full name
clathrin heavy chain
synonyms
CHC, CHC17, CLH-17, CLTCL2, Hc, CLTC, ENSG00000141367
HGNC
HGNC:2092
Entrez Gene
Gene:1213
ENSEMBL
ENSG00000141367
location
chr: 17
start: 57697050
stop: 57774317
strand: +
OMIM
OMIM:118955:
CLTC
OMIM:617854:
Mental retardation, autosomal dominant 56
transcripts
NM_004859.3
pathways
Adaptive Immune System
[NCBI:1269171]
[REACTOME:R-HSA-1280218]
[PUBMED:16551257]
[PUBMED:21682741]
[PUBMED:11861602]
Arf6 trafficking events
[NCBI:137954]
[Pathway Interaction Database:arf6_traffickingpathway]
[PUBMED:10748097]
[PUBMED:15590645]
[PUBMED:15980073]
[PUBMED:19644450]
[PUBMED:16461286]
[PUBMED:14675422]
[PUBMED:16139226]
[PUBMED:12589044]
[PUBMED:15802264]
[PUBMED:14585928]
[PUBMED:17664335]
[PUBMED:17719203]
[PUBMED:12960436]
[PUBMED:12447393]
[PUBMED:11535619]
[PUBMED:12657640]
[PUBMED:16280360]
[PUBMED:9314528]
[PUBMED:19211056]
[PUBMED:11533043]
[PUBMED:12847086]
[PUBMED:15146059]
[PUBMED:9685333]
[PUBMED:12925709]
[PUBMED:15231847]
[PUBMED:12810696]
[PUBMED:14662749]
[PUBMED:16030257]
[PUBMED:12379803]
[PUBMED:15775968]
[PUBMED:11532961]
[PUBMED:8769418]
Axon guidance
[NCBI:83065]
[KEGG:hsa04360]
[NCBI:1270303]
[REACTOME:R-HSA-422475]
[PUBMED:14682358]
[PUBMED:15084255]
[PUBMED:11687826]
[PUBMED:15818466]
[PUBMED:15363605]
[PUBMED:12471249]
[PUBMED:15630019]
[PUBMED:11891122]
[PUBMED:15960985]
[PUBMED:12677003]
Bacterial invasion of epithelial cells
[NCBI:149807]
[KEGG:hsa05100]
[PUBMED:17298394]
[PUBMED:16406780]
[PUBMED:19185531]
[PUBMED:19157959]
[PUBMED:17719540]
[PUBMED:19296488]
Beta-catenin independent WNT signaling
[NCBI:1269610]
[REACTOME:R-HSA-3858494]
[PUBMED:22935904]
[PUBMED:21903638]
[PUBMED:23256519]
[PUBMED:8065359]
[PUBMED:7739543]
[PUBMED:23140633]
Cargo recognition for clathrin-mediated endocytosis
[NCBI:1427859]
[REACTOME:R-HSA-8856825]
[PUBMED:24186068]
[PUBMED:12952941]
[PUBMED:19696796]
[PUBMED:14985334]
[PUBMED:20448150]
[PUBMED:20485680]
[PUBMED:16382132]
[PUBMED:23482940]
[PUBMED:16870701]
Clathrin derived vesicle budding
[NCBI:1269881]
[REACTOME:R-HSA-421837]
Clathrin-mediated endocytosis
[NCBI:1427858]
[REACTOME:R-HSA-8856828]
[PUBMED:16516836]
[PUBMED:15339664]
[PUBMED:19754444]
[PUBMED:8552632]
[PUBMED:21779028]
[PUBMED:12353027]
[PUBMED:23891661]
[PUBMED:21613550]
[PUBMED:20059951]
[PUBMED:21447041]
[PUBMED:17620409]
[PUBMED:16903783]
[PUBMED:21445324]
[PUBMED:19696798]
[PUBMED:26246598]
[PUBMED:25085911]
[PUBMED:24186068]
[PUBMED:26829388]
[PUBMED:27092250]
[PUBMED:24581490]
[PUBMED:26042225]
[PUBMED:23823722]
[PUBMED:24789820]
[PUBMED:9736607]
[PUBMED:23637288]
[PUBMED:22233676]
[PUBMED:19458185]
[PUBMED:26403691]
[PUBMED:19296720]
[PUBMED:15703209]
[PUBMED:20428113]
[PUBMED:8953040]
[PUBMED:1177317]
[PUBMED:9092476]
[PUBMED:26872272]
[PUBMED:19092055]
Developmental Biology
[NCBI:1270302]
[REACTOME:R-HSA-1266738]
