full name
sphingosine kinase 1

synonyms
SPHK, SPHK1, ENSG00000176170

HGNC
HGNC:11240

Entrez Gene
Gene:8877

ENSEMBL
ENSG00000176170

location
chr: 17
start: 74372742
stop: 74383941
strand: +

transcripts
NM_182965.2
NM_021972.3
NM_001142601.1
NM_001142602.1

pathways
Apelin signaling pathway [NCBI:1492886] [KEGG:hsa04371] [PUBMED:23973488] [PUBMED:16182514] [PUBMED:21725702] [PUBMED:22842084] [PUBMED:27825851] [PUBMED:27650065] [PUBMED:22140623] [PUBMED:23943882] [PUBMED:26944568] [PUBMED:24055369] [PUBMED:26385179] [PUBMED:26143239] [PUBMED:22028387] [PUBMED:26254105] [PUBMED:26756969] [PUBMED:22995518] [PUBMED:27979574] [PUBMED:23924696] [PUBMED:21464822] [PUBMED:25914650] [PUBMED:24990699] [PUBMED:26607438] [PUBMED:25164121] [PUBMED:25275559] [PUBMED:25139773] [PUBMED:25931124] [PUBMED:19093215] [PUBMED:20539939] [PUBMED:25652330] [PUBMED:18272138] [PUBMED:23603510]
Association of TriC/CCT with target proteins during biosynthesis [NCBI:1268699] [REACTOME:R-HSA-390471] [PUBMED:19011634]
Calcium signaling pathway [NCBI:83050] [KEGG:hsa04020] [PUBMED:11080247] [PUBMED:14572802] [PUBMED:11413485] [PUBMED:22129055] [PUBMED:10508738] [PUBMED:15000521] [PUBMED:9235901] [PUBMED:7861177] [PUBMED:9149541] [PUBMED:14517314] [PUBMED:15111104] [PUBMED:11698232] [PUBMED:10331643] [PUBMED:12838335] [PUBMED:8125957] [PUBMED:19172794] [PUBMED:10997573] [PUBMED:21338471] [PUBMED:11299192] [PUBMED:22002090] [PUBMED:12972622]
Chaperonin-mediated protein folding [NCBI:1268694] [REACTOME:R-HSA-390466] [PUBMED:11868281] [PUBMED:15519848]
Fc gamma R-mediated phagocytosis [NCBI:114228] [KEGG:hsa04666] [PUBMED:11304556] [PUBMED:11244038] [PUBMED:10755615] [PUBMED:17308335] [PUBMED:12821647] [PUBMED:15466916] [PUBMED:17050193] [PUBMED:11228151] [PUBMED:12488490] [PUBMED:10224668] [PUBMED:11708889] [PUBMED:9581795] [PUBMED:10586078] [PUBMED:9417101] [PUBMED:15485887] [PUBMED:18322649] [PUBMED:10577498] [PUBMED:10376013] [PUBMED:10601359] [PUBMED:9545263]
Fc-epsilon receptor I signaling in mast cells [NCBI:138050] [Pathway Interaction Database:fcer1pathway] [PUBMED:9556577] [PUBMED:8629002] [PUBMED:12217401] [PUBMED:15010370] [PUBMED:15608142] [PUBMED:7561053] [PUBMED:7537741] [PUBMED:7963537] [PUBMED:8947047] [PUBMED:1384468] [PUBMED:14757742] [PUBMED:16174756] [PUBMED:10583594] [PUBMED:7513150] [PUBMED:12089510] [PUBMED:10811803] [PUBMED:9268346] [PUBMED:12640123] [PUBMED:9108083] [PUBMED:8602265] [PUBMED:11340169] [PUBMED:12953098] [PUBMED:11465115] [PUBMED:7730640] [PUBMED:9550384] [PUBMED:7518558] [PUBMED:11137136] [PUBMED:15282299] [PUBMED:14634134] [PUBMED:8534912] [PUBMED:16002993] [PUBMED:12192036] [PUBMED:7608202] [PUBMED:11714805] [PUBMED:11970986] [PUBMED:10903718] [PUBMED:15265912] [PUBMED:15477350]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins [NCBI:1270001] [REACTOME:R-HSA-556833]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
PDGFR-beta signaling pathway [NCBI:138071] [Pathway Interaction Database:pdgfrbpathway] [PUBMED:7545675] [PUBMED:16769879] [PUBMED:12652307] [PUBMED:10463951] [PUBMED:9742401] [PUBMED:8086421] [PUBMED:10391677] [PUBMED:7739538] [PUBMED:9989826] [PUBMED:10734138] [PUBMED:15753096] [PUBMED:7692233] [PUBMED:11489946] [PUBMED:10837138] [PUBMED:10229199] [PUBMED:10821867] [PUBMED:11709084] [PUBMED:11389443] [PUBMED:12958184] [PUBMED:10734113] [PUBMED:15161943] [PUBMED:12149261] [PUBMED:16456542] [PUBMED:16224065] [PUBMED:8619809] [PUBMED:15494217] [PUBMED:1849073] [PUBMED:11085978] [PUBMED:2544881] [PUBMED:7622571] [PUBMED:10779329] [PUBMED:15944146] [PUBMED:11027258] [PUBMED:1708307] [PUBMED:8940081] [PUBMED:11854295] [PUBMED:8195171] [PUBMED:12424235] [PUBMED:7935392] [PUBMED:14966296] [PUBMED:16537894]
