Logo
full name
RB binding protein 8, endonuclease

synonyms
COM1, CTIP, JWDS, RIM, SAE2, SCKL2, RBBP8, ENSG00000101773

HGNC
HGNC:9891

Entrez Gene
Gene:5932

ENSEMBL
ENSG00000101773

location
chr: 18
start: 20513295
stop: 20606451
strand: +

OMIM
OMIM:604124: RBBP8 (Autosomal recessive inheritance)
OMIM:251255: Jawad syndrome
OMIM:606744: Seckel syndrome 2

transcripts
NM_002894.2
NM_203292.1
NM_203291.1

pathways
BARD1 signaling events [NCBI:137959] [Pathway Interaction Database:bard1pathway] [PUBMED:12086603] [PUBMED:15159397] [PUBMED:12732733] [PUBMED:14988723] [PUBMED:14647430] [PUBMED:11927591] [PUBMED:12183411] [PUBMED:8944023] [PUBMED:11278247] [PUBMED:15632137] [PUBMED:9811458] [PUBMED:12154023] [PUBMED:15905410] [PUBMED:12612651] [PUBMED:15665273] [PUBMED:12354784] [PUBMED:10910365] [PUBMED:16391231] [PUBMED:12431996] [PUBMED:15782130] [PUBMED:15184379] [PUBMED:11301010] [PUBMED:9267023] [PUBMED:15886201] [PUBMED:11943588] [PUBMED:10477523] [PUBMED:9738006] [PUBMED:11239454] [PUBMED:10764811]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle Checkpoints [NCBI:1269742] [REACTOME:R-HSA-69620]
DNA Double-Strand Break Repair [NCBI:1309095] [REACTOME:R-HSA-5693532] [PUBMED:12897142] [PUBMED:20965415]
DNA Repair [NCBI:1270350] [REACTOME:R-HSA-73894] [PUBMED:10583946] [PUBMED:23175119]
E2F transcription factor network [NCBI:137934] [Pathway Interaction Database:e2f_pathway] [PUBMED:15175242] [PUBMED:11034215] [PUBMED:8832394] [PUBMED:7479977] [PUBMED:12077144] [PUBMED:11274364] [PUBMED:8618861] [PUBMED:11857079] [PUBMED:7958837] [PUBMED:15014447] [PUBMED:9774682] [PUBMED:9704927] [PUBMED:9271400] [PUBMED:8334989] [PUBMED:16288221] [PUBMED:10766737] [PUBMED:8657141] [PUBMED:8552092] [PUBMED:11101847] [PUBMED:12757710] [PUBMED:17704056] [PUBMED:7705662] [PUBMED:15897886] [PUBMED:9192872] [PUBMED:9778043] [PUBMED:12766778] [PUBMED:15510213] [PUBMED:11418595] [PUBMED:10454584] [PUBMED:10783242] [PUBMED:11904439] [PUBMED:16179649] [PUBMED:7791762] [PUBMED:11719808] [PUBMED:12389032] [PUBMED:8264596] [PUBMED:19491197] [PUBMED:15713665] [PUBMED:16357170] [PUBMED:9689056] [PUBMED:12748276] [PUBMED:2524830] [PUBMED:14633988] [PUBMED:12697828] [PUBMED:12101096] [PUBMED:11799067] [PUBMED:15133492] [PUBMED:16892051] [PUBMED:8943353] [PUBMED:9724731] [PUBMED:10030670] [PUBMED:11459832] [PUBMED:8114719] [PUBMED:9520412] [PUBMED:18348985] [PUBMED:9020173] [PUBMED:11389439] [PUBMED:16211008] [PUBMED:12411495] [PUBMED:7958836] [PUBMED:12909625] [PUBMED:15306814] [PUBMED:10688648] [PUBMED:12611887] [PUBMED:9191053] [PUBMED:10373518] [PUBMED:10187822]
G2/M Checkpoints [NCBI:1269753] [REACTOME:R-HSA-69481]
G2/M DNA damage checkpoint [NCBI:1269754] [REACTOME:R-HSA-69473]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
Generic Transcription Pathway [NCBI:1269650] [REACTOME:R-HSA-212436] [PUBMED:15175151] [PUBMED:14744435] [PUBMED:15680972] [PUBMED:11395415] [PUBMED:15896744] [PUBMED:10235266] [PUBMED:14986688] [PUBMED:12023297] [PUBMED:15680973] [PUBMED:16751179] [PUBMED:11861166] [PUBMED:16429119] [PUBMED:16719718] [PUBMED:16921404] [PUBMED:15690163]
