Home
About
Citations
Statistics
Download
Login
Home
Genes
MAPKAPK2
Gene - MAPKAPK2
full name
mitogen-activated protein kinase-activated protein kinase 2
synonyms
MAPKAP-K2, MK-2, MK2, MAPKAPK2, ENSG00000162889
HGNC
HGNC:6887
Entrez Gene
Gene:9261
ENSEMBL
ENSG00000162889
ENSG00000266641
location
chr: 1
start: 206858295
stop: 206907630
strand: +
transcripts
NM_004759.4
NM_032960.3
pathways
Activated TLR4 signalling
[NCBI:1269236]
[REACTOME:R-HSA-166054]
[PUBMED:15276183]
[PUBMED:15588429]
[PUBMED:15845500]
[PUBMED:15596121]
Arachidonic acid metabolism
[NCBI:82991]
[KEGG:hsa00590]
[NCBI:1270087]
[REACTOME:R-HSA-2142753]
[PUBMED:14622984]
[PUBMED:15292194]
[PUBMED:10908295]
[PUBMED:15205388]
[PUBMED:9812980]
[PUBMED:14660610]
[PUBMED:11328810]
[PUBMED:14636671]
[PUBMED:14626496]
[PUBMED:11679404]
[PUBMED:19244215]
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
[NCBI:1269727]
[REACTOME:R-HSA-450385]
[PUBMED:12440953]
[PUBMED:12704645]
[PUBMED:11719186]
[PUBMED:15687258]
[PUBMED:16391004]
CREB phosphorylation
[NCBI:1269217]
[REACTOME:R-HSA-199920]
Cellular Senescence
[NCBI:1270426]
[REACTOME:R-HSA-2559583]
[PUBMED:21078816]
[PUBMED:18711403]
[PUBMED:22048312]
[PUBMED:19818705]
[PUBMED:17662938]
[PUBMED:23746838]
[PUBMED:9282108]
[PUBMED:17667954]
[PUBMED:13905658]
Cellular response to heat stress
[NCBI:1270421]
[REACTOME:R-HSA-3371556]
[PUBMED:8455624]
[PUBMED:8441385]
Cellular responses to stress
[NCBI:1270414]
[REACTOME:R-HSA-2262752]
[PUBMED:15709958]
Gene Expression
[NCBI:1269649]
[REACTOME:R-HSA-74160]
IL2-mediated signaling events
[NCBI:137976]
[Pathway Interaction Database:il2_1pathway]
[PUBMED:7568005]
[PUBMED:10962026]
[PUBMED:1545122]
[PUBMED:10602027]
[PUBMED:15170389]
[PUBMED:9092570]
[PUBMED:7509794]
[PUBMED:15356145]
[PUBMED:9973481]
[PUBMED:10899310]
[PUBMED:9195132]
[PUBMED:7544001]
[PUBMED:7777534]
[PUBMED:12681450]
[PUBMED:7665592]
[PUBMED:8702919]
[PUBMED:1708096]
[PUBMED:8643566]
[PUBMED:7988557]
[PUBMED:7737351]
[PUBMED:1532814]
[PUBMED:8262551]
[PUBMED:8025955]
[PUBMED:10993906]
[PUBMED:3095922]
[PUBMED:8805624]
[PUBMED:9391116]
[PUBMED:7973658]
[PUBMED:11331873]
[PUBMED:10421845]
[PUBMED:8119884]
[PUBMED:7781605]
[PUBMED:12543077]
[PUBMED:9133424]
[PUBMED:1618313]
[PUBMED:1940342]
[PUBMED:9382798]
[PUBMED:10514520]
[PUBMED:7973659]
[PUBMED:1639773]
[PUBMED:9029085]
[PUBMED:7760801]
[PUBMED:1460037]
[PUBMED:9202126]
[PUBMED:1652056]
[PUBMED:12393431]
[PUBMED:8397196]
