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Genes
SMAD7
Gene - SMAD7
full name
SMAD family member 7
synonyms
CRCS3, MADH7, MADH8, SMAD7, ENSG00000101665
HGNC
HGNC:6773
Entrez Gene
Gene:4092
ENSEMBL
ENSG00000101665
location
chr: 18
start: 46446223
stop: 46477081
strand: -
OMIM
OMIM:602932
: SMAD7
OMIM:612229
: {Colorectal cancer, susceptibility to, 3}
transcripts
NM_001190821.1
NM_005904.3
NM_001190822.1
NM_001190823.1
pathways
ALK1 signaling events
[NCBI:137968]
[Pathway Interaction Database:alk1pathway]
[PUBMED:9748228]
[PUBMED:17071858]
[PUBMED:14580334]
[PUBMED:9920917]
[PUBMED:17911401]
[PUBMED:17311849]
[PUBMED:8140412]
[PUBMED:17068149]
[PUBMED:8242742]
[PUBMED:16571110]
[PUBMED:9872992]
[PUBMED:8612709]
[PUBMED:18065769]
[PUBMED:1326540]
[PUBMED:15385967]
[PUBMED:8756725]
[PUBMED:11927558]
[PUBMED:10187774]
[PUBMED:8294451]
[PUBMED:15702480]
[PUBMED:10716993]
[PUBMED:17540773]
[PUBMED:19592636]
BMP receptor signaling
[NCBI:137948]
[Pathway Interaction Database:bmppathway]
[PUBMED:9136927]
[PUBMED:12857866]
[PUBMED:11158580]
[PUBMED:10748465]
[PUBMED:11401399]
[PUBMED:9442019]
[PUBMED:10814522]
[PUBMED:8752214]
[PUBMED:9660951]
[PUBMED:17085434]
[PUBMED:11714695]
[PUBMED:7644468]
[PUBMED:15671031]
[PUBMED:8065329]
[PUBMED:16604073]
[PUBMED:8006002]
[PUBMED:9436979]
[PUBMED:9689081]
[PUBMED:9335505]
[PUBMED:17289590]
[PUBMED:8893010]
[PUBMED:16931515]
[PUBMED:10748100]
[PUBMED:15020244]
[PUBMED:11121043]
[PUBMED:15975920]
[PUBMED:7937936]
[PUBMED:11016919]
[PUBMED:8752213]
[PUBMED:7673243]
[PUBMED:10519551]
[PUBMED:8662721]
[PUBMED:9878061]
[PUBMED:17356069]
[PUBMED:7791754]
[PUBMED:8653785]
[PUBMED:10504300]
[PUBMED:10458166]
Deubiquitination
[NCBI:1427860]
[REACTOME:R-HSA-5688426]
[PUBMED:19243136]
[PUBMED:20074029]
[PUBMED:15571815]
[PUBMED:20418328]
[PUBMED:16325574]
[PUBMED:12944365]
[PUBMED:23845989]
[PUBMED:22201797]
Downregulation of TGF-beta receptor signaling
[NCBI:1269525]
[REACTOME:R-HSA-2173788]
[PUBMED:10519551]
[PUBMED:16027725]
[PUBMED:9215638]
[PUBMED:20937913]
[PUBMED:20129061]
[PUBMED:11158580]
[PUBMED:9335507]
[PUBMED:15781469]
[PUBMED:12519765]
[PUBMED:16061177]
[PUBMED:10757800]
[PUBMED:11278251]
[PUBMED:12151385]
[PUBMED:20061380]
[PUBMED:22045334]
[PUBMED:14701756]
[PUBMED:15496141]
[PUBMED:19758997]
[PUBMED:14718519]
[PUBMED:22344298]
[PUBMED:11163210]
Gene Expression
[NCBI:1269649]
[REACTOME:R-HSA-74160]
Generic Transcription Pathway
[NCBI:1269650]
[REACTOME:R-HSA-212436]
[PUBMED:15175151]
[PUBMED:14744435]
[PUBMED:15680972]
[PUBMED:11395415]
[PUBMED:15896744]
[PUBMED:10235266]
[PUBMED:14986688]
[PUBMED:12023297]
[PUBMED:15680973]
[PUBMED:16751179]
[PUBMED:11861166]
[PUBMED:16429119]
[PUBMED:16719718]
[PUBMED:16921404]
[PUBMED:15690163]
Hippo signaling pathway
[NCBI:749777]
[KEGG:hsa04390]
[PUBMED:18955139]
[PUBMED:20439427]
[PUBMED:20951342]
[PUBMED:21138973]
[PUBMED:18328423]
[PUBMED:21324984]
[PUBMED:23034192]
[PUBMED:21808241]
[PUBMED:17975546]
[PUBMED:22750148]
[PUBMED:21084559]
[PUBMED:19846288]
[PUBMED:22895435]
[PUBMED:22683405]
