Logo
full name
dynamin 2

synonyms
CMT2M, CMTDI1, CMTDIB, DI-CMTB, DYN2, DYNII, DNM2, ENSG00000079805

HGNC
HGNC:2974

Entrez Gene
Gene:1785

ENSEMBL
ENSG00000079805

location
chr: 19
start: 10828729
stop: 10944169
strand: +

OMIM
OMIM:602378: DNM2 (Autosomal dominant inheritance)
OMIM:160150: Centronuclear myopathy 1
OMIM:606482: Charcot-Marie-Tooth disease, axonal type 2M
OMIM:606482: Charcot-Marie-Tooth disease, dominant intermediate B
OMIM:615368: Lethal congenital contracture syndrome 5

transcripts
NM_001005360.2
NM_001190716.1
NM_004945.3
NM_001005361.2
NM_001005362.2

pathways
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
Arf6 trafficking events [NCBI:137954] [Pathway Interaction Database:arf6_traffickingpathway] [PUBMED:10748097] [PUBMED:15590645] [PUBMED:15980073] [PUBMED:19644450] [PUBMED:16461286] [PUBMED:14675422] [PUBMED:16139226] [PUBMED:12589044] [PUBMED:15802264] [PUBMED:14585928] [PUBMED:17664335] [PUBMED:17719203] [PUBMED:12960436] [PUBMED:12447393] [PUBMED:11535619] [PUBMED:12657640] [PUBMED:16280360] [PUBMED:9314528] [PUBMED:19211056] [PUBMED:11533043] [PUBMED:12847086] [PUBMED:15146059] [PUBMED:9685333] [PUBMED:12925709] [PUBMED:15231847] [PUBMED:12810696] [PUBMED:14662749] [PUBMED:16030257] [PUBMED:12379803] [PUBMED:15775968] [PUBMED:11532961] [PUBMED:8769418]
Axon guidance [NCBI:83065] [KEGG:hsa04360] [NCBI:1270303] [REACTOME:R-HSA-422475] [PUBMED:14682358] [PUBMED:15084255] [PUBMED:11687826] [PUBMED:15818466] [PUBMED:15363605] [PUBMED:12471249] [PUBMED:15630019] [PUBMED:11891122] [PUBMED:15960985] [PUBMED:12677003]
Bacterial invasion of epithelial cells [NCBI:149807] [KEGG:hsa05100] [PUBMED:17298394] [PUBMED:16406780] [PUBMED:19185531] [PUBMED:19157959] [PUBMED:17719540] [PUBMED:19296488]
Clathrin derived vesicle budding [NCBI:1269881] [REACTOME:R-HSA-421837]
Clathrin-mediated endocytosis [NCBI:1427858] [REACTOME:R-HSA-8856828] [PUBMED:16516836] [PUBMED:15339664] [PUBMED:19754444] [PUBMED:8552632] [PUBMED:21779028] [PUBMED:12353027] [PUBMED:23891661] [PUBMED:21613550] [PUBMED:20059951] [PUBMED:21447041] [PUBMED:17620409] [PUBMED:16903783] [PUBMED:21445324] [PUBMED:19696798] [PUBMED:26246598] [PUBMED:25085911] [PUBMED:24186068] [PUBMED:26829388] [PUBMED:27092250] [PUBMED:24581490] [PUBMED:26042225] [PUBMED:23823722] [PUBMED:24789820] [PUBMED:9736607] [PUBMED:23637288] [PUBMED:22233676] [PUBMED:19458185] [PUBMED:26403691] [PUBMED:19296720] [PUBMED:15703209] [PUBMED:20428113] [PUBMED:8953040] [PUBMED:1177317] [PUBMED:9092476] [PUBMED:26872272] [PUBMED:19092055]
Developmental Biology [NCBI:1270302] [REACTOME:R-HSA-1266738]