[PUBMED:2047859]
[PUBMED:7688728]
[PUBMED:8700888]
[PUBMED:7528668]
[PUBMED:9305919]
[PUBMED:2303462]
[PUBMED:7568001]
[PUBMED:9822600]
[PUBMED:7543676]
[PUBMED:7499365]
[PUBMED:10843677]
[PUBMED:7600304]
[PUBMED:7719937]
[PUBMED:9590209]
[PUBMED:9794391]
[PUBMED:10849428]
[PUBMED:8294403]
[PUBMED:10373548]
[PUBMED:2590941]
[PUBMED:9512511]
[PUBMED:6434688]
[PUBMED:9697832]
[PUBMED:10982827]
[PUBMED:10214954]
[PUBMED:10825200]
[PUBMED:1535827]
[PUBMED:10369681]
[PUBMED:7719938]
[PUBMED:1655887]
[PUBMED:8376945]
[PUBMED:1996324]
[PUBMED:7479881]
[PUBMED:10962581]
[PUBMED:7973657]
[PUBMED:1631559]
[PUBMED:10066828]
[PUBMED:9169478]
[PUBMED:8552611]
[PUBMED:8483935]
[PUBMED:2106566]
[PUBMED:16199887]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
MAP kinase activation in TLR cascade
[NCBI:1269211]
[REACTOME:R-HSA-450294]
[PUBMED:17637696]
[PUBMED:11861597]
[PUBMED:19196711]
[PUBMED:11242034]
MAPK signaling pathway
[NCBI:83048]
[KEGG:hsa04010]
[PUBMED:11749383]
[PUBMED:12566928]
[PUBMED:12849693]
[PUBMED:12676795]
[PUBMED:12947395]
[PUBMED:14597384]
[PUBMED:11369511]
[PUBMED:12191611]
[PUBMED:12390245]
MAPK targets/ Nuclear events mediated by MAP kinases
[NCBI:1269214]
[REACTOME:R-HSA-450282]
[PUBMED:17158707]
[PUBMED:16393692]
[PUBMED:12471242]
Metabolism
[NCBI:1269956]
[REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins
[NCBI:1270001]
[REACTOME:R-HSA-556833]
MyD88 cascade initiated on plasma membrane
[NCBI:1269207]
[REACTOME:R-HSA-975871]
[PUBMED:15728506]
[PUBMED:16239509]
MyD88 dependent cascade initiated on endosome
[NCBI:1269228]
[REACTOME:R-HSA-975155]
[PUBMED:20237413]
[PUBMED:15276183]
[PUBMED:18652679]
MyD88-independent TLR3/TLR4 cascade
[NCBI:1269220]
[REACTOME:R-HSA-166166]
[PUBMED:15276183]
MyD88:Mal cascade initiated on plasma membrane
[NCBI:1269237]
[REACTOME:R-HSA-166058]
[PUBMED:15276183]
NGF signalling via TRKA from the plasma membrane
[NCBI:1269460]
[REACTOME:R-HSA-187037]
[PUBMED:11520933]
[PUBMED:12676795]
[PUBMED:10851172]
[PUBMED:10579918]
Neurotrophin signaling pathway
[NCBI:101143]
[KEGG:hsa04722]
[PUBMED:16699811]
[PUBMED:10812966]
[PUBMED:12676795]
[PUBMED:16939974]
[PUBMED:10851172]
[PUBMED:15499580]
[PUBMED:14704852]
[PUBMED:11399424]
[PUBMED:10764727]
[PUBMED:10985348]
[PUBMED:16856873]
[PUBMED:11529497]
Nuclear Events (kinase and transcription factor activation)
[NCBI:1269477]
[REACTOME:R-HSA-198725]
[PUBMED:8833451]
Oxidative Stress Induced Senescence