Phospholipase D signaling pathway [NCBI:1311074] [KEGG:hsa04072] [PUBMED:9310372] [PUBMED:9119890] [PUBMED:15310762] [PUBMED:18936782] [PUBMED:24990952] [PUBMED:14769825] [PUBMED:21936578] [PUBMED:10666319] [PUBMED:17210675] [PUBMED:19264150] [PUBMED:23076158] [PUBMED:17054901] [PUBMED:16622417] [PUBMED:10807766] [PUBMED:12217395] [PUBMED:11042115] [PUBMED:19815110] [PUBMED:24995811] [PUBMED:16143829] [PUBMED:8135758] [PUBMED:11991733] [PUBMED:19410013] [PUBMED:17245604]
Protein folding [NCBI:1268693] [REACTOME:R-HSA-391251] [PUBMED:15459659] [PUBMED:18395510] [PUBMED:15519848]
S1P1 pathway [NCBI:137937] [Pathway Interaction Database:s1p_s1p1_pathway] [PUBMED:10198065] [PUBMED:12782628] [PUBMED:15750791] [PUBMED:11741892] [PUBMED:12963813] [PUBMED:11150298] [PUBMED:10463951] [PUBMED:9660876] [PUBMED:12087059] [PUBMED:12796504] [PUBMED:12175535] [PUBMED:11709084] [PUBMED:17050692] [PUBMED:12586615] [PUBMED:17257496]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by VEGF [NCBI:1269480] [REACTOME:R-HSA-194138] [PUBMED:15585754] [PUBMED:13678960] [PUBMED:16336962] [PUBMED:16835467]
Sphingolipid de novo biosynthesis [NCBI:1270098] [REACTOME:R-HSA-1660661] [PUBMED:12011104] [PUBMED:20919643]
Sphingolipid metabolism [NCBI:82994] [KEGG:hsa00600] [NCBI:1270097] [REACTOME:R-HSA-428157] [PUBMED:11305904] [PUBMED:10652340] [PUBMED:12011104] [PUBMED:10366774] [PUBMED:8457204] [PUBMED:18165232] [PUBMED:1495423] [PUBMED:18216770]
Sphingolipid signaling pathway [NCBI:1144995] [KEGG:hsa04071] [PUBMED:23919551] [PUBMED:21705677] [PUBMED:18675379] [PUBMED:20534702] [PUBMED:15999095] [PUBMED:16470226] [PUBMED:11001563] [PUBMED:17913601] [PUBMED:17161984] [PUBMED:22654878] [PUBMED:17438574] [PUBMED:18216770] [PUBMED:11418646] [PUBMED:10880336] [PUBMED:15451787] [PUBMED:25309325] [PUBMED:18403224]
Sphingosine 1-phosphate (S1P) pathway [NCBI:137931] [Pathway Interaction Database:s1p_meta_pathway] [PUBMED:12815058] [PUBMED:17050692] [PUBMED:9854026] [PUBMED:16584625] [PUBMED:10617617] [PUBMED:16520486] [PUBMED:14570870] [PUBMED:11705398] [PUBMED:16996023] [PUBMED:12531554] [PUBMED:12761884]
Sphingosine degradation [NCBI:413389] [KEGG:hsa_M00100]
Tuberculosis [NCBI:213780] [KEGG:hsa05152] [PUBMED:20199890] [PUBMED:21274449] [PUBMED:17359235] [PUBMED:20415982] [PUBMED:18541216] [PUBMED:19369951] [PUBMED:15083155] [PUBMED:11378475] [PUBMED:15228522] [PUBMED:19634703] [PUBMED:21274433] [PUBMED:19563525] [PUBMED:18407066] [PUBMED:18288961] [PUBMED:16200082] [PUBMED:17785780] [PUBMED:11932234]
VEGF signaling pathway [NCBI:83066] [KEGG:hsa04370] [PUBMED:11741095] [PUBMED:16104843] [PUBMED:14641020] [PUBMED:15338053] [PUBMED:14724572] [PUBMED:12391145] [PUBMED:13678960] [PUBMED:15602010]
VEGFA-VEGFR2 Pathway [NCBI:1269483] [REACTOME:R-HSA-4420097] [PUBMED:17344076] [PUBMED:16633338] [PUBMED:19230644] [PUBMED:13678960]
VEGFR2 mediated cell proliferation [NCBI:1269485] [REACTOME:R-HSA-5218921] [PUBMED:22866201] [PUBMED:22180219] [PUBMED:22762016]
sphingosine and sphingosine-1-phosphate metabolism [NCBI:545351] [BIOCYC:HUMAN_PWY3DJ-11470] [PUBMED:15258913] [PUBMED:12531549]