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Genes
LIG1
Gene - LIG1
full name
DNA ligase 1
synonyms
LIG1, ENSG00000105486
HGNC
HGNC:6598
Entrez Gene
Gene:3978
ENSEMBL
ENSG00000105486
location
chr: 19
start: 48618702
stop: 48673852
strand: -
transcripts
ENST00000263274.7
pathways
Base Excision Repair
[NCBI:1270351]
[REACTOME:R-HSA-73884]
[PUBMED:11937636]
[PUBMED:10583946]
Base excision repair
[NCBI:83043]
[KEGG:hsa03410]
[PUBMED:17893748]
[PUBMED:11436317]
[PUBMED:17337257]
[PUBMED:21665970]
Cell Cycle
[NCBI:1269741]
[REACTOME:R-HSA-1640170]
Cell Cycle, Mitotic
[NCBI:1269763]
[REACTOME:R-HSA-69278]
Chromosome Maintenance
[NCBI:1269853]
[REACTOME:R-HSA-73886]
DNA Repair
[NCBI:1270350]
[REACTOME:R-HSA-73894]
[PUBMED:10583946]
[PUBMED:23175119]
DNA Replication
[NCBI:1269875]
[REACTOME:R-HSA-69306]
[PUBMED:11257218]
[PUBMED:12045100]
[PUBMED:1536007]
[PUBMED:10966477]
[PUBMED:1579437]
[PUBMED:8223461]
DNA replication
[NCBI:83039]
[KEGG:hsa03030]
[PUBMED:9759502]
[PUBMED:8087839]
DNA strand elongation
[NCBI:1269784]
[REACTOME:R-HSA-69190]
[PUBMED:9081985]
[PUBMED:1976634]
[PUBMED:7623835]
[PUBMED:1536007]
[PUBMED:8594377]
Disease
[NCBI:1268854]
[REACTOME:R-HSA-1643685]
Early Phase of HIV Life Cycle
[NCBI:1269059]
[REACTOME:R-HSA-162594]
[PUBMED:12091904]
Extension of Telomeres
[NCBI:1269857]
[REACTOME:R-HSA-180786]
[PUBMED:15189140]
Gap-filling DNA repair synthesis and ligation in GG-NER
[NCBI:1309116]
[REACTOME:R-HSA-5696397]
[PUBMED:17643379]
[PUBMED:19279666]
[PUBMED:20227374]
Gap-filling DNA repair synthesis and ligation in TC-NER
[NCBI:1309120]
[REACTOME:R-HSA-6782210]
[PUBMED:20227374]
[PUBMED:19279666]
[PUBMED:17643379]
Global Genome Nucleotide Excision Repair (GG-NER)
[NCBI:1309112]
[REACTOME:R-HSA-5696399]
[PUBMED:24954209]
HIV Infection
[NCBI:1269057]
[REACTOME:R-HSA-162906]
[PUBMED:16354571]
[PUBMED:9759480]
HIV Life Cycle
[NCBI:1269058]
[REACTOME:R-HSA-162587]
[PUBMED:9188609]
[PUBMED:9759480]
Infectious disease
[NCBI:1269056]
[REACTOME:R-HSA-5663205]
Lagging Strand Synthesis
[NCBI:1269788]
[REACTOME:R-HSA-69186]
[PUBMED:9081985]
Mismatch Repair
[NCBI:1270411]
[REACTOME:R-HSA-5358508]
[PUBMED:19138690]
[PUBMED:23545421]
[PUBMED:16464007]
[PUBMED:20725617]
[PUBMED:10072354]
[PUBMED:18157157]
[PUBMED:23572416]
Mismatch repair
[NCBI:83045]
[KEGG:hsa03430]
[PUBMED:11436301]
[PUBMED:18157157]
[PUBMED:16612326]
[PUBMED:11920679]
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
[NCBI:1270413]
[REACTOME:R-HSA-5358606]
[PUBMED:9677427]
[PUBMED:11920679]
[PUBMED:9294177]
[PUBMED:9671718]
[PUBMED:8805365]
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
[NCBI:1270412]
[REACTOME:R-HSA-5358565]
[PUBMED:9294177]
[PUBMED:23391514]
[PUBMED:9671718]
Nucleotide Excision Repair
[NCBI:1309111]
[REACTOME:R-HSA-5696398]
[PUBMED:11900249]
[PUBMED:23906714]
[PUBMED:14599765]
[PUBMED:10583946]
[PUBMED:24954209]
[PUBMED:19023283]
Nucleotide excision repair
[NCBI:83044]
[KEGG:hsa03420]
[PUBMED:11436323]
[PUBMED:18018633]
[PUBMED:11436316]
[PUBMED:17884153]
[PUBMED:11436314]
[PUBMED:17276014]
[PUBMED:16922398]
PCNA-Dependent Long Patch Base Excision Repair
[NCBI:1270366]
[REACTOME:R-HSA-5651801]
[PUBMED:9780000]
[PUBMED:11601988]
[PUBMED:9214649]
[PUBMED:12200445]
[PUBMED:10460157]
[PUBMED:10559261]
[PUBMED:11250913]
POLB-Dependent Long Patch Base Excision Repair
[NCBI:1270365]
[REACTOME:R-HSA-110362]
[PUBMED:15561706]
[PUBMED:11440997]
[PUBMED:15135726]
[PUBMED:9214649]
[PUBMED:11554294]
[PUBMED:12200445]
[PUBMED:11340072]
[PUBMED:9685411]
Processive synthesis on the C-strand of the telomere
[NCBI:1269862]
[REACTOME:R-HSA-174414]
[PUBMED:1671046]
Processive synthesis on the lagging strand
[NCBI:1269789]
[REACTOME:R-HSA-69183]
[PUBMED:1671046]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
[NCBI:1270364]
[REACTOME:R-HSA-110373]
[PUBMED:10583946]
[PUBMED:9214649]
[PUBMED:10559261]
[PUBMED:10460157]
[PUBMED:11440997]
[PUBMED:11601988]
Resolution of Abasic Sites (AP sites)
[NCBI:1270359]
[REACTOME:R-HSA-73933]
[PUBMED:11601988]
[PUBMED:15260972]
[PUBMED:17395641]
[PUBMED:19329425]
[PUBMED:9804798]
[PUBMED:15556996]
[PUBMED:9214649]
[PUBMED:7608159]
[PUBMED:11440997]
[PUBMED:15871698]
[PUBMED:9207062]
[PUBMED:16982218]
[PUBMED:8978692]
S Phase
[NCBI:1269777]
[REACTOME:R-HSA-69242]
Synthesis of DNA
[NCBI:1269779]
[REACTOME:R-HSA-69239]
Telomere C-strand (Lagging Strand) Synthesis
[NCBI:1269859]
[REACTOME:R-HSA-174417]
[PUBMED:15189140]
Telomere Maintenance
[NCBI:1269856]
[REACTOME:R-HSA-157579]
[PUBMED:16166375]
[PUBMED:4507727]
[PUBMED:14685173]
[PUBMED:642006]
[PUBMED:15189140]
[PUBMED:3907856]
[PUBMED:2463488]
[PUBMED:4754905]
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
[NCBI:1309117]
[REACTOME:R-HSA-6781827]
[PUBMED:24954209]
[PUBMED:11823795]
[PUBMED:19023283]
[PUBMED:23906714]
[PUBMED:3466163]