[NCBI:1270428]
[REACTOME:R-HSA-2559580]
[PUBMED:17344414]
[PUBMED:17332741]
[PUBMED:8622688]
[PUBMED:7588633]
[PUBMED:15563468]
[PUBMED:15287722]
[PUBMED:11062067]
[PUBMED:16337592]
[PUBMED:14532106]
[PUBMED:17254968]
[PUBMED:15866172]
[PUBMED:9628874]
[PUBMED:12171911]
[PUBMED:7816143]
[PUBMED:22020331]
[PUBMED:11564866]
[PUBMED:9162092]
[PUBMED:8974401]
[PUBMED:19451217]
[PUBMED:12808055]
[PUBMED:17210787]
[PUBMED:8846784]
[PUBMED:19462008]
[PUBMED:12134156]
[PUBMED:8626550]
[PUBMED:8774846]
[PUBMED:12189133]
[PUBMED:9195981]
[PUBMED:8622669]
[PUBMED:8259215]
[PUBMED:19528227]
[PUBMED:9564042]
[PUBMED:9529249]
[PUBMED:16436515]
[PUBMED:19451218]
[PUBMED:17395714]
[PUBMED:9030721]
[PUBMED:12435631]
[PUBMED:22325352]
Regulation of HSF1-mediated heat shock response
[NCBI:1270425]
[REACTOME:R-HSA-3371453]
[PUBMED:7623826]
Regulation of mRNA stability by proteins that bind AU-rich elements
[NCBI:1269725]
[REACTOME:R-HSA-450531]
[PUBMED:12440953]
[PUBMED:12704645]
[PUBMED:15460540]
[PUBMED:16391004]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by VEGF
[NCBI:1269480]
[REACTOME:R-HSA-194138]
[PUBMED:15585754]
[PUBMED:13678960]
[PUBMED:16336962]
[PUBMED:16835467]
Signaling mediated by p38-alpha and p38-beta
[NCBI:138012]
[Pathway Interaction Database:p38alphabetadownstreampathway]
[PUBMED:11909979]
[PUBMED:7923353]
[PUBMED:14612426]
[PUBMED:12138194]
[PUBMED:9069290]
[PUBMED:9130707]
[PUBMED:10362538]
[PUBMED:9155018]
[PUBMED:11239470]
[PUBMED:9685422]
[PUBMED:9628874]
[PUBMED:9873047]
[PUBMED:10978317]
[PUBMED:11741533]
[PUBMED:7923354]
[PUBMED:9468497]
[PUBMED:9647257]
[PUBMED:8910365]
[PUBMED:8626550]
[PUBMED:9776729]
[PUBMED:10581204]
[PUBMED:7839144]
[PUBMED:7750577]
[PUBMED:11604491]
[PUBMED:11792706]
[PUBMED:7535770]
[PUBMED:10212189]
[PUBMED:10747897]
[PUBMED:9687510]
[PUBMED:11777913]
[PUBMED:9155017]
[PUBMED:7737130]
[PUBMED:9792677]
[PUBMED:11532965]
[PUBMED:9822687]
[PUBMED:8650547]
[PUBMED:9582321]
[PUBMED:9858528]
Signalling by NGF
[NCBI:1269443]
[REACTOME:R-HSA-166520]
Signalling to ERKs
[NCBI:1269464]
[REACTOME:R-HSA-187687]
[PUBMED:10508738]
Signalling to RAS
[NCBI:1269465]
[REACTOME:R-HSA-167044]
[PUBMED:11520933]
Synthesis of Leukotrienes (LT) and Eoxins (EX)
[NCBI:1270089]
[REACTOME:R-HSA-2142691]
[PUBMED:6311078]
[PUBMED:19130894]
[PUBMED:17623009]
[PUBMED:19244215]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
[NCBI:1269229]
