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Genes
BBC3
Gene - BBC3
full name
BCL2 binding component 3
synonyms
JFY-1, JFY1, PUMA, BBC3, ENSG00000105327
HGNC
HGNC:17868
Entrez Gene
Gene:27113
ENSEMBL
ENSG00000105327
location
chr: 19
start: 47724079
stop: 47736023
strand: -
transcripts
NM_001127242.2
NM_001127241.2
NM_001127240.2
NM_014417.4
pathways
Activation of BH3-only proteins
[NCBI:1270270]
[REACTOME:R-HSA-114452]
[PUBMED:12209154]
[PUBMED:14634621]
Activation of PUMA and translocation to mitochondria
[NCBI:1270273]
[REACTOME:R-HSA-139915]
[PUBMED:14684737]
[PUBMED:11463392]
Apoptosis
[NCBI:83060]
[KEGG:hsa04210]
[NCBI:1270262]
[REACTOME:R-HSA-109581]
[PUBMED:12189384]
[PUBMED:20533903]
[PUBMED:18208375]
[PUBMED:22429822]
[PUBMED:15218528]
[PUBMED:24769728]
[PUBMED:18023214]
[PUBMED:25526085]
[PUBMED:23070002]
[PUBMED:15654015]
[PUBMED:15601572]
[PUBMED:14561771]
[PUBMED:24278747]
[PUBMED:21914490]
[PUBMED:22465226]
[PUBMED:21145844]
[PUBMED:12838338]
[PUBMED:18238895]
[PUBMED:12949498]
[PUBMED:18304445]
[PUBMED:14737178]
[PUBMED:26231733]
[PUBMED:9916983]
[PUBMED:14634621]
[PUBMED:19770840]
[PUBMED:22075987]
[PUBMED:4561027]
[PUBMED:20075940]
[PUBMED:9894605]
[PUBMED:26615431]
[PUBMED:12505355]
[PUBMED:11520933]
[PUBMED:19148180]
[PUBMED:16397578]
[PUBMED:15719025]
[PUBMED:15322527]
[PUBMED:15725726]
[PUBMED:12209154]
[PUBMED:23803157]
Apoptosis - multiple species
[NCBI:1384747]
[KEGG:hsa04215]
[PUBMED:23457257]
[PUBMED:11858838]
[PUBMED:15963254]
[PUBMED:20041301]
[PUBMED:24393571]
[PUBMED:21150934]
[PUBMED:15107838]
[PUBMED:10578171]
[PUBMED:15082313]
[PUBMED:19659442]
[PUBMED:20479784]
[PUBMED:22689371]
[PUBMED:20978240]
[PUBMED:25862972]
[PUBMED:20028968]
[PUBMED:25991373]
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
[NCBI:1270276]
[REACTOME:R-HSA-111453]
Direct p53 effectors
[NCBI:137939]
[Pathway Interaction Database:p53downstreampathway]
[PUBMED:7479001]
[PUBMED:19626115]
[PUBMED:10692390]
[PUBMED:15289308]
[PUBMED:14688482]
[PUBMED:16301995]
[PUBMED:11850816]
[PUBMED:12370809]
[PUBMED:16260627]
[PUBMED:15186775]
[PUBMED:15580302]
[PUBMED:10748162]
[PUBMED:10919640]
[PUBMED:19011621]
[PUBMED:12438652]
[PUBMED:11559530]
[PUBMED:11641774]
[PUBMED:11971958]
[PUBMED:9659898]
[PUBMED:9343394]
[PUBMED:10716435]
[PUBMED:17146433]
[PUBMED:17719542]
[PUBMED:17938176]
[PUBMED:17409421]
[PUBMED:11032029]
[PUBMED:15781865]
[PUBMED:11463392]
[PUBMED:9736732]
[PUBMED:17268548]
[PUBMED:8570655]
[PUBMED:18046411]
[PUBMED:12944906]
[PUBMED:16249378]
[PUBMED:15273740]
[PUBMED:15598651]
[PUBMED:10618379]
[PUBMED:15958553]
[PUBMED:17189187]
[PUBMED:17145718]
[PUBMED:11988847]
