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Genes
BIRC5
Gene - BIRC5
full name
baculoviral IAP repeat containing 5
synonyms
API4, EPR-1, BIRC5, ENSG00000089685
HGNC
HGNC:593
Entrez Gene
Gene:332
ENSEMBL
ENSG00000089685
location
chr: 17
start: 76210277
stop: 76221716
strand: +
transcripts
NM_001012271.1
NM_001168.2
NM_001012270.1
pathways
Apoptosis
[NCBI:83060]
[KEGG:hsa04210]
[NCBI:1270262]
[REACTOME:R-HSA-109581]
[PUBMED:12189384]
[PUBMED:20533903]
[PUBMED:18208375]
[PUBMED:22429822]
[PUBMED:15218528]
[PUBMED:24769728]
[PUBMED:18023214]
[PUBMED:25526085]
[PUBMED:23070002]
[PUBMED:15654015]
[PUBMED:15601572]
[PUBMED:14561771]
[PUBMED:24278747]
[PUBMED:21914490]
[PUBMED:22465226]
[PUBMED:21145844]
[PUBMED:12838338]
[PUBMED:18238895]
[PUBMED:12949498]
[PUBMED:18304445]
[PUBMED:14737178]
[PUBMED:26231733]
[PUBMED:9916983]
[PUBMED:14634621]
[PUBMED:19770840]
[PUBMED:22075987]
[PUBMED:4561027]
[PUBMED:20075940]
[PUBMED:9894605]
[PUBMED:26615431]
[PUBMED:12505355]
[PUBMED:11520933]
[PUBMED:19148180]
[PUBMED:16397578]
[PUBMED:15719025]
[PUBMED:15322527]
[PUBMED:15725726]
[PUBMED:12209154]
[PUBMED:23803157]
Apoptosis - multiple species
[NCBI:1384747]
[KEGG:hsa04215]
[PUBMED:23457257]
[PUBMED:11858838]
[PUBMED:15963254]
[PUBMED:20041301]
[PUBMED:24393571]
[PUBMED:21150934]
[PUBMED:15107838]
[PUBMED:10578171]
[PUBMED:15082313]
[PUBMED:19659442]
[PUBMED:20479784]
[PUBMED:22689371]
[PUBMED:20978240]
[PUBMED:25862972]
[PUBMED:20028968]
[PUBMED:25991373]
Aurora A signaling
[NCBI:137925]
[Pathway Interaction Database:aurora_a_pathway]
[PUBMED:17308110]
[PUBMED:16894566]
[PUBMED:16631581]
[PUBMED:17229885]
[PUBMED:15128871]
[PUBMED:14990569]
[PUBMED:12177045]
[PUBMED:14580337]
[PUBMED:14724178]
[PUBMED:17545617]
[PUBMED:15687499]
[PUBMED:11163242]
[PUBMED:14603251]
[PUBMED:17060449]
[PUBMED:12208850]
[PUBMED:12815066]
[PUBMED:17125467]
[PUBMED:13678582]
[PUBMED:15987997]
[PUBMED:15966895]
[PUBMED:11976319]
[PUBMED:14702041]
[PUBMED:16246726]
[PUBMED:17452972]
[PUBMED:12082625]
[PUBMED:11039908]
[PUBMED:14667408]
[PUBMED:12577065]
[PUBMED:14600264]
[PUBMED:11756469]
[PUBMED:16772293]
[PUBMED:12023018]
[PUBMED:15469940]
[PUBMED:16082213]
Aurora B signaling
[NCBI:138080]
[Pathway Interaction Database:aurora_b_pathway]
[PUBMED:14960279]
[PUBMED:15249581]
[PUBMED:17129783]
[PUBMED:15263015]
[PUBMED:15854913]
[PUBMED:14605209]
[PUBMED:12689593]
[PUBMED:15499654]
[PUBMED:17483322]
[PUBMED:15316025]
[PUBMED:11350965]
[PUBMED:11516652]
[PUBMED:11976319]
[PUBMED:16222246]
[PUBMED:12925766]
[PUBMED:15260989]
[PUBMED:16764853]
[PUBMED:15796717]
[PUBMED:16916643]
[PUBMED:14667408]
[PUBMED:17389228]
[PUBMED:16687578]
[PUBMED:14722118]
[PUBMED:12082625]
[PUBMED:17356064]
[PUBMED:16222244]
[PUBMED:11756469]
[PUBMED:17457057]
[PUBMED:15350530]
[PUBMED:17322402]
[PUBMED:11856369]
[PUBMED:17199039]
[PUBMED:17129782]
[PUBMED:12419797]
