Logo
full name
adaptor related protein complex 2 alpha 1 subunit

synonyms
ADTAA, AP2-ALPHA, CLAPA1, AP2A1, ENSG00000196961

HGNC
HGNC:561

Entrez Gene
Gene:160

ENSEMBL
ENSG00000196961

location
chr: 19
start: 50270180
stop: 50310369
strand: +

transcripts
NM_014203.2
NM_130787.2

pathways
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
Arf1 pathway [NCBI:137927] [Pathway Interaction Database:arf_3pathway] [PUBMED:11346801] [PUBMED:9694811] [PUBMED:9819391] [PUBMED:12376537] [PUBMED:8498538] [PUBMED:9405360] [PUBMED:11301005] [PUBMED:15793564] [PUBMED:11970962] [PUBMED:8530346] [PUBMED:10747089] [PUBMED:10212200] [PUBMED:9388229] [PUBMED:7961749] [PUBMED:10652308] [PUBMED:15781476] [PUBMED:11342560] [PUBMED:16100119] [PUBMED:9826657] [PUBMED:15202998] [PUBMED:10848997] [PUBMED:8144664] [PUBMED:9268368]
Axon guidance [NCBI:83065] [KEGG:hsa04360] [NCBI:1270303] [REACTOME:R-HSA-422475] [PUBMED:14682358] [PUBMED:15084255] [PUBMED:11687826] [PUBMED:15818466] [PUBMED:15363605] [PUBMED:12471249] [PUBMED:15630019] [PUBMED:11891122] [PUBMED:15960985] [PUBMED:12677003]
Beta-catenin independent WNT signaling [NCBI:1269610] [REACTOME:R-HSA-3858494] [PUBMED:22935904] [PUBMED:21903638] [PUBMED:23256519] [PUBMED:8065359] [PUBMED:7739543] [PUBMED:23140633]
Cargo recognition for clathrin-mediated endocytosis [NCBI:1427859] [REACTOME:R-HSA-8856825] [PUBMED:24186068] [PUBMED:12952941] [PUBMED:19696796] [PUBMED:14985334] [PUBMED:20448150] [PUBMED:20485680] [PUBMED:16382132] [PUBMED:23482940] [PUBMED:16870701]
Clathrin-mediated endocytosis [NCBI:1427858] [REACTOME:R-HSA-8856828] [PUBMED:16516836] [PUBMED:15339664] [PUBMED:19754444] [PUBMED:8552632] [PUBMED:21779028] [PUBMED:12353027] [PUBMED:23891661] [PUBMED:21613550] [PUBMED:20059951] [PUBMED:21447041] [PUBMED:17620409] [PUBMED:16903783] [PUBMED:21445324] [PUBMED:19696798] [PUBMED:26246598] [PUBMED:25085911] [PUBMED:24186068] [PUBMED:26829388] [PUBMED:27092250] [PUBMED:24581490] [PUBMED:26042225] [PUBMED:23823722] [PUBMED:24789820] [PUBMED:9736607] [PUBMED:23637288] [PUBMED:22233676] [PUBMED:19458185] [PUBMED:26403691] [PUBMED:19296720] [PUBMED:15703209] [PUBMED:20428113] [PUBMED:8953040] [PUBMED:1177317] [PUBMED:9092476] [PUBMED:26872272] [PUBMED:19092055]
Developmental Biology [NCBI:1270302] [REACTOME:R-HSA-1266738]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
EPH-Ephrin signaling [NCBI:1270330] [REACTOME:R-HSA-2682334] [PUBMED:18281458] [PUBMED:22120527]
EPH-ephrin mediated repulsion of cells [NCBI:1270334] [REACTOME:R-HSA-3928665] [PUBMED:10958785] [PUBMED:16239146] [PUBMED:12973357] [PUBMED:18713744] [PUBMED:17420126]
Endocrine and other factor-regulated calcium reabsorption [NCBI:213307] [KEGG:hsa04961] [PUBMED:15747113] [PUBMED:20969972] [PUBMED:15618484] [PUBMED:18989697] [PUBMED:19423690] [PUBMED:18293139] [PUBMED:18596722] [PUBMED:16518325] [PUBMED:17006539] [PUBMED:12684797] [PUBMED:17233615] [PUBMED:16044309]
Endocytosis [NCBI:102279] [KEGG:hsa04144] [PUBMED:19696797] [PUBMED:19007773] [PUBMED:16203612] [PUBMED:15687999] [PUBMED:19924646] [PUBMED:15261671] [PUBMED:18647649] [PUBMED:19325624] [PUBMED:20110990] [PUBMED:22193161]
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity [NCBI:1268794] [REACTOME:R-HSA-399721] [PUBMED:16904750] [PUBMED:16713244] [PUBMED:19217372]
HIV Infection [NCBI:1269057] [REACTOME:R-HSA-162906] [PUBMED:16354571] [PUBMED:9759480]
Host Interactions of HIV factors [NCBI:1269091] [REACTOME:R-HSA-162909]
Huntington's disease [NCBI:83100] [KEGG:hsa05016] [PUBMED:15336977] [PUBMED:11738471] [PUBMED:11807533] [PUBMED:15996546] [PUBMED:14526190] [PUBMED:15242639] [PUBMED:17041811] [PUBMED:15996541] [PUBMED:18951640] [PUBMED:15459747] [PUBMED:16288298] [PUBMED:17081970] [PUBMED:15695335] [PUBMED:12372277] [PUBMED:11839795]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Infectious disease [NCBI:1269056] [REACTOME:R-HSA-5663205]
