full name
cathepsin A

synonyms
GLB2, GSL, NGBE, PPCA, PPGB, CTSA, ENSG00000064601

HGNC
HGNC:9251

Entrez Gene
Gene:5476

ENSEMBL
ENSG00000064601

location
chr: 20
start: 44519591
stop: 44527459
strand: +

OMIM
OMIM:613111: CTSA (Autosomal recessive inheritance)
OMIM:256540: Galactosialidosis

transcripts
NM_001127695.1
NM_000308.2
NM_001167594.1

pathways
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
Asparagine N-linked glycosylation [NCBI:1268714] [REACTOME:R-HSA-446203] [PUBMED:16807922] [PUBMED:19647993] [PUBMED:10580125] [PUBMED:19616933] [PUBMED:20301507] [PUBMED:20301244]
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein [NCBI:1268715] [REACTOME:R-HSA-446193] [PUBMED:20301507]
Glycosphingolipid metabolism [NCBI:1270099] [REACTOME:R-HSA-1660662] [PUBMED:20919643]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Lysosome [NCBI:99052] [KEGG:hsa04142] [PUBMED:2943218] [PUBMED:12628346] [PUBMED:1883197] [PUBMED:18635948] [PUBMED:15987739]
MHC class II antigen presentation [NCBI:1269200] [REACTOME:R-HSA-2132295] [PUBMED:19703008] [PUBMED:9316394] [PUBMED:11684289] [PUBMED:19217269] [PUBMED:8689559]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins [NCBI:1270001] [REACTOME:R-HSA-556833]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Neutrophil degranulation [NCBI:1457780] [REACTOME:R-HSA-6798695] [PUBMED:20338884] [PUBMED:1378856] [PUBMED:17627888] [PUBMED:23650620] [PUBMED:8692836]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
Renin-angiotensin system [NCBI:83075] [KEGG:hsa04614] [PUBMED:16581295] [PUBMED:15549172] [PUBMED:12019279] [PUBMED:18793332] [PUBMED:12793984] [PUBMED:12505055] [PUBMED:23692861] [PUBMED:17229979] [PUBMED:12372844] [PUBMED:15173164] [PUBMED:15833268] [PUBMED:21951628] [PUBMED:25332897] [PUBMED:16286563] [PUBMED:12419208] [PUBMED:24760442] [PUBMED:15109615] [PUBMED:24273531] [PUBMED:16555051] [PUBMED:15549171] [PUBMED:17362841]
Sialic acid metabolism [NCBI:1268721] [REACTOME:R-HSA-4085001] [PUBMED:21689720] [PUBMED:22526796]
Sphingolipid metabolism [NCBI:82994] [KEGG:hsa00600] [NCBI:1270097] [REACTOME:R-HSA-428157] [PUBMED:11305904] [PUBMED:10652340] [PUBMED:12011104] [PUBMED:10366774] [PUBMED:8457204] [PUBMED:18165232] [PUBMED:1495423] [PUBMED:18216770]
Synthesis of substrates in N-glycan biosythesis [NCBI:1268716] [REACTOME:R-HSA-446219] [PUBMED:18597486]