full name
itchy E3 ubiquitin protein ligase

synonyms
AIF4, AIP4, dJ468O1.1, NAPP1, ITCH, ENSG00000078747

HGNC
HGNC:13890

Entrez Gene
Gene:83737

ENSEMBL
ENSG00000078747

location
chr: 20
start: 32951041
stop: 33099198
strand: +

OMIM
OMIM:606409: ITCH (Autosomal recessive inheritance)
OMIM:613385: Autoimmune disease, multisystem, with facial dysmorphism

transcripts
NM_001257137.1
NM_031483.5
NM_001257138.1

pathways
Activated NOTCH1 Transmits Signal to the Nucleus [NCBI:1269536] [REACTOME:R-HSA-2122948] [PUBMED:15574878] [PUBMED:19726682] [PUBMED:18628966] [PUBMED:9620803] [PUBMED:12530964] [PUBMED:15652348] [PUBMED:18237417] [PUBMED:10882063] [PUBMED:11006133] [PUBMED:18077452] [PUBMED:9462510] [PUBMED:14567914] [PUBMED:17003037] [PUBMED:19524514] [PUBMED:17028573] [PUBMED:10206645] [PUBMED:20418862] [PUBMED:15965470] [PUBMED:16284625] [PUBMED:11226752] [PUBMED:19567869] [PUBMED:12354787] [PUBMED:11740940] [PUBMED:9590294] [PUBMED:15824097] [PUBMED:9244301] [PUBMED:18043734] [PUBMED:9315665] [PUBMED:10879540] [PUBMED:9819428] [PUBMED:8313469] [PUBMED:18296446]
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
Antigen processing: Ubiquitination & Proteasome degradation [NCBI:1269193] [REACTOME:R-HSA-983168] [PUBMED:12648452] [PUBMED:11917093] [PUBMED:19489725] [PUBMED:14734113] [PUBMED:20351195] [PUBMED:17145306]
CXCR4-mediated signaling events [NCBI:137910] [Pathway Interaction Database:cxcr4_pathway] [PUBMED:18799424] [PUBMED:17537990] [PUBMED:10881171] [PUBMED:17675482] [PUBMED:11157475] [PUBMED:12077227] [PUBMED:11544290] [PUBMED:8752280] [PUBMED:12535795] [PUBMED:19380820] [PUBMED:10952719] [PUBMED:16230460] [PUBMED:12682230] [PUBMED:16503409] [PUBMED:10644702] [PUBMED:9722546] [PUBMED:11784854] [PUBMED:10491003] [PUBMED:10521508] [PUBMED:10606629] [PUBMED:15615703] [PUBMED:17568820] [PUBMED:10753828] [PUBMED:12519755] [PUBMED:12032308] [PUBMED:8752281] [PUBMED:10570282] [PUBMED:11369622] [PUBMED:15728464] [PUBMED:12590707] [PUBMED:16038794] [PUBMED:14662753] [PUBMED:18596232] [PUBMED:17056591] [PUBMED:14602072] [PUBMED:15994292] [PUBMED:16919488] [PUBMED:15872091] [PUBMED:10506573] [PUBMED:12036857] [PUBMED:15618472] [PUBMED:14704365] [PUBMED:18227351] [PUBMED:11641392] [PUBMED:18319399] [PUBMED:12133960] [PUBMED:15630457]
Calcineurin-regulated NFAT-dependent transcription in lymphocytes [NCBI:137993] [Pathway Interaction Database:nfat_tfpathway] [PUBMED:11254715] [PUBMED:11356833] [PUBMED:12121669] [PUBMED:10878360] [PUBMED:11786533] [PUBMED:8284217] [PUBMED:10816557] [PUBMED:11956291] [PUBMED:7510691] [PUBMED:9195954] [PUBMED:8240350] [PUBMED:12452838] [PUBMED:8623163] [PUBMED:15834410] [PUBMED:10894164] [PUBMED:10970869] [PUBMED:10755616] [PUBMED:14607827] [PUBMED:12705856] [PUBMED:12086671] [PUBMED:7982959] [PUBMED:9047239] [PUBMED:12374808] [PUBMED:14573767] [PUBMED:12560487] [PUBMED:10570264] [PUBMED:8397339] [PUBMED:12055628] [PUBMED:15308098] [PUBMED:12065418] [PUBMED:7891702] [PUBMED:7749982] [PUBMED:14973438] [PUBMED:8674125] [PUBMED:16873067] [PUBMED:12453415] [PUBMED:8441422] [PUBMED:1737937] [PUBMED:10671476] [PUBMED:8376940] [PUBMED:9545284]
