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Genes
TYK2
Gene - TYK2
full name
tyrosine kinase 2
synonyms
JTK1, TYK2, ENSG00000105397
HGNC
HGNC:12440
Entrez Gene
Gene:7297
ENSEMBL
ENSG00000105397
location
chr: 19
start: 10461204
stop: 10491248
strand: -
OMIM
OMIM:176941
: TYK2
(Autosomal recessive inheritance)
OMIM:611521
: Immunodeficiency 35
transcripts
NM_003331.4
pathways
Cytokine Signaling in Immune system
[NCBI:1269310]
[REACTOME:R-HSA-1280215]
[PUBMED:12613569]
Epstein-Barr virus infection
[NCBI:585562]
[KEGG:hsa05169]
[PUBMED:1658397]
[PUBMED:10683340]
[PUBMED:19375142]
[PUBMED:12438576]
[PUBMED:12910248]
[PUBMED:10400785]
[PUBMED:16007144]
[PUBMED:14576817]
[PUBMED:18559925]
[PUBMED:16352731]
[PUBMED:7895172]
[PUBMED:15510157]
[PUBMED:21518914]
[PUBMED:10891508]
[PUBMED:14673102]
[PUBMED:17159145]
[PUBMED:15542638]
[PUBMED:18786993]
[PUBMED:16603506]
[PUBMED:10644367]
[PUBMED:15021898]
[PUBMED:10666279]
[PUBMED:9565632]
Hepatitis C
[NCBI:173973]
[KEGG:hsa05160]
[PUBMED:19708811]
[PUBMED:16314558]
[PUBMED:17467654]
[PUBMED:19515018]
[PUBMED:18514579]
[PUBMED:16107833]
[PUBMED:19074178]
[PUBMED:12691459]
[PUBMED:15302943]
[PUBMED:20537953]
[PUBMED:11991644]
[PUBMED:19148799]
[PUBMED:19187070]
[PUBMED:12655344]
Herpes simplex infection
[NCBI:377873]
[KEGG:hsa05168]
[PUBMED:12224518]
[PUBMED:17913820]
[PUBMED:12844494]
[PUBMED:10998601]
[PUBMED:15163721]
[PUBMED:19694546]
[PUBMED:16297150]
[PUBMED:14747533]
[PUBMED:12826401]
[PUBMED:14963113]
[PUBMED:15056211]
[PUBMED:12797447]
[PUBMED:21107701]
[PUBMED:10918307]
[PUBMED:10696424]
[PUBMED:16076403]
[PUBMED:10364308]
[PUBMED:17222692]
[PUBMED:9621021]
[PUBMED:12224508]
[PUBMED:19879619]
[PUBMED:11070032]
[PUBMED:9499021]
[PUBMED:18596690]
[PUBMED:12525427]
[PUBMED:12224517]
[PUBMED:10196275]
[PUBMED:15047834]
[PUBMED:18508584]
[PUBMED:20036979]
IL-6-type cytokine receptor ligand interactions
[NCBI:1339143]
[REACTOME:R-HSA-6788467]
[PUBMED:9716487]
[PUBMED:12773095]
IL12-mediated signaling events
[NCBI:137922]
[Pathway Interaction Database:il12_2pathway]
[PUBMED:12874225]
[PUBMED:12221108]
[PUBMED:16380506]
[PUBMED:9768751]
[PUBMED:17114419]
[PUBMED:10358173]
[PUBMED:9890938]
[PUBMED:12213961]
[PUBMED:11120802]
[PUBMED:9202126]
[PUBMED:16641133]
[PUBMED:10198225]
[PUBMED:16763563]
[PUBMED:15728489]
[PUBMED:8103068]
[PUBMED:10903740]
[PUBMED:10201984]
[PUBMED:7638186]
[PUBMED:11894097]
[PUBMED:16220539]
[PUBMED:10961885]
[PUBMED:7594594]
[PUBMED:17110450]
[PUBMED:9582275]
[PUBMED:10320373]
[PUBMED:7528775]
[PUBMED:11207258]
[PUBMED:9038232]
[PUBMED:15522880]
[PUBMED:11175814]
[PUBMED:9531298]
