full name
apolipoprotein E

synonyms
AD2, LDLCQ5, LPG, APOE, ENSG00000130203

HGNC
HGNC:613

Entrez Gene
Gene:348

ENSEMBL
ENSG00000130203

location
chr: 19
start: 45409039
stop: 45412650
strand: +

OMIM
OMIM:107741: APOE
OMIM:104310: Alzheimer disease-2
OMIM:617347: Hyperlipoproteinemia, type III
OMIM:611771: Lipoprotein glomerulopathy
OMIM:269600: Sea-blue histiocyte disease
OMIM:603075: {?Macular degeneration, age-related}
OMIM:617347: {Coronary artery disease, severe, susceptibility to}

transcripts
NM_000041.2

pathways
Alzheimer's disease [NCBI:83097] [KEGG:hsa05010] [PUBMED:18782350] [PUBMED:18035450] [PUBMED:15177383] [PUBMED:10527810] [PUBMED:15363492] [PUBMED:16677790] [PUBMED:15295589] [PUBMED:17055782] [PUBMED:15864339] [PUBMED:15750290] [PUBMED:18675468] [PUBMED:15232608] [PUBMED:9848086] [PUBMED:11484003] [PUBMED:10830966] [PUBMED:16529745] [PUBMED:17568632]
Binding and Uptake of Ligands by Scavenger Receptors [NCBI:1269897] [REACTOME:R-HSA-2173782] [PUBMED:16511968] [PUBMED:15904923] [PUBMED:218198] [PUBMED:19388903] [PUBMED:19659436]
Chylomicron-mediated lipid transport [NCBI:1270006] [REACTOME:R-HSA-174800]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
Generic Transcription Pathway [NCBI:1269650] [REACTOME:R-HSA-212436] [PUBMED:15175151] [PUBMED:14744435] [PUBMED:15680972] [PUBMED:11395415] [PUBMED:15896744] [PUBMED:10235266] [PUBMED:14986688] [PUBMED:12023297] [PUBMED:15680973] [PUBMED:16751179] [PUBMED:11861166] [PUBMED:16429119] [PUBMED:16719718] [PUBMED:16921404] [PUBMED:15690163]
HDL-mediated lipid transport [NCBI:1270007] [REACTOME:R-HSA-194223] [PUBMED:16968945] [PUBMED:14592845] [PUBMED:18460328] [PUBMED:10488948] [PUBMED:15738977]
Lipid digestion, mobilization, and transport [NCBI:1270002] [REACTOME:R-HSA-73923]
Lipoprotein metabolism [NCBI:1270005] [REACTOME:R-HSA-174824]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of fat-soluble vitamins [NCBI:1339147] [REACTOME:R-HSA-6806667] [PUBMED:22516726] [PUBMED:15951480] [PUBMED:16011460]
Metabolism of lipids and lipoproteins [NCBI:1270001] [REACTOME:R-HSA-556833]
Metabolism of vitamins and cofactors [NCBI:1270144] [REACTOME:R-HSA-196854]
Retinoid metabolism and transport [NCBI:1269624] [REACTOME:R-HSA-975634] [PUBMED:16011460] [PUBMED:11340090]
Scavenging by Class A Receptors [NCBI:1269899] [REACTOME:R-HSA-3000480] [PUBMED:19120472] [PUBMED:11820786] [PUBMED:8429029] [PUBMED:2300208] [PUBMED:19388903]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors [NCBI:1427839] [REACTOME:R-HSA-8864260] [PUBMED:2010091] [PUBMED:11744733] [PUBMED:24469049] [PUBMED:23382213] [PUBMED:19798054] [PUBMED:9162057] [PUBMED:21084835] [PUBMED:22735262] [PUBMED:21375726] [PUBMED:14744778] [PUBMED:10648798] [PUBMED:26832794] [PUBMED:24835590] [PUBMED:9687504] [PUBMED:20805990] [PUBMED:10497269] [PUBMED:16420676] [PUBMED:12072434] [PUBMED:9850080] [PUBMED:9182571] [PUBMED:8988173] [PUBMED:1998122] [PUBMED:22371483] [PUBMED:15870067] [PUBMED:12586840] [PUBMED:8895516] [PUBMED:7891714] [PUBMED:11694877] [PUBMED:19115315] [PUBMED:15475956] [PUBMED:25114211]
Vesicle-mediated transport [NCBI:1269876] [REACTOME:R-HSA-5653656]
Visual phototransduction [NCBI:1269623] [REACTOME:R-HSA-2187338] [PUBMED:15384919] [PUBMED:22074928] [PUBMED:20188572] [PUBMED:21111842] [PUBMED:16688755] [PUBMED:8382952] [PUBMED:22658984] [PUBMED:20430952] [PUBMED:21350678] [PUBMED:22074927] [PUBMED:16011460] [PUBMED:11340090]