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Genes
GNA11
Gene - GNA11
full name
G protein subunit alpha 11
synonyms
GNA-11, GNA11, ENSG00000088256
HGNC
HGNC:4379
Entrez Gene
Gene:2767
ENSEMBL
ENSG00000088256
location
chr: 19
start: 3094408
stop: 3121468
strand: +
OMIM
OMIM:139313
: GNA11
(Autosomal dominant inheritance)
OMIM:615361
: Hypocalcemia, autosomal dominant 2
OMIM:145981
: Hypocalciuric hypercalcemia, type II
transcripts
NM_002067.2
pathways
ADP signalling through P2Y purinoceptor 1
[NCBI:1269354]
[REACTOME:R-HSA-418592]
[PUBMED:9442040]
Acetylcholine regulates insulin secretion
[NCBI:1270104]
[REACTOME:R-HSA-399997]
[PUBMED:11588141]
[PUBMED:12161432]
Aldosterone synthesis and secretion
[NCBI:1272485]
[KEGG:hsa04925]
[PUBMED:15044681]
[PUBMED:10536682]
[PUBMED:24944029]
[PUBMED:25788893]
[PUBMED:15026188]
[PUBMED:22689262]
[PUBMED:22364774]
[PUBMED:18406824]
[PUBMED:14645496]
[PUBMED:21839803]
[PUBMED:22395411]
[PUBMED:23628605]
[PUBMED:21962440]
Amoebiasis
[NCBI:167324]
[KEGG:hsa05146]
[PUBMED:9832261]
[PUBMED:16380324]
[PUBMED:14700586]
[PUBMED:18725798]
[PUBMED:12142490]
[PUBMED:10637584]
[PUBMED:20145703]
[PUBMED:11378035]
[PUBMED:12160867]
[PUBMED:15813717]
[PUBMED:19207103]
[PUBMED:12660071]
[PUBMED:20303955]
[PUBMED:11352795]
[PUBMED:14502002]
[PUBMED:10756002]
[PUBMED:17702556]
[PUBMED:17576362]
Arf6 signaling events
[NCBI:138034]
[Pathway Interaction Database:arf6_pathway]
[PUBMED:18164504]
[PUBMED:15509780]
[PUBMED:11481345]
[PUBMED:18084281]
[PUBMED:15775968]
[PUBMED:18094045]
[PUBMED:17409355]
[PUBMED:11532961]
[PUBMED:10480924]
[PUBMED:15126638]
[PUBMED:17398097]
[PUBMED:18026091]
[PUBMED:17353194]
[PUBMED:15793570]
[PUBMED:16650966]
[PUBMED:12920129]
[PUBMED:11278939]
[PUBMED:9742223]
[PUBMED:11062263]
[PUBMED:16461286]
[PUBMED:10779358]
[PUBMED:18003747]
[PUBMED:15923660]
[PUBMED:10642533]
[PUBMED:11342560]
[PUBMED:10448098]
[PUBMED:11226253]
[PUBMED:18490450]
[PUBMED:19193766]
[PUBMED:10913124]
[PUBMED:10811902]
[PUBMED:17077126]
[PUBMED:11533043]
[PUBMED:12447393]
[PUBMED:10333475]
[PUBMED:9550703]
[PUBMED:10075920]
[PUBMED:9417041]
[PUBMED:17719203]
[PUBMED:14625293]
[PUBMED:17122362]
[PUBMED:17846866]
Calcium signaling pathway
[NCBI:83050]
[KEGG:hsa04020]
[PUBMED:11080247]
[PUBMED:14572802]
[PUBMED:11413485]
[PUBMED:22129055]
[PUBMED:10508738]
[PUBMED:15000521]
[PUBMED:9235901]
[PUBMED:7861177]
[PUBMED:9149541]
[PUBMED:14517314]
[PUBMED:15111104]
[PUBMED:11698232]
[PUBMED:10331643]
[PUBMED:12838335]
[PUBMED:8125957]
[PUBMED:19172794]
[PUBMED:10997573]
[PUBMED:21338471]
[PUBMED:11299192]
[PUBMED:22002090]
[PUBMED:12972622]
Chagas disease (American trypanosomiasis)
[NCBI:147809]
[KEGG:hsa05142]
[PUBMED:12377585]
[PUBMED:9794425]
[PUBMED:1717552]
[PUBMED:16238097]
[PUBMED:10066513]
[PUBMED:12874238]
[PUBMED:12036740]
[PUBMED:15917295]
[PUBMED:12055254]