Endocrine and other factor-regulated calcium reabsorption [NCBI:213307] [KEGG:hsa04961] [PUBMED:15747113] [PUBMED:20969972] [PUBMED:15618484] [PUBMED:18989697] [PUBMED:19423690] [PUBMED:18293139] [PUBMED:18596722] [PUBMED:16518325] [PUBMED:17006539] [PUBMED:12684797] [PUBMED:17233615] [PUBMED:16044309]
Endocytosis [NCBI:102279] [KEGG:hsa04144] [PUBMED:19696797] [PUBMED:19007773] [PUBMED:16203612] [PUBMED:15687999] [PUBMED:19924646] [PUBMED:15261671] [PUBMED:18647649] [PUBMED:19325624] [PUBMED:20110990] [PUBMED:22193161]
Fc gamma R-mediated phagocytosis [NCBI:114228] [KEGG:hsa04666] [PUBMED:11304556] [PUBMED:11244038] [PUBMED:10755615] [PUBMED:17308335] [PUBMED:12821647] [PUBMED:15466916] [PUBMED:17050193] [PUBMED:11228151] [PUBMED:12488490] [PUBMED:10224668] [PUBMED:11708889] [PUBMED:9581795] [PUBMED:10586078] [PUBMED:9417101] [PUBMED:15485887] [PUBMED:18322649] [PUBMED:10577498] [PUBMED:10376013] [PUBMED:10601359] [PUBMED:9545263]
Formation of annular gap junctions [NCBI:1269892] [REACTOME:R-HSA-196025] [PUBMED:17108328]
Gap junction degradation [NCBI:1269891] [REACTOME:R-HSA-190873] [PUBMED:17108328] [PUBMED:8522583]
Gap junction trafficking [NCBI:1269885] [REACTOME:R-HSA-190828] [PUBMED:8522583] [PUBMED:15033576]
Gap junction trafficking and regulation [NCBI:1269884] [REACTOME:R-HSA-157858] [PUBMED:15033576] [PUBMED:11737941] [PUBMED:9861669] [PUBMED:11146276]
Golgi Associated Vesicle Biogenesis [NCBI:1269882] [REACTOME:R-HSA-432722]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
L1CAM interactions [NCBI:1270323] [REACTOME:R-HSA-373760] [PUBMED:9211984] [PUBMED:18760361] [PUBMED:14709786] [PUBMED:17189949] [PUBMED:19356150]
Lysosome Vesicle Biogenesis [NCBI:1269883] [REACTOME:R-HSA-432720]
MHC class II antigen presentation [NCBI:1269200] [REACTOME:R-HSA-2132295] [PUBMED:19703008] [PUBMED:9316394] [PUBMED:11684289] [PUBMED:19217269] [PUBMED:8689559]
Membrane Trafficking [NCBI:1269877] [REACTOME:R-HSA-199991] [PUBMED:11031247]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of nitric oxide [NCBI:1270115] [REACTOME:R-HSA-202131] [PUBMED:17237348]
NGF signalling via TRKA from the plasma membrane [NCBI:1269460] [REACTOME:R-HSA-187037] [PUBMED:11520933] [PUBMED:12676795] [PUBMED:10851172] [PUBMED:10579918]
NOSTRIN mediated eNOS trafficking [NCBI:1270119] [REACTOME:R-HSA-203641] [PUBMED:12842859] [PUBMED:16722822] [PUBMED:12446846] [PUBMED:16234328]
