full name
phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1

synonyms
P-REX1, PREX1, ENSG00000124126

HGNC
HGNC:32594

Entrez Gene
Gene:57580

ENSEMBL
ENSG00000124126

location
chr: 20
start: 47240787
stop: 47444420
strand: -

transcripts
ENST00000371941.3

pathways
Cell death signalling via NRAGE, NRIF and NADE [NCBI:1269447] [REACTOME:R-HSA-204998] [PUBMED:12787561]
Chemokine signaling pathway [NCBI:99051] [KEGG:hsa04062] [PUBMED:17371236] [PUBMED:19159344] [PUBMED:17169327] [PUBMED:10852130] [PUBMED:9765254] [PUBMED:15771581] [PUBMED:14607270] [PUBMED:18662984] [PUBMED:12495636] [PUBMED:15803148] [PUBMED:15046611] [PUBMED:12069927] [PUBMED:18711432] [PUBMED:17675482] [PUBMED:16144840] [PUBMED:17496928] [PUBMED:17537990] [PUBMED:11872087] [PUBMED:12051620] [PUBMED:14625285] [PUBMED:8576262] [PUBMED:11244042]
Class I PI3K signaling events [NCBI:138022] [Pathway Interaction Database:pi3kcipathway] [PUBMED:9072969] [PUBMED:15296756] [PUBMED:12780340] [PUBMED:11154281] [PUBMED:9326591] [PUBMED:10357815] [PUBMED:10586033] [PUBMED:9824312] [PUBMED:11001876] [PUBMED:9593664] [PUBMED:10770799] [PUBMED:9442017] [PUBMED:8643691] [PUBMED:7627555] [PUBMED:11102801] [PUBMED:9307042] [PUBMED:10506192] [PUBMED:11804589] [PUBMED:15879121] [PUBMED:11226282] [PUBMED:18024423] [PUBMED:8629002] [PUBMED:9550703] [PUBMED:14688341] [PUBMED:16418224] [PUBMED:8945478] [PUBMED:10333475] [PUBMED:10764758] [PUBMED:9417041] [PUBMED:8052307]
G alpha (12/13) signalling events [NCBI:1269579] [REACTOME:R-HSA-416482] [PUBMED:18814923] [PUBMED:19212140]
GPCR downstream signaling [NCBI:1269574] [REACTOME:R-HSA-388396] [PUBMED:12040175]
NRAGE signals death through JNK [NCBI:1269448] [REACTOME:R-HSA-193648] [PUBMED:12376548]
Regulation of RAC1 activity [NCBI:169346] [Pathway Interaction Database:rac1_reg_pathway] [PUBMED:8297393] [PUBMED:12134164] [PUBMED:15485841] [PUBMED:11707441] [PUBMED:17320046] [PUBMED:9857026] [PUBMED:9497316] [PUBMED:17254573] [PUBMED:15850775] [PUBMED:8352776] [PUBMED:15128856] [PUBMED:17403664] [PUBMED:8491184] [PUBMED:7753201] [PUBMED:9707409] [PUBMED:12432077] [PUBMED:8226937] [PUBMED:19934221] [PUBMED:17196961] [PUBMED:17640372] [PUBMED:11287617] [PUBMED:12515821] [PUBMED:16943182] [PUBMED:19861492] [PUBMED:10220378] [PUBMED:11431473] [PUBMED:10982832] [PUBMED:7673236] [PUBMED:10744696] [PUBMED:17599059] [PUBMED:17116687] [PUBMED:12923183] [PUBMED:10364228] [PUBMED:16628218] [PUBMED:8288572] [PUBMED:15306850] [PUBMED:11396949] [PUBMED:8496137] [PUBMED:11912491] [PUBMED:15649357] [PUBMED:7980444] [PUBMED:18325335] [PUBMED:15242348] [PUBMED:11955434] [PUBMED:15039778] [PUBMED:11685227] [PUBMED:15897194] [PUBMED:11130063] [PUBMED:10559863] [PUBMED:17052214] [PUBMED:11099046] [PUBMED:15728722] [PUBMED:16520382] [PUBMED:16492808] [PUBMED:12547822] [PUBMED:12446789] [PUBMED:11274357] [PUBMED:8419353] [PUBMED:16481401] [PUBMED:8276860] [PUBMED:15005707] [PUBMED:10499589] [PUBMED:11336673] [PUBMED:1903516] [PUBMED:12829596] [PUBMED:17332503] [PUBMED:11146652] [PUBMED:12134158] [PUBMED:8643598] [PUBMED:18212043]
Rho GTPase cycle [NCBI:1269508] [REACTOME:R-HSA-194840] [PUBMED:17222083] [PUBMED:9308960]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by GPCR [NCBI:1269543] [REACTOME:R-HSA-372790] [PUBMED:16902930] [PUBMED:10202136] [PUBMED:18043707]
Signaling by Rho GTPases [NCBI:1269507] [REACTOME:R-HSA-194315] [PUBMED:16212495] [PUBMED:15630019]
Signalling by NGF [NCBI:1269443] [REACTOME:R-HSA-166520]
p75 NTR receptor-mediated signalling [NCBI:1269445] [REACTOME:R-HSA-193704] [PUBMED:16699811] [PUBMED:16939974] [PUBMED:12671646]