[PUBMED:22658639]
[PUBMED:22153608]
[PUBMED:20945341]
[PUBMED:22830020]
[PUBMED:21874053]
[PUBMED:21376238]
IFN-gamma pathway
[NCBI:138040]
[Pathway Interaction Database:ifngpathway]
[PUBMED:9724754]
[PUBMED:10657627]
[PUBMED:10067896]
[PUBMED:9271410]
[PUBMED:8608598]
[PUBMED:15878863]
[PUBMED:11971965]
[PUBMED:11438544]
[PUBMED:15051500]
[PUBMED:17032168]
[PUBMED:11909529]
[PUBMED:11171987]
[PUBMED:7514165]
[PUBMED:12817007]
[PUBMED:8232552]
[PUBMED:10485906]
[PUBMED:8755534]
[PUBMED:10490100]
[PUBMED:8156998]
[PUBMED:11972023]
[PUBMED:8986769]
[PUBMED:12438563]
[PUBMED:10022928]
[PUBMED:12270932]
[PUBMED:7510216]
[PUBMED:15311277]
[PUBMED:14670297]
[PUBMED:12048245]
[PUBMED:10777554]
[PUBMED:12138178]
[PUBMED:9336467]
[PUBMED:7690989]
[PUBMED:1281555]
[PUBMED:17606919]
[PUBMED:10805787]
[PUBMED:12050152]
[PUBMED:8608597]
[PUBMED:15879117]
[PUBMED:12855578]
[PUBMED:10995751]
[PUBMED:10490099]
[PUBMED:7777519]
Metabolism of proteins
[NCBI:1268677]
[REACTOME:R-HSA-392499]
Post-translational protein modification
[NCBI:1268701]
[REACTOME:R-HSA-597592]
Regulation of nuclear SMAD2/3 signaling
[NCBI:137963]
[Pathway Interaction Database:smad2_3nuclearpathway]
[PUBMED:15009097]
[PUBMED:11790301]
[PUBMED:11836524]
[PUBMED:10995736]
[PUBMED:11114293]
[PUBMED:10973944]
[PUBMED:10022869]
[PUBMED:11058129]
[PUBMED:9722503]
[PUBMED:12904571]
[PUBMED:14993291]
[PUBMED:11013220]
[PUBMED:15363409]
[PUBMED:9702197]
[PUBMED:12718878]
[PUBMED:11331591]
[PUBMED:12167862]
[PUBMED:14729983]
[PUBMED:9707553]
[PUBMED:10878024]
[PUBMED:9679060]
[PUBMED:10887155]
[PUBMED:10199400]
[PUBMED:12631740]
[PUBMED:11555647]
[PUBMED:15688032]
[PUBMED:12150994]
[PUBMED:12374795]
[PUBMED:9606191]
[PUBMED:9702198]
[PUBMED:10518526]
[PUBMED:10575014]
[PUBMED:10485843]
[PUBMED:11283614]
[PUBMED:10722728]
[PUBMED:10037600]
[PUBMED:15241418]
[PUBMED:14691252]
[PUBMED:10748032]
[PUBMED:12551947]
[PUBMED:14671321]
[PUBMED:11427533]
[PUBMED:11711431]
[PUBMED:10531362]
[PUBMED:11571228]
[PUBMED:10085140]
[PUBMED:17478422]
[PUBMED:15044954]
[PUBMED:10964912]
[PUBMED:11707452]
[PUBMED:11801598]
[PUBMED:17074756]
[PUBMED:12226080]
[PUBMED:10557285]
[PUBMED:10843994]
[PUBMED:15084259]
[PUBMED:10531062]
[PUBMED:16959612]
[PUBMED:9679056]
[PUBMED:10652350]
[PUBMED:9618481]
[PUBMED:11927558]
[PUBMED:9732876]
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
[NCBI:1269528]
[REACTOME:R-HSA-2173796]
[PUBMED:22275377]
[PUBMED:18568018]
[PUBMED:15150273]
[PUBMED:10934479]
[PUBMED:11294908]
[PUBMED:12592392]
[PUBMED:10022869]
[PUBMED:14657019]
[PUBMED:11013220]
[PUBMED:11274402]
[PUBMED:19914168]
[PUBMED:12150994]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by BMP
[NCBI:1269522]
[REACTOME:R-HSA-201451]
[PUBMED:19762341]
Signaling by TGF-beta Receptor Complex
[NCBI:1269523]
[REACTOME:R-HSA-170834]
[PUBMED:19648010]
Signaling events mediated by HDAC Class I
[NCBI:137997]
[Pathway Interaction Database:hdac_classi_pathway]
[PUBMED:9885572]
[PUBMED:14701748]
[PUBMED:10888618]
[PUBMED:12393750]
[PUBMED:9804427]
[PUBMED:9139820]