[REACTOME:R-HSA-975138]
[PUBMED:22511786]
[PUBMED:18794297]
TRIF-mediated TLR3/TLR4 signaling
[NCBI:1269221]
[REACTOME:R-HSA-937061]
[PUBMED:15814722]
[PUBMED:12855817]
[PUBMED:14739303]
Toll Like Receptor 10 (TLR10) Cascade
[NCBI:1269206]
[REACTOME:R-HSA-168142]
[PUBMED:15728506]
[PUBMED:18332149]
Toll Like Receptor 2 (TLR2) Cascade
[NCBI:1269238]
[REACTOME:R-HSA-181438]
[PUBMED:10820283]
Toll Like Receptor 3 (TLR3) Cascade
[NCBI:1269219]
[REACTOME:R-HSA-168164]
[PUBMED:19627256]
[PUBMED:15733829]
[PUBMED:18202435]
Toll Like Receptor 4 (TLR4) Cascade
[NCBI:1269234]
[REACTOME:R-HSA-166016]
Toll Like Receptor 5 (TLR5) Cascade
[NCBI:1269226]
[REACTOME:R-HSA-168176]
[PUBMED:11489966]
[PUBMED:11323673]
Toll Like Receptor 7/8 (TLR7/8) Cascade
[NCBI:1269227]
[REACTOME:R-HSA-168181]
[PUBMED:14976262]
Toll Like Receptor 9 (TLR9) Cascade
[NCBI:1269233]
[REACTOME:R-HSA-168138]
[PUBMED:14751759]
Toll Like Receptor TLR1:TLR2 Cascade
[NCBI:1269239]
[REACTOME:R-HSA-168179]
[PUBMED:12975352]
Toll Like Receptor TLR6:TLR2 Cascade
[NCBI:1269240]
[REACTOME:R-HSA-168188]
[PUBMED:14977973]
Toll-Like Receptors Cascades
[NCBI:1269204]
[REACTOME:R-HSA-168898]
[PUBMED:15950447]
[PUBMED:12893815]
[PUBMED:15976490]
[PUBMED:15585605]
[PUBMED:14751757]
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
[NCBI:1269728]
[REACTOME:R-HSA-450513]
[PUBMED:18481987]
[PUBMED:16391004]
[PUBMED:12440953]
[PUBMED:12704645]
Trk receptor signaling mediated by the MAPK pathway
[NCBI:138044]
[Pathway Interaction Database:mapktrkpathway]
[PUBMED:15632082]
[PUBMED:11050086]
[PUBMED:9687510]
[PUBMED:17003042]
[PUBMED:7889942]
[PUBMED:11150318]
[PUBMED:11331872]
[PUBMED:8387505]
[PUBMED:1386920]
[PUBMED:8394352]
[PUBMED:11278445]
[PUBMED:15917464]
[PUBMED:9560161]
[PUBMED:11073940]
[PUBMED:12826611]
[PUBMED:16157584]
[PUBMED:15024033]
[PUBMED:9528766]
[PUBMED:12011113]
[PUBMED:10330161]
[PUBMED:11544482]
[PUBMED:12367506]
[PUBMED:12917366]
VEGF signaling pathway
[NCBI:83066]
[KEGG:hsa04370]
[PUBMED:11741095]
[PUBMED:16104843]
[PUBMED:14641020]
[PUBMED:15338053]
[PUBMED:14724572]
[PUBMED:12391145]
[PUBMED:13678960]
[PUBMED:15602010]
VEGFA-VEGFR2 Pathway
[NCBI:1269483]
[REACTOME:R-HSA-4420097]
[PUBMED:17344076]
[PUBMED:16633338]
[PUBMED:19230644]
[PUBMED:13678960]
Viral carcinogenesis
[NCBI:658418]
[KEGG:hsa05203]
[PUBMED:9990017]
[PUBMED:15173177]
[PUBMED:16036567]
[PUBMED:16581947]
[PUBMED:9060639]
[PUBMED:17457345]
[PUBMED:15956361]