L1CAM interactions [NCBI:1270323] [REACTOME:R-HSA-373760] [PUBMED:9211984] [PUBMED:18760361] [PUBMED:14709786] [PUBMED:17189949] [PUBMED:19356150]
LDL-mediated lipid transport [NCBI:1270008] [REACTOME:R-HSA-171052] [PUBMED:2088165] [PUBMED:15952897]
Lipid digestion, mobilization, and transport [NCBI:1270002] [REACTOME:R-HSA-73923]
Lipoprotein metabolism [NCBI:1270005] [REACTOME:R-HSA-174824]
MHC class II antigen presentation [NCBI:1269200] [REACTOME:R-HSA-2132295] [PUBMED:19703008] [PUBMED:9316394] [PUBMED:11684289] [PUBMED:19217269] [PUBMED:8689559]
Membrane Trafficking [NCBI:1269877] [REACTOME:R-HSA-199991] [PUBMED:11031247]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins [NCBI:1270001] [REACTOME:R-HSA-556833]
NGF signalling via TRKA from the plasma membrane [NCBI:1269460] [REACTOME:R-HSA-187037] [PUBMED:11520933] [PUBMED:12676795] [PUBMED:10851172] [PUBMED:10579918]
Nef Mediated CD4 Down-regulation [NCBI:1269105] [REACTOME:R-HSA-167590] [PUBMED:11264384] [PUBMED:2014052] [PUBMED:8124721] [PUBMED:7831289] [PUBMED:8756680]
Nef Mediated CD8 Down-regulation [NCBI:1269106] [REACTOME:R-HSA-182218] [PUBMED:16103193]
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters [NCBI:1269102] [REACTOME:R-HSA-164938] [PUBMED:9811606] [PUBMED:11208076] [PUBMED:9564030] [PUBMED:9586638] [PUBMED:12486136] [PUBMED:9811611] [PUBMED:9384576] [PUBMED:9736718]
Neuronal System [NCBI:1268763] [REACTOME:R-HSA-112316]
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell [NCBI:1268786] [REACTOME:R-HSA-112314]
PCP/CE pathway [NCBI:1269611] [REACTOME:R-HSA-4086400] [PUBMED:23140633] [PUBMED:18848778] [PUBMED:10811221] [PUBMED:19365405] [PUBMED:9598355] [PUBMED:21983142] [PUBMED:17433286] [PUBMED:20004982] [PUBMED:19204114]
Recycling pathway of L1 [NCBI:1270324] [REACTOME:R-HSA-437239] [PUBMED:10804209] [PUBMED:11717353] [PUBMED:14709786]
Retrograde neurotrophin signalling [NCBI:1269476] [REACTOME:R-HSA-177504]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by Wnt [NCBI:1269594] [REACTOME:R-HSA-195721] [PUBMED:19530173] [PUBMED:23256519] [PUBMED:22952392] [PUBMED:19204114] [PUBMED:19365405] [PUBMED:19619488] [PUBMED:17143292] [PUBMED:17230199] [PUBMED:18710302] [PUBMED:16099039] [PUBMED:20576942] [PUBMED:10858654] [PUBMED:12967557]
Signalling by NGF [NCBI:1269443] [REACTOME:R-HSA-166520]
Synaptic vesicle cycle [NCBI:373900] [KEGG:hsa04721] [PUBMED:20634814] [PUBMED:17767192] [PUBMED:12094216] [PUBMED:16990140] [PUBMED:18726177] [PUBMED:18275379] [PUBMED:12827282] [PUBMED:12154365] [PUBMED:10212473] [PUBMED:15217342] [PUBMED:7791897] [PUBMED:12563290]
The role of Nef in HIV-1 replication and disease pathogenesis [NCBI:1269100] [REACTOME:R-HSA-164952] [PUBMED:16354571]
Trafficking of AMPA receptors [NCBI:1268795] [REACTOME:R-HSA-399719] [PUBMED:19217372]
Trafficking of GluR2-containing AMPA receptors [NCBI:1268796] [REACTOME:R-HSA-416993] [PUBMED:18547676]
Transmission across Chemical Synapses [NCBI:1268766] [REACTOME:R-HSA-112315]
VLDL interactions [NCBI:1427851] [REACTOME:R-HSA-8855121] [PUBMED:22461740] [PUBMED:12870663] [PUBMED:25544176] [PUBMED:20525064] [PUBMED:14748713] [PUBMED:22510808]
VLDLR internalisation and degradation [NCBI:1427853] [REACTOME:R-HSA-8866427] [PUBMED:18039658]
Vesicle-mediated transport [NCBI:1269876] [REACTOME:R-HSA-5653656]
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 [NCBI:1269614] [REACTOME:R-HSA-5140745] [PUBMED:17117926] [PUBMED:22101459] [PUBMED:19910923] [PUBMED:19582886]
WNT5A-dependent internalization of FZD4 [NCBI:1269613] [REACTOME:R-HSA-5099900] [PUBMED:12958364] [PUBMED:20947020] [PUBMED:17199046]