[PUBMED:7722452]
[PUBMED:8943050]
[PUBMED:7553885]
[PUBMED:9454765]
IL23-mediated signaling events
[NCBI:138000]
[Pathway Interaction Database:il23pathway]
[PUBMED:16200068]
[PUBMED:12023338]
[PUBMED:17030949]
[PUBMED:16670770]
[PUBMED:17074928]
[PUBMED:15583831]
[PUBMED:16919486]
[PUBMED:12417590]
[PUBMED:16622035]
[PUBMED:16698929]
[PUBMED:14978083]
[PUBMED:12610626]
[PUBMED:15308705]
[PUBMED:16200070]
[PUBMED:15657292]
[PUBMED:16648837]
[PUBMED:11114383]
[PUBMED:12023369]
[PUBMED:9038232]
IL27-mediated signaling events
[NCBI:137929]
[Pathway Interaction Database:il27pathway]
[PUBMED:11672539]
[PUBMED:16365415]
[PUBMED:16906167]
[PUBMED:15356135]
[PUBMED:14657353]
[PUBMED:15944269]
[PUBMED:14764690]
[PUBMED:14614852]
[PUBMED:15308705]
[PUBMED:15004160]
[PUBMED:12734330]
[PUBMED:11057672]
[PUBMED:15494513]
[PUBMED:14614853]
[PUBMED:12121660]
[PUBMED:16906166]
[PUBMED:15749890]
IL6-mediated signaling events
[NCBI:137932]
[Pathway Interaction Database:il6_7pathway]
[PUBMED:8559663]
[PUBMED:8662591]
[PUBMED:11689697]
[PUBMED:11727828]
[PUBMED:10383440]
[PUBMED:10777583]
[PUBMED:16774741]
[PUBMED:12754507]
[PUBMED:9295319]
[PUBMED:15722452]
[PUBMED:10859312]
[PUBMED:9590172]
[PUBMED:9880505]
[PUBMED:12445202]
[PUBMED:8134389]
[PUBMED:10409724]
[PUBMED:8164674]
[PUBMED:8272872]
[PUBMED:9794795]
[PUBMED:7678052]
[PUBMED:8511589]
[PUBMED:8668165]
[PUBMED:9724754]
[PUBMED:8083235]
[PUBMED:12754505]
[PUBMED:8621622]
[PUBMED:16254248]
[PUBMED:12361954]
[PUBMED:10605021]
[PUBMED:9388184]
[PUBMED:15935617]
[PUBMED:11120832]
[PUBMED:7875298]
[PUBMED:9973404]
[PUBMED:11335711]
[PUBMED:9632795]
[PUBMED:11468294]
[PUBMED:7898939]
[PUBMED:8626374]
[PUBMED:8670868]
[PUBMED:7537214]
[PUBMED:15677447]
[PUBMED:2261637]
[PUBMED:9874564]
[PUBMED:12829785]
[PUBMED:8537375]
[PUBMED:8272873]
[PUBMED:7523403]
[PUBMED:11251120]
[PUBMED:9163525]
[PUBMED:3136546]
[PUBMED:10727406]
[PUBMED:10023775]
[PUBMED:12754506]
[PUBMED:12456685]
[PUBMED:2788034]
[PUBMED:10446219]
[PUBMED:15572665]
[PUBMED:1662392]
[PUBMED:15010462]
[PUBMED:8140422]
[PUBMED:8467812]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Influenza A
[NCBI:217173]
[KEGG:hsa05164]
[PUBMED:17267598]
[PUBMED:18049471]
[PUBMED:16882036]
[PUBMED:11907320]
[PUBMED:17944269]
[PUBMED:20629046]
[PUBMED:17072332]
[PUBMED:18588994]
[PUBMED:19864182]
[PUBMED:19290913]
[PUBMED:19420020]
[PUBMED:17213831]
[PUBMED:9060654]
[PUBMED:19481124]
[PUBMED:16494716]
[PUBMED:21147034]
[PUBMED:18980544]
[PUBMED:20020828]
[PUBMED:15502848]
[PUBMED:19782761]
Interferon Signaling
[NCBI:1269311]
[REACTOME:R-HSA-913531]
[PUBMED:18929502]