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) [NCBI:1309100] [REACTOME:R-HSA-5693567] [PUBMED:20965415]
HDR through Homologous Recombination (HRR) [NCBI:1309102] [REACTOME:R-HSA-5685942] [PUBMED:20965415]
HDR through MMEJ (alt-NHEJ) [NCBI:1309109] [REACTOME:R-HSA-5685939] [PUBMED:25642963] [PUBMED:25642960] [PUBMED:25643323] [PUBMED:21816818] [PUBMED:25201414] [PUBMED:20483915] [PUBMED:16012167] [PUBMED:19357644] [PUBMED:25789972]
HDR through Single Strand Annealing (SSA) [NCBI:1309108] [REACTOME:R-HSA-5685938] [PUBMED:12791985] [PUBMED:17962301] [PUBMED:25122754] [PUBMED:21804533] [PUBMED:12139939] [PUBMED:10212258] [PUBMED:10921897] [PUBMED:19357644] [PUBMED:21240188] [PUBMED:21325134] [PUBMED:9837724] [PUBMED:15485900] [PUBMED:17928296] [PUBMED:18539610] [PUBMED:12370410] [PUBMED:17965729] [PUBMED:22977173] [PUBMED:14734547] [PUBMED:21052091]
Homologous DNA Pairing and Strand Exchange [NCBI:1309103] [REACTOME:R-HSA-5693579] [PUBMED:9880493] [PUBMED:17996710] [PUBMED:12912992] [PUBMED:19369211] [PUBMED:19268590] [PUBMED:17996711] [PUBMED:24141787] [PUBMED:20871615] [PUBMED:20965415] [PUBMED:20871616] [PUBMED:23149936]
Homologous recombination [NCBI:83046] [KEGG:hsa03440] [PUBMED:12589470] [PUBMED:15902993] [PUBMED:16935872] [PUBMED:17395553] [PUBMED:18086882] [PUBMED:17571595] [PUBMED:18430459]
Homology Directed Repair [NCBI:1309099] [REACTOME:R-HSA-5693538] [PUBMED:11242102] [PUBMED:20965415] [PUBMED:11376695] [PUBMED:12427531]
Meiosis [NCBI:1269865] [REACTOME:R-HSA-1500620] [PUBMED:20051984] [PUBMED:20364103] [PUBMED:16543383] [PUBMED:18948708]
Meiotic recombination [NCBI:1269866] [REACTOME:R-HSA-912446] [PUBMED:16543383] [PUBMED:20364103] [PUBMED:20051984]
Notch signaling pathway [NCBI:83062] [KEGG:hsa04330] [NCBI:169345] [Pathway Interaction Database:notch_pathway] [PUBMED:11459941] [PUBMED:12682059] [PUBMED:11825871] [PUBMED:17658278] [PUBMED:15998794] [PUBMED:11101851] [PUBMED:19686683] [PUBMED:18490439] [PUBMED:11150244] [PUBMED:9694793] [PUBMED:10206645] [PUBMED:19704010] [PUBMED:16137758] [PUBMED:15288258] [PUBMED:17392792] [PUBMED:8749394] [PUBMED:15965470] [PUBMED:14566063] [PUBMED:19567869] [PUBMED:11585921] [PUBMED:18676613] [PUBMED:12913000] [PUBMED:10593990] [PUBMED:15274632] [PUBMED:11777909] [PUBMED:12015972] [PUBMED:10028969] [PUBMED:18043734] [PUBMED:17658279] [PUBMED:17575125] [PUBMED:10958687] [PUBMED:15300010] [PUBMED:10882062] [PUBMED:12374742] [PUBMED:11782429] [PUBMED:9653148] [PUBMED:9315665] [PUBMED:8643690] [PUBMED:17114293] [PUBMED:10837024] [PUBMED:15067010] [PUBMED:17296795] [PUBMED:10940313] [PUBMED:18628966] [PUBMED:12826675] [PUBMED:12681948] [PUBMED:16492672] [PUBMED:12551931] [PUBMED:15082708] [PUBMED:12464310] [PUBMED:12794186] [PUBMED:16107360] [PUBMED:19726682] [PUBMED:11486031] [PUBMED:16287852] [PUBMED:12297508] [PUBMED:16061358] [PUBMED:17107962] [PUBMED:9244302] [PUBMED:11425854] [PUBMED:9620803] [PUBMED:15272268] [PUBMED:18417156] [PUBMED:16000382] [PUBMED:11896183] [PUBMED:11604511] [PUBMED:16847353] [PUBMED:11432830] [PUBMED:15652348] [PUBMED:12417415] [PUBMED:14567914] [PUBMED:11006133] [PUBMED:18077452] [PUBMED:16144902] [PUBMED:15288257] [PUBMED:15585829] [PUBMED:12370315] [PUBMED:15288260] [PUBMED:17434929] [PUBMED:12814948] [PUBMED:10882063] [PUBMED:11518718]
