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Genes
ARHGEF1
Gene - ARHGEF1
full name
Rho guanine nucleotide exchange factor 1
synonyms
GEF1, LBCL2, LSC, P115-RHOGEF, SUB1.5, ARHGEF1, ENSG00000076928
HGNC
HGNC:681
Entrez Gene
Gene:9138
ENSEMBL
ENSG00000076928
ENSG00000272879
location
chr: 19
start: 42387240
stop: 42411604
strand: +
OMIM
OMIM:601855
: ARHGEF1
OMIM:618459
: ?Immunodeficiency 62
transcripts
NM_004706.3
NM_198977.1
NM_199002.1
pathways
Axonal growth inhibition (RHOA activation)
[NCBI:1269458]
[REACTOME:R-HSA-193634]
[PUBMED:12951563]
Cell death signalling via NRAGE, NRIF and NADE
[NCBI:1269447]
[REACTOME:R-HSA-204998]
[PUBMED:12787561]
G alpha (12/13) signalling events
[NCBI:1269579]
[REACTOME:R-HSA-416482]
[PUBMED:18814923]
[PUBMED:19212140]
GPCR downstream signaling
[NCBI:1269574]
[REACTOME:R-HSA-388396]
[PUBMED:12040175]
LPA receptor mediated events
[NCBI:137928]
[Pathway Interaction Database:lysophospholipid_pathway]
[PUBMED:10601262]
[PUBMED:16289596]
[PUBMED:7809106]
[PUBMED:10342794]
[PUBMED:15928312]
[PUBMED:16769764]
[PUBMED:11243883]
[PUBMED:14688263]
[PUBMED:10551845]
[PUBMED:16687414]
[PUBMED:9819398]
[PUBMED:7527052]
[PUBMED:9600933]
[PUBMED:2551506]
[PUBMED:15988003]
[PUBMED:10644509]
[PUBMED:16199135]
[PUBMED:15728708]
[PUBMED:1637305]
[PUBMED:7476905]
[PUBMED:7510708]
[PUBMED:8647803]
[PUBMED:10420989]
[PUBMED:12880866]
[PUBMED:10766839]
[PUBMED:12181443]
[PUBMED:15461590]
[PUBMED:16452634]
[PUBMED:16197369]
[PUBMED:10779388]
[PUBMED:10506190]
[PUBMED:9305878]
[PUBMED:16904289]
[PUBMED:15878967]
[PUBMED:15143197]
[PUBMED:11948806]
[PUBMED:11040035]
[PUBMED:12393875]
[PUBMED:9407095]
[PUBMED:15280372]
[PUBMED:16890224]
[PUBMED:8805276]
NRAGE signals death through JNK
[NCBI:1269448]
[REACTOME:R-HSA-193648]
[PUBMED:12376548]
Pathways in cancer
[NCBI:83105]
[KEGG:hsa05200]
[PUBMED:12244301]
[PUBMED:15156182]
[PUBMED:16899407]
[PUBMED:12621137]
[PUBMED:21193867]
[PUBMED:16001072]
[PUBMED:11707511]
[PUBMED:11253051]
[PUBMED:11071626]
[PUBMED:17251915]
[PUBMED:11736900]
[PUBMED:16557281]
[PUBMED:16699851]
[PUBMED:16189702]
[PUBMED:11902573]
[PUBMED:16555243]
[PUBMED:8069858]
[PUBMED:15310786]
[PUBMED:9834202]
[PUBMED:16700615]
[PUBMED:12545153]
[PUBMED:15656799]
[PUBMED:12154354]
[PUBMED:11895903]
[PUBMED:11527574]
[PUBMED:16326109]
[PUBMED:16339096]
[PUBMED:11160144]
[PUBMED:15724144]
[PUBMED:12951584]
[PUBMED:10647931]
[PUBMED:16881963]
[PUBMED:15557758]
[PUBMED:11477132]
[PUBMED:15721476]
[PUBMED:15625120]
[PUBMED:16236521]
[PUBMED:14967450]
[PUBMED:15942304]
[PUBMED:17287871]
[PUBMED:14634372]
[PUBMED:15573119]
[PUBMED:15009714]
[PUBMED:16112428]
[PUBMED:15611513]
[PUBMED:16001050]
[PUBMED:15349822]
[PUBMED:16551846]
[PUBMED:15978322]
[PUBMED:15774796]
[PUBMED:16352814]
[PUBMED:12951588]
[PUBMED:10944551]
[PUBMED:10740269]
[PUBMED:15639402]
[PUBMED:12407699]
[PUBMED:11130178]
[PUBMED:15109562]
[PUBMED:11170304]
[PUBMED:11276000]
[PUBMED:9643506]
[PUBMED:16248975]
[PUBMED:16242838]
[PUBMED:12946833]
[PUBMED:11559746]
[PUBMED:9196022]
[PUBMED:12079267]
[PUBMED:15468170]
[PUBMED:16064138]
[PUBMED:14580692]
[PUBMED:15082523]
[PUBMED:15551095]