[PUBMED:17651955]
[PUBMED:1396957]
[PUBMED:16175174]
[PUBMED:2194668]
[PUBMED:9190942]
[PUBMED:12377942]
[PUBMED:12427093]
[PUBMED:10234174]
[PUBMED:16030288]
[PUBMED:15223603]
[PUBMED:17110955]
Cholinergic synapse
[NCBI:217716]
[KEGG:hsa04725]
[PUBMED:20060019]
[PUBMED:11283752]
[PUBMED:15165747]
[PUBMED:12893537]
[PUBMED:11738031]
[PUBMED:21550798]
[PUBMED:19712465]
[PUBMED:12690458]
[PUBMED:12436417]
[PUBMED:19378880]
[PUBMED:11923408]
[PUBMED:20446119]
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
[NCBI:1270106]
[REACTOME:R-HSA-434316]
Free fatty acids regulate insulin secretion
[NCBI:1270105]
[REACTOME:R-HSA-400451]
[PUBMED:18606873]
[PUBMED:17395749]
[PUBMED:17130640]
[PUBMED:18827341]
[PUBMED:15047616]
G alpha (q) signalling events
[NCBI:1269578]
[REACTOME:R-HSA-416476]
[PUBMED:19212139]
GPCR downstream signaling
[NCBI:1269574]
[REACTOME:R-HSA-388396]
[PUBMED:12040175]
Gap junction
[NCBI:83072]
[KEGG:hsa04540]
[PUBMED:9535909]
[PUBMED:15033578]
[PUBMED:12566218]
[PUBMED:14506308]
[PUBMED:10751659]
[PUBMED:10873290]
[PUBMED:15955302]
[PUBMED:15033579]
[PUBMED:15033580]
[PUBMED:15094344]
Gastrin-CREB signalling pathway via PKC and MAPK
[NCBI:1269592]
[REACTOME:R-HSA-881907]
[PUBMED:10413847]
[PUBMED:7491953]
[PUBMED:17698287]
GnRH signaling pathway
[NCBI:83091]
[KEGG:hsa04912]
[PUBMED:15080147]
[PUBMED:15982836]
[PUBMED:14596811]
[PUBMED:15613448]
[PUBMED:12943720]
[PUBMED:10707049]
[PUBMED:15350605]
[PUBMED:12963732]
Hemostasis
[NCBI:1269340]
[REACTOME:R-HSA-109582]
Insulin secretion
[NCBI:777534]
[KEGG:hsa04911]
[PUBMED:9715374]
[PUBMED:10605628]
[PUBMED:9914469]
[PUBMED:17306374]
[PUBMED:20055708]
[PUBMED:15655710]
[PUBMED:19817784]
[PUBMED:19074620]
[PUBMED:14693691]
[PUBMED:17084085]
[PUBMED:20551594]
[PUBMED:19036624]
[PUBMED:22970724]
[PUBMED:20225132]
[PUBMED:19817800]
[PUBMED:22974438]
[PUBMED:21934040]
[PUBMED:15271645]
[PUBMED:19660440]
[PUBMED:11522660]
Integration of energy metabolism
[NCBI:1270101]
[REACTOME:R-HSA-163685]
[PUBMED:15509864]
[PUBMED:12721358]
[PUBMED:12626323]
LPA receptor mediated events
[NCBI:137928]
[Pathway Interaction Database:lysophospholipid_pathway]
[PUBMED:10601262]
[PUBMED:16289596]
[PUBMED:7809106]
[PUBMED:10342794]
[PUBMED:15928312]
[PUBMED:16769764]
[PUBMED:11243883]
[PUBMED:14688263]
[PUBMED:10551845]
[PUBMED:16687414]
[PUBMED:9819398]
[PUBMED:7527052]
[PUBMED:9600933]
[PUBMED:2551506]
[PUBMED:15988003]
[PUBMED:10644509]
[PUBMED:16199135]
[PUBMED:15728708]
[PUBMED:1637305]
[PUBMED:7476905]
[PUBMED:7510708]
[PUBMED:8647803]
[PUBMED:10420989]
[PUBMED:12880866]
[PUBMED:10766839]
[PUBMED:12181443]
[PUBMED:15461590]
[PUBMED:16452634]
[PUBMED:16197369]
[PUBMED:10779388]
[PUBMED:10506190]
[PUBMED:9305878]
[PUBMED:16904289]
[PUBMED:15878967]
[PUBMED:15143197]
[PUBMED:11948806]
[PUBMED:11040035]
[PUBMED:12393875]
[PUBMED:9407095]
[PUBMED:15280372]
