full name
small ubiquitin-like modifier 2

synonyms
HSMT3, Smt3A, SMT3B, SMT3H2, SUMO3, SUMO2, ENSG00000188612

HGNC
HGNC:11125

Entrez Gene
Gene:6613

ENSEMBL
ENSG00000188612

location
chr: 17
start: 73163825
stop: 73179098
strand: -

transcripts
NM_001005849.1
NM_006937.3

pathways
DNA Double-Strand Break Repair [NCBI:1309095] [REACTOME:R-HSA-5693532] [PUBMED:12897142] [PUBMED:20965415]
DNA Repair [NCBI:1270350] [REACTOME:R-HSA-73894] [PUBMED:10583946] [PUBMED:23175119]
Fluid shear stress and atherosclerosis [NCBI:1474302] [KEGG:hsa05418] [PUBMED:23429585] [PUBMED:21050140] [PUBMED:17599600] [PUBMED:24190880] [PUBMED:22003002] [PUBMED:24876354] [PUBMED:24947523] [PUBMED:23899566] [PUBMED:26597822] [PUBMED:20353494] [PUBMED:22076424] [PUBMED:20538799] [PUBMED:25165867] [PUBMED:20032497] [PUBMED:23084990] [PUBMED:26822720] [PUBMED:24573382] [PUBMED:23555159] [PUBMED:26212910] [PUBMED:21457103] [PUBMED:19151844] [PUBMED:15388638] [PUBMED:16765337] [PUBMED:27027326] [PUBMED:25638487] [PUBMED:21733876]
Formation of Incision Complex in GG-NER [NCBI:1309114] [REACTOME:R-HSA-5696395] [PUBMED:17948053] [PUBMED:17466626] [PUBMED:11511374] [PUBMED:9716411] [PUBMED:17000769] [PUBMED:15590680] [PUBMED:19940136] [PUBMED:14517266] [PUBMED:16491090] [PUBMED:23038248]
Global Genome Nucleotide Excision Repair (GG-NER) [NCBI:1309112] [REACTOME:R-HSA-5696399] [PUBMED:24954209]
Glucocorticoid receptor regulatory network [NCBI:138014] [Pathway Interaction Database:reg_gr_pathway] [PUBMED:8943293] [PUBMED:1708774] [PUBMED:15826950] [PUBMED:11027313] [PUBMED:12118039] [PUBMED:9388207] [PUBMED:11751894] [PUBMED:12151000] [PUBMED:9765258] [PUBMED:9407028] [PUBMED:19074285] [PUBMED:2838908] [PUBMED:15817653] [PUBMED:9722596] [PUBMED:12917342] [PUBMED:1387550] [PUBMED:10974006] [PUBMED:15790729] [PUBMED:10825196] [PUBMED:10623828] [PUBMED:2169352] [PUBMED:9315653] [PUBMED:7759501] [PUBMED:8290595] [PUBMED:2905764] [PUBMED:12351702] [PUBMED:11080152] [PUBMED:8428574] [PUBMED:9215863] [PUBMED:15459252] [PUBMED:10400612] [PUBMED:9426156] [PUBMED:17440046] [PUBMED:18838540] [PUBMED:2169353] [PUBMED:10820245] [PUBMED:12511605] [PUBMED:2586521] [PUBMED:1740658] [PUBMED:11555652] [PUBMED:11562347] [PUBMED:9482836] [PUBMED:18337589] [PUBMED:10958685] [PUBMED:9388192] [PUBMED:15834420] [PUBMED:15657031] [PUBMED:8878484] [PUBMED:10760263] [PUBMED:12730237] [PUBMED:8702844] [PUBMED:2169351] [PUBMED:17215482] [PUBMED:8898375]
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) [NCBI:1309100] [REACTOME:R-HSA-5693567] [PUBMED:20965415]
Homology Directed Repair [NCBI:1309099] [REACTOME:R-HSA-5693538] [PUBMED:11242102] [PUBMED:20965415] [PUBMED:11376695] [PUBMED:12427531]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Nucleotide Excision Repair [NCBI:1309111] [REACTOME:R-HSA-5696398] [PUBMED:11900249] [PUBMED:23906714] [PUBMED:14599765] [PUBMED:10583946] [PUBMED:24954209] [PUBMED:19023283]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
