full name
hepatocyte growth factor-regulated tyrosine kinase substrate

synonyms
HRS, HGS, ENSG00000185359

HGNC
HGNC:4897

Entrez Gene
Gene:9146

ENSEMBL
ENSG00000185359

location
chr: 17
start: 79650962
stop: 79669151
strand: +

transcripts
NM_004712.4

pathways
CXCR4-mediated signaling events [NCBI:137910] [Pathway Interaction Database:cxcr4_pathway] [PUBMED:18799424] [PUBMED:17537990] [PUBMED:10881171] [PUBMED:17675482] [PUBMED:11157475] [PUBMED:12077227] [PUBMED:11544290] [PUBMED:8752280] [PUBMED:12535795] [PUBMED:19380820] [PUBMED:10952719] [PUBMED:16230460] [PUBMED:12682230] [PUBMED:16503409] [PUBMED:10644702] [PUBMED:9722546] [PUBMED:11784854] [PUBMED:10491003] [PUBMED:10521508] [PUBMED:10606629] [PUBMED:15615703] [PUBMED:17568820] [PUBMED:10753828] [PUBMED:12519755] [PUBMED:12032308] [PUBMED:8752281] [PUBMED:10570282] [PUBMED:11369622] [PUBMED:15728464] [PUBMED:12590707] [PUBMED:16038794] [PUBMED:14662753] [PUBMED:18596232] [PUBMED:17056591] [PUBMED:14602072] [PUBMED:15994292] [PUBMED:16919488] [PUBMED:15872091] [PUBMED:10506573] [PUBMED:12036857] [PUBMED:15618472] [PUBMED:14704365] [PUBMED:18227351] [PUBMED:11641392] [PUBMED:18319399] [PUBMED:12133960] [PUBMED:15630457]
Cargo recognition for clathrin-mediated endocytosis [NCBI:1427859] [REACTOME:R-HSA-8856825] [PUBMED:24186068] [PUBMED:12952941] [PUBMED:19696796] [PUBMED:14985334] [PUBMED:20448150] [PUBMED:20485680] [PUBMED:16382132] [PUBMED:23482940] [PUBMED:16870701]
Clathrin derived vesicle budding [NCBI:1269881] [REACTOME:R-HSA-421837]
Clathrin-mediated endocytosis [NCBI:1427858] [REACTOME:R-HSA-8856828] [PUBMED:16516836] [PUBMED:15339664] [PUBMED:19754444] [PUBMED:8552632] [PUBMED:21779028] [PUBMED:12353027] [PUBMED:23891661] [PUBMED:21613550] [PUBMED:20059951] [PUBMED:21447041] [PUBMED:17620409] [PUBMED:16903783] [PUBMED:21445324] [PUBMED:19696798] [PUBMED:26246598] [PUBMED:25085911] [PUBMED:24186068] [PUBMED:26829388] [PUBMED:27092250] [PUBMED:24581490] [PUBMED:26042225] [PUBMED:23823722] [PUBMED:24789820] [PUBMED:9736607] [PUBMED:23637288] [PUBMED:22233676] [PUBMED:19458185] [PUBMED:26403691] [PUBMED:19296720] [PUBMED:15703209] [PUBMED:20428113] [PUBMED:8953040] [PUBMED:1177317] [PUBMED:9092476] [PUBMED:26872272] [PUBMED:19092055]
Deubiquitination [NCBI:1427860] [REACTOME:R-HSA-5688426] [PUBMED:19243136] [PUBMED:20074029] [PUBMED:15571815] [PUBMED:20418328] [PUBMED:16325574] [PUBMED:12944365] [PUBMED:23845989] [PUBMED:22201797]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
EGFR downregulation [NCBI:1269385] [REACTOME:R-HSA-182971] [PUBMED:11283727] [PUBMED:15021893] [PUBMED:14641021]
Endocytosis [NCBI:102279] [KEGG:hsa04144] [PUBMED:19696797] [PUBMED:19007773] [PUBMED:16203612] [PUBMED:15687999] [PUBMED:19924646] [PUBMED:15261671] [PUBMED:18647649] [PUBMED:19325624] [PUBMED:20110990] [PUBMED:22193161]