[PUBMED:16890224]
[PUBMED:8805276]
Long-term depression
[NCBI:83086]
[KEGG:hsa04730]
[PUBMED:9602501]
[PUBMED:9735948]
[PUBMED:14509570]
[PUBMED:11427694]
[PUBMED:12415297]
Metabolism
[NCBI:1269956]
[REACTOME:R-HSA-1430728]
Pathways in cancer
[NCBI:83105]
[KEGG:hsa05200]
[PUBMED:12244301]
[PUBMED:15156182]
[PUBMED:16899407]
[PUBMED:12621137]
[PUBMED:21193867]
[PUBMED:16001072]
[PUBMED:11707511]
[PUBMED:11253051]
[PUBMED:11071626]
[PUBMED:17251915]
[PUBMED:11736900]
[PUBMED:16557281]
[PUBMED:16699851]
[PUBMED:16189702]
[PUBMED:11902573]
[PUBMED:16555243]
[PUBMED:8069858]
[PUBMED:15310786]
[PUBMED:9834202]
[PUBMED:16700615]
[PUBMED:12545153]
[PUBMED:15656799]
[PUBMED:12154354]
[PUBMED:11895903]
[PUBMED:11527574]
[PUBMED:16326109]
[PUBMED:16339096]
[PUBMED:11160144]
[PUBMED:15724144]
[PUBMED:12951584]
[PUBMED:10647931]
[PUBMED:16881963]
[PUBMED:15557758]
[PUBMED:11477132]
[PUBMED:15721476]
[PUBMED:15625120]
[PUBMED:16236521]
[PUBMED:14967450]
[PUBMED:15942304]
[PUBMED:17287871]
[PUBMED:14634372]
[PUBMED:15573119]
[PUBMED:15009714]
[PUBMED:16112428]
[PUBMED:15611513]
[PUBMED:16001050]
[PUBMED:15349822]
[PUBMED:16551846]
[PUBMED:15978322]
[PUBMED:15774796]
[PUBMED:16352814]
[PUBMED:12951588]
[PUBMED:10944551]
[PUBMED:10740269]
[PUBMED:15639402]
[PUBMED:12407699]
[PUBMED:11130178]
[PUBMED:15109562]
[PUBMED:11170304]
[PUBMED:11276000]
[PUBMED:9643506]
[PUBMED:16248975]
[PUBMED:16242838]
[PUBMED:12946833]
[PUBMED:11559746]
[PUBMED:9196022]
[PUBMED:12079267]
[PUBMED:15468170]
[PUBMED:16064138]
[PUBMED:14580692]
[PUBMED:15082523]
[PUBMED:15551095]
[PUBMED:17062879]
[PUBMED:17211469]
[PUBMED:11720739]
[PUBMED:12588368]
[PUBMED:11057895]
[PUBMED:9422516]
[PUBMED:12894244]
[PUBMED:15479695]
[PUBMED:16189154]
[PUBMED:12878745]
[PUBMED:11900250]
[PUBMED:11103787]
[PUBMED:15122209]
[PUBMED:12711111]
[PUBMED:12243753]
[PUBMED:16306523]
[PUBMED:16702400]
[PUBMED:15270885]
[PUBMED:14685170]
[PUBMED:14586404]
[PUBMED:11078609]
[PUBMED:15284264]
[PUBMED:10505543]
[PUBMED:11223406]
[PUBMED:14982876]
[PUBMED:12648469]
[PUBMED:12867060]
[PUBMED:15711891]
[PUBMED:12094241]
[PUBMED:16642045]
[PUBMED:11463388]
[PUBMED:12762887]
[PUBMED:15746962]
[PUBMED:15823750]
[PUBMED:16750612]
[PUBMED:16484590]
[PUBMED:11459867]
[PUBMED:16146838]
[PUBMED:14556242]
[PUBMED:15947972]
[PUBMED:12563308]
[PUBMED:16946003]
[PUBMED:15948971]
[PUBMED:11407945]
[PUBMED:12737309]
[PUBMED:16095998]
[PUBMED:12351585]
[PUBMED:24508914]
[PUBMED:12084351]
[PUBMED:11807782]
[PUBMED:14695152]
[PUBMED:10453277]
[PUBMED:17554387]
[PUBMED:15841168]
[PUBMED:12616528]
[PUBMED:10403855]
[PUBMED:16054233]
[PUBMED:16474624]
[PUBMED:16822996]
[PUBMED:17028294]
[PUBMED:11224709]
[PUBMED:11750244]
[PUBMED:11905738]
[PUBMED:15719031]
[PUBMED:10843728]
[PUBMED:16110317]
[PUBMED:11721960]
[PUBMED:12741677]
[PUBMED:7585656]
[PUBMED:12801837]
[PUBMED:16551847]