Notch-mediated HES/HEY network [NCBI:169347] [Pathway Interaction Database:hes_heypathway] [PUBMED:15546612] [PUBMED:11038350] [PUBMED:12065598] [PUBMED:11741889] [PUBMED:10851137] [PUBMED:10205173] [PUBMED:10747963] [PUBMED:10913198] [PUBMED:11101851] [PUBMED:16201968] [PUBMED:12488457] [PUBMED:12370315] [PUBMED:19116245] [PUBMED:16025100] [PUBMED:11486044] [PUBMED:15607978] [PUBMED:15467735] [PUBMED:14739937] [PUBMED:9694793] [PUBMED:8749394] [PUBMED:16782059] [PUBMED:12972610] [PUBMED:17392792] [PUBMED:11334435] [PUBMED:11486045] [PUBMED:16753023] [PUBMED:15485867] [PUBMED:15866158] [PUBMED:16199874] [PUBMED:12374742] [PUBMED:9570950] [PUBMED:10964718] [PUBMED:16682003] [PUBMED:16287852] [PUBMED:10692439] [PUBMED:11095750] [PUBMED:11287612] [PUBMED:15314183] [PUBMED:15156153] [PUBMED:15684393] [PUBMED:7566092] [PUBMED:11604511] [PUBMED:9819403] [PUBMED:15563463] [PUBMED:15870295]
Presynaptic phase of homologous DNA pairing and strand exchange [NCBI:1309104] [REACTOME:R-HSA-5693616] [PUBMED:20729858] [PUBMED:15665856] [PUBMED:20729832] [PUBMED:23149936] [PUBMED:23810717] [PUBMED:15703751] [PUBMED:18317453] [PUBMED:20729859] [PUBMED:11751635]
Processing of DNA double-strand break ends [NCBI:1309101] [REACTOME:R-HSA-5693607] [PUBMED:25122754] [PUBMED:18171670] [PUBMED:20965415] [PUBMED:22231403] [PUBMED:25558984] [PUBMED:19357644] [PUBMED:21325134] [PUBMED:21240188] [PUBMED:21659603] [PUBMED:23468639] [PUBMED:25659039]
Regulation of TP53 Activity [NCBI:1383076] [REACTOME:R-HSA-5633007] [PUBMED:19450511] [PUBMED:20457558] [PUBMED:23825024] [PUBMED:25641576]
Regulation of TP53 Activity through Phosphorylation [NCBI:1383080] [REACTOME:R-HSA-6804756] [PUBMED:11780126] [PUBMED:21317932] [PUBMED:15866171] [PUBMED:12393879] [PUBMED:11740489] [PUBMED:11447225] [PUBMED:9733515] [PUBMED:12851404] [PUBMED:10884347] [PUBMED:10710310] [PUBMED:11239457] [PUBMED:9925639] [PUBMED:11546806] [PUBMED:11551930] [PUBMED:10570149] [PUBMED:18490454] [PUBMED:17591690] [PUBMED:19965871] [PUBMED:12064478] [PUBMED:10673501] [PUBMED:22611192] [PUBMED:9843217] [PUBMED:15053879] [PUBMED:12914926] [PUBMED:10673500] [PUBMED:17349958] [PUBMED:14702041] [PUBMED:20959462] [PUBMED:10435622] [PUBMED:9733514]
Resolution of D-Loop Structures [NCBI:1309105] [REACTOME:R-HSA-5693537] [PUBMED:12902160] [PUBMED:20965415]
Resolution of D-loop Structures through Holliday Junction Intermediates [NCBI:1309106] [REACTOME:R-HSA-5693568] [PUBMED:24831703] [PUBMED:23509288] [PUBMED:22645308] [PUBMED:14527420] [PUBMED:19596236] [PUBMED:24509834] [PUBMED:14685245] [PUBMED:24076221] [PUBMED:24371268]
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) [NCBI:1309107] [REACTOME:R-HSA-5693554] [PUBMED:16855289] [PUBMED:22593209] [PUBMED:24115439] [PUBMED:20417600] [PUBMED:16648486] [PUBMED:19305001] [PUBMED:18957201]
Transcriptional Regulation by TP53 [NCBI:1269654] [REACTOME:R-HSA-3700989] [PUBMED:26122615] [PUBMED:19410540]