full name
DNA methyltransferase 3 beta

synonyms
ICF, ICF1, M.HsaIIIB, DNMT3B, ENSG00000088305

HGNC
HGNC:2979

Entrez Gene
Gene:1789

ENSEMBL
ENSG00000088305

location
chr: 20
start: 31350191
stop: 31397162
strand: +

OMIM
OMIM:602900: DNMT3B (Autosomal recessive inheritance)
OMIM:242860: Immunodeficiency-centromeric instability-facial anomalies syndrome 1

transcripts
NM_006892.3
NM_175848.1
NM_175849.1
NM_001207055.1
NM_001207056.1
NM_175850.2

pathways
Cysteine and methionine metabolism [NCBI:104488] [KEGG:hsa00270] [PUBMED:18391471] [PUBMED:14551435] [PUBMED:15102328] [PUBMED:12644499] [PUBMED:12670965] [PUBMED:18625006] [PUBMED:19270684] [PUBMED:17169919] [PUBMED:17030798] [PUBMED:10613873] [PUBMED:18520135] [PUBMED:12022921]
DNA methylation [NCBI:1269740] [REACTOME:R-HSA-5334118] [PUBMED:24560929] [PUBMED:21243710] [PUBMED:23587238] [PUBMED:23938249] [PUBMED:22781841] [PUBMED:24214338] [PUBMED:16403636] [PUBMED:24589714] [PUBMED:23687512] [PUBMED:23166392] [PUBMED:19657014] [PUBMED:7079182] [PUBMED:24059801]
Epigenetic regulation of gene expression [NCBI:1269734] [REACTOME:R-HSA-212165] [PUBMED:12610534]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Methionine degradation [NCBI:413353] [KEGG:hsa_M00035]
MicroRNAs in cancer [NCBI:852705] [KEGG:hsa05206] [PUBMED:23075324] [PUBMED:21742789] [PUBMED:22351564] [PUBMED:18817506] [PUBMED:22345301] [PUBMED:21402473] [PUBMED:22926415] [PUBMED:23165235] [PUBMED:19630570] [PUBMED:21565290] [PUBMED:23091478] [PUBMED:23462054] [PUBMED:23316212] [PUBMED:19773200] [PUBMED:22035854] [PUBMED:20221895] [PUBMED:20345848] [PUBMED:22580099] [PUBMED:20128019]
Negative epigenetic regulation of rRNA expression [NCBI:1269737] [REACTOME:R-HSA-5250941] [PUBMED:23063748] [PUBMED:23150253] [PUBMED:18616426]
NoRC negatively regulates rRNA expression [NCBI:1269739] [REACTOME:R-HSA-427413] [PUBMED:17439825] [PUBMED:17613545] [PUBMED:23063748] [PUBMED:11583633] [PUBMED:18631128] [PUBMED:18616426]
PRC2 methylates histones and DNA [NCBI:1269735] [REACTOME:R-HSA-212300] [PUBMED:23473600] [PUBMED:18974828] [PUBMED:24096405] [PUBMED:21248841] [PUBMED:19738629] [PUBMED:21941108]