Disease
[NCBI:1268854]
[REACTOME:R-HSA-1643685]
EPH-Ephrin signaling
[NCBI:1270330]
[REACTOME:R-HSA-2682334]
[PUBMED:18281458]
[PUBMED:22120527]
EPH-ephrin mediated repulsion of cells
[NCBI:1270334]
[REACTOME:R-HSA-3928665]
[PUBMED:10958785]
[PUBMED:16239146]
[PUBMED:12973357]
[PUBMED:18713744]
[PUBMED:17420126]
Endocrine and other factor-regulated calcium reabsorption
[NCBI:213307]
[KEGG:hsa04961]
[PUBMED:15747113]
[PUBMED:20969972]
[PUBMED:15618484]
[PUBMED:18989697]
[PUBMED:19423690]
[PUBMED:18293139]
[PUBMED:18596722]
[PUBMED:16518325]
[PUBMED:17006539]
[PUBMED:12684797]
[PUBMED:17233615]
[PUBMED:16044309]
Endocytosis
[NCBI:102279]
[KEGG:hsa04144]
[PUBMED:19696797]
[PUBMED:19007773]
[PUBMED:16203612]
[PUBMED:15687999]
[PUBMED:19924646]
[PUBMED:15261671]
[PUBMED:18647649]
[PUBMED:19325624]
[PUBMED:20110990]
[PUBMED:22193161]
Entry of Influenza Virion into Host Cell via Endocytosis
[NCBI:1269110]
[REACTOME:R-HSA-168275]
FAS (CD95) signaling pathway
[NCBI:138081]
[Pathway Interaction Database:faspathway]
[PUBMED:9765224]
[PUBMED:11717445]
[PUBMED:9727491]
[PUBMED:11279218]
[PUBMED:12110583]
[PUBMED:11739735]
[PUBMED:8521815]
[PUBMED:9184224]
[PUBMED:20153221]
[PUBMED:9126929]
[PUBMED:10200443]
[PUBMED:16033886]
[PUBMED:8681377]
[PUBMED:9880544]
[PUBMED:9501089]
[PUBMED:10535980]
[PUBMED:9727492]
[PUBMED:7523573]
[PUBMED:11101870]
[PUBMED:9321399]
[PUBMED:9362518]
[PUBMED:12724420]
[PUBMED:16498403]
[PUBMED:11583996]
[PUBMED:15557123]
[PUBMED:7536343]
[PUBMED:12832037]
[PUBMED:9576928]
[PUBMED:9228058]
[PUBMED:7538908]
[PUBMED:18635548]
[PUBMED:20038679]
[PUBMED:10894163]
[PUBMED:12545171]
[PUBMED:16619028]
[PUBMED:9351817]
[PUBMED:9045686]
[PUBMED:15289496]
Formation of annular gap junctions
[NCBI:1269892]
[REACTOME:R-HSA-196025]
[PUBMED:17108328]
Gap junction degradation
[NCBI:1269891]
[REACTOME:R-HSA-190873]
[PUBMED:17108328]
[PUBMED:8522583]
Gap junction trafficking
[NCBI:1269885]
[REACTOME:R-HSA-190828]
[PUBMED:8522583]
[PUBMED:15033576]
Gap junction trafficking and regulation
[NCBI:1269884]
[REACTOME:R-HSA-157858]
[PUBMED:15033576]
[PUBMED:11737941]
[PUBMED:9861669]
[PUBMED:11146276]
Golgi Associated Vesicle Biogenesis
[NCBI:1269882]
[REACTOME:R-HSA-432722]
Huntington's disease
[NCBI:83100]
[KEGG:hsa05016]
[PUBMED:15336977]
[PUBMED:11738471]
[PUBMED:11807533]
[PUBMED:15996546]
[PUBMED:14526190]
[PUBMED:15242639]
[PUBMED:17041811]
[PUBMED:15996541]
[PUBMED:18951640]
[PUBMED:15459747]
[PUBMED:16288298]
[PUBMED:17081970]
[PUBMED:15695335]
[PUBMED:12372277]
[PUBMED:11839795]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Infectious disease
[NCBI:1269056]
[REACTOME:R-HSA-5663205]
Influenza Infection
[NCBI:1269108]
[REACTOME:R-HSA-168254]
Influenza Life Cycle
[NCBI:1269109]
[REACTOME:R-HSA-168255]
L1CAM interactions
[NCBI:1270323]
[REACTOME:R-HSA-373760]
[PUBMED:9211984]