[PUBMED:17062879]
[PUBMED:17211469]
[PUBMED:11720739]
[PUBMED:12588368]
[PUBMED:11057895]
[PUBMED:9422516]
[PUBMED:12894244]
[PUBMED:15479695]
[PUBMED:16189154]
[PUBMED:12878745]
[PUBMED:11900250]
[PUBMED:11103787]
[PUBMED:15122209]
[PUBMED:12711111]
[PUBMED:12243753]
[PUBMED:16306523]
[PUBMED:16702400]
[PUBMED:15270885]
[PUBMED:14685170]
[PUBMED:14586404]
[PUBMED:11078609]
[PUBMED:15284264]
[PUBMED:10505543]
[PUBMED:11223406]
[PUBMED:14982876]
[PUBMED:12648469]
[PUBMED:12867060]
[PUBMED:15711891]
[PUBMED:12094241]
[PUBMED:16642045]
[PUBMED:11463388]
[PUBMED:12762887]
[PUBMED:15746962]
[PUBMED:15823750]
[PUBMED:16750612]
[PUBMED:16484590]
[PUBMED:11459867]
[PUBMED:16146838]
[PUBMED:14556242]
[PUBMED:15947972]
[PUBMED:12563308]
[PUBMED:16946003]
[PUBMED:15948971]
[PUBMED:11407945]
[PUBMED:12737309]
[PUBMED:16095998]
[PUBMED:12351585]
[PUBMED:24508914]
[PUBMED:12084351]
[PUBMED:11807782]
[PUBMED:14695152]
[PUBMED:10453277]
[PUBMED:17554387]
[PUBMED:15841168]
[PUBMED:12616528]
[PUBMED:10403855]
[PUBMED:16054233]
[PUBMED:16474624]
[PUBMED:16822996]
[PUBMED:17028294]
[PUBMED:11224709]
[PUBMED:11750244]
[PUBMED:11905738]
[PUBMED:15719031]
[PUBMED:10843728]
[PUBMED:16110317]
[PUBMED:11721960]
[PUBMED:12741677]
[PUBMED:7585656]
[PUBMED:12801837]
[PUBMED:16551847]
[PUBMED:12459728]
[PUBMED:11431710]
[PUBMED:12468433]
[PUBMED:11165748]
[PUBMED:16042571]
[PUBMED:16508724]
[PUBMED:15000146]
[PUBMED:17149381]
[PUBMED:15948711]
[PUBMED:14747944]
[PUBMED:14737121]
[PUBMED:12379883]
[PUBMED:17158541]
[PUBMED:12850530]
[PUBMED:10835690]
[PUBMED:16870043]
Platelet activation
[NCBI:952858]
[KEGG:hsa04611]
[PUBMED:20002545]
[PUBMED:18363565]
[PUBMED:18544684]
[PUBMED:18174460]
[PUBMED:23106920]
[PUBMED:18550847]
[PUBMED:22119499]
[PUBMED:19630797]
[PUBMED:19286885]
[PUBMED:17158345]
[PUBMED:20089227]
[PUBMED:22701130]
[PUBMED:21071698]
[PUBMED:23805129]
[PUBMED:16149014]
[PUBMED:18641368]
Proteoglycans in cancer
[NCBI:782000]
[KEGG:hsa05205]
[PUBMED:19433454]
[PUBMED:20655987]
[PUBMED:18798267]
[PUBMED:10633082]
[PUBMED:10687947]
[PUBMED:22735579]
[PUBMED:24412155]
[PUBMED:9346940]
[PUBMED:22087031]
[PUBMED:22194599]
[PUBMED:14711376]
[PUBMED:19255147]
[PUBMED:15655247]
[PUBMED:11717317]
[PUBMED:17971838]
[PUBMED:18413366]
[PUBMED:20974860]
[PUBMED:11830493]
[PUBMED:23058688]
[PUBMED:18450475]
[PUBMED:12748184]
[PUBMED:19733083]
[PUBMED:18812315]
[PUBMED:12509413]
[PUBMED:21155971]
[PUBMED:11931647]
[PUBMED:18949819]
[PUBMED:12729888]
[PUBMED:15994311]
[PUBMED:23305321]
[PUBMED:18505598]
[PUBMED:22563565]
[PUBMED:22033227]
Regulation of RhoA activity
[NCBI:138070]
[Pathway Interaction Database:rhoa_reg_pathway]
[PUBMED:10579713]
[PUBMED:15039571]
[PUBMED:19605563]
[PUBMED:19755152]
[PUBMED:16954208]
[PUBMED:10744696]
[PUBMED:17702745]
[PUBMED:10837491]
[PUBMED:12454018]
[PUBMED:15023524]
[PUBMED:11396949]
[PUBMED:10523675]
[PUBMED:10026210]
[PUBMED:18948007]
[PUBMED:16112081]
[PUBMED:19713215]
[PUBMED:9425278]
[PUBMED:11085924]
[PUBMED:9582072]
[PUBMED:12071859]
[PUBMED:19066281]
[PUBMED:14512443]
[PUBMED:18851832]
[PUBMED:12775584]
[PUBMED:15632174]
[PUBMED:8356058]
[PUBMED:1907371]
[PUBMED:11058585]
