full name
protein inhibitor of activated STAT 2

synonyms
ARIP3, DIP, MIZ, MIZ1, PIASX, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4, PIAS2, ENSG00000078043

HGNC
HGNC:17311

Entrez Gene
Gene:9063

ENSEMBL
ENSG00000078043

location
chr: 18
start: 44388900
stop: 44500130
strand: -

transcripts
NM_004671.3
NM_173206.3

pathways
Activation of HOX genes during differentiation [NCBI:1339139] [REACTOME:R-HSA-5619507] [PUBMED:19923920] [PUBMED:25804734] [PUBMED:23973942] [PUBMED:23650639] [PUBMED:20435029] [PUBMED:24529385]
Activation of anterior HOX genes in hindbrain development during early embryogenesis [NCBI:1339140] [REACTOME:R-HSA-5617472] [PUBMED:19575673] [PUBMED:23973942] [PUBMED:18394579] [PUBMED:24529385] [PUBMED:24115586] [PUBMED:18412118] [PUBMED:19651303] [PUBMED:25804734] [PUBMED:22770981] [PUBMED:19923920] [PUBMED:16155570] [PUBMED:18816852] [PUBMED:25560970] [PUBMED:10068641] [PUBMED:10662633] [PUBMED:20435029] [PUBMED:17368312] [PUBMED:21497760] [PUBMED:10668974]
Developmental Biology [NCBI:1270302] [REACTOME:R-HSA-1266738]
IL12 signaling mediated by STAT4 [NCBI:137936] [Pathway Interaction Database:il12_stat4pathway] [PUBMED:2504877] [PUBMED:7722452] [PUBMED:16365415] [PUBMED:9558063] [PUBMED:8700209] [PUBMED:9325300] [PUBMED:12213961] [PUBMED:10037767] [PUBMED:7737303] [PUBMED:10358173] [PUBMED:16641133] [PUBMED:12372421] [PUBMED:10946290] [PUBMED:11046021] [PUBMED:14660657] [PUBMED:15728489] [PUBMED:10097133] [PUBMED:11207258] [PUBMED:11801649] [PUBMED:11786644] [PUBMED:10229825] [PUBMED:11466347] [PUBMED:12716907] [PUBMED:8700208] [PUBMED:15522880]
Jak-STAT signaling pathway [NCBI:83077] [KEGG:hsa04630] [PUBMED:21034406] [PUBMED:22339650] [PUBMED:16204702] [PUBMED:25587654] [PUBMED:24069565] [PUBMED:22383755] [PUBMED:24606160] [PUBMED:10851053] [PUBMED:23735217] [PUBMED:25217450] [PUBMED:21372217]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Pathways in cancer [NCBI:83105] [KEGG:hsa05200] [PUBMED:12244301] [PUBMED:15156182] [PUBMED:16899407] [PUBMED:12621137] [PUBMED:21193867] [PUBMED:16001072] [PUBMED:11707511] [PUBMED:11253051] [PUBMED:11071626] [PUBMED:17251915] [PUBMED:11736900] [PUBMED:16557281] [PUBMED:16699851] [PUBMED:16189702] [PUBMED:11902573] [PUBMED:16555243] [PUBMED:8069858] [PUBMED:15310786] [PUBMED:9834202] [PUBMED:16700615] [PUBMED:12545153] [PUBMED:15656799] [PUBMED:12154354] [PUBMED:11895903] [PUBMED:11527574] [PUBMED:16326109] [PUBMED:16339096] [PUBMED:11160144] [PUBMED:15724144] [PUBMED:12951584] [PUBMED:10647931] [PUBMED:16881963] [PUBMED:15557758] [PUBMED:11477132] [PUBMED:15721476] [PUBMED:15625120] [PUBMED:16236521] [PUBMED:14967450] [PUBMED:15942304] [PUBMED:17287871] [PUBMED:14634372] [PUBMED:15573119] [PUBMED:15009714] [PUBMED:16112428] [PUBMED:15611513] [PUBMED:16001050] [PUBMED:15349822] [PUBMED:16551846] [PUBMED:15978322] [PUBMED:15774796] [PUBMED:16352814] [PUBMED:12951588] [PUBMED:10944551] [PUBMED:10740269] [PUBMED:15639402] [PUBMED:12407699] [PUBMED:11130178] [PUBMED:15109562] [PUBMED:11170304] [PUBMED:11276000] [PUBMED:9643506] [PUBMED:16248975] [PUBMED:16242838] [PUBMED:12946833] [PUBMED:11559746] [PUBMED:9196022] [PUBMED:12079267] [PUBMED:15468170] [PUBMED:16064138] [PUBMED:14580692] [PUBMED:15082523] [PUBMED