[PUBMED:21421561]
[PUBMED:18391203]
[PUBMED:21040832]
[PUBMED:9837909]
[PUBMED:17645777]
[PUBMED:15967719]
[PUBMED:12686421]
[PUBMED:17049016]
[PUBMED:21152115]
[PUBMED:11160754]
[PUBMED:21966251]
[PUBMED:17979705]
[PUBMED:8617242]
[PUBMED:12925958]
[PUBMED:10873631]
[PUBMED:21250384]
[PUBMED:15614436]
[PUBMED:10354594]
[PUBMED:20494113]
[PUBMED:18702816]
[PUBMED:9651361]
[PUBMED:16459163]
[PUBMED:11278402]
[PUBMED:15510157]
[PUBMED:19956178]
[PUBMED:18251977]
[PUBMED:11766888]
[PUBMED:10824878]
[PUBMED:21372216]
[PUBMED:11244044]
[PUBMED:17894800]
[PUBMED:11905817]
[PUBMED:21347341]
[PUBMED:12186904]
[PUBMED:9374493]
[PUBMED:16352731]
[PUBMED:12770701]
[PUBMED:17384582]
[PUBMED:14506283]
[PUBMED:11091847]
[PUBMED:17267064]
[PUBMED:11886269]
[PUBMED:21177815]
[PUBMED:10400746]
[PUBMED:19156753]
[PUBMED:9882379]
[PUBMED:14559998]
[PUBMED:15767449]
[PUBMED:22110506]
[PUBMED:20534855]
[PUBMED:15542638]
[PUBMED:9343405]
[PUBMED:10405893]
[PUBMED:19400863]
[PUBMED:9349482]
[PUBMED:14747563]
[PUBMED:21647825]
[PUBMED:12970441]
[PUBMED:11669605]
[PUBMED:15795286]
[PUBMED:21994562]
[PUBMED:14530271]
[PUBMED:9594662]
[PUBMED:22566809]
[PUBMED:19651473]
[PUBMED:8756622]
[PUBMED:15105524]
[PUBMED:15452270]
[PUBMED:18948197]
[PUBMED:16760382]
[PUBMED:10793105]
[PUBMED:21084867]
[PUBMED:16308315]
[PUBMED:16155604]
[PUBMED:16381817]
[PUBMED:16828973]
[PUBMED:15342967]
[PUBMED:15692053]
[PUBMED:10855768]
[PUBMED:19078975]
[PUBMED:12379483]
[PUBMED:15310405]
[PUBMED:8223437]
[PUBMED:16939421]
[PUBMED:12910250]
[PUBMED:16039586]
[PUBMED:18201576]
[PUBMED:21102637]
[PUBMED:21743832]
[PUBMED:20592731]
[PUBMED:10644344]
[PUBMED:10074132]
[PUBMED:19715458]
[PUBMED:16155601]
[PUBMED:11604508]
[PUBMED:15919895]
[PUBMED:11099494]
[PUBMED:18385245]
[PUBMED:19854353]
[PUBMED:12101418]
activated TAK1 mediates p38 MAPK activation
[NCBI:1269213]
[REACTOME:R-HSA-450302]
[PUBMED:10878576]
[PUBMED:8533096]
[PUBMED:15837794]
p38 signaling mediated by MAPKAP kinases
[NCBI:138078]
[Pathway Interaction Database:p38_mk2pathway]
[PUBMED:10559880]
[PUBMED:10779545]
[PUBMED:9288946]
[PUBMED:12861023]
[PUBMED:17481585]
[PUBMED:1332886]
[PUBMED:9057088]
[PUBMED:8887554]
[PUBMED:10781029]
[PUBMED:11333986]
[PUBMED:8626550]
[PUBMED:11551945]
[PUBMED:8714691]
[PUBMED:10318869]
[PUBMED:11844797]
[PUBMED:7750577]
[PUBMED:8995217]
[PUBMED:12582162]
[PUBMED:15629715]
p38MAPK events
[NCBI:1269467]
[REACTOME:R-HSA-171007]
[PUBMED:9297626]