Logo
full name
G protein subunit alpha 11

synonyms
GNA-11, GNA11, ENSG00000088256

HGNC
HGNC:4379

Entrez Gene
Gene:2767

ENSEMBL
ENSG00000088256

location
chr: 19
start: 3094408
stop: 3121468
strand: +

OMIM
OMIM:139313: GNA11 (Autosomal dominant inheritance)
OMIM:615361: Hypocalcemia, autosomal dominant 2
OMIM:145981: Hypocalciuric hypercalcemia, type II

transcripts
NM_002067.2

pathways
ADP signalling through P2Y purinoceptor 1 [NCBI:1269354] [REACTOME:R-HSA-418592] [PUBMED:9442040]
Acetylcholine regulates insulin secretion [NCBI:1270104] [REACTOME:R-HSA-399997] [PUBMED:11588141] [PUBMED:12161432]
Aldosterone synthesis and secretion [NCBI:1272485] [KEGG:hsa04925] [PUBMED:15044681] [PUBMED:10536682] [PUBMED:24944029] [PUBMED:25788893] [PUBMED:15026188] [PUBMED:22689262] [PUBMED:22364774] [PUBMED:18406824] [PUBMED:14645496] [PUBMED:21839803] [PUBMED:22395411] [PUBMED:23628605] [PUBMED:21962440]
Amoebiasis [NCBI:167324] [KEGG:hsa05146] [PUBMED:9832261] [PUBMED:16380324] [PUBMED:14700586] [PUBMED:18725798] [PUBMED:12142490] [PUBMED:10637584] [PUBMED:20145703] [PUBMED:11378035] [PUBMED:12160867] [PUBMED:15813717] [PUBMED:19207103] [PUBMED:12660071] [PUBMED:20303955] [PUBMED:11352795] [PUBMED:14502002] [PUBMED:10756002] [PUBMED:17702556] [PUBMED:17576362]
Arf6 signaling events [NCBI:138034] [Pathway Interaction Database:arf6_pathway] [PUBMED:18164504] [PUBMED:15509780] [PUBMED:11481345] [PUBMED:18084281] [PUBMED:15775968] [PUBMED:18094045] [PUBMED:17409355] [PUBMED:11532961] [PUBMED:10480924] [PUBMED:15126638] [PUBMED:17398097] [PUBMED:18026091] [PUBMED:17353194] [PUBMED:15793570] [PUBMED:16650966] [PUBMED:12920129] [PUBMED:11278939] [PUBMED:9742223] [PUBMED:11062263] [PUBMED:16461286] [PUBMED:10779358] [PUBMED:18003747] [PUBMED:15923660] [PUBMED:10642533] [PUBMED:11342560] [PUBMED:10448098] [PUBMED:11226253] [PUBMED:18490450] [PUBMED:19193766] [PUBMED:10913124] [PUBMED:10811902] [PUBMED:17077126] [PUBMED:11533043] [PUBMED:12447393] [PUBMED:10333475] [PUBMED:9550703] [PUBMED:10075920] [PUBMED:9417041] [PUBMED:17719203] [PUBMED:14625293] [PUBMED:17122362] [PUBMED:17846866]
Calcium signaling pathway [NCBI:83050] [KEGG:hsa04020] [PUBMED:11080247] [PUBMED:14572802] [PUBMED:11413485] [PUBMED:22129055] [PUBMED:10508738] [PUBMED:15000521] [PUBMED:9235901] [PUBMED:7861177] [PUBMED:9149541] [PUBMED:14517314] [PUBMED:15111104] [PUBMED:11698232] [PUBMED:10331643] [PUBMED:12838335] [PUBMED:8125957] [PUBMED:19172794] [PUBMED:10997573] [PUBMED:21338471] [PUBMED:11299192] [PUBMED:22002090] [PUBMED:12972622]
Chagas disease (American trypanosomiasis) [NCBI:147809] [KEGG:hsa05142] [PUBMED:12377585] [PUBMED:9794425] [PUBMED:1717552] [PUBMED:16238097] [PUBMED:10066513] [PUBMED:12874238] [PUBMED:12036740] [PUBMED:15917295] [PUBMED:12055254] [PUBMED:17651955] [PUBMED:1396957] [PUBMED:16175174] [PUBMED:2194668] [PUBMED:9190942] [PUBMED:12377942] [PUBMED:12427093] [PUBMED:10234174] [PUBMED:16030288] [PUBMED:15223603] [PUBMED:17110955]