Class I MHC mediated antigen processing & presentation [NCBI:1269192] [REACTOME:R-HSA-983169] [PUBMED:8717519] [PUBMED:17145306] [PUBMED:18926908] [PUBMED:17055423] [PUBMED:12495737] [PUBMED:18641646] [PUBMED:18243674]
Degradation of GLI1 by the proteasome [NCBI:1269639] [REACTOME:R-HSA-5610780] [PUBMED:17283082] [PUBMED:10075717] [PUBMED:10725236] [PUBMED:21921029] [PUBMED:12361967]
Downregulation of ERBB4 signaling [NCBI:1269500] [REACTOME:R-HSA-1253288]
Endocytosis [NCBI:102279] [KEGG:hsa04144] [PUBMED:19696797] [PUBMED:19007773] [PUBMED:16203612] [PUBMED:15687999] [PUBMED:19924646] [PUBMED:15261671] [PUBMED:18647649] [PUBMED:19325624] [PUBMED:20110990] [PUBMED:22193161]
ErbB4 signaling events [NCBI:137991] [Pathway Interaction Database:erbb4_pathway] [PUBMED:16815842] [PUBMED:8617750] [PUBMED:9663464] [PUBMED:12466964] [PUBMED:15345710] [PUBMED:16061658] [PUBMED:12954715] [PUBMED:17463226] [PUBMED:17646177] [PUBMED:17085783] [PUBMED:18721752] [PUBMED:15023535] [PUBMED:9556621] [PUBMED:12807903] [PUBMED:17486069] [PUBMED:10358079] [PUBMED:12454007] [PUBMED:8702723] [PUBMED:10693928] [PUBMED:18334649] [PUBMED:10725395] [PUBMED:11731109] [PUBMED:7477376] [PUBMED:16837552] [PUBMED:15863494] [PUBMED:19047365] [PUBMED:10722704] [PUBMED:19193720] [PUBMED:10348342] [PUBMED:17018285] [PUBMED:9135143] [PUBMED:9618494] [PUBMED:12716924] [PUBMED:18819924] [PUBMED:10867024] [PUBMED:15985438] [PUBMED:7559778] [PUBMED:7759543] [PUBMED:12824469] [PUBMED:10744726] [PUBMED:15746097] [PUBMED:18653779] [PUBMED:15534001] [PUBMED:17460065] [PUBMED:10508857] [PUBMED:15282549] [PUBMED:9362517] [PUBMED:9685416] [PUBMED:11679632] [PUBMED:10839362] [PUBMED:10353604]
Hedgehog 'off' state [NCBI:1269636] [REACTOME:R-HSA-5610787] [PUBMED:21801010] [PUBMED:20395968] [PUBMED:23719536] [PUBMED:21502959]
Hedgehog 'on' state [NCBI:1269640] [REACTOME:R-HSA-5632684] [PUBMED:23719536] [PUBMED:21502959] [PUBMED:21801010] [PUBMED:20395968]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
NOD1/2 Signaling Pathway [NCBI:1269252] [REACTOME:R-HSA-168638] [PUBMED:18928408] [PUBMED:18585455] [PUBMED:18414735]
Negative regulators of RIG-I/MDA5 signaling [NCBI:1269264] [REACTOME:R-HSA-936440] [PUBMED:18703349] [PUBMED:18549796]
Non-alcoholic fatty liver disease (NAFLD) [NCBI:862188] [KEGG:hsa04932] [PUBMED:21038418] [PUBMED:17498512] [PUBMED:19352614] [PUBMED:23299992] [PUBMED:22570745] [PUBMED:9285483] [PUBMED:12891546] [PUBMED:18061659] [PUBMED:22705006] [PUBMED:16364488] [PUBMED:18242193] [PUBMED:16374858] [PUBMED:22940046] [PUBMED:20619513] [PUBMED:20303879] [PUBMED:14685853] [PUBMED:16406828] [PUBMED:23545492] [PUBMED:21145844]