[PUBMED:15607020]
[PUBMED:15864272]
[PUBMED:14525967]
[PUBMED:19059436]
Interferon alpha/beta signaling
[NCBI:1269312]
[REACTOME:R-HSA-909733]
[PUBMED:8621447]
[PUBMED:8605876]
[PUBMED:8702790]
[PUBMED:17969444]
Interleukin-10 signaling
[NCBI:1470924]
[REACTOME:R-HSA-6783783]
[PUBMED:11244051]
Interleukin-4 and 13 signaling
[NCBI:1470923]
[REACTOME:R-HSA-6785807]
[PUBMED:12704343]
[PUBMED:10358772]
Interleukin-6 family signaling
[NCBI:1339142]
[REACTOME:R-HSA-6783589]
[PUBMED:9685167]
[PUBMED:8666978]
[PUBMED:12773095]
[PUBMED:9143707]
[PUBMED:9716487]
[PUBMED:7632928]
Interleukin-6 signaling
[NCBI:1269325]
[REACTOME:R-HSA-1059683]
[PUBMED:20410258]
Jak-STAT signaling pathway
[NCBI:83077]
[KEGG:hsa04630]
[PUBMED:21034406]
[PUBMED:22339650]
[PUBMED:16204702]
[PUBMED:25587654]
[PUBMED:24069565]
[PUBMED:22383755]
[PUBMED:24606160]
[PUBMED:10851053]
[PUBMED:23735217]
[PUBMED:25217450]
[PUBMED:21372217]
MAPK family signaling cascades
[NCBI:1269501]
[REACTOME:R-HSA-5683057]
[PUBMED:21167873]
[PUBMED:17161475]
[PUBMED:22535895]
[PUBMED:21372320]
MAPK1 (ERK2) activation
[NCBI:1269505]
[REACTOME:R-HSA-112411]
[PUBMED:22177953]
[PUBMED:8131746]
MAPK1/MAPK3 signaling
[NCBI:1269502]
[REACTOME:R-HSA-5684996]
[PUBMED:25378393]
[PUBMED:18199641]
[PUBMED:17496909]
[PUBMED:21779496]
[PUBMED:15520807]
[PUBMED:16393692]
[PUBMED:19520853]
[PUBMED:17496910]
[PUBMED:22569528]
MAPK3 (ERK1) activation
[NCBI:1269504]
[REACTOME:R-HSA-110056]
Measles
[NCBI:213306]
[KEGG:hsa05162]
[PUBMED:16237742]
[PUBMED:12804771]
[PUBMED:19198562]
[PUBMED:20376484]
[PUBMED:11385511]
[PUBMED:16963735]
[PUBMED:19198566]
[PUBMED:18922877]
[PUBMED:19203114]
[PUBMED:12620806]
[PUBMED:16690907]
[PUBMED:17720800]
[PUBMED:20636817]
[PUBMED:12410527]
[PUBMED:11582511]
[PUBMED:19203109]
[PUBMED:19203113]
[PUBMED:14585342]
[PUBMED:12805463]
NOD-like receptor signaling pathway
[NCBI:122191]
[KEGG:hsa04621]
[PUBMED:25330206]
[PUBMED:21575908]
[PUBMED:23846113]
[PUBMED:26549800]
[PUBMED:16493424]
[PUBMED:23124073]
[PUBMED:24840700]
[PUBMED:27291964]
[PUBMED:27012466]
[PUBMED:24707857]
[PUBMED:19767725]
[PUBMED:25879280]
[PUBMED:23215645]
[PUBMED:22819539]
[PUBMED:23702978]
[PUBMED:20643110]
[PUBMED:25879288]
[PUBMED:26655628]
[PUBMED:25145756]
[PUBMED:24718315]
[PUBMED:26482951]
[PUBMED:25526305]
[PUBMED:26121197]
[PUBMED:22430786]
Osteoclast differentiation
[NCBI:193147]
[KEGG:hsa04380]
[PUBMED:17633024]
[PUBMED:18382763]
[PUBMED:18329366]
[PUBMED:17869613]
[PUBMED:18722561]
[PUBMED:15122243]
[PUBMED:20703218]
[PUBMED:12748652]
[PUBMED:12110142]
[PUBMED:19585227]
[PUBMED:15546140]
[PUBMED:16184196]