Cholinergic synapse [NCBI:217716] [KEGG:hsa04725] [PUBMED:20060019] [PUBMED:11283752] [PUBMED:15165747] [PUBMED:12893537] [PUBMED:11738031] [PUBMED:21550798] [PUBMED:19712465] [PUBMED:12690458] [PUBMED:12436417] [PUBMED:19378880] [PUBMED:11923408] [PUBMED:20446119]
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion [NCBI:1270106] [REACTOME:R-HSA-434316]
Free fatty acids regulate insulin secretion [NCBI:1270105] [REACTOME:R-HSA-400451] [PUBMED:18606873] [PUBMED:17395749] [PUBMED:17130640] [PUBMED:18827341] [PUBMED:15047616]
G alpha (q) signalling events [NCBI:1269578] [REACTOME:R-HSA-416476] [PUBMED:19212139]
GPCR downstream signaling [NCBI:1269574] [REACTOME:R-HSA-388396] [PUBMED:12040175]
Gap junction [NCBI:83072] [KEGG:hsa04540] [PUBMED:9535909] [PUBMED:15033578] [PUBMED:12566218] [PUBMED:14506308] [PUBMED:10751659] [PUBMED:10873290] [PUBMED:15955302] [PUBMED:15033579] [PUBMED:15033580] [PUBMED:15094344]
Gastrin-CREB signalling pathway via PKC and MAPK [NCBI:1269592] [REACTOME:R-HSA-881907] [PUBMED:10413847] [PUBMED:7491953] [PUBMED:17698287]
GnRH signaling pathway [NCBI:83091] [KEGG:hsa04912] [PUBMED:15080147] [PUBMED:15982836] [PUBMED:14596811] [PUBMED:15613448] [PUBMED:12943720] [PUBMED:10707049] [PUBMED:15350605] [PUBMED:12963732]
Hemostasis [NCBI:1269340] [REACTOME:R-HSA-109582]
Insulin secretion [NCBI:777534] [KEGG:hsa04911] [PUBMED:9715374] [PUBMED:10605628] [PUBMED:9914469] [PUBMED:17306374] [PUBMED:20055708] [PUBMED:15655710] [PUBMED:19817784] [PUBMED:19074620] [PUBMED:14693691] [PUBMED:17084085] [PUBMED:20551594] [PUBMED:19036624] [PUBMED:22970724] [PUBMED:20225132] [PUBMED:19817800] [PUBMED:22974438] [PUBMED:21934040] [PUBMED:15271645] [PUBMED:19660440] [PUBMED:11522660]
Integration of energy metabolism [NCBI:1270101] [REACTOME:R-HSA-163685] [PUBMED:15509864] [PUBMED:12721358] [PUBMED:12626323]
LPA receptor mediated events [NCBI:137928] [Pathway Interaction Database:lysophospholipid_pathway] [PUBMED:10601262] [PUBMED:16289596] [PUBMED:7809106] [PUBMED:10342794] [PUBMED:15928312] [PUBMED:16769764] [PUBMED:11243883] [PUBMED:14688263] [PUBMED:10551845] [PUBMED:16687414] [PUBMED:9819398] [PUBMED:7527052] [PUBMED:9600933] [PUBMED:2551506] [PUBMED:15988003] [PUBMED:10644509] [PUBMED:16199135] [PUBMED:15728708] [PUBMED:1637305] [PUBMED:7476905] [PUBMED:7510708] [PUBMED:8647803] [PUBMED:10420989] [PUBMED:12880866] [PUBMED:10766839] [PUBMED:12181443] [PUBMED:15461590] [PUBMED:16452634] [PUBMED:16197369] [PUBMED:10779388] [PUBMED:10506190] [PUBMED:9305878] [PUBMED:16904289] [PUBMED:15878967] [PUBMED:15143197] [PUBMED:11948806] [PUBMED:11040035] [PUBMED:12393875] [PUBMED:9407095] [PUBMED:15280372] [PUBMED:16890224] [PUBMED:8805276]