[PUBMED:12459728]
[PUBMED:11431710]
[PUBMED:12468433]
[PUBMED:11165748]
[PUBMED:16042571]
[PUBMED:16508724]
[PUBMED:15000146]
[PUBMED:17149381]
[PUBMED:15948711]
[PUBMED:14747944]
[PUBMED:14737121]
[PUBMED:12379883]
[PUBMED:17158541]
[PUBMED:12850530]
[PUBMED:10835690]
[PUBMED:16870043]
Platelet activation, signaling and aggregation
[NCBI:1269350]
[REACTOME:R-HSA-76002]
[PUBMED:16543958]
[PUBMED:8704248]
[PUBMED:2018971]
[PUBMED:1672265]
[PUBMED:17059469]
[PUBMED:12681240]
[PUBMED:12411949]
[PUBMED:11511514]
Regulation of insulin secretion
[NCBI:1270102]
[REACTOME:R-HSA-422356]
[PUBMED:18200017]
[PUBMED:11078440]
[PUBMED:16321791]
[PUBMED:11815463]
[PUBMED:16556766]
S1P2 pathway
[NCBI:138059]
[Pathway Interaction Database:s1p_s1p2_pathway]
[PUBMED:9854026]
[PUBMED:10617617]
[PUBMED:17431187]
[PUBMED:12588974]
[PUBMED:11094076]
[PUBMED:15240112]
[PUBMED:11853542]
[PUBMED:12810709]
S1P3 pathway
[NCBI:138063]
[Pathway Interaction Database:s1p_s1p3_pathway]
[PUBMED:12577307]
[PUBMED:11853542]
[PUBMED:17158356]
[PUBMED:15138255]
[PUBMED:14732717]
[PUBMED:11150298]
[PUBMED:14657000]
[PUBMED:9854026]
[PUBMED:10617617]
[PUBMED:16527273]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signal amplification
[NCBI:1269352]
[REACTOME:R-HSA-392518]
[PUBMED:18077812]
Signaling by GPCR
[NCBI:1269543]
[REACTOME:R-HSA-372790]
[PUBMED:16902930]
[PUBMED:10202136]
[PUBMED:18043707]
Sphingosine 1-phosphate (S1P) pathway
[NCBI:137931]
[Pathway Interaction Database:s1p_meta_pathway]
[PUBMED:12815058]
[PUBMED:17050692]
[PUBMED:9854026]
[PUBMED:16584625]
[PUBMED:10617617]
[PUBMED:16520486]
[PUBMED:14570870]
[PUBMED:11705398]
[PUBMED:16996023]
[PUBMED:12531554]
[PUBMED:12761884]
Thrombin signalling through proteinase activated receptors (PARs)
[NCBI:1269356]
[REACTOME:R-HSA-456926]
[PUBMED:11001069]
Thromboxane signalling through TP receptor
[NCBI:1269355]
[REACTOME:R-HSA-428930]
[PUBMED:18374420]
Vascular smooth muscle contraction
[NCBI:96530]
[KEGG:hsa04270]
[PUBMED:16870827]
[PUBMED:10911373]
[PUBMED:11679404]
[PUBMED:16339747]
[PUBMED:10221985]
[PUBMED:12689814]
[PUBMED:11165670]
[PUBMED:18552454]
[PUBMED:12060106]
[PUBMED:9458738]
[PUBMED:15725705]
[PUBMED:18040024]
[PUBMED:12693609]
[PUBMED:11773611]
[PUBMED:17158339]
[PUBMED:17458653]
[PUBMED:15026027]
[PUBMED:19120701]
[PUBMED:15269340]
[PUBMED:18703404]
[PUBMED:11709400]
[PUBMED:17200683]
cGMP-PKG signaling pathway
[NCBI:983748]
[KEGG:hsa04022]
[PUBMED:18006449]
[PUBMED:9003029]
[PUBMED:18040025]
[PUBMED:19306895]
[PUBMED:21666108]
[PUBMED:12524221]
[PUBMED:16460276]
[PUBMED:20716671]
[PUBMED:22785374]
[PUBMED:11522789]
[PUBMED:16439998]
[PUBMED:16371594]
[PUBMED:20388537]
[PUBMED:18757523]
[PUBMED:16815627]
[PUBMED:23212367]
[PUBMED:21685243]
[PUBMED:20024580]
[PUBMED:15894227]
[PUBMED:22965426]
[PUBMED:17643091]
[PUBMED:19176601]
[PUBMED:19961855]