:7753201] [PUBMED:9707409] [PUBMED:12432077] [PUBMED:8226937] [PUBMED:19934221] [PUBMED:17196961] [PUBMED:17640372] [PUBMED:11287617] [PUBMED:12515821] [PUBMED:16943182] [PUBMED:19861492] [PUBMED:10220378] [PUBMED:11431473] [PUBMED:10982832] [PUBMED:7673236] [PUBMED:10744696] [PUBMED:17599059] [PUBMED:17116687] [PUBMED:12923183] [PUBMED:10364228] [PUBMED:16628218] [PUBMED:8288572] [PUBMED:15306850] [PUBMED:11396949] [PUBMED:8496137] [PUBMED:11912491] [PUBMED:15649357] [PUBMED:7980444] [PUBMED:18325335] [PUBMED:15242348] [PUBMED:11955434] [PUBMED:15039778] [PUBMED:11685227] [PUBMED:15897194] [PUBMED:11130063] [PUBMED:10559863] [PUBMED:17052214] [PUBMED:11099046] [PUBMED:15728722] [PUBMED:16520382] [PUBMED:16492808] [PUBMED:12547822] [PUBMED:12446789] [PUBMED:11274357] [PUBMED:8419353] [PUBMED:16481401] [PUBMED:8276860] [PUBMED:15005707] [PUBMED:10499589] [PUBMED:11336673] [PUBMED:1903516] [PUBMED:12829596] [PUBMED:17332503] [PUBMED:11146652] [PUBMED:12134158] [PUBMED:8643598] [PUBMED:18212043]
Synthesis and interconversion of nucleotide di- and triphosphates [NCBI:1270142] [REACTOME:R-HSA-499943] [PUBMED:177353] [PUBMED:11008000] [PUBMED:5940]
UTP and CTP de novo biosynthesis [NCBI:782388] [BIOCYC:HUMAN_PWY-7176]
Validated targets of C-MYC transcriptional activation [NCBI:169351] [Pathway Interaction Database:myc_activpathway] [PUBMED:18987359] [PUBMED:16537449] [PUBMED:9924025] [PUBMED:17643117] [PUBMED:8356088] [PUBMED:10688915] [PUBMED:1562593] [PUBMED:19020761] [PUBMED:10823814] [PUBMED:12637527] [PUBMED:9178906] [PUBMED:17967894] [PUBMED:15723053] [PUBMED:16508012] [PUBMED:8700224] [PUBMED:12091391] [PUBMED:20173740] [PUBMED:11522645] [PUBMED:15774466] [PUBMED:12776737] [PUBMED:12011429] [PUBMED:12138190] [PUBMED:10022128] [PUBMED:11511539] [PUBMED:12177005] [PUBMED:17599065] [PUBMED:6438521] [PUBMED:19745813] [PUBMED:8196628] [PUBMED:10891489] [PUBMED:8934531] [PUBMED:15723054] [PUBMED:9192621] [PUBMED:18042711] [PUBMED:10779353] [PUBMED:1989881] [PUBMED:8861962] [PUBMED:12529648] [PUBMED:16269333] [PUBMED:16172399] [PUBMED:8494784] [PUBMED:15282543] [PUBMED:8297793] [PUBMED:12776177] [PUBMED:9811896] [PUBMED:11103792] [PUBMED:17170079] [PUBMED:18593934] [PUBMED:11673469] [PUBMED:18408012] [PUBMED:1340466] [PUBMED:17088530] [PUBMED:8327497] [PUBMED:16423995] [PUBMED:12816956] [PUBMED:11598121] [PUBMED:14724288] [PUBMED:17848523] [PUBMED:10508165] [PUBMED:12695333] [PUBMED:17822678] [PUBMED:10606642] [PUBMED:9869632] [PUBMED:9212167] [PUBMED:19211792] [PUBMED:16287840] [PUBMED:18978814] [PUBMED:11511535] [PUBMED:15944709] [PUBMED:11604407] [PUBMED:11909865]
adenosine deoxyribonucleotides de novo biosynthesis [NCBI:835388] [BIOCYC:HUMAN_PWY-7227]
guanosine deoxyribonucleotides de novo biosynthesis [NCBI:835387] [BIOCYC:HUMAN_PWY-7226]
guanosine nucleotides de novo biosynthesis [NCBI:907941] [BIOCYC:HUMAN_PWY-7228] [PUBMED:2404765]
guanosine ribonucleotides de novo biosynthesis [NCBI:835390] [BIOCYC:HUMAN_PWY-7221]
purine deoxyribonucleosides salvage [NCBI:782395] [BIOCYC:HUMAN_PWY-7224] [PUBMED:12009894] [PUBMED:1659321] [PUBMED:3044582] [PUBMED:6295492] [PUBMED:3030413] [PUBMED:2021937] [PUBMED:3048401] [PUBMED:7494863] [PUBMED:1696835] [PUBMED:11008000] [PUBMED:1406603]
purine nucleotides de novo biosynthesis [NCBI:142277] [BIOCYC:HUMAN_PWY-841] [PUBMED:23575936] [PUBMED:22955281] [PUBMED:18365665] [PUBMED:20575936] [PUBMED:20157113] [PUBMED:18712276] [PUBMED:23359685] [PUBMED:8938402] [PUBMED:20615962] [PUBMED:18388293]
pyrimidine deoxyribonucleotide phosphorylation [NCBI:782379] [BIOCYC:HUMAN_PWY-7197]
pyrimidine deoxyribonucleotides biosynthesis from CTP [NCBI:782381] [BIOCYC:HUMAN_PWY-7210]
pyrimidine deoxyribonucleotides de novo biosynthesis [NCBI:782380] [BIOCYC:HUMAN_PWY-7184]
superpathway of purine nucleotide salvage [NCBI:907942] [BIOCYC:HUMAN_PWY66-409] [PUBMED:18712276] [PUBMED:18365665] [PUBMED:16176880] [PUBMED:23575936] [PUBMED:1301916]
superpathway of pyrimidine deoxyribonucleoside salvage [NCBI:782391] [BIOCYC:HUMAN_PWY-7200]
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis [NCBI:782390] [BIOCYC:HUMAN_PWY-7211] [PUBMED:9042911] [PUBMED:2767686] [PUBMED:6893554] [PUBMED:3279416] [PUBMED:6574608]
superpathway of pyrimidine ribonucleotides de novo biosynthesis [NCBI:142283] [BIOCYC:HUMAN_PWY0-162] [PUBMED:15604701] [PUBMED:6893554] [PUBMED:9576794] [PUBMED:16669783] [PUBMED:12369616] [PUBMED:2767686] [PUBMED:9042911] [PUBMED:16024685] [PUBMED:3279416] [PUBMED:6574608]