Long-term depression [NCBI:83086] [KEGG:hsa04730] [PUBMED:9602501] [PUBMED:9735948] [PUBMED:14509570] [PUBMED:11427694] [PUBMED:12415297]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Pathways in cancer [NCBI:83105] [KEGG:hsa05200] [PUBMED:12244301] [PUBMED:15156182] [PUBMED:16899407] [PUBMED:12621137] [PUBMED:21193867] [PUBMED:16001072] [PUBMED:11707511] [PUBMED:11253051] [PUBMED:11071626] [PUBMED:17251915] [PUBMED:11736900] [PUBMED:16557281] [PUBMED:16699851] [PUBMED:16189702] [PUBMED:11902573] [PUBMED:16555243] [PUBMED:8069858] [PUBMED:15310786] [PUBMED:9834202] [PUBMED:16700615] [PUBMED:12545153] [PUBMED:15656799] [PUBMED:12154354] [PUBMED:11895903] [PUBMED:11527574] [PUBMED:16326109] [PUBMED:16339096] [PUBMED:11160144] [PUBMED:15724144] [PUBMED:12951584] [PUBMED:10647931] [PUBMED:16881963] [PUBMED:15557758] [PUBMED:11477132] [PUBMED:15721476] [PUBMED:15625120] [PUBMED:16236521] [PUBMED:14967450] [PUBMED:15942304] [PUBMED:17287871] [PUBMED:14634372] [PUBMED:15573119] [PUBMED:15009714] [PUBMED:16112428] [PUBMED:15611513] [PUBMED:16001050] [PUBMED:15349822] [PUBMED:16551846] [PUBMED:15978322] [PUBMED:15774796] [PUBMED:16352814] [PUBMED:12951588] [PUBMED:10944551] [PUBMED:10740269] [PUBMED:15639402] [PUBMED:12407699] [PUBMED:11130178] [PUBMED:15109562] [PUBMED:11170304] [PUBMED:11276000] [PUBMED:9643506] [PUBMED:16248975] [PUBMED:16242838] [PUBMED:12946833] [PUBMED:11559746] [PUBMED:9196022] [PUBMED:12079267] [PUBMED:15468170] [PUBMED:16064138] [PUBMED:14580692] [PUBMED:15082523] [PUBMED:15551095] [PUBMED:17062879] [PUBMED:17211469] [PUBMED:11720739] [PUBMED:12588368] [PUBMED:11057895] [PUBMED:9422516] [PUBMED:12894244] [PUBMED:15479695] [PUBMED:16189154] [PUBMED:12878745] [PUBMED:11900250] [PUBMED:11103787] [PUBMED:15122209] [PUBMED:12711111] [PUBMED:12243753] [PUBMED:16306523] [PUBMED:16702400] [PUBMED:15270885] [PUBMED:14685170] [PUBMED:14586404] [PUBMED:11078609] [PUBMED:15284264] [PUBMED:10505543] [PUBMED:11223406] [PUBMED:14982876] [PUBMED:12648469] [PUBMED:12867060] [PUBMED:15711891] [PUBMED:12094241] [PUBMED:16642045] [PUBMED:11463388] [PUBMED:12762887] [PUBMED:15746962] [PUBMED:15823750] [PUBMED:16750612] [PUBMED:16484590] [PUBMED:11459867] [PUBMED:16146838] [PUBMED:14556242] [PUBMED:15947972] [PUBMED:12563308] [PUBMED:16946003] [PUBMED:15948971] [PUBMED:11407945] [PUBMED:12737309] [PUBMED:16095998] [PUBMED:12351585] [PUBMED:24508914] [PUBMED:12084351] [PUBMED:11807782] [PUBMED:14695152] [PUBMED:10453277] [PUBMED:17554387] [PUBMED:15841168] [PUBMED:12616528] [PUBMED:10403855] [PUBMED:16054233] [PUBMED:16474624] [PUBMED:16822996] [PUBMED:17028294] [PUBMED:11224709] [PUBMED:11750244] [PUBMED:11905738] [PUBMED:15719031] [PUBMED:10843728] [PUBMED:16110317] [PUBMED:11721960] [PUBMED:12741677] [PUBMED:7585656] [PUBMED:12801837] [PUBMED:16551847] [PUBMED:12459728] [PUBMED:11431710] [PUBMED:12468433] [PUBMED:11165748] [PUBMED:16042571] [PUBMED:16508724] [PUBMED:15000146] [PUBMED:17149381] [PUBMED:15948711] [PUBMED:14747944] [PUBMED:14737121] [PUBMED:12379883] [PUBMED:17158541] [PUBMED:12850530] [PUBMED:10835690] [PUBMED:16870043]
