full name
SH3 domain containing GRB2 like 1, endophilin A2

synonyms
CNSA1, EEN, SH3D2B, SH3P8, SH3GL1, ENSG00000141985

HGNC
HGNC:10830

Entrez Gene
Gene:6455

ENSEMBL
ENSG00000141985

location
chr: 19
start: 4360364
stop: 4400565
strand: -

OMIM
OMIM:601768: SH3GL1 (Autosomal dominant inheritance)
OMIM:601626: Leukemia, acute myeloid

transcripts
NM_001199943.1
NM_003025.3
NM_001199944.1

pathways
Cargo recognition for clathrin-mediated endocytosis [NCBI:1427859] [REACTOME:R-HSA-8856825] [PUBMED:24186068] [PUBMED:12952941] [PUBMED:19696796] [PUBMED:14985334] [PUBMED:20448150] [PUBMED:20485680] [PUBMED:16382132] [PUBMED:23482940] [PUBMED:16870701]
Clathrin-mediated endocytosis [NCBI:1427858] [REACTOME:R-HSA-8856828] [PUBMED:16516836] [PUBMED:15339664] [PUBMED:19754444] [PUBMED:8552632] [PUBMED:21779028] [PUBMED:12353027] [PUBMED:23891661] [PUBMED:21613550] [PUBMED:20059951] [PUBMED:21447041] [PUBMED:17620409] [PUBMED:16903783] [PUBMED:21445324] [PUBMED:19696798] [PUBMED:26246598] [PUBMED:25085911] [PUBMED:24186068] [PUBMED:26829388] [PUBMED:27092250] [PUBMED:24581490] [PUBMED:26042225] [PUBMED:23823722] [PUBMED:24789820] [PUBMED:9736607] [PUBMED:23637288] [PUBMED:22233676] [PUBMED:19458185] [PUBMED:26403691] [PUBMED:19296720] [PUBMED:15703209] [PUBMED:20428113] [PUBMED:8953040] [PUBMED:1177317] [PUBMED:9092476] [PUBMED:26872272] [PUBMED:19092055]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
EGFR downregulation [NCBI:1269385] [REACTOME:R-HSA-182971] [PUBMED:11283727] [PUBMED:15021893] [PUBMED:14641021]
Endocytosis [NCBI:102279] [KEGG:hsa04144] [PUBMED:19696797] [PUBMED:19007773] [PUBMED:16203612] [PUBMED:15687999] [PUBMED:19924646] [PUBMED:15261671] [PUBMED:18647649] [PUBMED:19325624] [PUBMED:20110990] [PUBMED:22193161]
Infectious disease [NCBI:1269056] [REACTOME:R-HSA-5663205]
InlB-mediated entry of Listeria monocytogenes into host cell [NCBI:1470919] [REACTOME:R-HSA-8875360] [PUBMED:20670691] [PUBMED:11081636] [PUBMED:19900460] [PUBMED:19432801] [PUBMED:17662939] [PUBMED:16113677]
Listeria monocytogenes entry into host cells [NCBI:1470917] [REACTOME:R-HSA-8876384] [PUBMED:23125201] [PUBMED:21921683] [PUBMED:23376167] [PUBMED:25624443] [PUBMED:19191787] [PUBMED:20485518] [PUBMED:15337781]
Membrane Trafficking [NCBI:1269877] [REACTOME:R-HSA-199991] [PUBMED:11031247]
Negative regulation of MET activity [NCBI:1457805] [REACTOME:R-HSA-6807004] [PUBMED:24828152] [PUBMED:11894096] [PUBMED:14684163] [PUBMED:12475979] [PUBMED:23208509] [PUBMED:9001234] [PUBMED:11420688] [PUBMED:18819921] [PUBMED:11741535] [PUBMED:15314156]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by EGFR [NCBI:1269380] [REACTOME:R-HSA-177929] [PUBMED:10459005] [PUBMED:10404636] [PUBMED:12297041] [PUBMED:15142631]