Notch signaling pathway [NCBI:83062] [KEGG:hsa04330] [NCBI:169345] [Pathway Interaction Database:notch_pathway] [PUBMED:11459941] [PUBMED:12682059] [PUBMED:11825871] [PUBMED:17658278] [PUBMED:15998794] [PUBMED:11101851] [PUBMED:19686683] [PUBMED:18490439] [PUBMED:11150244] [PUBMED:9694793] [PUBMED:10206645] [PUBMED:19704010] [PUBMED:16137758] [PUBMED:15288258] [PUBMED:17392792] [PUBMED:8749394] [PUBMED:15965470] [PUBMED:14566063] [PUBMED:19567869] [PUBMED:11585921] [PUBMED:18676613] [PUBMED:12913000] [PUBMED:10593990] [PUBMED:15274632] [PUBMED:11777909] [PUBMED:12015972] [PUBMED:10028969] [PUBMED:18043734] [PUBMED:17658279] [PUBMED:17575125] [PUBMED:10958687] [PUBMED:15300010] [PUBMED:10882062] [PUBMED:12374742] [PUBMED:11782429] [PUBMED:9653148] [PUBMED:9315665] [PUBMED:8643690] [PUBMED:17114293] [PUBMED:10837024] [PUBMED:15067010] [PUBMED:17296795] [PUBMED:10940313] [PUBMED:18628966] [PUBMED:12826675] [PUBMED:12681948] [PUBMED:16492672] [PUBMED:12551931] [PUBMED:15082708] [PUBMED:12464310] [PUBMED:12794186] [PUBMED:16107360] [PUBMED:19726682] [PUBMED:11486031] [PUBMED:16287852] [PUBMED:12297508] [PUBMED:16061358] [PUBMED:17107962] [PUBMED:9244302] [PUBMED:11425854] [PUBMED:9620803] [PUBMED:15272268] [PUBMED:18417156] [PUBMED:16000382] [PUBMED:11896183] [PUBMED:11604511] [PUBMED:16847353] [PUBMED:11432830] [PUBMED:15652348] [PUBMED:12417415] [PUBMED:14567914] [PUBMED:11006133] [PUBMED:18077452] [PUBMED:16144902] [PUBMED:15288257] [PUBMED:15585829] [PUBMED:12370315] [PUBMED:15288260] [PUBMED:17434929] [PUBMED:12814948] [PUBMED:10882063] [PUBMED:11518718]
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways [NCBI:1269251] [REACTOME:R-HSA-168643] [PUBMED:18928408]
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways [NCBI:1269259] [REACTOME:R-HSA-168928] [PUBMED:17395582] [PUBMED:17942531] [PUBMED:18701081] [PUBMED:17683970] [PUBMED:18989317] [PUBMED:16214811]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by ERBB4 [NCBI:1269496] [REACTOME:R-HSA-1236394] [PUBMED:9275162] [PUBMED:9168115] [PUBMED:17545517] [PUBMED:19193720] [PUBMED:16914727] [PUBMED:7929212] [PUBMED:16912174] [PUBMED:9135143] [PUBMED:10867024] [PUBMED:16778220] [PUBMED:17018285] [PUBMED:15534001] [PUBMED:8665853] [PUBMED:1706616] [PUBMED:10744726] [PUBMED:18653779] [PUBMED:11679632] [PUBMED:8617750] [PUBMED:7565730] [PUBMED:15023535] [PUBMED:16061658] [PUBMED:18721752] [PUBMED:16978839] [PUBMED:17463226] [PUBMED:10722704] [PUBMED:12869563] [PUBMED:19047365] [PUBMED:12807903] [PUBMED:9556621]
Signaling by Hedgehog [NCBI:1269633] [REACTOME:R-HSA-5358351] [PUBMED:19081070] [PUBMED:21801010] [PUBMED:15549094] [PUBMED:23719536]
Signaling by NOTCH [NCBI:1269530] [REACTOME:R-HSA-157118]