PDGFR-beta signaling pathway [NCBI:138071] [Pathway Interaction Database:pdgfrbpathway] [PUBMED:7545675] [PUBMED:16769879] [PUBMED:12652307] [PUBMED:10463951] [PUBMED:9742401] [PUBMED:8086421] [PUBMED:10391677] [PUBMED:7739538] [PUBMED:9989826] [PUBMED:10734138] [PUBMED:15753096] [PUBMED:7692233] [PUBMED:11489946] [PUBMED:10837138] [PUBMED:10229199] [PUBMED:10821867] [PUBMED:11709084] [PUBMED:11389443] [PUBMED:12958184] [PUBMED:10734113] [PUBMED:15161943] [PUBMED:12149261] [PUBMED:16456542] [PUBMED:16224065] [PUBMED:8619809] [PUBMED:15494217] [PUBMED:1849073] [PUBMED:11085978] [PUBMED:2544881] [PUBMED:7622571] [PUBMED:10779329] [PUBMED:15944146] [PUBMED:11027258] [PUBMED:1708307] [PUBMED:8940081] [PUBMED:11854295] [PUBMED:8195171] [PUBMED:12424235] [PUBMED:7935392] [PUBMED:14966296] [PUBMED:16537894]
Phospholipase D signaling pathway [NCBI:1311074] [KEGG:hsa04072] [PUBMED:9310372] [PUBMED:9119890] [PUBMED:15310762] [PUBMED:18936782] [PUBMED:24990952] [PUBMED:14769825] [PUBMED:21936578] [PUBMED:10666319] [PUBMED:17210675] [PUBMED:19264150] [PUBMED:23076158] [PUBMED:17054901] [PUBMED:16622417] [PUBMED:10807766] [PUBMED:12217395] [PUBMED:11042115] [PUBMED:19815110] [PUBMED:24995811] [PUBMED:16143829] [PUBMED:8135758] [PUBMED:11991733] [PUBMED:19410013] [PUBMED:17245604]
Recycling pathway of L1 [NCBI:1270324] [REACTOME:R-HSA-437239] [PUBMED:10804209] [PUBMED:11717353] [PUBMED:14709786]
Retrograde neurotrophin signalling [NCBI:1269476] [REACTOME:R-HSA-177504]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signalling by NGF [NCBI:1269443] [REACTOME:R-HSA-166520]
Synaptic vesicle cycle [NCBI:373900] [KEGG:hsa04721] [PUBMED:20634814] [PUBMED:17767192] [PUBMED:12094216] [PUBMED:16990140] [PUBMED:18726177] [PUBMED:18275379] [PUBMED:12827282] [PUBMED:12154365] [PUBMED:10212473] [PUBMED:15217342] [PUBMED:7791897] [PUBMED:12563290]
Syndecan-4-mediated signaling events [NCBI:138064] [Pathway Interaction Database:syndecan_4_pathway] [PUBMED:16604063] [PUBMED:8621465] [PUBMED:17485492] [PUBMED:10633082] [PUBMED:14580209] [PUBMED:14670076] [PUBMED:16357320] [PUBMED:11373281] [PUBMED:11805099] [PUBMED:12087088] [PUBMED:16087677] [PUBMED:8589452] [PUBMED:17901052] [PUBMED:12571249] [PUBMED:16310216] [PUBMED:15694365] [PUBMED:17130131] [PUBMED:17879962] [PUBMED:8609172] [PUBMED:12493766] [PUBMED:10640397] [PUBMED:15819887] [PUBMED:10625452] [PUBMED:9582338] [PUBMED:14637022] [PUBMED:12509413] [PUBMED:16141413] [PUBMED:10734086] [PUBMED:10911369]
Toll Like Receptor 4 (TLR4) Cascade [NCBI:1269234] [REACTOME:R-HSA-166016]
Toll-Like Receptors Cascades [NCBI:1269204] [REACTOME:R-HSA-168898] [PUBMED:15950447] [PUBMED:12893815] [PUBMED:15976490] [PUBMED:15585605] [PUBMED:14751757]
Vesicle-mediated transport [NCBI:1269876] [REACTOME:R-HSA-5653656]
eNOS activation and regulation [NCBI:1270116] [REACTOME:R-HSA-203765] [PUBMED:12842859] [PUBMED:16722822]
trans-Golgi Network Vesicle Budding [NCBI:1269880] [REACTOME:R-HSA-199992] [PUBMED:11252894]