[PUBMED:16046481]
[PUBMED:15064709]
[PUBMED:12458200]
[PUBMED:15064354]
[PUBMED:14674694]
[PUBMED:16179162]
[PUBMED:17543862]
[PUBMED:17215513]
[PUBMED:12686604]
[PUBMED:16537398]
Cell Cycle
[NCBI:1269741]
[REACTOME:R-HSA-1640170]
Cell Cycle, Mitotic
[NCBI:1269763]
[REACTOME:R-HSA-69278]
Colorectal cancer
[NCBI:83106]
[KEGG:hsa05210]
[PUBMED:15479695]
[PUBMED:11459867]
[PUBMED:9196022]
[PUBMED:11170304]
[PUBMED:12951588]
[PUBMED:15349822]
[PUBMED:15711891]
[PUBMED:16042571]
[PUBMED:15000146]
[PUBMED:12737309]
[PUBMED:10505543]
[PUBMED:11078609]
[PUBMED:11223406]
[PUBMED:16326109]
[PUBMED:16699851]
[PUBMED:11477132]
[PUBMED:12621137]
[PUBMED:15573119]
[PUBMED:16555243]
[PUBMED:15310786]
Cytokine Signaling in Immune system
[NCBI:1269310]
[REACTOME:R-HSA-1280215]
[PUBMED:12613569]
FOXM1 transcription factor network
[NCBI:137935]
[Pathway Interaction Database:foxm1pathway]
[PUBMED:17141659]
[PUBMED:12482952]
[PUBMED:16913845]
[PUBMED:16809346]
[PUBMED:15671063]
[PUBMED:16504183]
[PUBMED:15082532]
[PUBMED:15531365]
[PUBMED:17366632]
[PUBMED:16314512]
[PUBMED:17173139]
[PUBMED:16618419]
[PUBMED:15024056]
[PUBMED:11682060]
[PUBMED:15654331]
[PUBMED:15817462]
[PUBMED:17404569]
[PUBMED:16875671]
[PUBMED:16965535]
[PUBMED:17101782]
Gene Expression
[NCBI:1269649]
[REACTOME:R-HSA-74160]
Generic Transcription Pathway
[NCBI:1269650]
[REACTOME:R-HSA-212436]
[PUBMED:15175151]
[PUBMED:14744435]
[PUBMED:15680972]
[PUBMED:11395415]
[PUBMED:15896744]
[PUBMED:10235266]
[PUBMED:14986688]
[PUBMED:12023297]
[PUBMED:15680973]
[PUBMED:16751179]
[PUBMED:11861166]
[PUBMED:16429119]
[PUBMED:16719718]
[PUBMED:16921404]
[PUBMED:15690163]
Hepatitis B
[NCBI:694606]
[KEGG:hsa05161]
[PUBMED:19854353]
[PUBMED:11604508]
[PUBMED:11325602]
[PUBMED:18931690]
[PUBMED:16891440]
[PUBMED:17158882]
[PUBMED:11099494]
[PUBMED:9325306]
[PUBMED:18024894]
[PUBMED:11483993]
[PUBMED:15107488]
[PUBMED:11278872]
[PUBMED:21647825]
[PUBMED:11287574]
[PUBMED:18481805]
[PUBMED:17188775]
[PUBMED:19784739]
[PUBMED:19263472]
[PUBMED:16203685]
[PUBMED:18605975]
[PUBMED:10454581]
[PUBMED:22504921]
[PUBMED:21334391]
[PUBMED:20657822]
[PUBMED:18046710]
[PUBMED:9843511]
[PUBMED:15542625]
[PUBMED:21618535]
[PUBMED:15132991]
[PUBMED:15173177]
[PUBMED:12771941]
[PUBMED:21994545]
[PUBMED:8764004]
[PUBMED:16459163]
[PUBMED:9738022]
[PUBMED:11821950]
[PUBMED:12839924]
Hippo signaling pathway
[NCBI:749777]
[KEGG:hsa04390]
[PUBMED:18955139]
[PUBMED:20439427]
[PUBMED:20951342]
[PUBMED:21138973]
[PUBMED:18328423]
[PUBMED:21324984]
[PUBMED:23034192]
[PUBMED:21808241]
[PUBMED:17975546]
[PUBMED:22750148]
[PUBMED:21084559]
[PUBMED:19846288]
[PUBMED:22895435]
[PUBMED:22683405]
[PUBMED:22658639]
[PUBMED:22153608]
[PUBMED:20945341]
[PUBMED:22830020]
[PUBMED:21874053]
[PUBMED:21376238]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Interleukin-4 and 13 signaling