[PUBMED:8119988]
[PUBMED:12089322]
[PUBMED:16286009]
[PUBMED:12890671]
[PUBMED:12402042]
[PUBMED:10618714]
[PUBMED:14730312]
[PUBMED:12857899]
[PUBMED:14963330]
[PUBMED:11278953]
[PUBMED:11973653]
[PUBMED:12692263]
[PUBMED:10984493]
[PUBMED:10640990]
[PUBMED:11545734]
[PUBMED:16151013]
[PUBMED:12372430]
[PUBMED:16651407]
[PUBMED:9891062]
[PUBMED:12606722]
[PUBMED:12453409]
[PUBMED:15377670]
[PUBMED:12667443]
[PUBMED:17707234]
[PUBMED:9920903]
[PUBMED:14992722]
[PUBMED:15790310]
[PUBMED:15831478]
[PUBMED:11314010]
[PUBMED:10329733]
[PUBMED:17264218]
[PUBMED:11511362]
[PUBMED:11919562]
[PUBMED:11814693]
[PUBMED:17554199]
[PUBMED:18250150]
[PUBMED:10518217]
[PUBMED:10891498]
[PUBMED:10973264]
[PUBMED:15077116]
[PUBMED:16230375]
[PUBMED:18485870]
[PUBMED:7796420]
[PUBMED:15710382]
[PUBMED:17409411]
[PUBMED:8319905]
[PUBMED:10684646]
[PUBMED:7566179]
[PUBMED:8887630]
[PUBMED:11807984]
[PUBMED:9841917]
[PUBMED:12654245]
[PUBMED:9023107]
[PUBMED:15103385]
[PUBMED:11684014]
[PUBMED:17110336]
[PUBMED:11278253]
[PUBMED:14576823]
[PUBMED:8418500]
[PUBMED:11350971]
[PUBMED:11840333]
[PUBMED:7651818]
[PUBMED:7651386]
[PUBMED:15378026]
[PUBMED:15607964]
[PUBMED:11279192]
[PUBMED:10777218]
[PUBMED:15334053]
[PUBMED:12138177]
[PUBMED:9619826]
[PUBMED:16278683]
[PUBMED:17189186]
[PUBMED:16140933]
[PUBMED:10094469]
[PUBMED:9926927]
[PUBMED:17719541]
[PUBMED:15735003]
[PUBMED:12853982]
[PUBMED:14707288]
[PUBMED:10777207]
Gene Expression
[NCBI:1269649]
[REACTOME:R-HSA-74160]
Generic Transcription Pathway
[NCBI:1269650]
[REACTOME:R-HSA-212436]
[PUBMED:15175151]
[PUBMED:14744435]
[PUBMED:15680972]
[PUBMED:11395415]
[PUBMED:15896744]
[PUBMED:10235266]
[PUBMED:14986688]
[PUBMED:12023297]
[PUBMED:15680973]
[PUBMED:16751179]
[PUBMED:11861166]
[PUBMED:16429119]
[PUBMED:16719718]
[PUBMED:16921404]
[PUBMED:15690163]
Hippo signaling pathway
[NCBI:749777]
[KEGG:hsa04390]
[PUBMED:18955139]
[PUBMED:20439427]
[PUBMED:20951342]
[PUBMED:21138973]
[PUBMED:18328423]
[PUBMED:21324984]
[PUBMED:23034192]
[PUBMED:21808241]
[PUBMED:17975546]
[PUBMED:22750148]
[PUBMED:21084559]
[PUBMED:19846288]
[PUBMED:22895435]
[PUBMED:22683405]
[PUBMED:22658639]
[PUBMED:22153608]
[PUBMED:20945341]
[PUBMED:22830020]
[PUBMED:21874053]
[PUBMED:21376238]
Huntington's disease
[NCBI:83100]
[KEGG:hsa05016]
[PUBMED:15336977]
[PUBMED:11738471]
[PUBMED:11807533]
[PUBMED:15996546]
[PUBMED:14526190]
[PUBMED:15242639]
[PUBMED:17041811]
[PUBMED:15996541]
[PUBMED:18951640]
[PUBMED:15459747]
[PUBMED:16288298]
[PUBMED:17081970]
[PUBMED:15695335]
[PUBMED:12372277]
[PUBMED:11839795]
Intrinsic Pathway for Apoptosis
[NCBI:1270268]
[REACTOME:R-HSA-109606]
