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Genes
MCM8
Gene - MCM8
full name
minichromosome maintenance 8 homologous recombination repair factor
synonyms
C20orf154, dJ967N21.5, MCM8, ENSG00000125885
HGNC
HGNC:16147
Entrez Gene
Gene:84515
ENSEMBL
ENSG00000125885
location
chr: 20
start: 5931298
stop: 5975852
strand: +
OMIM
OMIM:608187
: MCM8
OMIM:612885
: ?Premature ovarian failure 10
transcripts
NM_001281520.1
NM_182802.2
NM_032485.5
NM_001281522.1
NM_001281521.1
pathways
Activation of ATR in response to replication stress
[NCBI:1269757]
[REACTOME:R-HSA-176187]
[PUBMED:12791985]
Activation of the pre-replicative complex
[NCBI:1269773]
[REACTOME:R-HSA-68962]
[PUBMED:10402192]
[PUBMED:11779870]
[PUBMED:10801458]
[PUBMED:12169736]
[PUBMED:11323433]
[PUBMED:9038340]
[PUBMED:9765232]
[PUBMED:9829972]
[PUBMED:10970868]
[PUBMED:9353276]
[PUBMED:7502077]
[PUBMED:11459976]
[PUBMED:11395502]
Assembly of the pre-replicative complex
[NCBI:1269833]
[REACTOME:R-HSA-68867]
[PUBMED:11801723]
[PUBMED:9829972]
[PUBMED:9288745]
[PUBMED:9407030]
[PUBMED:9927482]
[PUBMED:9335335]
[PUBMED:11046155]
CDC6 association with the ORC:origin complex
[NCBI:1269835]
[REACTOME:R-HSA-68689]
[PUBMED:11532947]
[PUBMED:11046155]
[PUBMED:9566895]
[PUBMED:9312054]
[PUBMED:10712901]
[PUBMED:9520412]
[PUBMED:9889196]
[PUBMED:10339564]
[PUBMED:10995389]
[PUBMED:7641697]
[PUBMED:10801458]
CDT1 association with the CDC6:ORC:origin complex
[NCBI:1269836]
[REACTOME:R-HSA-68827]
[PUBMED:11125146]
[PUBMED:11836525]
[PUBMED:10766247]
[PUBMED:11175741]
[PUBMED:10898791]
[PUBMED:10766248]
[PUBMED:9442876]
[PUBMED:9635433]
Cell Cycle
[NCBI:1269741]
[REACTOME:R-HSA-1640170]
Cell Cycle Checkpoints
[NCBI:1269742]
[REACTOME:R-HSA-69620]
Cell Cycle, Mitotic
[NCBI:1269763]
[REACTOME:R-HSA-69278]
DNA Replication
[NCBI:1269875]
[REACTOME:R-HSA-69306]
[PUBMED:11257218]
[PUBMED:12045100]
[PUBMED:1536007]
[PUBMED:10966477]
[PUBMED:1579437]
[PUBMED:8223461]
DNA Replication Pre-Initiation
[NCBI:1269832]
[REACTOME:R-HSA-69002]
DNA strand elongation
[NCBI:1269784]
[REACTOME:R-HSA-69190]
[PUBMED:9081985]
[PUBMED:1976634]
[PUBMED:7623835]
[PUBMED:1536007]
[PUBMED:8594377]
E2F mediated regulation of DNA replication
[NCBI:1269774]
[REACTOME:R-HSA-113510]
[PUBMED:12393009]
[PUBMED:12726857]
[PUBMED:12473340]
E2F-enabled inhibition of pre-replication complex formation
[NCBI:1269776]
[REACTOME:R-HSA-113507]
[PUBMED:11090133]
G1/S Transition
[NCBI:1269768]
[REACTOME:R-HSA-69206]
G2/M Checkpoints
[NCBI:1269753]
[REACTOME:R-HSA-69481]
M/G1 Transition
[NCBI:1269831]
[REACTOME:R-HSA-68874]
Mitotic G1-G1/S phases
[NCBI:1269764]
[REACTOME:R-HSA-453279]
Orc1 removal from chromatin
[NCBI:1269782]
[REACTOME:R-HSA-68949]
[PUBMED:11931757]
[PUBMED:11739726]
[PUBMED:11809796]
[PUBMED:1110244]
Regulation of DNA replication
[NCBI:1269794]
[REACTOME:R-HSA-69304]
Removal of licensing factors from origins
[NCBI:1269796]
[REACTOME:R-HSA-69300]
S Phase
[NCBI:1269777]
[REACTOME:R-HSA-69242]
Switching of origins to a post-replicative state
[NCBI:1269781]
[REACTOME:R-HSA-69052]
Synthesis of DNA
[NCBI:1269779]
[REACTOME:R-HSA-69239]
Unwinding of DNA
[NCBI:1269785]
[REACTOME:R-HSA-176974]
[PUBMED:10834843]
[PUBMED:15707891]