[PUBMED:9032261]
[PUBMED:18211802]
[PUBMED:12414125]
[PUBMED:17971419]
[PUBMED:19625450]
[PUBMED:15069594]
[PUBMED:12221096]
[PUBMED:17804252]
[PUBMED:8276860]
[PUBMED:19635168]
[PUBMED:8910315]
[PUBMED:18096806]
[PUBMED:12183458]
[PUBMED:15601624]
[PUBMED:9464532]
[PUBMED:11336673]
[PUBMED:16721066]
[PUBMED:12215546]
[PUBMED:15078817]
[PUBMED:12196628]
[PUBMED:11553710]
[PUBMED:7479768]
[PUBMED:8643598]
[PUBMED:10699171]
[PUBMED:9490638]
[PUBMED:8491184]
[PUBMED:8352776]
[PUBMED:20018869]
[PUBMED:12944407]
[PUBMED:11804590]
[PUBMED:8297393]
[PUBMED:11672528]
[PUBMED:15296756]
[PUBMED:17488622]
[PUBMED:9670022]
[PUBMED:8537347]
[PUBMED:19261619]
[PUBMED:16896804]
[PUBMED:11094164]
[PUBMED:15691829]
[PUBMED:19103606]
[PUBMED:9641916]
Regulation of actin cytoskeleton
[NCBI:83089]
[KEGG:hsa04810]
[PUBMED:11152757]
[PUBMED:11082272]
[PUBMED:10574699]
[PUBMED:11082269]
[PUBMED:14657486]
[PUBMED:14744429]
[PUBMED:12700767]
Rho GTPase cycle
[NCBI:1269508]
[REACTOME:R-HSA-194840]
[PUBMED:17222083]
[PUBMED:9308960]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by GPCR
[NCBI:1269543]
[REACTOME:R-HSA-372790]
[PUBMED:16902930]
[PUBMED:10202136]
[PUBMED:18043707]
Signaling by Rho GTPases
[NCBI:1269507]
[REACTOME:R-HSA-194315]
[PUBMED:16212495]
[PUBMED:15630019]
Signalling by NGF
[NCBI:1269443]
[REACTOME:R-HSA-166520]
Thromboxane A2 receptor signaling
[NCBI:138060]
[Pathway Interaction Database:txa2pathway]
[PUBMED:15100160]
[PUBMED:11160627]
[PUBMED:16859489]
[PUBMED:7476920]
[PUBMED:12193606]
[PUBMED:8474027]
[PUBMED:16595906]
[PUBMED:11748077]
[PUBMED:8948507]
[PUBMED:11055976]
[PUBMED:15884057]
[PUBMED:1825698]
[PUBMED:9054415]
[PUBMED:1851174]
[PUBMED:9862451]
[PUBMED:11901221]
[PUBMED:14976202]
[PUBMED:9915793]
[PUBMED:12796499]
[PUBMED:16212421]
[PUBMED:16956790]
[PUBMED:8034687]
[PUBMED:17466390]
[PUBMED:12183468]
[PUBMED:10085139]
[PUBMED:9649216]
[PUBMED:11873244]
[PUBMED:12038794]
[PUBMED:10771086]
[PUBMED:11015313]
[PUBMED:9417126]
[PUBMED:12626493]
[PUBMED:10827090]
[PUBMED:7969066]
[PUBMED:8119906]
[PUBMED:11389977]
[PUBMED:16876780]
[PUBMED:16126723]
[PUBMED:8636072]
[PUBMED:8894620]
[PUBMED:11526402]
[PUBMED:17229546]
[PUBMED:10037795]
[PUBMED:15845539]
[PUBMED:10670835]
[PUBMED:14530262]
[PUBMED:8290554]
[PUBMED:11443056]
[PUBMED:10800962]
[PUBMED:9560198]
[PUBMED:11389883]
[PUBMED:7961988]
[PUBMED:10212262]
[PUBMED:8245033]
[PUBMED:8613548]
[PUBMED:7591017]
[PUBMED:12187125]
[PUBMED:11516166]
[PUBMED:10318854]
Vascular smooth muscle contraction
[NCBI:96530]
[KEGG:hsa04270]
[PUBMED:16870827]
[PUBMED:10911373]
[PUBMED:11679404]
[PUBMED:16339747]
[PUBMED:10221985]
[PUBMED:12689814]
[PUBMED:11165670]
[PUBMED:18552454]
[PUBMED:12060106]
[PUBMED:9458738]
[PUBMED:15725705]
[PUBMED:18040024]
[PUBMED:12693609]
[PUBMED:11773611]
[PUBMED:17158339]
[PUBMED:17458653]
[PUBMED:15026027]
[PUBMED:19120701]
[PUBMED:15269340]
[PUBMED:18703404]
[PUBMED:11709400]
[PUBMED:17200683]
p75 NTR receptor-mediated signalling
[NCBI:1269445]
[REACTOME:R-HSA-193704]
[PUBMED:16699811]
[PUBMED:16939974]
[PUBMED:12671646]
p75NTR regulates axonogenesis
[NCBI:1269456]
[REACTOME:R-HSA-193697]
[PUBMED:17335080]