Platelet activation, signaling and aggregation [NCBI:1269350] [REACTOME:R-HSA-76002] [PUBMED:16543958] [PUBMED:8704248] [PUBMED:2018971] [PUBMED:1672265] [PUBMED:17059469] [PUBMED:12681240] [PUBMED:12411949] [PUBMED:11511514]
Regulation of insulin secretion [NCBI:1270102] [REACTOME:R-HSA-422356] [PUBMED:18200017] [PUBMED:11078440] [PUBMED:16321791] [PUBMED:11815463] [PUBMED:16556766]
S1P2 pathway [NCBI:138059] [Pathway Interaction Database:s1p_s1p2_pathway] [PUBMED:9854026] [PUBMED:10617617] [PUBMED:17431187] [PUBMED:12588974] [PUBMED:11094076] [PUBMED:15240112] [PUBMED:11853542] [PUBMED:12810709]
S1P3 pathway [NCBI:138063] [Pathway Interaction Database:s1p_s1p3_pathway] [PUBMED:12577307] [PUBMED:11853542] [PUBMED:17158356] [PUBMED:15138255] [PUBMED:14732717] [PUBMED:11150298] [PUBMED:14657000] [PUBMED:9854026] [PUBMED:10617617] [PUBMED:16527273]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signal amplification [NCBI:1269352] [REACTOME:R-HSA-392518] [PUBMED:18077812]
Signaling by GPCR [NCBI:1269543] [REACTOME:R-HSA-372790] [PUBMED:16902930] [PUBMED:10202136] [PUBMED:18043707]
Sphingosine 1-phosphate (S1P) pathway [NCBI:137931] [Pathway Interaction Database:s1p_meta_pathway] [PUBMED:12815058] [PUBMED:17050692] [PUBMED:9854026] [PUBMED:16584625] [PUBMED:10617617] [PUBMED:16520486] [PUBMED:14570870] [PUBMED:11705398] [PUBMED:16996023] [PUBMED:12531554] [PUBMED:12761884]
Thrombin signalling through proteinase activated receptors (PARs) [NCBI:1269356] [REACTOME:R-HSA-456926] [PUBMED:11001069]
Thromboxane signalling through TP receptor [NCBI:1269355] [REACTOME:R-HSA-428930] [PUBMED:18374420]
Vascular smooth muscle contraction [NCBI:96530] [KEGG:hsa04270] [PUBMED:16870827] [PUBMED:10911373] [PUBMED:11679404] [PUBMED:16339747] [PUBMED:10221985] [PUBMED:12689814] [PUBMED:11165670] [PUBMED:18552454] [PUBMED:12060106] [PUBMED:9458738] [PUBMED:15725705] [PUBMED:18040024] [PUBMED:12693609] [PUBMED:11773611] [PUBMED:17158339] [PUBMED:17458653] [PUBMED:15026027] [PUBMED:19120701] [PUBMED:15269340] [PUBMED:18703404] [PUBMED:11709400] [PUBMED:17200683]
cGMP-PKG signaling pathway [NCBI:983748] [KEGG:hsa04022] [PUBMED:18006449] [PUBMED:9003029] [PUBMED:18040025] [PUBMED:19306895] [PUBMED:21666108] [PUBMED:12524221] [PUBMED:16460276] [PUBMED:20716671] [PUBMED:22785374] [PUBMED:11522789] [PUBMED:16439998] [PUBMED:16371594] [PUBMED:20388537] [PUBMED:18757523] [PUBMED:16815627] [PUBMED:23212367] [PUBMED:21685243] [PUBMED:20024580] [PUBMED:15894227] [PUBMED:22965426] [PUBMED:17643091] [PUBMED:19176601] [PUBMED:19961855]