[NCBI:1470923]
[REACTOME:R-HSA-6785807]
[PUBMED:12704343]
[PUBMED:10358772]
M Phase
[NCBI:1269810]
[REACTOME:R-HSA-68886]
Metabolism of proteins
[NCBI:1268677]
[REACTOME:R-HSA-392499]
Mitotic Anaphase
[NCBI:1269825]
[REACTOME:R-HSA-68882]
Mitotic Metaphase and Anaphase
[NCBI:1269823]
[REACTOME:R-HSA-2555396]
Mitotic Prometaphase
[NCBI:1269820]
[REACTOME:R-HSA-68877]
Pathways in cancer
[NCBI:83105]
[KEGG:hsa05200]
[PUBMED:12244301]
[PUBMED:15156182]
[PUBMED:16899407]
[PUBMED:12621137]
[PUBMED:21193867]
[PUBMED:16001072]
[PUBMED:11707511]
[PUBMED:11253051]
[PUBMED:11071626]
[PUBMED:17251915]
[PUBMED:11736900]
[PUBMED:16557281]
[PUBMED:16699851]
[PUBMED:16189702]
[PUBMED:11902573]
[PUBMED:16555243]
[PUBMED:8069858]
[PUBMED:15310786]
[PUBMED:9834202]
[PUBMED:16700615]
[PUBMED:12545153]
[PUBMED:15656799]
[PUBMED:12154354]
[PUBMED:11895903]
[PUBMED:11527574]
[PUBMED:16326109]
[PUBMED:16339096]
[PUBMED:11160144]
[PUBMED:15724144]
[PUBMED:12951584]
[PUBMED:10647931]
[PUBMED:16881963]
[PUBMED:15557758]
[PUBMED:11477132]
[PUBMED:15721476]
[PUBMED:15625120]
[PUBMED:16236521]
[PUBMED:14967450]
[PUBMED:15942304]
[PUBMED:17287871]
[PUBMED:14634372]
[PUBMED:15573119]
[PUBMED:15009714]
[PUBMED:16112428]
[PUBMED:15611513]
[PUBMED:16001050]
[PUBMED:15349822]
[PUBMED:16551846]
[PUBMED:15978322]
[PUBMED:15774796]
[PUBMED:16352814]
[PUBMED:12951588]
[PUBMED:10944551]
[PUBMED:10740269]
[PUBMED:15639402]
[PUBMED:12407699]
[PUBMED:11130178]
[PUBMED:15109562]
[PUBMED:11170304]
[PUBMED:11276000]
[PUBMED:9643506]
[PUBMED:16248975]
[PUBMED:16242838]
[PUBMED:12946833]
[PUBMED:11559746]
[PUBMED:9196022]
[PUBMED:12079267]
[PUBMED:15468170]
[PUBMED:16064138]
[PUBMED:14580692]
[PUBMED:15082523]
[PUBMED:15551095]
[PUBMED:17062879]
[PUBMED:17211469]
[PUBMED:11720739]
[PUBMED:12588368]
[PUBMED:11057895]
[PUBMED:9422516]
[PUBMED:12894244]
[PUBMED:15479695]
[PUBMED:16189154]
[PUBMED:12878745]
[PUBMED:11900250]
[PUBMED:11103787]
[PUBMED:15122209]
[PUBMED:12711111]
[PUBMED:12243753]
[PUBMED:16306523]
[PUBMED:16702400]
[PUBMED:15270885]
[PUBMED:14685170]
[PUBMED:14586404]
[PUBMED:11078609]
[PUBMED:15284264]
[PUBMED:10505543]
[PUBMED:11223406]
[PUBMED:14982876]
[PUBMED:12648469]
[PUBMED:12867060]
[PUBMED:15711891]
[PUBMED:12094241]
[PUBMED:16642045]
[PUBMED:11463388]
[PUBMED:12762887]
[PUBMED:15746962]
[PUBMED:15823750]
[PUBMED:16750612]
[PUBMED:16484590]
[PUBMED:11459867]
[PUBMED:16146838]
[PUBMED:14556242]
[PUBMED:15947972]
[PUBMED:12563308]
[PUBMED:16946003]
[PUBMED:15948971]
[PUBMED:11407945]
[PUBMED:12737309]
[PUBMED:16095998]
[PUBMED:12351585]
[PUBMED:24508914]
[PUBMED:12084351]
[PUBMED:11807782]
[PUBMED:14695152]
[PUBMED:10453277]
[PUBMED:17554387]
[PUBMED:15841168]
[PUBMED:12616528]
[PUBMED:10403855]
[PUBMED:16054233]
[PUBMED:16474624]
[PUBMED:16822996]
[PUBMED:17028294]
[PUBMED:11224709]
[PUBMED:11750244]
[PUBMED:11905738]
[PUBMED:15719031]