Signaling by NOTCH1 [NCBI:1269535] [REACTOME:R-HSA-1980143] [PUBMED:20972443] [PUBMED:8649374] [PUBMED:11740940] [PUBMED:15965470] [PUBMED:16284625] [PUBMED:9694793] [PUBMED:19567869] [PUBMED:12354787] [PUBMED:11585921] [PUBMED:20418862] [PUBMED:11226752] [PUBMED:9590294] [PUBMED:9315665] [PUBMED:17114293] [PUBMED:18094723] [PUBMED:10964718] [PUBMED:10879540] [PUBMED:8001118] [PUBMED:12050117] [PUBMED:18043734] [PUBMED:9819428] [PUBMED:15824097] [PUBMED:9244301] [PUBMED:16256737] [PUBMED:8687460] [PUBMED:19726682] [PUBMED:8313469] [PUBMED:15574878] [PUBMED:18296446] [PUBMED:16530044] [PUBMED:9620803] [PUBMED:18237417] [PUBMED:7566092] [PUBMED:18628966] [PUBMED:12391150] [PUBMED:12530964] [PUBMED:11006133] [PUBMED:18374649] [PUBMED:15107403] [PUBMED:18077452] [PUBMED:15652348] [PUBMED:15546612] [PUBMED:10882063] [PUBMED:14980219] [PUBMED:10713164] [PUBMED:9462510] [PUBMED:11461910] [PUBMED:14567914] [PUBMED:17003037] [PUBMED:17028573] [PUBMED:11044625] [PUBMED:10206645] [PUBMED:19524514]
TGF-beta receptor signaling [NCBI:138024] [Pathway Interaction Database:tgfbrpathway] [PUBMED:12118366] [PUBMED:8242743] [PUBMED:15221015] [PUBMED:9335507] [PUBMED:11278302] [PUBMED:16601693] [PUBMED:8391934] [PUBMED:1333888] [PUBMED:11438668] [PUBMED:17327236] [PUBMED:2879635] [PUBMED:11483955] [PUBMED:12717440] [PUBMED:8047140] [PUBMED:8576253] [PUBMED:9865696] [PUBMED:9346908] [PUBMED:17197390] [PUBMED:8533096] [PUBMED:8756725] [PUBMED:10615055] [PUBMED:10934479] [PUBMED:16251192] [PUBMED:7706248] [PUBMED:15946939] [PUBMED:7774578] [PUBMED:7988555] [PUBMED:11278251] [PUBMED:11027280] [PUBMED:17420258] [PUBMED:9169454] [PUBMED:12151385] [PUBMED:10757800] [PUBMED:12543979] [PUBMED:12475967] [PUBMED:9679059] [PUBMED:17673906] [PUBMED:9774674] [PUBMED:8893010] [PUBMED:1544886] [PUBMED:12958365] [PUBMED:12110587] [PUBMED:9233797] [PUBMED:11163210] [PUBMED:15496141] [PUBMED:7693660] [PUBMED:14657019] [PUBMED:12429842] [PUBMED:11124802] [PUBMED:11389444] [PUBMED:8798398] [PUBMED:15356634] [PUBMED:17272273] [PUBMED:1657407] [PUBMED:12589052] [PUBMED:11016919] [PUBMED:14718519] [PUBMED:10777621] [PUBMED:17384642] [PUBMED:1310899] [PUBMED:9856985] [PUBMED:10519551] [PUBMED:9155023] [PUBMED:12134160] [PUBMED:9215638] [PUBMED:12134149] [PUBMED:16157589] [PUBMED:12356868] [PUBMED:11387212] [PUBMED:12034739] [PUBMED:11739411] [PUBMED:15761148] [PUBMED:9463378] [PUBMED:11583628] [PUBMED:15684397] [PUBMED:8947046] [PUBMED:11781097]
TNF signaling pathway [NCBI:812256] [KEGG:hsa04668] [PUBMED:20489699] [PUBMED:14532286] [PUBMED:21232019] [PUBMED:11897488] [PUBMED:22296764] [PUBMED:10581243] [PUBMED:23085193] [PUBMED:23531747]
Ubiquitin mediated proteolysis [NCBI:83056] [KEGG:hsa04120] [PUBMED:16405856] [PUBMED:12944364] [PUBMED:16922408] [PUBMED:17588513] [PUBMED:16922367] [PUBMED:16922370] [PUBMED:16816840]