full name
eukaryotic translation initiation factor 4A3

synonyms
DDX48, eIF4AIII, NMP265, NUK34, EIF4A3, ENSG00000141543

HGNC
HGNC:18683

Entrez Gene
Gene:9775

ENSEMBL
ENSG00000141543

location
chr: 17
start: 78109013
stop: 78120982
strand: -

OMIM
OMIM:608546: EIF4A3 (Autosomal recessive inheritance)
OMIM:268305: Robin sequence with cleft mandible and limb anomalies

transcripts
NM_014740.3

pathways
Antiviral mechanism by IFN-stimulated genes [NCBI:1269316] [REACTOME:R-HSA-1169410]
Cleavage of Growing Transcript in the Termination Region [NCBI:1269686] [REACTOME:R-HSA-109688]
Cytokine Signaling in Immune system [NCBI:1269310] [REACTOME:R-HSA-1280215] [PUBMED:12613569]
Deadenylation of mRNA [NCBI:1269713] [REACTOME:R-HSA-429947] [PUBMED:17245413] [PUBMED:17052452] [PUBMED:15475613] [PUBMED:18608124] [PUBMED:11283721] [PUBMED:16141059] [PUBMED:19239894] [PUBMED:14749774]
Deadenylation-dependent mRNA decay [NCBI:1269712] [REACTOME:R-HSA-429914] [PUBMED:19239894] [PUBMED:14749774] [PUBMED:17245413] [PUBMED:15475613] [PUBMED:16141059] [PUBMED:11283721]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
ISG15 antiviral mechanism [NCBI:1269317] [REACTOME:R-HSA-1169408] [PUBMED:20153823] [PUBMED:12582176] [PUBMED:16009940] [PUBMED:20946978] [PUBMED:15970528]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Interferon Signaling [NCBI:1269311] [REACTOME:R-HSA-913531] [PUBMED:18929502] [PUBMED:15607020] [PUBMED:15864272] [PUBMED:14525967] [PUBMED:19059436]
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) [NCBI:1269717] [REACTOME:R-HSA-975957] [PUBMED:19859661] [PUBMED:21496649] [PUBMED:17352659] [PUBMED:20795950] [PUBMED:19359157] [PUBMED:17531985] [PUBMED:17671086] [PUBMED:19410547]
Nonsense-Mediated Decay (NMD) [NCBI:1269716] [REACTOME:R-HSA-927802] [PUBMED:18524595] [PUBMED:17671086] [PUBMED:19359157] [PUBMED:17531985] [PUBMED:17352659] [PUBMED:21496649] [PUBMED:19859661] [PUBMED:20795950] [PUBMED:19010255]
Processing of Capped Intron-Containing Pre-mRNA [NCBI:1269688] [REACTOME:R-HSA-72203]
RNA Polymerase II Transcription [NCBI:1269675] [REACTOME:R-HSA-73857]
RNA Polymerase II Transcription Termination [NCBI:1269685] [REACTOME:R-HSA-73856]
RNA transport [NCBI:177876] [KEGG:hsa03013] [PUBMED:10872469] [PUBMED:17401408] [PUBMED:20733056] [PUBMED:11018020] [PUBMED:15519698] [PUBMED:16314458] [PUBMED:15901496] [PUBMED:9548260] [PUBMED:18313922]
Spliceosome [NCBI:125136] [KEGG:hsa03040] [PUBMED:10978320] [PUBMED:19239890] [PUBMED:19733268] [PUBMED:17537823]
Transport of Mature Transcript to Cytoplasm [NCBI:1269693] [REACTOME:R-HSA-72202]
Transport of Mature mRNA derived from an Intron-Containing Transcript [NCBI:1269694] [REACTOME:R-HSA-159236]
mRNA 3'-end processing [NCBI:1269692] [REACTOME:R-HSA-72187] [PUBMED:10371034] [PUBMED:10357856] [PUBMED:2408761] [PUBMED:11909521]
mRNA Splicing [NCBI:1269689] [REACTOME:R-HSA-72172] [PUBMED:12226669]
mRNA Splicing - Major Pathway [NCBI:1269690] [REACTOME:R-HSA-72163]
mRNA surveillance pathway [NCBI:193328] [KEGG:hsa03015] [PUBMED:16723977] [PUBMED:18158581] [PUBMED:16715045] [PUBMED:17183357] [PUBMED:15040442]