[PUBMED:10843728]
[PUBMED:16110317]
[PUBMED:11721960]
[PUBMED:12741677]
[PUBMED:7585656]
[PUBMED:12801837]
[PUBMED:16551847]
[PUBMED:12459728]
[PUBMED:11431710]
[PUBMED:12468433]
[PUBMED:11165748]
[PUBMED:16042571]
[PUBMED:16508724]
[PUBMED:15000146]
[PUBMED:17149381]
[PUBMED:15948711]
[PUBMED:14747944]
[PUBMED:14737121]
[PUBMED:12379883]
[PUBMED:17158541]
[PUBMED:12850530]
[PUBMED:10835690]
[PUBMED:16870043]
Platinum drug resistance
[NCBI:1404797]
[KEGG:hsa01524]
[PUBMED:24074238]
[PUBMED:26867799]
[PUBMED:14609433]
[PUBMED:26184483]
[PUBMED:24874729]
[PUBMED:15607932]
[PUBMED:25546083]
[PUBMED:25058905]
[PUBMED:19190080]
[PUBMED:14576837]
[PUBMED:20811617]
[PUBMED:21892204]
[PUBMED:20647037]
[PUBMED:17336087]
[PUBMED:26886018]
[PUBMED:23442359]
[PUBMED:17625587]
Post-translational protein modification
[NCBI:1268701]
[REACTOME:R-HSA-597592]
RHO GTPase Effectors
[NCBI:1269509]
[REACTOME:R-HSA-195258]
[PUBMED:9694656]
[PUBMED:18066052]
[PUBMED:11018042]
[PUBMED:10470034]
[PUBMED:8702756]
[PUBMED:21730051]
[PUBMED:8571126]
[PUBMED:19513348]
[PUBMED:17244649]
[PUBMED:11145705]
[PUBMED:24128008]
[PUBMED:23716662]
[PUBMED:8617235]
[PUBMED:8543060]
[PUBMED:11804587]
[PUBMED:24969695]
[PUBMED:12635176]
[PUBMED:12778124]
[PUBMED:18006505]
[PUBMED:1660188]
[PUBMED:21351730]
[PUBMED:16507994]
[PUBMED:14595335]
[PUBMED:10072071]
[PUBMED:10591629]
[PUBMED:10753910]
[PUBMED:23875749]
[PUBMED:17151359]
[PUBMED:10652353]
[PUBMED:12221077]
[PUBMED:10559936]
[PUBMED:12783890]
[PUBMED:11948177]
[PUBMED:18237546]
[PUBMED:16079795]
[PUBMED:10924361]
[PUBMED:14514689]
[PUBMED:8107774]
[PUBMED:8756646]
[PUBMED:16979770]
[PUBMED:16636067]
[PUBMED:9751706]
[PUBMED:10619026]
[PUBMED:23444367]
[PUBMED:15546864]
[PUBMED:12473120]
[PUBMED:8816443]
[PUBMED:9199170]
[PUBMED:12514133]
[PUBMED:16762923]
[PUBMED:12110184]
[PUBMED:16431929]
[PUBMED:10975528]
[PUBMED:10940294]
[PUBMED:9535855]
[PUBMED:7559638]
[PUBMED:11162552]
[PUBMED:19737400]
[PUBMED:9988689]
[PUBMED:12732141]
[PUBMED:8798539]
[PUBMED:24914801]
[PUBMED:11689693]
[PUBMED:8769096]
[PUBMED:9368021]
RHO GTPases Activate Formins
[NCBI:1269519]
[REACTOME:R-HSA-5663220]
[PUBMED:20233848]
[PUBMED:15507212]
[PUBMED:16292343]
[PUBMED:12906795]
[PUBMED:11779461]
[PUBMED:21397845]
[PUBMED:12577064]
[PUBMED:17198702]
[PUBMED:15006353]
[PUBMED:20101212]
[PUBMED:15944396]
[PUBMED:10678165]
[PUBMED:16943183]
[PUBMED:16439214]
[PUBMED:16472745]
[PUBMED:10958683]
[PUBMED:12732141]
[PUBMED:15085137]
[PUBMED:24914801]
[PUBMED:9497258]
[PUBMED:21576392]
[PUBMED:21868368]
Resolution of Sister Chromatid Cohesion
[NCBI:1269821]
[REACTOME:R-HSA-2500257]
[PUBMED:16541025]
[PUBMED:15339662]
[PUBMED:17112726]
[PUBMED:9649503]
[PUBMED:21111234]
[PUBMED:15737063]
[PUBMED:17113138]
[PUBMED:21987589]
[PUBMED:14730319]
[PUBMED:11509732]
[PUBMED:19696148]
[PUBMED:21878504]
[PUBMED:15723797]