Processing and activation of SUMO [NCBI:1268739] [REACTOME:R-HSA-3215018] [PUBMED:16253240] [PUBMED:17591783] [PUBMED:11896061] [PUBMED:19923268] [PUBMED:16738315] [PUBMED:12192048] [PUBMED:20462400] [PUBMED:17099700] [PUBMED:17768054] [PUBMED:20674646] [PUBMED:21102611] [PUBMED:17099698] [PUBMED:16738331] [PUBMED:14563852]
Processing of DNA double-strand break ends [NCBI:1309101] [REACTOME:R-HSA-5693607] [PUBMED:25122754] [PUBMED:18171670] [PUBMED:20965415] [PUBMED:22231403] [PUBMED:25558984] [PUBMED:19357644] [PUBMED:21325134] [PUBMED:21240188] [PUBMED:21659603] [PUBMED:23468639] [PUBMED:25659039]
RNA transport [NCBI:177876] [KEGG:hsa03013] [PUBMED:10872469] [PUBMED:17401408] [PUBMED:20733056] [PUBMED:11018020] [PUBMED:15519698] [PUBMED:16314458] [PUBMED:15901496] [PUBMED:9548260] [PUBMED:18313922]
SUMO E3 ligases SUMOylate target proteins [NCBI:1268743] [REACTOME:R-HSA-3108232] [PUBMED:20674646] [PUBMED:17763827] [PUBMED:19471022] [PUBMED:23746258] [PUBMED:24016193] [PUBMED:23503365] [PUBMED:21252943] [PUBMED:17000644] [PUBMED:24273646] [PUBMED:22811915] [PUBMED:21693764] [PUBMED:23277067] [PUBMED:21102611]
SUMO is conjugated to E1 (UBA2:SAE1) [NCBI:1268741] [REACTOME:R-HSA-3065676] [PUBMED:20164921] [PUBMED:19923268] [PUBMED:21102611] [PUBMED:20674646]
SUMO is proteolytically processed [NCBI:1268740] [REACTOME:R-HSA-3065679] [PUBMED:20462400] [PUBMED:16608850] [PUBMED:21102611] [PUBMED:20674646] [PUBMED:14563852] [PUBMED:16253240] [PUBMED:16738331] [PUBMED:11896061] [PUBMED:17591783] [PUBMED:19923268] [PUBMED:12192048] [PUBMED:16738315]
SUMO is transferred from E1 to E2 (UBE2I, UBC9) [NCBI:1268742] [REACTOME:R-HSA-3065678] [PUBMED:20462400] [PUBMED:20674646] [PUBMED:21102611] [PUBMED:19923268]
SUMOylation [NCBI:1268738] [REACTOME:R-HSA-2990846] [PUBMED:21102611] [PUBMED:20674646] [PUBMED:23514139] [PUBMED:19923268] [PUBMED:20462400] [PUBMED:17768054]
SUMOylation of DNA damage response and repair proteins [NCBI:1268744] [REACTOME:R-HSA-3108214] [PUBMED:22018829] [PUBMED:24926426] [PUBMED:23122649] [PUBMED:23781231] [PUBMED:23416108] [PUBMED:21486569] [PUBMED:23746258] [PUBMED:21896653] [PUBMED:22357966] [PUBMED:21664912]
SUMOylation of DNA replication proteins [NCBI:1339113] [REACTOME:R-HSA-4615885] [PUBMED:22812528] [PUBMED:17031663] [PUBMED:22918591] [PUBMED:22732495] [PUBMED:16368276]
SUMOylation of RNA binding proteins [NCBI:1339112] [REACTOME:R-HSA-4570464] [PUBMED:23979992] [PUBMED:15161980]
SUMOylation of chromatin organization proteins [NCBI:1339111] [REACTOME:R-HSA-4551638] [PUBMED:23328396]
SUMOylation of transcription factors [NCBI:1339110] [REACTOME:R-HSA-3232118] [PUBMED:16095902] [PUBMED:21892772] [PUBMED:19107415] [PUBMED:19616654] [PUBMED:15209380] [PUBMED:18031228]