Endosomal Sorting Complex Required For Transport (ESCRT) [NCBI:1269895] [REACTOME:R-HSA-917729] [PUBMED:19345195] [PUBMED:17450176] [PUBMED:17988873]
Infectious disease [NCBI:1269056] [REACTOME:R-HSA-5663205]
InlB-mediated entry of Listeria monocytogenes into host cell [NCBI:1470919] [REACTOME:R-HSA-8875360] [PUBMED:20670691] [PUBMED:11081636] [PUBMED:19900460] [PUBMED:19432801] [PUBMED:17662939] [PUBMED:16113677]
Internalization of ErbB1 [NCBI:138013] [Pathway Interaction Database:erbb1_internalization_pathway] [PUBMED:9733512] [PUBMED:9950686] [PUBMED:12839496] [PUBMED:10953014] [PUBMED:17052190] [PUBMED:15212941] [PUBMED:19460345] [PUBMED:18316398] [PUBMED:11823423] [PUBMED:18657070] [PUBMED:12242303] [PUBMED:17940017] [PUBMED:15465819] [PUBMED:17121848] [PUBMED:15772153] [PUBMED:18508924] [PUBMED:18031739] [PUBMED:16914641] [PUBMED:11408594] [PUBMED:11099046] [PUBMED:16543144] [PUBMED:11703925] [PUBMED:11894095] [PUBMED:15282549] [PUBMED:9851973] [PUBMED:16554368] [PUBMED:12897150] [PUBMED:11983899] [PUBMED:18362181] [PUBMED:15475003] [PUBMED:12631709] [PUBMED:15701692] [PUBMED:16862145] [PUBMED:16735510] [PUBMED:18694561] [PUBMED:14505571] [PUBMED:10567412] [PUBMED:15635092] [PUBMED:15210722] [PUBMED:16892055] [PUBMED:1645724] [PUBMED:16407834] [PUBMED:17363458] [PUBMED:16382132] [PUBMED:10428778] [PUBMED:15314065] [PUBMED:16120644] [PUBMED:7925272] [PUBMED:12234920] [PUBMED:8175702] [PUBMED:10085141] [PUBMED:11375397] [PUBMED:10635327] [PUBMED:19723633] [PUBMED:10788520] [PUBMED:12218189] [PUBMED:19054389]
Listeria monocytogenes entry into host cells [NCBI:1470917] [REACTOME:R-HSA-8876384] [PUBMED:23125201] [PUBMED:21921683] [PUBMED:23376167] [PUBMED:25624443] [PUBMED:19191787] [PUBMED:20485518] [PUBMED:15337781]
Lysosome Vesicle Biogenesis [NCBI:1269883] [REACTOME:R-HSA-432720]
Membrane Trafficking [NCBI:1269877] [REACTOME:R-HSA-199991] [PUBMED:11031247]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Negative regulation of MET activity [NCBI:1457805] [REACTOME:R-HSA-6807004] [PUBMED:24828152] [PUBMED:11894096] [PUBMED:14684163] [PUBMED:12475979] [PUBMED:23208509] [PUBMED:9001234] [PUBMED:11420688] [PUBMED:18819921] [PUBMED:11741535] [PUBMED:15314156]
Phagosome [NCBI:153910] [KEGG:hsa04145] [PUBMED:17637737] [PUBMED:18513324] [PUBMED:15894272] [PUBMED:10684585] [PUBMED:18492791] [PUBMED:15036145] [PUBMED:17245426]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by EGFR [NCBI:1269380] [REACTOME:R-HSA-177929] [PUBMED:10459005] [PUBMED:10404636] [PUBMED:12297041] [PUBMED:15142631]