SUMO E3 ligases SUMOylate target proteins
[NCBI:1268743]
[REACTOME:R-HSA-3108232]
[PUBMED:20674646]
[PUBMED:17763827]
[PUBMED:19471022]
[PUBMED:23746258]
[PUBMED:24016193]
[PUBMED:23503365]
[PUBMED:21252943]
[PUBMED:17000644]
[PUBMED:24273646]
[PUBMED:22811915]
[PUBMED:21693764]
[PUBMED:23277067]
[PUBMED:21102611]
SUMOylation
[NCBI:1268738]
[REACTOME:R-HSA-2990846]
[PUBMED:21102611]
[PUBMED:20674646]
[PUBMED:23514139]
[PUBMED:19923268]
[PUBMED:20462400]
[PUBMED:17768054]
SUMOylation of DNA replication proteins
[NCBI:1339113]
[REACTOME:R-HSA-4615885]
[PUBMED:22812528]
[PUBMED:17031663]
[PUBMED:22918591]
[PUBMED:22732495]
[PUBMED:16368276]
Separation of Sister Chromatids
[NCBI:1269826]
[REACTOME:R-HSA-2467813]
[PUBMED:11081627]
[PUBMED:10411507]
[PUBMED:12070128]
[PUBMED:12194817]
[PUBMED:11509732]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by Interleukins
[NCBI:1269318]
[REACTOME:R-HSA-449147]
[PUBMED:19302047]
[PUBMED:12445398]
Signaling by Rho GTPases
[NCBI:1269507]
[REACTOME:R-HSA-194315]
[PUBMED:16212495]
[PUBMED:15630019]
TP53 Regulates Transcription of Cell Death Genes
[NCBI:1383066]
[REACTOME:R-HSA-5633008]
[PUBMED:20353938]
[PUBMED:18676979]
[PUBMED:11511362]
[PUBMED:11919562]
[PUBMED:10973264]
[PUBMED:15797384]
[PUBMED:17442733]
[PUBMED:15607964]
[PUBMED:11278253]
[PUBMED:23059823]
[PUBMED:19549844]
[PUBMED:11684014]
[PUBMED:7566179]
[PUBMED:17349958]
[PUBMED:24739573]
[PUBMED:18719709]
[PUBMED:17284521]
[PUBMED:23703390]
[PUBMED:10807576]
[PUBMED:10733530]
[PUBMED:12402042]
[PUBMED:12851404]
[PUBMED:14729977]
[PUBMED:18431400]
[PUBMED:15377670]
[PUBMED:12089322]
[PUBMED:15273740]
[PUBMED:11382926]
[PUBMED:12606722]
[PUBMED:14623878]
[PUBMED:15577913]
[PUBMED:16230375]
[PUBMED:26122615]
[PUBMED:11559530]
[PUBMED:11054413]
[PUBMED:22766503]
[PUBMED:11463392]
[PUBMED:16249378]
[PUBMED:9326928]
[PUBMED:14614825]
[PUBMED:19615968]
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[PUBMED:7834749]
[PUBMED:16135520]
[PUBMED:15126337]
[PUBMED:15580302]
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[PUBMED:10777207]
[PUBMED:23365256]
[PUBMED:19040420]
[PUBMED:15735003]
[PUBMED:14688482]
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
[NCBI:1383070]
[REACTOME:R-HSA-6803205]
[PUBMED:10733530]
[PUBMED:16249378]
[PUBMED:14729977]
[PUBMED:15377670]
[PUBMED:15577913]
[PUBMED:19040420]
[PUBMED:11054413]
[PUBMED:17442733]
[PUBMED:14614825]
[PUBMED:16140933]
[PUBMED:11919562]
[PUBMED:19549844]
[PUBMED:23059823]
[PUBMED:11684014]
Transcriptional Regulation by TP53
[NCBI:1269654]
[REACTOME:R-HSA-3700989]
[PUBMED:26122615]
[PUBMED:19410540]
Validated targets of C-MYC transcriptional activation
[NCBI:169351]
[Pathway Interaction Database:myc_activpathway]
[PUBMED:18987359]
[PUBMED:16537449]
[PUBMED:9924025]
[PUBMED:17643117]
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[PUBMED:11909865]