[PUBMED:12408818]
[PUBMED:16809764]
[PUBMED:12788099]
[PUBMED:11533489]
[PUBMED:15831498]
[PUBMED:15701600]
[PUBMED:11532945]
[PUBMED:12183469]
[PUBMED:16428440]
[PUBMED:9150134]
[PUBMED:12972430]
[PUBMED:11486036]
[PUBMED:15920470]
[PUBMED:9150135]
[PUBMED:9651585]
[PUBMED:11960997]
[PUBMED:9326634]
[PUBMED:11278251]
[PUBMED:14521922]
[PUBMED:9197243]
[PUBMED:9346952]
[PUBMED:16371367]
[PUBMED:10444591]
[PUBMED:15653507]
[PUBMED:15920471]
[PUBMED:11919195]
TGF-beta receptor signaling
[NCBI:138024]
[Pathway Interaction Database:tgfbrpathway]
[PUBMED:12118366]
[PUBMED:8242743]
[PUBMED:15221015]
[PUBMED:9335507]
[PUBMED:11278302]
[PUBMED:16601693]
[PUBMED:8391934]
[PUBMED:1333888]
[PUBMED:11438668]
[PUBMED:17327236]
[PUBMED:2879635]
[PUBMED:11483955]
[PUBMED:12717440]
[PUBMED:8047140]
[PUBMED:8576253]
[PUBMED:9865696]
[PUBMED:9346908]
[PUBMED:17197390]
[PUBMED:8533096]
[PUBMED:8756725]
[PUBMED:10615055]
[PUBMED:10934479]
[PUBMED:16251192]
[PUBMED:7706248]
[PUBMED:15946939]
[PUBMED:7774578]
[PUBMED:7988555]
[PUBMED:11278251]
[PUBMED:11027280]
[PUBMED:17420258]
[PUBMED:9169454]
[PUBMED:12151385]
[PUBMED:10757800]
[PUBMED:12543979]
[PUBMED:12475967]
[PUBMED:9679059]
[PUBMED:17673906]
[PUBMED:9774674]
[PUBMED:8893010]
[PUBMED:1544886]
[PUBMED:12958365]
[PUBMED:12110587]
[PUBMED:9233797]
[PUBMED:11163210]
[PUBMED:15496141]
[PUBMED:7693660]
[PUBMED:14657019]
[PUBMED:12429842]
[PUBMED:11124802]
[PUBMED:11389444]
[PUBMED:8798398]
[PUBMED:15356634]
[PUBMED:17272273]
[PUBMED:1657407]
[PUBMED:12589052]
[PUBMED:11016919]
[PUBMED:14718519]
[PUBMED:10777621]
[PUBMED:17384642]
[PUBMED:1310899]
[PUBMED:9856985]
[PUBMED:10519551]
[PUBMED:9155023]
[PUBMED:12134160]
[PUBMED:9215638]
[PUBMED:12134149]
[PUBMED:16157589]
[PUBMED:12356868]
[PUBMED:11387212]
[PUBMED:12034739]
[PUBMED:11739411]
[PUBMED:15761148]
[PUBMED:9463378]
[PUBMED:11583628]
[PUBMED:15684397]
[PUBMED:8947046]
[PUBMED:11781097]
TGF-beta receptor signaling activates SMADs
[NCBI:1269524]
[REACTOME:R-HSA-2173789]
[PUBMED:9346966]
[PUBMED:15350224]
[PUBMED:7737999]
[PUBMED:11100470]
[PUBMED:7693660]
[PUBMED:9670020]
[PUBMED:15564041]
[PUBMED:9233797]
[PUBMED:20207738]
[PUBMED:11779505]
[PUBMED:18243111]
[PUBMED:8947046]
[PUBMED:1333888]
[PUBMED:9311995]
[PUBMED:12482908]
[PUBMED:8980228]
[PUBMED:8242743]
[PUBMED:9865696]
[PUBMED:8047140]
[PUBMED:21423151]
TGF-beta signaling pathway
[NCBI:83064]
[KEGG:hsa04350]
[PUBMED:11836504]
[PUBMED:14534577]
[PUBMED:10021351]
[PUBMED:12809600]
[PUBMED:14557817]
[PUBMED:14769828]
[PUBMED:10519551]
[PUBMED:12163231]
[PUBMED:19758997]
[PUBMED:12466190]
[PUBMED:11252746]
[PUBMED:15063168]
[PUBMED:9847239]
[PUBMED:11252892]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
[NCBI:1269527]
[REACTOME:R-HSA-2173793]
[PUBMED:12150994]
[PUBMED:16751101]
[PUBMED:10199400]
[PUBMED:18568018]
[PUBMED:19135894]
[PUBMED:10531062]
UCH proteinases
[NCBI:1427861]
[REACTOME:R-HSA-5689603]
[PUBMED:16325574]
[PUBMED:19243136]
Ub-specific processing proteases
[NCBI:1427862]
[REACTOME:R-HSA-5689880]
[PUBMED:16325574]