Signaling by MET [NCBI:1457794] [REACTOME:R-HSA-6806834] [PUBMED:1846706] [PUBMED:12948444] [PUBMED:16782899] [PUBMED:15249655] [PUBMED:22270953] [PUBMED:15167892] [PUBMED:7708691] [PUBMED:11081636] [PUBMED:8384622] [PUBMED:21102609] [PUBMED:16461907] [PUBMED:9407027] [PUBMED:7854453] [PUBMED:7651534] [PUBMED:9070211] [PUBMED:8208547] [PUBMED:24518591] [PUBMED:6590967] [PUBMED:15180923] [PUBMED:20802513] [PUBMED:10521801] [PUBMED:9038378] [PUBMED:17403932] [PUBMED:1655790] [PUBMED:12006644] [PUBMED:7513258] [PUBMED:18614017] [PUBMED:10753869] [PUBMED:17662939] [PUBMED:14685170] [PUBMED:10734310] [PUBMED:1827664] [PUBMED:7731718] [PUBMED:19996456] [PUBMED:11430831] [PUBMED:8302603] [PUBMED:15218027] [PUBMED:9140397] [PUBMED:2423252] [PUBMED:16113677] [PUBMED:12147692] [PUBMED:10648629] [PUBMED:7854452] [PUBMED:15070743] [PUBMED:15301554] [PUBMED:19881549] [PUBMED:25992381] [PUBMED:10871282] [PUBMED:12726861]
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) [NCBI:137930] [Pathway Interaction Database:met_pathway] [PUBMED:10793146] [PUBMED:8906793] [PUBMED:11929826] [PUBMED:10022866] [PUBMED:11532961] [PUBMED:12475979] [PUBMED:1718989] [PUBMED:1846706] [PUBMED:10970810] [PUBMED:10516287] [PUBMED:12138161] [PUBMED:11046147] [PUBMED:18073207] [PUBMED:12951049] [PUBMED:15494312] [PUBMED:9001234] [PUBMED:11352916] [PUBMED:11896055] [PUBMED:9440692] [PUBMED:8607979] [PUBMED:12244132] [PUBMED:11162460] [PUBMED:11809798] [PUBMED:9693375] [PUBMED:14636584] [PUBMED:17297451] [PUBMED:17682062] [PUBMED:19628037] [PUBMED:11069926] [PUBMED:18819921] [PUBMED:16423831] [PUBMED:10558875] [PUBMED:16858414] [PUBMED:10995442] [PUBMED:20332103] [PUBMED:11146548] [PUBMED:18346875] [PUBMED:17894413] [PUBMED:9252406] [PUBMED:17635922] [PUBMED:11134526] [PUBMED:2005882] [PUBMED:19609305] [PUBMED:8380735] [PUBMED:16537482] [PUBMED:10618718] [PUBMED:9591773] [PUBMED:12894582] [PUBMED:9748249] [PUBMED:11741535] [PUBMED:17881575] [PUBMED:10713050] [PUBMED:1655790] [PUBMED:11784715] [PUBMED:10753869] [PUBMED:10713700] [PUBMED:11118451] [PUBMED:16952352] [PUBMED:15314156] [PUBMED:19272169] [PUBMED:12802068] [PUBMED:17363898] [PUBMED:7513258] [PUBMED:1827664] [PUBMED:2541345] [PUBMED:8387483] [PUBMED:16620780] [PUBMED:11445578] [PUBMED:10734310] [PUBMED:16227611] [PUBMED:12941962] [PUBMED:15735664] [PUBMED:19071214] [PUBMED:7731718] [PUBMED:19289496] [PUBMED:11438654] [PUBMED:11896612] [PUBMED:11894096] [PUBMED:11896575] [PUBMED:7499247] [PUBMED:12147692] [PUBMED:11948414] [PUBMED:19881549] [PUBMED:19525225] [PUBMED:14684163] [PUBMED:17055484] [PUBMED:9668053] [PUBMED:10531383] [PUBMED:9681449] [PUBMED:1655405] [PUBMED:12686592] [PUBMED:19109251] [PUBMED:10679787] [PUBMED:9487126] [PUBMED:9886295] [PUBMED:12058075] [PUBMED:15452053] [PUBMED:9184210] [PUBMED:10871282] [PUBMED:17329361] [PUBMED:2554238]
Ub-specific processing proteases [NCBI:1427862] [REACTOME:R-HSA-5689880] [PUBMED:16325574]
Vesicle-mediated transport [NCBI:1269876] [REACTOME:R-HSA-5653656]
trans-Golgi Network Vesicle Budding [NCBI:1269880] [REACTOME:R-HSA-199992] [PUBMED:11252894]