full name
toll like receptor adaptor molecule 1
synonyms
IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF, TICAM1, ENSG00000127666
HGNC
HGNC:18348
Entrez Gene
Gene:148022
ENSEMBL
ENSG00000127666
location
chr: 19
start: 4815936
stop: 4831754
strand: -
OMIM
OMIM:607601:
TICAM1
(Autosomal dominant inheritance,Autosomal recessive inheritance)
OMIM:614850:
{Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 6}
transcripts
NM_182919.3
pathways
Activated TLR4 signalling
[NCBI:1269236]
[REACTOME:R-HSA-166054]
[PUBMED:15276183]
[PUBMED:15588429]
[PUBMED:15845500]
[PUBMED:15596121]
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
[NCBI:1269222]
[REACTOME:R-HSA-936964]
[PUBMED:15210742]
[PUBMED:14679297]
[PUBMED:15502848]
[PUBMED:17332413]
Apoptosis
[NCBI:83060]
[KEGG:hsa04210]
[NCBI:1270262]
[REACTOME:R-HSA-109581]
[PUBMED:12189384]
[PUBMED:20533903]
[PUBMED:18208375]
[PUBMED:22429822]
[PUBMED:15218528]
[PUBMED:24769728]
[PUBMED:18023214]
[PUBMED:25526085]
[PUBMED:23070002]
[PUBMED:15654015]
[PUBMED:15601572]
[PUBMED:14561771]
[PUBMED:24278747]
[PUBMED:21914490]
[PUBMED:22465226]
[PUBMED:21145844]
[PUBMED:12838338]
[PUBMED:18238895]
[PUBMED:12949498]
[PUBMED:18304445]
[PUBMED:14737178]
[PUBMED:26231733]
[PUBMED:9916983]
[PUBMED:14634621]
[PUBMED:19770840]
[PUBMED:22075987]
[PUBMED:4561027]
[PUBMED:20075940]
[PUBMED:9894605]
[PUBMED:26615431]
[PUBMED:12505355]
[PUBMED:11520933]
[PUBMED:19148180]
[PUBMED:16397578]
[PUBMED:15719025]
[PUBMED:15322527]
[PUBMED:15725726]
[PUBMED:12209154]
[PUBMED:23803157]
Caspase activation via extrinsic apoptotic signalling pathway
[NCBI:1270263]
[REACTOME:R-HSA-5357769]
[PUBMED:11048727]
Chagas disease (American trypanosomiasis)
[NCBI:147809]
[KEGG:hsa05142]
[PUBMED:12377585]
[PUBMED:9794425]
[PUBMED:1717552]
[PUBMED:16238097]
[PUBMED:10066513]
[PUBMED:12874238]
[PUBMED:12036740]
[PUBMED:15917295]
[PUBMED:12055254]
[PUBMED:17651955]
[PUBMED:1396957]
[PUBMED:16175174]
[PUBMED:2194668]
[PUBMED:9190942]
[PUBMED:12377942]
[PUBMED:12427093]
[PUBMED:10234174]
[PUBMED:16030288]
[PUBMED:15223603]
[PUBMED:17110955]
Cytosolic sensors of pathogen-associated DNA
[NCBI:1269268]
[REACTOME:R-HSA-1834949]
[PUBMED:23706668]
[PUBMED:21533068]
[PUBMED:23706667]
Disease
[NCBI:1268854]
[REACTOME:R-HSA-1643685]
Diseases associated with the TLR signaling cascade
[NCBI:1269157]
[REACTOME:R-HSA-5602358]
[PUBMED:23622315]
[PUBMED:21734245]
[PUBMED:22610250]
[PUBMED:16176658]
Diseases of Immune System
[NCBI:1269156]
[REACTOME:R-HSA-5260271]
[PUBMED:24795713]
[PUBMED:22165913]
Hepatitis B
[NCBI:694606]
[KEGG:hsa05161]
[PUBMED:19854353]
[PUBMED:11604508]
[PUBMED:11325602]
[PUBMED:18931690]
[PUBMED:16891440]
[PUBMED:17158882]
[PUBMED:11099494]
[PUBMED:9325306]
[PUBMED:18024894]
[PUBMED:11483993]
[PUBMED:15107488]
[PUBMED:11278872]
[PUBMED:21647825]
[PUBMED:11287574]
[PUBMED:18481805]
[PUBMED:17188775]
[PUBMED:19784739]
[PUBMED:19263472]
[PUBMED:16203685]
