Logo
full name
minichromosome maintenance 8 homologous recombination repair factor

synonyms
C20orf154, dJ967N21.5, MCM8, ENSG00000125885

HGNC
HGNC:16147

Entrez Gene
Gene:84515

ENSEMBL
ENSG00000125885

location
chr: 20
start: 5931298
stop: 5975852
strand: +

OMIM
OMIM:608187: MCM8
OMIM:612885: ?Premature ovarian failure 10

transcripts
NM_001281520.1
NM_182802.2
NM_032485.5
NM_001281522.1
NM_001281521.1

pathways
Activation of ATR in response to replication stress [NCBI:1269757] [REACTOME:R-HSA-176187] [PUBMED:12791985]
Activation of the pre-replicative complex [NCBI:1269773] [REACTOME:R-HSA-68962] [PUBMED:10402192] [PUBMED:11779870] [PUBMED:10801458] [PUBMED:12169736] [PUBMED:11323433] [PUBMED:9038340] [PUBMED:9765232] [PUBMED:9829972] [PUBMED:10970868] [PUBMED:9353276] [PUBMED:7502077] [PUBMED:11459976] [PUBMED:11395502]
Assembly of the pre-replicative complex [NCBI:1269833] [REACTOME:R-HSA-68867] [PUBMED:11801723] [PUBMED:9829972] [PUBMED:9288745] [PUBMED:9407030] [PUBMED:9927482] [PUBMED:9335335] [PUBMED:11046155]
CDC6 association with the ORC:origin complex [NCBI:1269835] [REACTOME:R-HSA-68689] [PUBMED:11532947] [PUBMED:11046155] [PUBMED:9566895] [PUBMED:9312054] [PUBMED:10712901] [PUBMED:9520412] [PUBMED:9889196] [PUBMED:10339564] [PUBMED:10995389] [PUBMED:7641697] [PUBMED:10801458]
CDT1 association with the CDC6:ORC:origin complex [NCBI:1269836] [REACTOME:R-HSA-68827] [PUBMED:11125146] [PUBMED:11836525] [PUBMED:10766247] [PUBMED:11175741] [PUBMED:10898791] [PUBMED:10766248] [PUBMED:9442876] [PUBMED:9635433]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle Checkpoints [NCBI:1269742] [REACTOME:R-HSA-69620]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
DNA Replication [NCBI:1269875] [REACTOME:R-HSA-69306] [PUBMED:11257218] [PUBMED:12045100] [PUBMED:1536007] [PUBMED:10966477] [PUBMED:1579437] [PUBMED:8223461]
DNA Replication Pre-Initiation [NCBI:1269832] [REACTOME:R-HSA-69002]
DNA strand elongation [NCBI:1269784] [REACTOME:R-HSA-69190] [PUBMED:9081985] [PUBMED:1976634] [PUBMED:7623835] [PUBMED:1536007] [PUBMED:8594377]
E2F mediated regulation of DNA replication [NCBI:1269774] [REACTOME:R-HSA-113510] [PUBMED:12393009] [PUBMED:12726857] [PUBMED:12473340]
E2F-enabled inhibition of pre-replication complex formation [NCBI:1269776] [REACTOME:R-HSA-113507] [PUBMED:11090133]
G1/S Transition [NCBI:1269768] [REACTOME:R-HSA-69206]
G2/M Checkpoints [NCBI:1269753] [REACTOME:R-HSA-69481]
M/G1 Transition [NCBI:1269831] [REACTOME:R-HSA-68874]
Mitotic G1-G1/S phases [NCBI:1269764] [REACTOME:R-HSA-453279]
Orc1 removal from chromatin [NCBI:1269782] [REACTOME:R-HSA-68949] [PUBMED:11931757] [PUBMED:11739726] [PUBMED:11809796] [PUBMED:1110244]
Regulation of DNA replication [NCBI:1269794] [REACTOME:R-HSA-69304]
Removal of licensing factors from origins [NCBI:1269796] [REACTOME:R-HSA-69300]
S Phase [NCBI:1269777] [REACTOME:R-HSA-69242]
Switching of origins to a post-replicative state [NCBI:1269781] [REACTOME:R-HSA-69052]
Synthesis of DNA [NCBI:1269779] [REACTOME:R-HSA-69239]
Unwinding of DNA [NCBI:1269785] [REACTOME:R-HSA-176974] [PUBMED:10834843] [PUBMED:15707891]