full name
cytochrome P450 family 2 subfamily A member 6

synonyms
CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB, CYP2A6, ENSG00000255974

HGNC
HGNC:2610

Entrez Gene
Gene:1548

ENSEMBL
ENSG00000255974

location
chr: 19
start: 41349441
stop: 41356360
strand: -

OMIM
OMIM:122720: CYP2A6 (Autosomal dominant inheritance)
OMIM:122700: Coumarin resistance
OMIM:211980: {Lung cancer, resistance to}
OMIM:188890: {Nicotine addiction, protection from}

transcripts
ENST00000301141.5

pathways
Biological oxidations [NCBI:1270189] [REACTOME:R-HSA-211859]
CYP2E1 reactions [NCBI:1270196] [REACTOME:R-HSA-211999] [PUBMED:15603755] [PUBMED:10397283] [PUBMED:14744237]
Caffeine metabolism [NCBI:82945] [KEGG:hsa00232] [PUBMED:16333668] [PUBMED:14977550] [PUBMED:9705852] [PUBMED:11393735] [PUBMED:11544129]
Chemical carcinogenesis [NCBI:673221] [KEGG:hsa05204] [PUBMED:21473878] [PUBMED:15489140] [PUBMED:21255676] [PUBMED:11376689] [PUBMED:15298956] [PUBMED:17445838] [PUBMED:22705365] [PUBMED:9152590] [PUBMED:8759017] [PUBMED:20570348] [PUBMED:11275476] [PUBMED:9202760] [PUBMED:21163908] [PUBMED:10753215] [PUBMED:10913381] [PUBMED:21217854] [PUBMED:15582261] [PUBMED:16959879] [PUBMED:11092599] [PUBMED:20159989] [PUBMED:21234336] [PUBMED:17459420] [PUBMED:9275165] [PUBMED:17292678] [PUBMED:11978484] [PUBMED:11222868] [PUBMED:15660110] [PUBMED:8702479] [PUBMED:9356303] [PUBMED:20232918] [PUBMED:12435844] [PUBMED:19657920] [PUBMED:8951235] [PUBMED:15532073] [PUBMED:16084004] [PUBMED:18066431] [PUBMED:14570033] [PUBMED:16421178] [PUBMED:21154658] [PUBMED:12928348] [PUBMED:19531241] [PUBMED:20669524] [PUBMED:11467078] [PUBMED:22178655] [PUBMED:21456541]
Cytochrome P450 - arranged by substrate type [NCBI:1270191] [REACTOME:R-HSA-211897] [PUBMED:16584116] [PUBMED:15102545] [PUBMED:12369887]
Drug metabolism - cytochrome P450 [NCBI:83032] [KEGG:hsa00982] [PUBMED:16550168] [PUBMED:10575324] [PUBMED:11226815] [PUBMED:16393888] [PUBMED:12399158] [PUBMED:11504799] [PUBMED:16038189] [PUBMED:10901707] [PUBMED:18043895] [PUBMED:18463198] [PUBMED:9698084] [PUBMED:12386121] [PUBMED:10859160]
Drug metabolism - other enzymes [NCBI:83033] [KEGG:hsa00983] [PUBMED:15514566] [PUBMED:15173095] [PUBMED:15788214] [PUBMED:11379777] [PUBMED:10976516] [PUBMED:11489791] [PUBMED:16048561] [PUBMED:16880012]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of xenobiotics by cytochrome P450 [NCBI:83031] [KEGG:hsa00980] [PUBMED:9107551] [PUBMED:10570027] [PUBMED:4395686] [PUBMED:10490505] [PUBMED:15987776] [PUBMED:15298956] [PUBMED:15319346] [PUBMED:12487150] [PUBMED:10725110]
Phase 1 - Functionalization of compounds [NCBI:1270190] [REACTOME:R-HSA-211945] [PUBMED:12369887] [PUBMED:17125408] [PUBMED:16584116]
Retinol metabolism [NCBI:83020] [KEGG:hsa00830] [PUBMED:17893666] [PUBMED:16968212] [PUBMED:16688755] [PUBMED:16428379] [PUBMED:17618621] [PUBMED:11093772]