[PUBMED:18605975]
[PUBMED:10454581]
[PUBMED:22504921]
[PUBMED:21334391]
[PUBMED:20657822]
[PUBMED:18046710]
[PUBMED:9843511]
[PUBMED:15542625]
[PUBMED:21618535]
[PUBMED:15132991]
[PUBMED:15173177]
[PUBMED:12771941]
[PUBMED:21994545]
[PUBMED:8764004]
[PUBMED:16459163]
[PUBMED:9738022]
[PUBMED:11821950]
[PUBMED:12839924]
Hepatitis C
[NCBI:173973]
[KEGG:hsa05160]
[PUBMED:19708811]
[PUBMED:16314558]
[PUBMED:17467654]
[PUBMED:19515018]
[PUBMED:18514579]
[PUBMED:16107833]
[PUBMED:19074178]
[PUBMED:12691459]
[PUBMED:15302943]
[PUBMED:20537953]
[PUBMED:11991644]
[PUBMED:19148799]
[PUBMED:19187070]
[PUBMED:12655344]
Herpes simplex infection
[NCBI:377873]
[KEGG:hsa05168]
[PUBMED:12224518]
[PUBMED:17913820]
[PUBMED:12844494]
[PUBMED:10998601]
[PUBMED:15163721]
[PUBMED:19694546]
[PUBMED:16297150]
[PUBMED:14747533]
[PUBMED:12826401]
[PUBMED:14963113]
[PUBMED:15056211]
[PUBMED:12797447]
[PUBMED:21107701]
[PUBMED:10918307]
[PUBMED:10696424]
[PUBMED:16076403]
[PUBMED:10364308]
[PUBMED:17222692]
[PUBMED:9621021]
[PUBMED:12224508]
[PUBMED:19879619]
[PUBMED:11070032]
[PUBMED:9499021]
[PUBMED:18596690]
[PUBMED:12525427]
[PUBMED:12224517]
[PUBMED:10196275]
[PUBMED:15047834]
[PUBMED:18508584]
[PUBMED:20036979]
IKK complex recruitment mediated by RIP1
[NCBI:1269223]
[REACTOME:R-HSA-937041]
[PUBMED:16603398]
[PUBMED:16115877]
[PUBMED:14530355]
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
[NCBI:1269231]
[REACTOME:R-HSA-975163]
[PUBMED:12140561]
[PUBMED:16831874]
[PUBMED:17878161]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Influenza A
[NCBI:217173]
[KEGG:hsa05164]
[PUBMED:17267598]
[PUBMED:18049471]
[PUBMED:16882036]
[PUBMED:11907320]
[PUBMED:17944269]
[PUBMED:20629046]
[PUBMED:17072332]
[PUBMED:18588994]
[PUBMED:19864182]
[PUBMED:19290913]
[PUBMED:19420020]
[PUBMED:17213831]
[PUBMED:9060654]
[PUBMED:19481124]
[PUBMED:16494716]
[PUBMED:21147034]
[PUBMED:18980544]
[PUBMED:20020828]
[PUBMED:15502848]
[PUBMED:19782761]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Ligand-dependent caspase activation
[NCBI:1270264]
[REACTOME:R-HSA-140534]
[PUBMED:12620240]
[PUBMED:14644197]
[PUBMED:20308068]
[PUBMED:19851329]
[PUBMED:12620239]
MyD88 dependent cascade initiated on endosome
[NCBI:1269228]
[REACTOME:R-HSA-975155]
[PUBMED:20237413]
[PUBMED:15276183]
[PUBMED:18652679]
MyD88-independent TLR3/TLR4 cascade
[NCBI:1269220]
[REACTOME:R-HSA-166166]
[PUBMED:15276183]
NF-kappa B signaling pathway
[NCBI:634527]
[KEGG:hsa04064]
[PUBMED:22119011]
[PUBMED:16264088]
[PUBMED:21187855]
[PUBMED:15546385]
[PUBMED:17607554]
[PUBMED:21135871]
[PUBMED:16984817]
[PUBMED:17047224]
[PUBMED:19203223]
[PUBMED:20300215]
[PUBMED:14657271]
[PUBMED:17431096]
[PUBMED:15134788]
[PUBMED:16356770]
[PUBMED:21772278]
[PUBMED:12654254]
[PUBMED:22390971]
[PUBMED:22017435]
[PUBMED:17183360]
[PUBMED:21173796]
[PUBMED:15905862]
[PUBMED:19302050]
[PUBMED:17098202]
[PUBMED:21872579]
[PUBMED:22152226]
[PUBMED:18613837]
