full name
ubiquitin conjugating enzyme E2 C

synonyms
dJ447F3.2, UBCH10, UBE2C, ENSG00000175063

HGNC
HGNC:15937

Entrez Gene
Gene:11065

ENSEMBL
ENSG00000175063

location
chr: 20
start: 44441255
stop: 44445596
strand: +

transcripts
NM_181802.1
NM_181799.1
NM_007019.2
NM_181800.1
NM_181803.1
NM_181801.2

pathways
APC-Cdc20 mediated degradation of Nek2A [NCBI:1269847] [REACTOME:R-HSA-179409] [PUBMED:11742988] [PUBMED:16648845]
APC/C-mediated degradation of cell cycle proteins [NCBI:1269838] [REACTOME:R-HSA-174143] [PUBMED:15678131] [PUBMED:12049731]
APC/C:Cdc20 mediated degradation of Cyclin B [NCBI:1269848] [REACTOME:R-HSA-174048] [PUBMED:11285280]
APC/C:Cdc20 mediated degradation of Securin [NCBI:1269849] [REACTOME:R-HSA-174154] [PUBMED:12070128] [PUBMED:10827941]
APC/C:Cdc20 mediated degradation of mitotic proteins [NCBI:1269844] [REACTOME:R-HSA-176409] [PUBMED:15949434] [PUBMED:10465783]
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 [NCBI:1269851] [REACTOME:R-HSA-174178] [PUBMED:16413484] [PUBMED:15678131]
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint [NCBI:1269845] [REACTOME:R-HSA-179419]
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins [NCBI:1269842] [REACTOME:R-HSA-176814] [PUBMED:15678131]
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
Antigen processing: Ubiquitination & Proteasome degradation [NCBI:1269193] [REACTOME:R-HSA-983168] [PUBMED:12648452] [PUBMED:11917093] [PUBMED:19489725] [PUBMED:14734113] [PUBMED:20351195] [PUBMED:17145306]
Autodegradation of Cdh1 by Cdh1:APC/C [NCBI:1269852] [REACTOME:R-HSA-174084] [PUBMED:15029244]
Cdc20:Phospho-APC/C mediated degradation of Cyclin A [NCBI:1269846] [REACTOME:R-HSA-174184] [PUBMED:11285280]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle Checkpoints [NCBI:1269742] [REACTOME:R-HSA-69620]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
Cellular Senescence [NCBI:1270426] [REACTOME:R-HSA-2559583] [PUBMED:21078816] [PUBMED:18711403] [PUBMED:22048312] [PUBMED:19818705] [PUBMED:17662938] [PUBMED:23746838] [PUBMED:9282108] [PUBMED:17667954] [PUBMED:13905658]
Cellular responses to stress [NCBI:1270414] [REACTOME:R-HSA-2262752] [PUBMED:15709958]
Class I MHC mediated antigen processing & presentation [NCBI:1269192] [REACTOME:R-HSA-983169] [PUBMED:8717519] [PUBMED:17145306] [PUBMED:18926908] [PUBMED:17055423] [PUBMED:12495737] [PUBMED:18641646] [PUBMED:18243674]
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase [NCBI:1269850] [REACTOME:R-HSA-176407] [PUBMED:15678131]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Inactivation of APC/C via direct inhibition of the APC/C complex [NCBI:1269762] [REACTOME:R-HSA-141430] [PUBMED:14593737] [PUBMED:11535616] [PUBMED:9637688]
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components [NCBI:1269761] [REACTOME:R-HSA-141405] [PUBMED:14593737]
M Phase [NCBI:1269810] [REACTOME:R-HSA-68886]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Mitotic Anaphase [NCBI:1269825] [REACTOME:R-HSA-68882]
Mitotic Metaphase and Anaphase [NCBI:1269823] [REACTOME:R-HSA-2555396]
Mitotic Spindle Checkpoint [NCBI:1269758] [REACTOME:R-HSA-69618] [PUBMED:14593737] [PUBMED:12360190]
Phosphorylation of the APC/C [NCBI:1269843] [REACTOME:R-HSA-176412] [PUBMED:10793135]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
Protein ubiquitination [NCBI:1457808] [REACTOME:R-HSA-8852135] [PUBMED:23912815] [PUBMED:17588513] [PUBMED:25175772] [PUBMED:19940261] [PUBMED:19775879] [PUBMED:23624913] [PUBMED:23657496] [PUBMED:23800009] [PUBMED:22708562] [PUBMED:26235645] [PUBMED:25833379] [PUBMED:26187467] [PUBMED:24699078] [PUBMED:26085183] [PUBMED:21883762] [PUBMED:23747565] [PUBMED:27002219] [PUBMED:27312108] [PUBMED:19436320] [PUBMED:23061719] [PUBMED:24457024] [PUBMED:24652853] [PUBMED:23732108] [PUBMED:22389392] [PUBMED:19754430] [PUBMED:19489725] [PUBMED:25815272]
Regulation of APC/C activators between G1/S and early anaphase [NCBI:1269839] [REACTOME:R-HSA-176408] [PUBMED:16508672] [PUBMED:12049731] [PUBMED:12208841] [PUBMED:15678131]
Regulation of mitotic cell cycle [NCBI:1269837] [REACTOME:R-HSA-453276]
Senescence-Associated Secretory Phenotype (SASP) [NCBI:1270431] [REACTOME:R-HSA-2559582] [PUBMED:18411265] [PUBMED:21979375] [PUBMED:18267069] [PUBMED:19597488] [PUBMED:19218920] [PUBMED:20818427] [PUBMED:11114305] [PUBMED:8617720] [PUBMED:22178396] [PUBMED:19805069] [PUBMED:23770676] [PUBMED:8384717] [PUBMED:18555777] [PUBMED:21686281] [PUBMED:20351173] [PUBMED:8688489] [PUBMED:19053174] [PUBMED:8234276] [PUBMED:18555778]
Separation of Sister Chromatids [NCBI:1269826] [REACTOME:R-HSA-2467813] [PUBMED:11081627] [PUBMED:10411507] [PUBMED:12070128] [PUBMED:12194817] [PUBMED:11509732]
Synthesis of active ubiquitin: roles of E1 and E2 enzymes [NCBI:1457809] [REACTOME:R-HSA-8866652] [PUBMED:26235645] [PUBMED:24457024] [PUBMED:27002219] [PUBMED:17597759] [PUBMED:19940261] [PUBMED:6277905] [PUBMED:6305978]
Ubiquitin mediated proteolysis [NCBI:83056] [KEGG:hsa04120] [PUBMED:16405856] [PUBMED:12944364] [PUBMED:16922408] [PUBMED:17588513] [PUBMED:16922367] [PUBMED:16922370] [PUBMED:16816840]