Xenobiotics [NCBI:1270194] [REACTOME:R-HSA-211981] [PUBMED:12369887] [PUBMED:15102545] [PUBMED:16584116]
acetone degradation I (to methylglyoxal) [NCBI:545352] [BIOCYC:HUMAN_PWY-5451] [PUBMED:6389978] [PUBMED:10424765] [PUBMED:6706932] [PUBMED:963888] [PUBMED:12726989] [PUBMED:4624981] [PUBMED:3943633] [PUBMED:4055750] [PUBMED:4358273] [PUBMED:2806080]
bupropion degradation [NCBI:142436] [BIOCYC:HUMAN_PWY66-241] [PUBMED:15081921] [PUBMED:6406469] [PUBMED:22628] [PUBMED:11454731] [PUBMED:9378846] [PUBMED:6804243] [PUBMED:8830063] [PUBMED:10997944] [PUBMED:3931955] [PUBMED:12911050] [PUBMED:3107223]
estradiol biosynthesis I [NCBI:545303] [BIOCYC:HUMAN_PWY66-380]
estradiol biosynthesis II [NCBI:907948] [BIOCYC:HUMAN_PWY-7306]
melatonin degradation I [NCBI:545356] [BIOCYC:HUMAN_PWY-6398] [PUBMED:18344019] [PUBMED:18717775] [PUBMED:12899443] [PUBMED:17198536] [PUBMED:16219483] [PUBMED:9181522] [PUBMED:15981996] [PUBMED:12662344] [PUBMED:11485009] [PUBMED:18155917] [PUBMED:15616152] [PUBMED:16793870]
nicotine degradation III [NCBI:142438] [BIOCYC:HUMAN_PWY66-221] [PUBMED:11712903] [PUBMED:12433823] [PUBMED:10548320] [PUBMED:10224986] [PUBMED:3443673] [PUBMED:8123688] [PUBMED:12376133] [PUBMED:3391001] [PUBMED:7955812] [PUBMED:14166990] [PUBMED:2249376] [PUBMED:8646831] [PUBMED:10336551] [PUBMED:13932077] [PUBMED:8245272] [PUBMED:1352209] [PUBMED:10027795] [PUBMED:3557628] [PUBMED:14680362] [PUBMED:10482401] [PUBMED:8725403] [PUBMED:3806608] [PUBMED:10409404] [PUBMED:2362266] [PUBMED:2075752] [PUBMED:6705448] [PUBMED:8012160] [PUBMED:11050152] [PUBMED:14570768] [PUBMED:14004224] [PUBMED:8301571] [PUBMED:14257634] [PUBMED:8079500] [PUBMED:15734728] [PUBMED:13872096] [PUBMED:3054551] [PUBMED:43154] [PUBMED:9209247] [PUBMED:1643259]
nicotine degradation IV [NCBI:142437] [BIOCYC:HUMAN_PWY66-201] [PUBMED:8117928] [PUBMED:6705448] [PUBMED:423207] [PUBMED:1593921] [PUBMED:6896399] [PUBMED:2897456] [PUBMED:9512938] [PUBMED:8301571] [PUBMED:14570768] [PUBMED:3806608] [PUBMED:8725403] [PUBMED:15734728] [PUBMED:13872096] [PUBMED:14257634] [PUBMED:43154] [PUBMED:14004224] [PUBMED:3391001] [PUBMED:9209247] [PUBMED:1976062] [PUBMED:3054551] [PUBMED:4394772] [PUBMED:3557628] [PUBMED:10482401] [PUBMED:4144545] [PUBMED:10224986] [PUBMED:12376133] [PUBMED:12433823] [PUBMED:10548320] [PUBMED:11712903] [PUBMED:10336551] [PUBMED:8245272] [PUBMED:11050152] [PUBMED:10027795] [PUBMED:2249376] [PUBMED:8646831] [PUBMED:7955812] [PUBMED:1446003] [PUBMED:1352209] [PUBMED:13932077] [PUBMED:14166990]
superpathway of melatonin degradation [NCBI:545359] [BIOCYC:HUMAN_PWY-6402]
superpathway of steroid hormone biosynthesis [NCBI:907943] [BIOCYC:HUMAN_PWY-7305] [PUBMED:16973755]
superpathway of tryptophan utilization [NCBI:835392] [BIOCYC:HUMAN_PWY66-401]