[PUBMED:15817678]
[PUBMED:20392226]
[PUBMED:16313349]
[PUBMED:16313342]
[PUBMED:17380158]
[PUBMED:18451259]
RAF-independent MAPK1/3 activation
[NCBI:1269503]
[REACTOME:R-HSA-112409]
[PUBMED:21135874]
[PUBMED:22569528]
[PUBMED:23954936]
Regulation of IFNA signaling
[NCBI:1269313]
[REACTOME:R-HSA-912694]
[PUBMED:16710296]
[PUBMED:16311601]
[PUBMED:10526574]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by Interleukins
[NCBI:1269318]
[REACTOME:R-HSA-449147]
[PUBMED:19302047]
[PUBMED:12445398]
Signaling events mediated by PTP1B
[NCBI:138017]
[Pathway Interaction Database:ptp1bpathway]
[PUBMED:12414790]
[PUBMED:8223493]
[PUBMED:12857726]
[PUBMED:8999839]
[PUBMED:14766979]
[PUBMED:9355745]
[PUBMED:11579209]
[PUBMED:8940134]
[PUBMED:12802338]
[PUBMED:10807907]
[PUBMED:15866871]
[PUBMED:10751417]
[PUBMED:11346638]
[PUBMED:11970899]
[PUBMED:9083103]
[PUBMED:7693694]
[PUBMED:11900546]
[PUBMED:7983051]
[PUBMED:11694501]
[PUBMED:10514492]
[PUBMED:12176037]
[PUBMED:16644720]
[PUBMED:16388599]
[PUBMED:9624118]
[PUBMED:9786960]
[PUBMED:14966267]
[PUBMED:15894168]
[PUBMED:11773439]
[PUBMED:11864611]
[PUBMED:8548812]
[PUBMED:16477024]
[PUBMED:9418872]
[PUBMED:9050838]
[PUBMED:12424235]
[PUBMED:12748279]
[PUBMED:1383688]
[PUBMED:8782827]
[PUBMED:8626723]
[PUBMED:11007774]
[PUBMED:10993888]
[PUBMED:15226396]
[PUBMED:10066179]
[PUBMED:10660596]
[PUBMED:12554649]
[PUBMED:11970898]
[PUBMED:9566916]
Th1 and Th2 cell differentiation
[NCBI:1458885]
[KEGG:hsa04658]
[PUBMED:15819694]
[PUBMED:12171942]
[PUBMED:19165228]
[PUBMED:23336087]
[PUBMED:26044597]
[PUBMED:19151746]
[PUBMED:19362457]
[PUBMED:22044277]
[PUBMED:11752608]
[PUBMED:23405903]
[PUBMED:19375293]
[PUBMED:24113868]
[PUBMED:19151747]
[PUBMED:23624818]
[PUBMED:22566933]
[PUBMED:11121747]
[PUBMED:20969597]
[PUBMED:20065998]
Th17 cell differentiation
[NCBI:1469482]
[KEGG:hsa04659]
[PUBMED:23325835]
[PUBMED:23036716]
[PUBMED:20488727]
[PUBMED:21151104]
[PUBMED:21084214]
[PUBMED:20054607]
[PUBMED:22754770]
[PUBMED:22640807]
[PUBMED:19379825]
[PUBMED:22133865]
[PUBMED:22324470]
[PUBMED:17768419]
[PUBMED:18408735]
[PUBMED:21776333]
[PUBMED:26253381]
[PUBMED:16200068]
[PUBMED:18362914]
[PUBMED:24325586]
[PUBMED:19381306]
[PUBMED:18166487]
Toxoplasmosis
[NCBI:169642]
[KEGG:hsa05145]
[PUBMED:18617274]
[PUBMED:19400868]
[PUBMED:17024357]
[PUBMED:19744886]
[PUBMED:19891610]
[PUBMED:17110955]
[PUBMED:12106793]
[PUBMED:12580944]
[PUBMED:12857995]
[PUBMED:10234174]
[PUBMED:18327664]
[PUBMED:10525166]
[PUBMED:18059289]
[PUBMED:18775432]
[PUBMED:14642303]
[PUBMED:15361242]
[PUBMED:16339966]
[PUBMED:14987366]
[PUBMED:15639739]