[PUBMED:18760361]
[PUBMED:14709786]
[PUBMED:17189949]
[PUBMED:19356150]
LDL-mediated lipid transport
[NCBI:1270008]
[REACTOME:R-HSA-171052]
[PUBMED:2088165]
[PUBMED:15952897]
Lipid digestion, mobilization, and transport
[NCBI:1270002]
[REACTOME:R-HSA-73923]
Lipoprotein metabolism
[NCBI:1270005]
[REACTOME:R-HSA-174824]
Lysosome
[NCBI:99052]
[KEGG:hsa04142]
[PUBMED:2943218]
[PUBMED:12628346]
[PUBMED:1883197]
[PUBMED:18635948]
[PUBMED:15987739]
Lysosome Vesicle Biogenesis
[NCBI:1269883]
[REACTOME:R-HSA-432720]
MHC class II antigen presentation
[NCBI:1269200]
[REACTOME:R-HSA-2132295]
[PUBMED:19703008]
[PUBMED:9316394]
[PUBMED:11684289]
[PUBMED:19217269]
[PUBMED:8689559]
Membrane Trafficking
[NCBI:1269877]
[REACTOME:R-HSA-199991]
[PUBMED:11031247]
Metabolism
[NCBI:1269956]
[REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins
[NCBI:1270001]
[REACTOME:R-HSA-556833]
NGF signalling via TRKA from the plasma membrane
[NCBI:1269460]
[REACTOME:R-HSA-187037]
[PUBMED:11520933]
[PUBMED:12676795]
[PUBMED:10851172]
[PUBMED:10579918]
PCP/CE pathway
[NCBI:1269611]
[REACTOME:R-HSA-4086400]
[PUBMED:23140633]
[PUBMED:18848778]
[PUBMED:10811221]
[PUBMED:19365405]
[PUBMED:9598355]
[PUBMED:21983142]
[PUBMED:17433286]
[PUBMED:20004982]
[PUBMED:19204114]
Recycling pathway of L1
[NCBI:1270324]
[REACTOME:R-HSA-437239]
[PUBMED:10804209]
[PUBMED:11717353]
[PUBMED:14709786]
Retrograde neurotrophin signalling
[NCBI:1269476]
[REACTOME:R-HSA-177504]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by Wnt
[NCBI:1269594]
[REACTOME:R-HSA-195721]
[PUBMED:19530173]
[PUBMED:23256519]
[PUBMED:22952392]
[PUBMED:19204114]
[PUBMED:19365405]
[PUBMED:19619488]
[PUBMED:17143292]
[PUBMED:17230199]
[PUBMED:18710302]
[PUBMED:16099039]
[PUBMED:20576942]
[PUBMED:10858654]
[PUBMED:12967557]
Signalling by NGF
[NCBI:1269443]
[REACTOME:R-HSA-166520]
Synaptic vesicle cycle
[NCBI:373900]
[KEGG:hsa04721]
[PUBMED:20634814]
[PUBMED:17767192]
[PUBMED:12094216]
[PUBMED:16990140]
[PUBMED:18726177]
[PUBMED:18275379]
[PUBMED:12827282]
[PUBMED:12154365]
[PUBMED:10212473]
[PUBMED:15217342]
[PUBMED:7791897]
[PUBMED:12563290]
VLDL interactions
[NCBI:1427851]
[REACTOME:R-HSA-8855121]
[PUBMED:22461740]
[PUBMED:12870663]
[PUBMED:25544176]
[PUBMED:20525064]
[PUBMED:14748713]
[PUBMED:22510808]
VLDLR internalisation and degradation
[NCBI:1427853]
[REACTOME:R-HSA-8866427]
[PUBMED:18039658]
Vesicle-mediated transport
[NCBI:1269876]
[REACTOME:R-HSA-5653656]
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
[NCBI:1269614]
[REACTOME:R-HSA-5140745]
[PUBMED:17117926]
[PUBMED:22101459]
[PUBMED:19910923]
[PUBMED:19582886]
WNT5A-dependent internalization of FZD4
[NCBI:1269613]
[REACTOME:R-HSA-5099900]
[PUBMED:12958364]
[PUBMED:20947020]
[PUBMED:17199046]
trans-Golgi Network Vesicle Budding
[NCBI:1269880]
[REACTOME:R-HSA-199992]
[PUBMED:11252894]