Signaling by MET [NCBI:1457794] [REACTOME:R-HSA-6806834] [PUBMED:1846706] [PUBMED:12948444] [PUBMED:16782899] [PUBMED:15249655] [PUBMED:22270953] [PUBMED:15167892] [PUBMED:7708691] [PUBMED:11081636] [PUBMED:8384622] [PUBMED:21102609] [PUBMED:16461907] [PUBMED:9407027] [PUBMED:7854453] [PUBMED:7651534] [PUBMED:9070211] [PUBMED:8208547] [PUBMED:24518591] [PUBMED:6590967] [PUBMED:15180923] [PUBMED:20802513] [PUBMED:10521801] [PUBMED:9038378] [PUBMED:17403932] [PUBMED:1655790] [PUBMED:12006644] [PUBMED:7513258] [PUBMED:18614017] [PUBMED:10753869] [PUBMED:17662939] [PUBMED:14685170] [PUBMED:10734310] [PUBMED:1827664] [PUBMED:7731718] [PUBMED:19996456] [PUBMED:11430831] [PUBMED:8302603] [PUBMED:15218027] [PUBMED:9140397] [PUBMED:2423252] [PUBMED:16113677] [PUBMED:12147692] [PUBMED:10648629] [PUBMED:7854452] [PUBMED:15070743] [PUBMED:15301554] [PUBMED:19881549] [PUBMED:25992381] [PUBMED:10871282] [PUBMED:12726861]
Signaling events mediated by focal adhesion kinase [NCBI:169348] [Pathway Interaction Database:fak_pathway] [PUBMED:18793427] [PUBMED:15340073] [PUBMED:16054026] [PUBMED:12932330] [PUBMED:20038548] [PUBMED:7542255] [PUBMED:8939916] [PUBMED:16000375] [PUBMED:10856236] [PUBMED:17164291] [PUBMED:9148935] [PUBMED:10893408] [PUBMED:10512882] [PUBMED:11839772] [PUBMED:11553710] [PUBMED:7566154] [PUBMED:20018869] [PUBMED:12839996] [PUBMED:11799111] [PUBMED:16308318] [PUBMED:11331870] [PUBMED:12681445] [PUBMED:11369769] [PUBMED:11739801] [PUBMED:9860979] [PUBMED:8947559] [PUBMED:11017882] [PUBMED:7509446] [PUBMED:10791986] [PUBMED:9128257] [PUBMED:19297531] [PUBMED:17325207] [PUBMED:17093062] [PUBMED:10593973] [PUBMED:20308429] [PUBMED:8922390] [PUBMED:19776348] [PUBMED:9374537] [PUBMED:10976102] [PUBMED:10373530] [PUBMED:19883375] [PUBMED:10430888] [PUBMED:12820964] [PUBMED:9425168] [PUBMED:14743221] [PUBMED:18854312] [PUBMED:12952943] [PUBMED:15962308] [PUBMED:11927607] [PUBMED:15657076] [PUBMED:15039571] [PUBMED:18303050] [PUBMED:11799401] [PUBMED:15247219] [PUBMED:12702722] [PUBMED:10998418] [PUBMED:7615549] [PUBMED:18195107] [PUBMED:9032297] [PUBMED:10873807] [PUBMED:10777511] [PUBMED:12502711] [PUBMED:9566877] [PUBMED:8649427] [PUBMED:19473962] [PUBMED:9808620] [PUBMED:15914540] [PUBMED:1385445] [PUBMED:18223254] [PUBMED:11909938] [PUBMED:15166238] [PUBMED:7622520] [PUBMED:8824286] [PUBMED:8662921] [PUBMED:8707856] [PUBMED:10330411] [PUBMED:10446223] [PUBMED:20150423] [PUBMED:11604500] [PUBMED:9234699] [PUBMED:18773890] [PUBMED:18757826] [PUBMED:9864370] [PUBMED:7983066] [PUBMED:18322799] [PUBMED:12006652] [PUBMED:16461767] [PUBMED:10385525] [PUBMED:14676198] [PUBMED:9858476] [PUBMED:18070912] [PUBMED:11058585] [PUBMED:12890755] [PUBMED:9184223] [PUBMED:12058076] [PUBMED:12226752] [PUBMED:19435801] [PUBMED:10212207] [PUBMED:10521463] [PUBMED:16159962] [PUBMED:7579684] [PUBMED:18362184] [PUBMED:7997267] [PUBMED:8816475] [PUBMED:11279163] [PUBMED:7537852] [PUBMED:11418135] [PUBMED:12167697] [PUBMED:12615911] [PUBMED:12876277]
Vesicle-mediated transport [NCBI:1269876] [REACTOME:R-HSA-5653656]