:15551095] [PUBMED:17062879] [PUBMED:17211469] [PUBMED:11720739] [PUBMED:12588368] [PUBMED:11057895] [PUBMED:9422516] [PUBMED:12894244] [PUBMED:15479695] [PUBMED:16189154] [PUBMED:12878745] [PUBMED:11900250] [PUBMED:11103787] [PUBMED:15122209] [PUBMED:12711111] [PUBMED:12243753] [PUBMED:16306523] [PUBMED:16702400] [PUBMED:15270885] [PUBMED:14685170] [PUBMED:14586404] [PUBMED:11078609] [PUBMED:15284264] [PUBMED:10505543] [PUBMED:11223406] [PUBMED:14982876] [PUBMED:12648469] [PUBMED:12867060] [PUBMED:15711891] [PUBMED:12094241] [PUBMED:16642045] [PUBMED:11463388] [PUBMED:12762887] [PUBMED:15746962] [PUBMED:15823750] [PUBMED:16750612] [PUBMED:16484590] [PUBMED:11459867] [PUBMED:16146838] [PUBMED:14556242] [PUBMED:15947972] [PUBMED:12563308] [PUBMED:16946003] [PUBMED:15948971] [PUBMED:11407945] [PUBMED:12737309] [PUBMED:16095998] [PUBMED:12351585] [PUBMED:24508914] [PUBMED:12084351] [PUBMED:11807782] [PUBMED:14695152] [PUBMED:10453277] [PUBMED:17554387] [PUBMED:15841168] [PUBMED:12616528] [PUBMED:10403855] [PUBMED:16054233] [PUBMED:16474624] [PUBMED:16822996] [PUBMED:17028294] [PUBMED:11224709] [PUBMED:11750244] [PUBMED:11905738] [PUBMED:15719031] [PUBMED:10843728] [PUBMED:16110317] [PUBMED:11721960] [PUBMED:12741677] [PUBMED:7585656] [PUBMED:12801837] [PUBMED:16551847] [PUBMED:12459728] [PUBMED:11431710] [PUBMED:12468433] [PUBMED:11165748] [PUBMED:16042571] [PUBMED:16508724] [PUBMED:15000146] [PUBMED:17149381] [PUBMED:15948711] [PUBMED:14747944] [PUBMED:14737121] [PUBMED:12379883] [PUBMED:17158541] [PUBMED:12850530] [PUBMED:10835690] [PUBMED:16870043]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
SUMO E3 ligases SUMOylate target proteins [NCBI:1268743] [REACTOME:R-HSA-3108232] [PUBMED:20674646] [PUBMED:17763827] [PUBMED:19471022] [PUBMED:23746258] [PUBMED:24016193] [PUBMED:23503365] [PUBMED:21252943] [PUBMED:17000644] [PUBMED:24273646] [PUBMED:22811915] [PUBMED:21693764] [PUBMED:23277067] [PUBMED:21102611]
SUMOylation [NCBI:1268738] [REACTOME:R-HSA-2990846] [PUBMED:21102611] [PUBMED:20674646] [PUBMED:23514139] [PUBMED:19923268] [PUBMED:20462400] [PUBMED:17768054]
SUMOylation of DNA damage response and repair proteins [NCBI:1268744] [REACTOME:R-HSA-3108214] [PUBMED:22018829] [PUBMED:24926426] [PUBMED:23122649] [PUBMED:23781231] [PUBMED:23416108] [PUBMED:21486569] [PUBMED:23746258] [PUBMED:21896653] [PUBMED:22357966] [PUBMED:21664912]
Small cell lung cancer [NCBI:83118] [KEGG:hsa05222] [PUBMED:12711111] [PUBMED:11463388] [PUBMED:12741677] [PUBMED:11905738] [PUBMED:11807782] [PUBMED:12379883] [PUBMED:12243753] [PUBMED:12616528] [PUBMED:11720739] [PUBMED:15109562] [PUBMED:12407699] [PUBMED:10944551] [PUBMED:16112428] [PUBMED:11559746] [PUBMED:16064138] [PUBMED:11902573]
Sumoylation by RanBP2 regulates transcriptional repression [NCBI:138029] [Pathway Interaction Database:ranbp2pathway] [PUBMED:11960997] [PUBMED:12393906] [PUBMED:8978815] [PUBMED:9456312] [PUBMED:12032081] [PUBMED:9019411] [PUBMED:9427648] [PUBMED:9108047] [PUBMED:12393750] [PUBMED:10892746] [PUBMED:9323132] [PUBMED:10454574]
Ubiquitin mediated proteolysis [NCBI:83056] [KEGG:hsa04120] [PUBMED:16405856] [PUBMED:12944364] [PUBMED:16922408] [PUBMED:17588513] [PUBMED:16922367] [PUBMED:16922370] [PUBMED:16816840]