[PUBMED:12042762]
[PUBMED:11711427]
[PUBMED:15077149]
Measles
[NCBI:213306]
[KEGG:hsa05162]
[PUBMED:16237742]
[PUBMED:12804771]
[PUBMED:19198562]
[PUBMED:20376484]
[PUBMED:11385511]
[PUBMED:16963735]
[PUBMED:19198566]
[PUBMED:18922877]
[PUBMED:19203114]
[PUBMED:12620806]
[PUBMED:16690907]
[PUBMED:17720800]
[PUBMED:20636817]
[PUBMED:12410527]
[PUBMED:11582511]
[PUBMED:19203109]
[PUBMED:19203113]
[PUBMED:14585342]
[PUBMED:12805463]
Platinum drug resistance
[NCBI:1404797]
[KEGG:hsa01524]
[PUBMED:24074238]
[PUBMED:26867799]
[PUBMED:14609433]
[PUBMED:26184483]
[PUBMED:24874729]
[PUBMED:15607932]
[PUBMED:25546083]
[PUBMED:25058905]
[PUBMED:19190080]
[PUBMED:14576837]
[PUBMED:20811617]
[PUBMED:21892204]
[PUBMED:20647037]
[PUBMED:17336087]
[PUBMED:26886018]
[PUBMED:23442359]
[PUBMED:17625587]
Programmed Cell Death
[NCBI:1270261]
[REACTOME:R-HSA-5357801]
[PUBMED:25236395]
TP53 Regulates Transcription of Cell Death Genes
[NCBI:1383066]
[REACTOME:R-HSA-5633008]
[PUBMED:20353938]
[PUBMED:18676979]
[PUBMED:11511362]
[PUBMED:11919562]
[PUBMED:10973264]
[PUBMED:15797384]
[PUBMED:17442733]
[PUBMED:15607964]
[PUBMED:11278253]
[PUBMED:23059823]
[PUBMED:19549844]
[PUBMED:11684014]
[PUBMED:7566179]
[PUBMED:17349958]
[PUBMED:24739573]
[PUBMED:18719709]
[PUBMED:17284521]
[PUBMED:23703390]
[PUBMED:10807576]
[PUBMED:10733530]
[PUBMED:12402042]
[PUBMED:12851404]
[PUBMED:14729977]
[PUBMED:18431400]
[PUBMED:15377670]
[PUBMED:12089322]
[PUBMED:15273740]
[PUBMED:11382926]
[PUBMED:12606722]
[PUBMED:14623878]
[PUBMED:15577913]
[PUBMED:16230375]
[PUBMED:26122615]
[PUBMED:11559530]
[PUBMED:11054413]
[PUBMED:22766503]
[PUBMED:11463392]
[PUBMED:16249378]
[PUBMED:9326928]
[PUBMED:14614825]
[PUBMED:19615968]
[PUBMED:16140933]
[PUBMED:7834749]
[PUBMED:16135520]
[PUBMED:15126337]
[PUBMED:15580302]
[PUBMED:15289308]
[PUBMED:10777207]
[PUBMED:23365256]
[PUBMED:19040420]
[PUBMED:15735003]
[PUBMED:14688482]
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
[NCBI:1383068]
[REACTOME:R-HSA-6803204]
[PUBMED:12606722]
[PUBMED:18676979]
[PUBMED:11511362]
[PUBMED:11463392]
[PUBMED:10807576]
[PUBMED:12851404]
[PUBMED:12402042]
[PUBMED:15273740]
[PUBMED:14729977]
[PUBMED:15735003]
[PUBMED:15126337]
[PUBMED:23365256]
[PUBMED:22766503]
[PUBMED:11684014]
[PUBMED:15607964]
[PUBMED:7834749]
Transcriptional Regulation by TP53
[NCBI:1269654]
[REACTOME:R-HSA-3700989]
[PUBMED:26122615]
[PUBMED:19410540]
p53 signaling pathway
[NCBI:83055]
[KEGG:hsa04115]
[PUBMED:16557269]
[PUBMED:10714958]
[PUBMED:12505356]
[PUBMED:16915296]
[PUBMED:16697662]
[PUBMED:15116721]
[PUBMED:11313928]
[PUBMED:11747320]
[PUBMED:17409411]
[PUBMED:15838523]