[PUBMED:19489733]
[PUBMED:11875461]
[PUBMED:19726767]
[PUBMED:22017430]
[PUBMED:21232019]
[PUBMED:18832076]
NOD-like receptor signaling pathway
[NCBI:122191]
[KEGG:hsa04621]
[PUBMED:25330206]
[PUBMED:21575908]
[PUBMED:23846113]
[PUBMED:26549800]
[PUBMED:16493424]
[PUBMED:23124073]
[PUBMED:24840700]
[PUBMED:27291964]
[PUBMED:27012466]
[PUBMED:24707857]
[PUBMED:19767725]
[PUBMED:25879280]
[PUBMED:23215645]
[PUBMED:22819539]
[PUBMED:23702978]
[PUBMED:20643110]
[PUBMED:25879288]
[PUBMED:26655628]
[PUBMED:25145756]
[PUBMED:24718315]
[PUBMED:26482951]
[PUBMED:25526305]
[PUBMED:26121197]
[PUBMED:22430786]
Pertussis
[NCBI:218111]
[KEGG:hsa05133]
[PUBMED:20610650]
[PUBMED:12701623]
[PUBMED:15201703]
[PUBMED:18401006]
[PUBMED:20210554]
[PUBMED:16622221]
[PUBMED:17148436]
[PUBMED:21204863]
[PUBMED:20404851]
[PUBMED:10540218]
[PUBMED:16999837]
[PUBMED:16481212]
[PUBMED:16863919]
[PUBMED:16390441]
[PUBMED:21423776]
[PUBMED:17328678]
[PUBMED:12915094]
Programmed Cell Death
[NCBI:1270261]
[REACTOME:R-HSA-5357801]
[PUBMED:25236395]
RIP-mediated NFkB activation via ZBP1
[NCBI:1269271]
[REACTOME:R-HSA-1810476]
[PUBMED:18941233]
[PUBMED:19590578]
TICAM1 deficiency - HSE
[NCBI:1269164]
[REACTOME:R-HSA-5602566]
[PUBMED:22105173]
TRAF3 deficiency - HSE
[NCBI:1269165]
[REACTOME:R-HSA-5602571]
[PUBMED:20832341]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
[NCBI:1269229]
[REACTOME:R-HSA-975138]
[PUBMED:22511786]
[PUBMED:18794297]
TRAF6 mediated induction of TAK1 complex
[NCBI:1269225]
[REACTOME:R-HSA-937072]
[PUBMED:19112497]
[PUBMED:19675569]
TRIF-mediated TLR3/TLR4 signaling
[NCBI:1269221]
[REACTOME:R-HSA-937061]
[PUBMED:15814722]
[PUBMED:12855817]
[PUBMED:14739303]
TRIF-mediated programmed cell death
[NCBI:1269224]
[REACTOME:R-HSA-2562578]
[PUBMED:12181749]
[PUBMED:15814722]
[PUBMED:20019748]
[PUBMED:22421964]
[PUBMED:21737329]
[PUBMED:14739303]
[PUBMED:21737330]
Toll Like Receptor 3 (TLR3) Cascade
[NCBI:1269219]
[REACTOME:R-HSA-168164]
[PUBMED:19627256]
[PUBMED:15733829]
[PUBMED:18202435]
Toll Like Receptor 4 (TLR4) Cascade
[NCBI:1269234]
[REACTOME:R-HSA-166016]
Toll Like Receptor 7/8 (TLR7/8) Cascade
[NCBI:1269227]
[REACTOME:R-HSA-168181]
[PUBMED:14976262]
Toll Like Receptor 9 (TLR9) Cascade
[NCBI:1269233]
[REACTOME:R-HSA-168138]
[PUBMED:14751759]
Toll-Like Receptors Cascades
[NCBI:1269204]
[REACTOME:R-HSA-168898]
[PUBMED:15950447]
[PUBMED:12893815]
[PUBMED:15976490]
[PUBMED:15585605]
[PUBMED:14751757]
Toll-like receptor signaling pathway
[NCBI:83076]
[KEGG:hsa04620]
[PUBMED:16924467]
[PUBMED:17395581]
[PUBMED:17637696]
[PUBMED:12734364]
[PUBMED:17507094]
[PUBMED:14698224]
[PUBMED:11101877]
[PUBMED:16497588]
[PUBMED:14751764]
[PUBMED:17275323]
[PUBMED:17457343]
[PUBMED:16932750]
ZBP1(DAI) mediated induction of type I IFNs
[NCBI:1269269]
[REACTOME:R-HSA-1606322]
[PUBMED:18375758]
[PUBMED:18941233]
[PUBMED:11842111]
[PUBMED:19590578]
[PUBMED:17618271]
[PUBMED:18771559]
[PUBMED:19846511]
